Intraflagellar transport protein 46 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Intraflagellar transport complex B protein 46 C terminal, putative

Species:

Leishmania mexicana

UniProt:

E9B0U9_LEIMU

TriTrypDb:

LmxM.29.1770

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	10
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0031514	motile cilium	5	2
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9B0U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0U9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.391
CLV_C14_Caspase3-7	338	342	PF00656	0.403
CLV_PCSK_SKI1_1	275	279	PF00082	0.297
DEG_Nend_UBRbox_2	1	3	PF02207	0.551
DEG_SCF_FBW7_1	32	38	PF00400	0.645
DOC_CKS1_1	32	37	PF01111	0.529
DOC_CKS1_1	78	83	PF01111	0.561
DOC_PP2B_LxvP_1	331	334	PF13499	0.416
DOC_USP7_MATH_1	157	161	PF00917	0.446
DOC_USP7_MATH_1	35	39	PF00917	0.648
DOC_USP7_MATH_1	73	77	PF00917	0.708
DOC_USP7_UBL2_3	271	275	PF12436	0.403
DOC_WW_Pin1_4	31	36	PF00397	0.529
DOC_WW_Pin1_4	69	74	PF00397	0.607
DOC_WW_Pin1_4	77	82	PF00397	0.554
LIG_14-3-3_CanoR_1	154	163	PF00244	0.455
LIG_14-3-3_CanoR_1	264	272	PF00244	0.503
LIG_14-3-3_CanoR_1	36	40	PF00244	0.668
LIG_AP2alpha_2	199	201	PF02296	0.403
LIG_APCC_ABBA_1	347	352	PF00400	0.403
LIG_FHA_2	108	114	PF00498	0.732
LIG_FHA_2	192	198	PF00498	0.428
LIG_FHA_2	346	352	PF00498	0.558
LIG_GBD_Chelix_1	244	252	PF00786	0.255
LIG_LIR_Apic_2	280	286	PF02991	0.416
LIG_LIR_Gen_1	199	207	PF02991	0.403
LIG_LIR_Gen_1	335	343	PF02991	0.403
LIG_LIR_Nem_3	165	170	PF02991	0.453
LIG_LIR_Nem_3	172	176	PF02991	0.403
LIG_LIR_Nem_3	199	204	PF02991	0.403
LIG_LIR_Nem_3	335	339	PF02991	0.403
LIG_LIR_Nem_3	348	353	PF02991	0.403
LIG_PCNA_yPIPBox_3	317	325	PF02747	0.455
LIG_Pex14_1	297	301	PF04695	0.403
LIG_SH2_CRK	152	156	PF00017	0.403
LIG_SH2_CRK	283	287	PF00017	0.430
LIG_SH2_CRK	336	340	PF00017	0.403
LIG_SH2_NCK_1	152	156	PF00017	0.403
LIG_SH2_STAP1	336	340	PF00017	0.459
LIG_SH2_STAT3	123	126	PF00017	0.507
LIG_SH2_STAT5	191	194	PF00017	0.403
LIG_SH2_STAT5	323	326	PF00017	0.410
LIG_SH2_STAT5	43	46	PF00017	0.521
LIG_SH3_1	183	189	PF00018	0.403
LIG_SH3_3	13	19	PF00018	0.662
LIG_SH3_3	137	143	PF00018	0.548
LIG_SH3_3	183	189	PF00018	0.472
LIG_SH3_3	199	205	PF00018	0.403
LIG_SH3_3	216	222	PF00018	0.503
LIG_SH3_3	29	35	PF00018	0.527
LIG_SH3_3	306	312	PF00018	0.459
LIG_SH3_3	67	73	PF00018	0.651
LIG_SH3_3	75	81	PF00018	0.533
LIG_SUMO_SIM_par_1	230	235	PF11976	0.403
LIG_SUMO_SIM_par_1	329	335	PF11976	0.403
MOD_CDK_SPK_2	31	36	PF00069	0.526
MOD_CK2_1	345	351	PF00069	0.513
MOD_GlcNHglycan	6	9	PF01048	0.622
MOD_GlcNHglycan	73	76	PF01048	0.661
MOD_GSK3_1	31	38	PF00069	0.602
MOD_GSK3_1	335	342	PF00069	0.421
MOD_GSK3_1	69	76	PF00069	0.566
MOD_N-GLC_1	155	160	PF02516	0.205
MOD_N-GLC_1	236	241	PF02516	0.297
MOD_NEK2_1	1	6	PF00069	0.688
MOD_NEK2_1	236	241	PF00069	0.403
MOD_NEK2_1	339	344	PF00069	0.422
MOD_PIKK_1	73	79	PF00454	0.658
MOD_PKA_2	35	41	PF00069	0.695
MOD_Plk_2-3	107	113	PF00069	0.681
MOD_Plk_4	289	295	PF00069	0.416
MOD_Plk_4	335	341	PF00069	0.420
MOD_Plk_4	39	45	PF00069	0.550
MOD_ProDKin_1	31	37	PF00069	0.527
MOD_ProDKin_1	69	75	PF00069	0.607
MOD_ProDKin_1	77	83	PF00069	0.554
MOD_SUMO_rev_2	263	272	PF00179	0.403
TRG_ENDOCYTIC_2	152	155	PF00928	0.403
TRG_ENDOCYTIC_2	173	176	PF00928	0.416
TRG_ENDOCYTIC_2	336	339	PF00928	0.403
TRG_ENDOCYTIC_2	350	353	PF00928	0.403
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.210

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW27	Leptomonas seymouri	76%	81%
A0A1X0P2W6	Trypanosomatidae	59%	85%
A0A3S7X3G9	Leishmania donovani	96%	100%
A0A422P3H3	Trypanosoma rangeli	58%	80%
A2T2X4	Chlamydomonas reinhardtii	37%	100%
A4H935	Leishmania braziliensis	86%	100%
A4I5K4	Leishmania infantum	96%	100%
C9ZQY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	83%
Q4Q7B7	Leishmania major	96%	100%
V5BU25	Trypanosoma cruzi	57%	79%