Hsp33 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0T9_LEIMU

TriTrypDb:

LmxM.29.1670

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B0T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0T9

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0042026	protein refolding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0051082	unfolded protein binding	3	12
GO:0044183	protein folding chaperone	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.582
CLV_C14_Caspase3-7	161	165	PF00656	0.558
CLV_C14_Caspase3-7	213	217	PF00656	0.530
CLV_MEL_PAP_1	280	286	PF00089	0.300
CLV_NRD_NRD_1	176	178	PF00675	0.557
CLV_NRD_NRD_1	200	202	PF00675	0.476
CLV_NRD_NRD_1	36	38	PF00675	0.417
CLV_NRD_NRD_1	365	367	PF00675	0.463
CLV_NRD_NRD_1	427	429	PF00675	0.339
CLV_PCSK_KEX2_1	176	178	PF00082	0.557
CLV_PCSK_KEX2_1	200	202	PF00082	0.507
CLV_PCSK_KEX2_1	36	38	PF00082	0.396
CLV_PCSK_KEX2_1	365	367	PF00082	0.490
CLV_PCSK_KEX2_1	427	429	PF00082	0.356
CLV_PCSK_SKI1_1	184	188	PF00082	0.463
CLV_PCSK_SKI1_1	257	261	PF00082	0.529
CLV_PCSK_SKI1_1	28	32	PF00082	0.455
CLV_PCSK_SKI1_1	365	369	PF00082	0.514
CLV_PCSK_SKI1_1	7	11	PF00082	0.400
DEG_APCC_DBOX_1	256	264	PF00400	0.524
DOC_CKS1_1	270	275	PF01111	0.532
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	270	276	PF00134	0.279
DOC_MAPK_DCC_7	201	211	PF00069	0.504
DOC_MAPK_gen_1	5	13	PF00069	0.427
DOC_MAPK_MEF2A_6	5	13	PF00069	0.409
DOC_PP2B_LxvP_1	11	14	PF13499	0.449
DOC_PP2B_LxvP_1	142	145	PF13499	0.554
DOC_PP2B_LxvP_1	169	172	PF13499	0.573
DOC_PP4_FxxP_1	373	376	PF00568	0.544
DOC_USP7_MATH_1	129	133	PF00917	0.424
DOC_USP7_MATH_1	149	153	PF00917	0.663
DOC_USP7_MATH_1	182	186	PF00917	0.498
DOC_USP7_MATH_1	409	413	PF00917	0.556
DOC_USP7_UBL2_3	246	250	PF12436	0.360
DOC_WW_Pin1_4	269	274	PF00397	0.479
DOC_WW_Pin1_4	444	449	PF00397	0.679
LIG_14-3-3_CanoR_1	176	181	PF00244	0.365
LIG_14-3-3_CanoR_1	200	207	PF00244	0.472
LIG_14-3-3_CanoR_1	21	25	PF00244	0.411
LIG_14-3-3_CanoR_1	283	291	PF00244	0.276
LIG_14-3-3_CanoR_1	322	330	PF00244	0.468
LIG_14-3-3_CanoR_1	348	357	PF00244	0.326
LIG_14-3-3_CanoR_1	443	448	PF00244	0.631
LIG_14-3-3_CanoR_1	77	85	PF00244	0.400
LIG_Actin_RPEL_3	35	54	PF02755	0.429
LIG_deltaCOP1_diTrp_1	181	187	PF00928	0.500
LIG_FHA_1	112	118	PF00498	0.491
LIG_FHA_1	229	235	PF00498	0.518
LIG_FHA_1	307	313	PF00498	0.540
LIG_FHA_1	4	10	PF00498	0.445
LIG_FHA_1	85	91	PF00498	0.384
LIG_FHA_2	383	389	PF00498	0.433
LIG_FHA_2	77	83	PF00498	0.451
LIG_LIR_Apic_2	372	376	PF02991	0.555
LIG_LIR_Gen_1	127	138	PF02991	0.443
LIG_LIR_Gen_1	435	441	PF02991	0.486
LIG_LIR_Gen_1	49	58	PF02991	0.378
LIG_LIR_Gen_1	59	68	PF02991	0.329
LIG_LIR_Nem_3	127	133	PF02991	0.474
LIG_LIR_Nem_3	164	170	PF02991	0.570
LIG_LIR_Nem_3	181	186	PF02991	0.475
LIG_LIR_Nem_3	266	270	PF02991	0.380
LIG_LIR_Nem_3	435	439	PF02991	0.470
LIG_LIR_Nem_3	49	53	PF02991	0.398
LIG_LIR_Nem_3	59	63	PF02991	0.336
LIG_MAD2	121	129	PF02301	0.480
LIG_NRBOX	137	143	PF00104	0.529
LIG_PCNA_yPIPBox_3	392	403	PF02747	0.556
LIG_Pex14_1	183	187	PF04695	0.491
LIG_REV1ctd_RIR_1	387	396	PF16727	0.517
LIG_SH2_CRK	196	200	PF00017	0.482
LIG_SH2_STAP1	341	345	PF00017	0.335
LIG_SH2_STAT3	103	106	PF00017	0.519
LIG_SH2_STAT5	170	173	PF00017	0.526
LIG_SH2_STAT5	198	201	PF00017	0.456
LIG_SH2_STAT5	98	101	PF00017	0.415
LIG_SH3_2	113	118	PF14604	0.445
LIG_SH3_3	110	116	PF00018	0.476
LIG_SH3_3	357	363	PF00018	0.495
LIG_SH3_3	400	406	PF00018	0.506
LIG_SUMO_SIM_par_1	328	334	PF11976	0.448
LIG_TRAF2_1	79	82	PF00917	0.470
LIG_WW_3	405	409	PF00397	0.539
MOD_CK1_1	185	191	PF00069	0.497
MOD_CK1_1	202	208	PF00069	0.308
MOD_CK1_1	23	29	PF00069	0.470
MOD_CK1_1	331	337	PF00069	0.423
MOD_CK1_1	401	407	PF00069	0.523
MOD_CK1_1	416	422	PF00069	0.495
MOD_CK1_1	444	450	PF00069	0.726
MOD_CK2_1	63	69	PF00069	0.465
MOD_CK2_1	76	82	PF00069	0.353
MOD_Cter_Amidation	425	428	PF01082	0.356
MOD_GlcNHglycan	25	28	PF01048	0.340
MOD_GlcNHglycan	301	304	PF01048	0.664
MOD_GlcNHglycan	309	312	PF01048	0.579
MOD_GlcNHglycan	333	336	PF01048	0.429
MOD_GlcNHglycan	403	406	PF01048	0.359
MOD_GlcNHglycan	442	446	PF01048	0.632
MOD_GlcNHglycan	65	68	PF01048	0.483
MOD_GSK3_1	156	163	PF00069	0.528
MOD_GSK3_1	185	192	PF00069	0.456
MOD_GSK3_1	3	10	PF00069	0.469
MOD_GSK3_1	409	416	PF00069	0.502
MOD_N-GLC_1	189	194	PF02516	0.346
MOD_N-GLC_1	298	303	PF02516	0.337
MOD_NEK2_1	20	25	PF00069	0.409
MOD_NEK2_1	298	303	PF00069	0.374
MOD_NEK2_1	31	36	PF00069	0.334
MOD_NEK2_1	40	45	PF00069	0.218
MOD_NEK2_1	441	446	PF00069	0.600
MOD_NEK2_1	53	58	PF00069	0.339
MOD_NEK2_1	63	68	PF00069	0.339
MOD_NEK2_2	182	187	PF00069	0.474
MOD_NEK2_2	189	194	PF00069	0.399
MOD_NEK2_2	409	414	PF00069	0.556
MOD_PIKK_1	282	288	PF00454	0.521
MOD_PIKK_1	53	59	PF00454	0.456
MOD_PKA_1	176	182	PF00069	0.269
MOD_PKA_2	176	182	PF00069	0.272
MOD_PKA_2	199	205	PF00069	0.423
MOD_PKA_2	20	26	PF00069	0.393
MOD_PKA_2	282	288	PF00069	0.423
MOD_PKA_2	321	327	PF00069	0.482
MOD_PKA_2	391	397	PF00069	0.486
MOD_PKA_2	41	47	PF00069	0.432
MOD_PKA_2	76	82	PF00069	0.417
MOD_PKB_1	5	13	PF00069	0.418
MOD_Plk_1	189	195	PF00069	0.346
MOD_Plk_1	416	422	PF00069	0.450
MOD_Plk_1	7	13	PF00069	0.404
MOD_Plk_1	81	87	PF00069	0.410
MOD_Plk_2-3	241	247	PF00069	0.700
MOD_Plk_4	129	135	PF00069	0.516
MOD_Plk_4	182	188	PF00069	0.506
MOD_Plk_4	328	334	PF00069	0.444
MOD_Plk_4	398	404	PF00069	0.556
MOD_Plk_4	81	87	PF00069	0.382
MOD_ProDKin_1	269	275	PF00069	0.498
MOD_ProDKin_1	444	450	PF00069	0.691
MOD_SUMO_rev_2	244	252	PF00179	0.584
TRG_DiLeu_BaEn_1	293	298	PF01217	0.483
TRG_DiLeu_BaEn_4	81	87	PF01217	0.522
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.258
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.523
TRG_ENDOCYTIC_2	196	199	PF00928	0.391
TRG_ER_diArg_1	176	178	PF00400	0.554
TRG_ER_diArg_1	199	201	PF00400	0.498
TRG_ER_diArg_1	35	37	PF00400	0.400
TRG_ER_diArg_1	364	366	PF00400	0.468
TRG_ER_diArg_1	4	7	PF00400	0.480
TRG_ER_diArg_1	427	429	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI4	Leptomonas seymouri	63%	88%
A0A0S4J763	Bodo saltans	24%	100%
A0A1X0P2N8	Trypanosomatidae	38%	99%
A0A3Q8IES4	Leishmania donovani	92%	98%
A0A422P4Y1	Trypanosoma rangeli	36%	100%
A4HIB0	Leishmania braziliensis	78%	100%
A4I5J4	Leishmania infantum	93%	98%
C9ZQT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q7C7	Leishmania major	91%	100%
V5DQR0	Trypanosoma cruzi	34%	100%