LeishMANIAdb
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AAA domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AAA domain-containing protein
Gene product:
AAA domain (Cdc48 subfamily), putative
Species:
Leishmania mexicana
UniProt:
E9B0U2_LEIMU
TriTrypDb:
LmxM.29.1700
Length:
860

Annotations

LeishMANIAdb annotations

These proteins are apparently divergent members of the greater ClpB family found in both Eukaryota and Prokaryota. The TM segments are unusual additions.. Anchored into the membrane using the very last 3 helical segment (similar to tail-anchored proteins)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9B0U2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0U2

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 1
GO:0009266 response to temperature stimulus 3 1
GO:0009408 response to heat 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034605 cellular response to heat 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 517 519 PF00675 0.367
CLV_NRD_NRD_1 586 588 PF00675 0.453
CLV_NRD_NRD_1 694 696 PF00675 0.623
CLV_NRD_NRD_1 71 73 PF00675 0.720
CLV_PCSK_FUR_1 86 90 PF00082 0.766
CLV_PCSK_KEX2_1 274 276 PF00082 0.427
CLV_PCSK_KEX2_1 344 346 PF00082 0.296
CLV_PCSK_KEX2_1 517 519 PF00082 0.358
CLV_PCSK_KEX2_1 586 588 PF00082 0.453
CLV_PCSK_KEX2_1 694 696 PF00082 0.626
CLV_PCSK_KEX2_1 71 73 PF00082 0.721
CLV_PCSK_KEX2_1 88 90 PF00082 0.699
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.452
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.362
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.761
CLV_PCSK_SKI1_1 163 167 PF00082 0.445
CLV_PCSK_SKI1_1 274 278 PF00082 0.446
CLV_PCSK_SKI1_1 434 438 PF00082 0.271
CLV_PCSK_SKI1_1 480 484 PF00082 0.353
CLV_PCSK_SKI1_1 527 531 PF00082 0.366
CLV_PCSK_SKI1_1 641 645 PF00082 0.557
CLV_PCSK_SKI1_1 753 757 PF00082 0.423
CLV_PCSK_SKI1_1 769 773 PF00082 0.307
CLV_PCSK_SKI1_1 77 81 PF00082 0.717
CLV_PCSK_SKI1_1 827 831 PF00082 0.386
DEG_APCC_DBOX_1 162 170 PF00400 0.362
DEG_APCC_DBOX_1 264 272 PF00400 0.684
DEG_SCF_FBW7_1 684 691 PF00400 0.682
DEG_SCF_FBW7_1 709 715 PF00400 0.679
DEG_SPOP_SBC_1 225 229 PF00917 0.716
DEG_SPOP_SBC_1 615 619 PF00917 0.800
DEG_SPOP_SBC_1 703 707 PF00917 0.751
DOC_CKS1_1 540 545 PF01111 0.545
DOC_CKS1_1 709 714 PF01111 0.752
DOC_CYCLIN_RxL_1 738 748 PF00134 0.607
DOC_CYCLIN_RxL_1 750 760 PF00134 0.569
DOC_CYCLIN_RxL_1 769 783 PF00134 0.477
DOC_CYCLIN_yCln2_LP_2 815 821 PF00134 0.447
DOC_CYCLIN_yCln2_LP_2 832 838 PF00134 0.447
DOC_MAPK_gen_1 161 168 PF00069 0.314
DOC_MAPK_gen_1 514 523 PF00069 0.551
DOC_MAPK_HePTP_8 772 784 PF00069 0.562
DOC_MAPK_JIP1_4 325 331 PF00069 0.562
DOC_MAPK_MEF2A_6 161 170 PF00069 0.335
DOC_MAPK_MEF2A_6 325 332 PF00069 0.482
DOC_MAPK_MEF2A_6 517 525 PF00069 0.537
DOC_MAPK_MEF2A_6 775 784 PF00069 0.493
DOC_MAPK_MEF2A_6 837 845 PF00069 0.447
DOC_PP2B_LxvP_1 681 684 PF13499 0.763
DOC_PP2B_LxvP_1 815 818 PF13499 0.447
DOC_PP4_FxxP_1 331 334 PF00568 0.534
DOC_USP7_MATH_1 136 140 PF00917 0.555
DOC_USP7_MATH_1 188 192 PF00917 0.613
DOC_USP7_MATH_1 225 229 PF00917 0.697
DOC_USP7_MATH_1 254 258 PF00917 0.703
DOC_USP7_MATH_1 285 289 PF00917 0.662
DOC_USP7_MATH_1 296 300 PF00917 0.609
DOC_USP7_MATH_1 310 314 PF00917 0.588
DOC_USP7_MATH_1 439 443 PF00917 0.482
DOC_USP7_MATH_1 457 461 PF00917 0.482
DOC_USP7_MATH_1 599 603 PF00917 0.703
DOC_USP7_MATH_1 610 614 PF00917 0.781
DOC_USP7_MATH_1 647 651 PF00917 0.710
DOC_USP7_MATH_1 688 692 PF00917 0.704
DOC_USP7_MATH_1 702 706 PF00917 0.786
DOC_USP7_MATH_1 712 716 PF00917 0.699
DOC_USP7_MATH_1 720 724 PF00917 0.730
DOC_WW_Pin1_4 286 291 PF00397 0.682
DOC_WW_Pin1_4 469 474 PF00397 0.586
DOC_WW_Pin1_4 539 544 PF00397 0.547
DOC_WW_Pin1_4 64 69 PF00397 0.584
DOC_WW_Pin1_4 679 684 PF00397 0.830
DOC_WW_Pin1_4 686 691 PF00397 0.765
DOC_WW_Pin1_4 708 713 PF00397 0.783
DOC_WW_Pin1_4 89 94 PF00397 0.530
LIG_14-3-3_CanoR_1 221 230 PF00244 0.687
LIG_14-3-3_CanoR_1 265 269 PF00244 0.648
LIG_14-3-3_CanoR_1 305 315 PF00244 0.576
LIG_14-3-3_CanoR_1 345 350 PF00244 0.562
LIG_14-3-3_CanoR_1 441 447 PF00244 0.478
LIG_14-3-3_CanoR_1 478 483 PF00244 0.417
LIG_14-3-3_CanoR_1 552 557 PF00244 0.623
LIG_14-3-3_CanoR_1 9 17 PF00244 0.503
LIG_Actin_WH2_2 784 800 PF00022 0.447
LIG_AP2alpha_2 497 499 PF02296 0.465
LIG_APCC_ABBA_1 147 152 PF00400 0.500
LIG_BRCT_BRCA1_1 785 789 PF00533 0.285
LIG_EH1_1 788 796 PF00400 0.402
LIG_eIF4E_1 836 842 PF01652 0.480
LIG_FHA_1 144 150 PF00498 0.462
LIG_FHA_1 212 218 PF00498 0.806
LIG_FHA_1 235 241 PF00498 0.633
LIG_FHA_1 325 331 PF00498 0.505
LIG_FHA_1 446 452 PF00498 0.487
LIG_FHA_1 565 571 PF00498 0.624
LIG_FHA_1 590 596 PF00498 0.629
LIG_FHA_1 704 710 PF00498 0.777
LIG_FHA_1 735 741 PF00498 0.641
LIG_FHA_1 750 756 PF00498 0.592
LIG_FHA_2 108 114 PF00498 0.454
LIG_FHA_2 287 293 PF00498 0.650
LIG_FHA_2 492 498 PF00498 0.488
LIG_FHA_2 511 517 PF00498 0.528
LIG_FHA_2 558 564 PF00498 0.655
LIG_FHA_2 598 604 PF00498 0.710
LIG_FHA_2 621 627 PF00498 0.605
LIG_FHA_2 749 755 PF00498 0.640
LIG_FHA_2 97 103 PF00498 0.583
LIG_GBD_Chelix_1 777 785 PF00786 0.338
LIG_GBD_Chelix_1 807 815 PF00786 0.393
LIG_LIR_Apic_2 538 543 PF02991 0.610
LIG_LIR_Gen_1 109 118 PF02991 0.452
LIG_LIR_Gen_1 376 387 PF02991 0.482
LIG_LIR_Gen_1 542 553 PF02991 0.578
LIG_LIR_Gen_1 646 655 PF02991 0.671
LIG_LIR_Gen_1 730 740 PF02991 0.682
LIG_LIR_Nem_3 146 150 PF02991 0.479
LIG_LIR_Nem_3 376 382 PF02991 0.482
LIG_LIR_Nem_3 504 509 PF02991 0.516
LIG_LIR_Nem_3 542 548 PF02991 0.574
LIG_LIR_Nem_3 646 651 PF02991 0.691
LIG_LIR_Nem_3 730 736 PF02991 0.689
LIG_NRBOX 524 530 PF00104 0.603
LIG_NRBOX 780 786 PF00104 0.408
LIG_NRBOX 828 834 PF00104 0.402
LIG_NRBOX 840 846 PF00104 0.250
LIG_PCNA_PIPBox_1 476 485 PF02747 0.562
LIG_PCNA_yPIPBox_3 161 169 PF02747 0.369
LIG_PCNA_yPIPBox_3 476 488 PF02747 0.574
LIG_Pex14_1 423 427 PF04695 0.471
LIG_RPA_C_Plants 275 286 PF08784 0.517
LIG_SH2_CRK 540 544 PF00017 0.637
LIG_SH2_GRB2like 468 471 PF00017 0.516
LIG_SH2_NCK_1 379 383 PF00017 0.482
LIG_SH2_NCK_1 512 516 PF00017 0.589
LIG_SH2_NCK_1 540 544 PF00017 0.637
LIG_SH2_SRC 468 471 PF00017 0.516
LIG_SH2_STAP1 150 154 PF00017 0.470
LIG_SH2_STAP1 177 181 PF00017 0.527
LIG_SH2_STAT3 301 304 PF00017 0.534
LIG_SH2_STAT5 301 304 PF00017 0.527
LIG_SH2_STAT5 366 369 PF00017 0.498
LIG_SH2_STAT5 468 471 PF00017 0.482
LIG_SH2_STAT5 512 515 PF00017 0.611
LIG_SH3_3 179 185 PF00018 0.632
LIG_SH3_3 214 220 PF00018 0.816
LIG_SH3_3 28 34 PF00018 0.546
LIG_SH3_3 379 385 PF00018 0.482
LIG_SH3_3 505 511 PF00018 0.513
LIG_SH3_3 592 598 PF00018 0.575
LIG_SH3_3 649 655 PF00018 0.758
LIG_SH3_3 719 725 PF00018 0.733
LIG_SUMO_SIM_anti_2 241 246 PF11976 0.645
LIG_SUMO_SIM_anti_2 403 410 PF11976 0.484
LIG_SUMO_SIM_anti_2 592 597 PF11976 0.619
LIG_SUMO_SIM_par_1 403 410 PF11976 0.484
LIG_SUMO_SIM_par_1 579 585 PF11976 0.544
LIG_SUMO_SIM_par_1 741 746 PF11976 0.666
LIG_SUMO_SIM_par_1 778 783 PF11976 0.398
LIG_SUMO_SIM_par_1 840 846 PF11976 0.393
LIG_TRAF2_1 474 477 PF00917 0.528
LIG_TRAF2_1 560 563 PF00917 0.626
LIG_UBA3_1 394 400 PF00899 0.480
LIG_UBA3_1 482 488 PF00899 0.460
LIG_UBA3_1 742 747 PF00899 0.644
LIG_UBA3_1 770 775 PF00899 0.645
LIG_UBA3_1 790 798 PF00899 0.297
LIG_UBA3_1 829 837 PF00899 0.424
LIG_WRC_WIRS_1 108 113 PF05994 0.490
LIG_WRC_WIRS_1 144 149 PF05994 0.457
LIG_WRC_WIRS_1 369 374 PF05994 0.482
LIG_WRC_WIRS_1 553 558 PF05994 0.569
MOD_CDK_SPxxK_3 286 293 PF00069 0.674
MOD_CDK_SPxxK_3 64 71 PF00069 0.576
MOD_CK1_1 107 113 PF00069 0.514
MOD_CK1_1 224 230 PF00069 0.725
MOD_CK1_1 288 294 PF00069 0.525
MOD_CK1_1 371 377 PF00069 0.482
MOD_CK1_1 442 448 PF00069 0.480
MOD_CK1_1 45 51 PF00069 0.546
MOD_CK1_1 629 635 PF00069 0.697
MOD_CK1_1 698 704 PF00069 0.760
MOD_CK1_1 705 711 PF00069 0.723
MOD_CK1_1 783 789 PF00069 0.424
MOD_CK1_1 91 97 PF00069 0.541
MOD_CK2_1 254 260 PF00069 0.686
MOD_CK2_1 286 292 PF00069 0.610
MOD_CK2_1 353 359 PF00069 0.412
MOD_CK2_1 411 417 PF00069 0.562
MOD_CK2_1 432 438 PF00069 0.513
MOD_CK2_1 510 516 PF00069 0.523
MOD_CK2_1 528 534 PF00069 0.490
MOD_CK2_1 557 563 PF00069 0.532
MOD_CK2_1 597 603 PF00069 0.701
MOD_CK2_1 748 754 PF00069 0.612
MOD_GlcNHglycan 12 15 PF01048 0.693
MOD_GlcNHglycan 137 141 PF01048 0.756
MOD_GlcNHglycan 223 226 PF01048 0.512
MOD_GlcNHglycan 281 284 PF01048 0.478
MOD_GlcNHglycan 316 319 PF01048 0.444
MOD_GlcNHglycan 334 337 PF01048 0.225
MOD_GlcNHglycan 359 363 PF01048 0.296
MOD_GlcNHglycan 390 393 PF01048 0.308
MOD_GlcNHglycan 395 398 PF01048 0.282
MOD_GlcNHglycan 424 427 PF01048 0.295
MOD_GlcNHglycan 45 48 PF01048 0.816
MOD_GlcNHglycan 578 581 PF01048 0.389
MOD_GlcNHglycan 589 592 PF01048 0.374
MOD_GlcNHglycan 700 703 PF01048 0.605
MOD_GlcNHglycan 715 718 PF01048 0.548
MOD_GlcNHglycan 722 725 PF01048 0.514
MOD_GlcNHglycan 845 848 PF01048 0.407
MOD_GlcNHglycan 854 857 PF01048 0.685
MOD_GlcNHglycan 93 96 PF01048 0.794
MOD_GSK3_1 126 133 PF00069 0.521
MOD_GSK3_1 220 227 PF00069 0.761
MOD_GSK3_1 306 313 PF00069 0.551
MOD_GSK3_1 38 45 PF00069 0.567
MOD_GSK3_1 437 444 PF00069 0.479
MOD_GSK3_1 446 453 PF00069 0.470
MOD_GSK3_1 535 542 PF00069 0.633
MOD_GSK3_1 576 583 PF00069 0.625
MOD_GSK3_1 610 617 PF00069 0.766
MOD_GSK3_1 625 632 PF00069 0.772
MOD_GSK3_1 684 691 PF00069 0.769
MOD_GSK3_1 694 701 PF00069 0.760
MOD_GSK3_1 704 711 PF00069 0.740
MOD_GSK3_1 84 91 PF00069 0.557
MOD_N-GLC_1 469 474 PF02516 0.316
MOD_N-GLC_1 684 689 PF02516 0.609
MOD_N-GLC_1 749 754 PF02516 0.268
MOD_N-GLC_1 84 89 PF02516 0.541
MOD_NEK2_1 264 269 PF00069 0.644
MOD_NEK2_1 358 363 PF00069 0.534
MOD_NEK2_1 411 416 PF00069 0.556
MOD_NEK2_1 422 427 PF00069 0.366
MOD_NEK2_1 450 455 PF00069 0.472
MOD_NEK2_1 528 533 PF00069 0.589
MOD_NEK2_1 616 621 PF00069 0.636
MOD_NEK2_1 797 802 PF00069 0.337
MOD_NEK2_1 843 848 PF00069 0.320
MOD_PIKK_1 138 144 PF00454 0.505
MOD_PIKK_1 296 302 PF00454 0.631
MOD_PIKK_1 528 534 PF00454 0.616
MOD_PIKK_1 564 570 PF00454 0.630
MOD_PIKK_1 754 760 PF00454 0.472
MOD_PK_1 345 351 PF00069 0.562
MOD_PKA_1 694 700 PF00069 0.806
MOD_PKA_1 88 94 PF00069 0.585
MOD_PKA_2 220 226 PF00069 0.728
MOD_PKA_2 254 260 PF00069 0.695
MOD_PKA_2 264 270 PF00069 0.654
MOD_PKA_2 279 285 PF00069 0.585
MOD_PKA_2 446 452 PF00069 0.515
MOD_PKA_2 694 700 PF00069 0.760
MOD_PKA_2 88 94 PF00069 0.585
MOD_Plk_1 104 110 PF00069 0.539
MOD_Plk_1 39 45 PF00069 0.492
MOD_Plk_1 695 701 PF00069 0.759
MOD_Plk_2-3 104 110 PF00069 0.539
MOD_Plk_2-3 626 632 PF00069 0.596
MOD_Plk_4 12 18 PF00069 0.438
MOD_Plk_4 229 235 PF00069 0.594
MOD_Plk_4 324 330 PF00069 0.528
MOD_Plk_4 345 351 PF00069 0.562
MOD_Plk_4 374 380 PF00069 0.478
MOD_Plk_4 446 452 PF00069 0.487
MOD_Plk_4 780 786 PF00069 0.374
MOD_Plk_4 797 803 PF00069 0.211
MOD_Plk_4 817 823 PF00069 0.150
MOD_ProDKin_1 286 292 PF00069 0.680
MOD_ProDKin_1 469 475 PF00069 0.586
MOD_ProDKin_1 539 545 PF00069 0.544
MOD_ProDKin_1 64 70 PF00069 0.579
MOD_ProDKin_1 679 685 PF00069 0.832
MOD_ProDKin_1 686 692 PF00069 0.765
MOD_ProDKin_1 708 714 PF00069 0.781
MOD_ProDKin_1 89 95 PF00069 0.531
MOD_SUMO_for_1 727 730 PF00179 0.506
MOD_SUMO_rev_2 148 154 PF00179 0.482
TRG_DiLeu_BaEn_1 273 278 PF01217 0.555
TRG_DiLeu_BaEn_2 515 521 PF01217 0.583
TRG_DiLeu_BaEn_4 103 109 PF01217 0.548
TRG_DiLeu_BaLyEn_6 524 529 PF01217 0.602
TRG_ENDOCYTIC_2 366 369 PF00928 0.496
TRG_ENDOCYTIC_2 379 382 PF00928 0.374
TRG_ENDOCYTIC_2 733 736 PF00928 0.682
TRG_ER_diArg_1 160 163 PF00400 0.371
TRG_ER_diArg_1 586 588 PF00400 0.653
TRG_ER_diArg_1 71 74 PF00400 0.528
TRG_NES_CRM1_1 734 748 PF08389 0.570
TRG_Pf-PMV_PEXEL_1 275 279 PF00026 0.361
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.282
TRG_Pf-PMV_PEXEL_1 480 484 PF00026 0.386
TRG_Pf-PMV_PEXEL_1 527 532 PF00026 0.330
TRG_Pf-PMV_PEXEL_1 641 646 PF00026 0.567
TRG_Pf-PMV_PEXEL_1 741 746 PF00026 0.441
TRG_Pf-PMV_PEXEL_1 753 758 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 759 764 PF00026 0.327

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHZ4 Leptomonas seymouri 56% 87%
A0A1X0P2X6 Trypanosomatidae 42% 98%
A0A3Q8IEX3 Leishmania donovani 90% 100%
A0A422P3I3 Trypanosoma rangeli 41% 100%
A4HIB3 Leishmania braziliensis 81% 100%
A4I5J7 Leishmania infantum 90% 100%
C9ZQX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
Q4Q7C4 Leishmania major 90% 100%
V5BPI4 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS