Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B0V0_LEIMU

TriTrypDb:

LmxM.29.1780

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0016592	mediator complex	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B0V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0V0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.607
CLV_C14_Caspase3-7	195	199	PF00656	0.604
CLV_NRD_NRD_1	143	145	PF00675	0.453
CLV_NRD_NRD_1	268	270	PF00675	0.672
CLV_NRD_NRD_1	329	331	PF00675	0.442
CLV_NRD_NRD_1	89	91	PF00675	0.572
CLV_PCSK_KEX2_1	114	116	PF00082	0.598
CLV_PCSK_KEX2_1	143	145	PF00082	0.431
CLV_PCSK_KEX2_1	148	150	PF00082	0.358
CLV_PCSK_KEX2_1	268	270	PF00082	0.616
CLV_PCSK_KEX2_1	329	331	PF00082	0.439
CLV_PCSK_KEX2_1	89	91	PF00082	0.563
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.402
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.387
CLV_PCSK_PC7_1	144	150	PF00082	0.506
CLV_PCSK_PC7_1	325	331	PF00082	0.435
CLV_PCSK_SKI1_1	115	119	PF00082	0.708
CLV_PCSK_SKI1_1	148	152	PF00082	0.406
CLV_PCSK_SKI1_1	168	172	PF00082	0.396
CLV_PCSK_SKI1_1	329	333	PF00082	0.333
CLV_PCSK_SKI1_1	347	351	PF00082	0.255
CLV_PCSK_SKI1_1	377	381	PF00082	0.362
CLV_PCSK_SKI1_1	449	453	PF00082	0.349
CLV_PCSK_SKI1_1	537	541	PF00082	0.414
CLV_PCSK_SKI1_1	569	573	PF00082	0.537
CLV_PCSK_SKI1_1	591	595	PF00082	0.647
DEG_APCC_DBOX_1	114	122	PF00400	0.414
DEG_APCC_DBOX_1	590	598	PF00400	0.617
DOC_CKS1_1	405	410	PF01111	0.428
DOC_CYCLIN_RxL_1	325	335	PF00134	0.291
DOC_CYCLIN_RxL_1	446	456	PF00134	0.361
DOC_MAPK_gen_1	137	147	PF00069	0.611
DOC_MAPK_gen_1	268	276	PF00069	0.673
DOC_MAPK_gen_1	347	356	PF00069	0.230
DOC_PP1_RVXF_1	561	567	PF00149	0.514
DOC_PP2B_LxvP_1	480	483	PF13499	0.443
DOC_PP4_FxxP_1	372	375	PF00568	0.435
DOC_USP7_MATH_1	138	142	PF00917	0.491
DOC_USP7_MATH_1	187	191	PF00917	0.591
DOC_USP7_MATH_1	294	298	PF00917	0.588
DOC_USP7_MATH_1	309	313	PF00917	0.552
DOC_USP7_MATH_1	375	379	PF00917	0.481
DOC_USP7_MATH_1	481	485	PF00917	0.328
DOC_USP7_MATH_1	501	505	PF00917	0.411
DOC_USP7_MATH_1	71	75	PF00917	0.734
DOC_USP7_MATH_2	107	113	PF00917	0.391
DOC_WW_Pin1_4	103	108	PF00397	0.612
DOC_WW_Pin1_4	22	27	PF00397	0.629
DOC_WW_Pin1_4	292	297	PF00397	0.792
DOC_WW_Pin1_4	312	317	PF00397	0.711
DOC_WW_Pin1_4	384	389	PF00397	0.476
DOC_WW_Pin1_4	404	409	PF00397	0.306
LIG_14-3-3_CanoR_1	174	183	PF00244	0.323
LIG_14-3-3_CanoR_1	412	416	PF00244	0.313
LIG_14-3-3_CanoR_1	533	540	PF00244	0.317
LIG_14-3-3_CanoR_1	569	574	PF00244	0.503
LIG_Actin_WH2_1	320	335	PF00022	0.451
LIG_Actin_WH2_2	348	365	PF00022	0.428
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BRCT_BRCA1_1	368	372	PF00533	0.393
LIG_deltaCOP1_diTrp_1	434	442	PF00928	0.301
LIG_EH1_1	325	333	PF00400	0.313
LIG_eIF4E_1	326	332	PF01652	0.435
LIG_EVH1_1	390	394	PF00568	0.178
LIG_FHA_1	297	303	PF00498	0.554
LIG_FHA_1	333	339	PF00498	0.353
LIG_FHA_1	577	583	PF00498	0.552
LIG_FHA_2	104	110	PF00498	0.585
LIG_FHA_2	242	248	PF00498	0.494
LIG_FHA_2	380	386	PF00498	0.387
LIG_FHA_2	429	435	PF00498	0.435
LIG_FHA_2	533	539	PF00498	0.313
LIG_FHA_2	553	559	PF00498	0.441
LIG_LIR_Apic_2	369	375	PF02991	0.435
LIG_LIR_Apic_2	414	420	PF02991	0.301
LIG_LIR_Apic_2	471	476	PF02991	0.434
LIG_LIR_Nem_3	25	31	PF02991	0.509
LIG_Pex14_2	372	376	PF04695	0.178
LIG_SH2_CRK	473	477	PF00017	0.362
LIG_SH2_NCK_1	473	477	PF00017	0.362
LIG_SH2_STAT5	183	186	PF00017	0.363
LIG_SH2_STAT5	326	329	PF00017	0.330
LIG_SH2_STAT5	34	37	PF00017	0.579
LIG_SH3_3	225	231	PF00018	0.432
LIG_SH3_3	385	391	PF00018	0.394
LIG_SH3_3	41	47	PF00018	0.717
LIG_SH3_3	480	486	PF00018	0.433
LIG_SH3_3	493	499	PF00018	0.423
LIG_SH3_3	60	66	PF00018	0.666
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.355
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.319
LIG_UBA3_1	441	449	PF00899	0.430
LIG_UBA3_1	460	466	PF00899	0.182
LIG_WW_3	487	491	PF00397	0.362
MOD_CK1_1	190	196	PF00069	0.720
MOD_CK1_1	197	203	PF00069	0.671
MOD_CK1_1	279	285	PF00069	0.698
MOD_CK1_1	292	298	PF00069	0.580
MOD_CK1_1	312	318	PF00069	0.684
MOD_CK1_1	410	416	PF00069	0.352
MOD_CK1_1	471	477	PF00069	0.241
MOD_CK1_1	73	79	PF00069	0.498
MOD_CK2_1	103	109	PF00069	0.456
MOD_CK2_1	241	247	PF00069	0.496
MOD_CK2_1	379	385	PF00069	0.367
MOD_CK2_1	386	392	PF00069	0.385
MOD_CK2_1	451	457	PF00069	0.339
MOD_CK2_1	532	538	PF00069	0.358
MOD_Cter_Amidation	141	144	PF01082	0.529
MOD_GlcNHglycan	109	114	PF01048	0.599
MOD_GlcNHglycan	140	143	PF01048	0.503
MOD_GlcNHglycan	161	165	PF01048	0.566
MOD_GlcNHglycan	194	197	PF01048	0.680
MOD_GlcNHglycan	216	220	PF01048	0.560
MOD_GlcNHglycan	279	282	PF01048	0.699
MOD_GlcNHglycan	292	295	PF01048	0.565
MOD_GlcNHglycan	312	315	PF01048	0.587
MOD_GlcNHglycan	368	371	PF01048	0.324
MOD_GlcNHglycan	377	380	PF01048	0.304
MOD_GlcNHglycan	470	473	PF01048	0.397
MOD_GlcNHglycan	550	553	PF01048	0.562
MOD_GlcNHglycan	68	71	PF01048	0.714
MOD_GlcNHglycan	97	100	PF01048	0.484
MOD_GSK3_1	190	197	PF00069	0.628
MOD_GSK3_1	22	29	PF00069	0.616
MOD_GSK3_1	272	279	PF00069	0.707
MOD_GSK3_1	290	297	PF00069	0.744
MOD_GSK3_1	312	319	PF00069	0.675
MOD_GSK3_1	375	382	PF00069	0.341
MOD_GSK3_1	407	414	PF00069	0.330
MOD_GSK3_1	471	478	PF00069	0.325
MOD_GSK3_1	53	60	PF00069	0.561
MOD_GSK3_1	548	555	PF00069	0.583
MOD_GSK3_1	66	73	PF00069	0.500
MOD_NEK2_1	241	246	PF00069	0.389
MOD_NEK2_1	276	281	PF00069	0.728
MOD_NEK2_1	289	294	PF00069	0.492
MOD_NEK2_1	332	337	PF00069	0.396
MOD_NEK2_1	338	343	PF00069	0.461
MOD_NEK2_1	349	354	PF00069	0.480
MOD_NEK2_1	4	9	PF00069	0.610
MOD_NEK2_1	451	456	PF00069	0.193
MOD_NEK2_1	468	473	PF00069	0.161
MOD_NEK2_2	26	31	PF00069	0.552
MOD_NEK2_2	272	277	PF00069	0.659
MOD_OFUCOSY	336	342	PF10250	0.428
MOD_PIKK_1	36	42	PF00454	0.718
MOD_PKA_2	332	338	PF00069	0.208
MOD_PKA_2	411	417	PF00069	0.301
MOD_PKA_2	532	538	PF00069	0.301
MOD_Plk_1	168	174	PF00069	0.400
MOD_Plk_4	162	168	PF00069	0.432
MOD_Plk_4	272	278	PF00069	0.662
MOD_Plk_4	475	481	PF00069	0.438
MOD_Plk_4	569	575	PF00069	0.549
MOD_ProDKin_1	103	109	PF00069	0.607
MOD_ProDKin_1	22	28	PF00069	0.623
MOD_ProDKin_1	292	298	PF00069	0.792
MOD_ProDKin_1	312	318	PF00069	0.703
MOD_ProDKin_1	384	390	PF00069	0.476
MOD_ProDKin_1	404	410	PF00069	0.306
MOD_SUMO_for_1	82	85	PF00179	0.587
MOD_SUMO_rev_2	557	561	PF00179	0.379
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.592
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.474
TRG_ENDOCYTIC_2	225	228	PF00928	0.509
TRG_ENDOCYTIC_2	97	100	PF00928	0.519
TRG_ER_diArg_1	143	145	PF00400	0.453
TRG_ER_diArg_1	267	269	PF00400	0.543
TRG_ER_diArg_1	328	330	PF00400	0.435
TRG_ER_diArg_1	88	90	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJY2	Leptomonas seymouri	48%	96%
A0A0S4IN21	Bodo saltans	27%	100%
A0A1X0P246	Trypanosomatidae	31%	100%
A0A3S5H7N0	Leishmania donovani	87%	100%
A0A422P3I6	Trypanosoma rangeli	30%	100%
A4H934	Leishmania braziliensis	75%	100%
A4I5K5	Leishmania infantum	87%	100%
C9ZQY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q7B6	Leishmania major	89%	100%
V5DQL7	Trypanosoma cruzi	31%	100%