Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0U5_LEIMU

TriTrypDb:

LmxM.29.1730

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.576
CLV_NRD_NRD_1	205	207	PF00675	0.676
CLV_NRD_NRD_1	331	333	PF00675	0.429
CLV_NRD_NRD_1	364	366	PF00675	0.540
CLV_NRD_NRD_1	60	62	PF00675	0.596
CLV_PCSK_KEX2_1	205	207	PF00082	0.778
CLV_PCSK_KEX2_1	331	333	PF00082	0.337
CLV_PCSK_KEX2_1	60	62	PF00082	0.596
CLV_PCSK_SKI1_1	177	181	PF00082	0.637
CLV_PCSK_SKI1_1	307	311	PF00082	0.558
DEG_APCC_KENBOX_2	134	138	PF00400	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DOC_CYCLIN_RxL_1	123	136	PF00134	0.452
DOC_CYCLIN_RxL_1	220	234	PF00134	0.631
DOC_MAPK_gen_1	365	371	PF00069	0.362
DOC_MAPK_MEF2A_6	380	389	PF00069	0.558
DOC_PP1_RVXF_1	127	134	PF00149	0.544
DOC_USP7_MATH_1	119	123	PF00917	0.496
DOC_USP7_MATH_1	208	212	PF00917	0.598
DOC_USP7_MATH_1	54	58	PF00917	0.707
DOC_WW_Pin1_4	189	194	PF00397	0.670
LIG_14-3-3_CanoR_1	116	124	PF00244	0.500
LIG_14-3-3_CanoR_1	127	132	PF00244	0.419
LIG_14-3-3_CanoR_1	169	175	PF00244	0.412
LIG_14-3-3_CanoR_1	177	183	PF00244	0.499
LIG_14-3-3_CanoR_1	232	239	PF00244	0.733
LIG_14-3-3_CanoR_1	300	304	PF00244	0.618
LIG_14-3-3_CanoR_1	307	316	PF00244	0.472
LIG_14-3-3_CanoR_1	358	363	PF00244	0.557
LIG_14-3-3_CanoR_1	43	49	PF00244	0.582
LIG_AP2alpha_2	9	11	PF02296	0.511
LIG_BIR_III_2	41	45	PF00653	0.645
LIG_BRCT_BRCA1_1	129	133	PF00533	0.525
LIG_BRCT_BRCA1_1	243	247	PF00533	0.492
LIG_BRCT_BRCA1_2	129	135	PF00533	0.524
LIG_CtBP_PxDLS_1	221	225	PF00389	0.596
LIG_FHA_1	182	188	PF00498	0.694
LIG_FHA_1	275	281	PF00498	0.685
LIG_FHA_1	333	339	PF00498	0.522
LIG_FHA_1	346	352	PF00498	0.501
LIG_FHA_1	357	363	PF00498	0.576
LIG_FHA_1	54	60	PF00498	0.597
LIG_FHA_2	178	184	PF00498	0.602
LIG_FHA_2	208	214	PF00498	0.542
LIG_FHA_2	359	365	PF00498	0.481
LIG_LIR_Gen_1	17	24	PF02991	0.561
LIG_LIR_Gen_1	244	253	PF02991	0.454
LIG_LIR_Gen_1	391	396	PF02991	0.378
LIG_LIR_Nem_3	17	23	PF02991	0.534
LIG_LIR_Nem_3	244	250	PF02991	0.469
LIG_LIR_Nem_3	391	395	PF02991	0.373
LIG_PCNA_yPIPBox_3	202	216	PF02747	0.624
LIG_Rb_LxCxE_1	97	118	PF01857	0.364
LIG_SH2_CRK	392	396	PF00017	0.379
LIG_SH2_NCK_1	7	11	PF00017	0.484
LIG_SH2_SRC	20	23	PF00017	0.630
LIG_SH2_SRC	7	10	PF00017	0.577
LIG_SH2_STAP1	20	24	PF00017	0.702
LIG_SH2_STAP1	392	396	PF00017	0.379
LIG_SH2_STAP1	96	100	PF00017	0.420
LIG_SH2_STAT3	268	271	PF00017	0.491
LIG_SH2_STAT5	188	191	PF00017	0.465
LIG_SH3_3	190	196	PF00018	0.650
LIG_SUMO_SIM_anti_2	160	168	PF11976	0.402
LIG_SUMO_SIM_par_1	218	225	PF11976	0.586
LIG_TRAF2_1	158	161	PF00917	0.504
LIG_TRAF2_1	317	320	PF00917	0.520
LIG_TYR_ITIM	18	23	PF00017	0.530
LIG_Vh1_VBS_1	152	170	PF01044	0.527
MOD_CK1_1	181	187	PF00069	0.695
MOD_CK1_1	231	237	PF00069	0.667
MOD_CK1_1	299	305	PF00069	0.669
MOD_CK2_1	119	125	PF00069	0.416
MOD_CK2_1	154	160	PF00069	0.544
MOD_CK2_1	177	183	PF00069	0.701
MOD_CK2_1	188	194	PF00069	0.623
MOD_CK2_1	207	213	PF00069	0.769
MOD_GlcNHglycan	156	159	PF01048	0.499
MOD_GlcNHglycan	171	174	PF01048	0.399
MOD_GlcNHglycan	392	395	PF01048	0.443
MOD_GlcNHglycan	56	59	PF01048	0.634
MOD_GlcNHglycan	67	70	PF01048	0.670
MOD_GlcNHglycan	85	88	PF01048	0.647
MOD_GSK3_1	115	122	PF00069	0.478
MOD_GSK3_1	123	130	PF00069	0.468
MOD_GSK3_1	165	172	PF00069	0.529
MOD_GSK3_1	177	184	PF00069	0.562
MOD_GSK3_1	224	231	PF00069	0.662
MOD_GSK3_1	237	244	PF00069	0.566
MOD_GSK3_1	295	302	PF00069	0.550
MOD_GSK3_1	44	51	PF00069	0.646
MOD_GSK3_1	77	84	PF00069	0.652
MOD_N-GLC_1	208	213	PF02516	0.601
MOD_NEK2_1	165	170	PF00069	0.423
MOD_NEK2_1	182	187	PF00069	0.727
MOD_NEK2_1	222	227	PF00069	0.724
MOD_NEK2_1	228	233	PF00069	0.532
MOD_NEK2_1	338	343	PF00069	0.499
MOD_NEK2_2	243	248	PF00069	0.459
MOD_NEK2_2	77	82	PF00069	0.676
MOD_PIKK_1	200	206	PF00454	0.718
MOD_PIKK_1	302	308	PF00454	0.691
MOD_PIKK_1	315	321	PF00454	0.427
MOD_PIKK_1	332	338	PF00454	0.506
MOD_PKA_1	60	66	PF00069	0.590
MOD_PKA_2	115	121	PF00069	0.467
MOD_PKA_2	168	174	PF00069	0.444
MOD_PKA_2	231	237	PF00069	0.739
MOD_PKA_2	299	305	PF00069	0.656
MOD_PKA_2	59	65	PF00069	0.638
MOD_PKB_1	127	135	PF00069	0.469
MOD_PKB_1	356	364	PF00069	0.559
MOD_Plk_1	182	188	PF00069	0.679
MOD_Plk_1	208	214	PF00069	0.575
MOD_Plk_2-3	22	28	PF00069	0.535
MOD_Plk_4	183	189	PF00069	0.457
MOD_Plk_4	77	83	PF00069	0.579
MOD_ProDKin_1	189	195	PF00069	0.671
MOD_SUMO_rev_2	101	110	PF00179	0.447
MOD_SUMO_rev_2	372	382	PF00179	0.500
TRG_DiLeu_BaEn_1	161	166	PF01217	0.563
TRG_DiLeu_BaEn_3	161	167	PF01217	0.515
TRG_ENDOCYTIC_2	20	23	PF00928	0.544
TRG_ENDOCYTIC_2	392	395	PF00928	0.374
TRG_ER_diArg_1	148	151	PF00400	0.528
TRG_ER_diArg_1	330	332	PF00400	0.387
TRG_ER_diArg_1	357	360	PF00400	0.548
TRG_ER_diArg_1	59	61	PF00400	0.604
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I207	Leptomonas seymouri	42%	100%
A0A3Q8IBZ6	Leishmania donovani	85%	100%
A0A422P3J4	Trypanosoma rangeli	30%	100%
A4HIB6	Leishmania braziliensis	68%	98%
A4I5K0	Leishmania infantum	85%	100%
Q4Q7C1	Leishmania major	85%	98%
V5B8Y5	Trypanosoma cruzi	28%	100%