CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0U0_LEIMU

TriTrypDb:

LmxM.29.1680

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0U0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005319	lipid transporter activity	2	1
GO:0005548	phospholipid transporter activity	3	1
GO:0008526	phosphatidylinositol transfer activity	5	1
GO:0120013	lipid transfer activity	3	1
GO:0120014	phospholipid transfer activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.494
CLV_NRD_NRD_1	126	128	PF00675	0.327
CLV_NRD_NRD_1	153	155	PF00675	0.317
CLV_NRD_NRD_1	18	20	PF00675	0.286
CLV_NRD_NRD_1	63	65	PF00675	0.318
CLV_PCSK_FUR_1	114	118	PF00082	0.170
CLV_PCSK_KEX2_1	116	118	PF00082	0.256
CLV_PCSK_KEX2_1	18	20	PF00082	0.286
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.170
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.286
CLV_PCSK_SKI1_1	171	175	PF00082	0.421
CLV_PCSK_SKI1_1	182	186	PF00082	0.280
DOC_CDC14_PxL_1	235	243	PF14671	0.567
DOC_CKS1_1	266	271	PF01111	0.498
DOC_CYCLIN_RxL_1	168	178	PF00134	0.445
DOC_MAPK_gen_1	114	121	PF00069	0.344
DOC_MAPK_gen_1	151	160	PF00069	0.338
DOC_MAPK_MEF2A_6	93	101	PF00069	0.284
DOC_PP1_RVXF_1	130	136	PF00149	0.378
DOC_PP2B_LxvP_1	103	106	PF13499	0.170
DOC_USP7_MATH_1	141	145	PF00917	0.344
DOC_USP7_MATH_1	280	284	PF00917	0.659
DOC_USP7_MATH_1	51	55	PF00917	0.261
DOC_USP7_UBL2_3	151	155	PF12436	0.369
DOC_USP7_UBL2_3	5	9	PF12436	0.472
DOC_WW_Pin1_4	265	270	PF00397	0.499
LIG_14-3-3_CanoR_1	132	136	PF00244	0.359
LIG_14-3-3_CanoR_1	176	180	PF00244	0.250
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BIR_III_3	1	5	PF00653	0.531
LIG_BIR_III_4	257	261	PF00653	0.496
LIG_Clathr_ClatBox_1	232	236	PF01394	0.290
LIG_FHA_1	1	7	PF00498	0.626
LIG_FHA_1	113	119	PF00498	0.404
LIG_FHA_1	132	138	PF00498	0.348
LIG_FHA_1	155	161	PF00498	0.348
LIG_FHA_2	108	114	PF00498	0.379
LIG_FHA_2	204	210	PF00498	0.391
LIG_FHA_2	224	230	PF00498	0.420
LIG_FHA_2	5	11	PF00498	0.433
LIG_FHA_2	71	77	PF00498	0.522
LIG_LIR_Gen_1	177	188	PF02991	0.378
LIG_LIR_Gen_1	36	45	PF02991	0.386
LIG_LIR_Nem_3	36	42	PF02991	0.385
LIG_PCNA_PIPBox_1	158	167	PF02747	0.324
LIG_PDZ_Class_1	292	297	PF00595	0.484
LIG_Pex14_1	135	139	PF04695	0.324
LIG_SH2_NCK_1	130	134	PF00017	0.419
LIG_SH2_STAP1	70	74	PF00017	0.515
LIG_SH2_STAT5	120	123	PF00017	0.343
LIG_SH2_STAT5	180	183	PF00017	0.301
LIG_SH2_STAT5	39	42	PF00017	0.370
LIG_TRAF2_1	110	113	PF00917	0.378
LIG_TRAF2_1	206	209	PF00917	0.391
LIG_TRAF2_1	73	76	PF00917	0.555
MOD_CK1_1	240	246	PF00069	0.656
MOD_CK1_1	35	41	PF00069	0.445
MOD_CK2_1	107	113	PF00069	0.379
MOD_CK2_1	203	209	PF00069	0.394
MOD_CK2_1	4	10	PF00069	0.425
MOD_CK2_1	70	76	PF00069	0.547
MOD_GlcNHglycan	229	232	PF01048	0.509
MOD_GlcNHglycan	293	297	PF01048	0.484
MOD_GSK3_1	223	230	PF00069	0.468
MOD_N-GLC_1	280	285	PF02516	0.516
MOD_N-GLC_2	107	109	PF02516	0.378
MOD_NEK2_1	122	127	PF00069	0.378
MOD_NEK2_1	174	179	PF00069	0.277
MOD_NEK2_1	227	232	PF00069	0.446
MOD_NEK2_1	291	296	PF00069	0.482
MOD_NEK2_1	34	39	PF00069	0.495
MOD_NEK2_1	57	62	PF00069	0.499
MOD_NEK2_1	81	86	PF00069	0.484
MOD_NEK2_2	223	228	PF00069	0.538
MOD_PIKK_1	122	128	PF00454	0.366
MOD_PKA_1	154	160	PF00069	0.348
MOD_PKA_1	64	70	PF00069	0.476
MOD_PKA_2	131	137	PF00069	0.378
MOD_PKA_2	175	181	PF00069	0.319
MOD_Plk_1	107	113	PF00069	0.415
MOD_Plk_1	35	41	PF00069	0.393
MOD_Plk_4	175	181	PF00069	0.225
MOD_Plk_4	35	41	PF00069	0.452
MOD_Plk_4	82	88	PF00069	0.434
MOD_ProDKin_1	265	271	PF00069	0.499
TRG_DiLeu_BaEn_3	208	214	PF01217	0.391
TRG_DiLeu_BaEn_4	236	242	PF01217	0.600
TRG_ENDOCYTIC_2	130	133	PF00928	0.363
TRG_ENDOCYTIC_2	180	183	PF00928	0.378
TRG_ENDOCYTIC_2	39	42	PF00928	0.370
TRG_NLS_MonoExtC_3	17	22	PF00514	0.261
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSE8	Leptomonas seymouri	60%	100%
A0A0S4IM09	Bodo saltans	29%	100%
A0A0S4INM2	Bodo saltans	24%	73%
A0A0S4IP40	Bodo saltans	25%	100%
A0A0S4JUF9	Bodo saltans	39%	100%
A0A3R7MB63	Trypanosoma rangeli	49%	100%
A0A3S7X3C3	Leishmania donovani	88%	100%
A4I5J5	Leishmania infantum	88%	100%
F4JYJ3	Arabidopsis thaliana	27%	79%
O76054	Homo sapiens	26%	74%
P46250	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	99%
P53844	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	85%
P53989	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	98%
Q10137	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4Q7C6	Leishmania major	91%	100%
Q55CU8	Dictyostelium discoideum	25%	82%
Q757H2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	68%
Q75DK1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	96%
Q8R0F9	Mus musculus	25%	74%
Q99J08	Mus musculus	26%	74%
Q99MS0	Rattus norvegicus	27%	74%
Q9SCU1	Arabidopsis thaliana	24%	73%
Q9UDX3	Homo sapiens	26%	73%
V5DQM7	Trypanosoma cruzi	50%	100%