Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0T4_LEIMU

TriTrypDb:

LmxM.29.1600

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	468	472	PF00656	0.711
CLV_NRD_NRD_1	123	125	PF00675	0.504
CLV_NRD_NRD_1	375	377	PF00675	0.653
CLV_PCSK_FUR_1	373	377	PF00082	0.708
CLV_PCSK_KEX2_1	123	125	PF00082	0.504
CLV_PCSK_KEX2_1	361	363	PF00082	0.658
CLV_PCSK_KEX2_1	375	377	PF00082	0.563
CLV_PCSK_KEX2_1	379	381	PF00082	0.513
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.665
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.434
CLV_PCSK_PC7_1	375	381	PF00082	0.667
CLV_PCSK_SKI1_1	245	249	PF00082	0.457
CLV_PCSK_SKI1_1	93	97	PF00082	0.470
CLV_Separin_Metazoa	38	42	PF03568	0.509
DEG_APCC_DBOX_1	92	100	PF00400	0.439
DEG_SPOP_SBC_1	100	104	PF00917	0.484
DEG_SPOP_SBC_1	274	278	PF00917	0.565
DOC_CDC14_PxL_1	84	92	PF14671	0.484
DOC_CKS1_1	325	330	PF01111	0.688
DOC_CKS1_1	482	487	PF01111	0.695
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.563
DOC_MAPK_MEF2A_6	93	101	PF00069	0.407
DOC_PP1_RVXF_1	111	117	PF00149	0.421
DOC_PP2B_LxvP_1	347	350	PF13499	0.550
DOC_PP2B_LxvP_1	97	100	PF13499	0.468
DOC_USP7_MATH_1	100	104	PF00917	0.506
DOC_USP7_MATH_1	219	223	PF00917	0.580
DOC_USP7_MATH_1	410	414	PF00917	0.795
DOC_USP7_MATH_1	53	57	PF00917	0.746
DOC_USP7_MATH_1	59	63	PF00917	0.770
DOC_USP7_UBL2_3	280	284	PF12436	0.732
DOC_WW_Pin1_4	238	243	PF00397	0.585
DOC_WW_Pin1_4	324	329	PF00397	0.753
DOC_WW_Pin1_4	481	486	PF00397	0.632
LIG_14-3-3_CanoR_1	165	174	PF00244	0.525
LIG_14-3-3_CanoR_1	192	198	PF00244	0.477
LIG_14-3-3_CanoR_1	378	383	PF00244	0.735
LIG_14-3-3_CanoR_1	435	443	PF00244	0.737
LIG_14-3-3_CanoR_1	503	509	PF00244	0.651
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BRCT_BRCA1_1	201	205	PF00533	0.541
LIG_BRCT_BRCA1_1	329	333	PF00533	0.689
LIG_CSL_BTD_1	491	494	PF09270	0.603
LIG_deltaCOP1_diTrp_1	109	116	PF00928	0.478
LIG_eIF4E_1	84	90	PF01652	0.479
LIG_FHA_1	127	133	PF00498	0.459
LIG_FHA_1	26	32	PF00498	0.548
LIG_FHA_2	216	222	PF00498	0.773
LIG_FHA_2	262	268	PF00498	0.350
LIG_FHA_2	435	441	PF00498	0.522
LIG_FHA_2	49	55	PF00498	0.756
LIG_FHA_2	503	509	PF00498	0.623
LIG_FHA_2	513	519	PF00498	0.554
LIG_FHA_2	65	71	PF00498	0.523
LIG_LIR_Gen_1	109	116	PF02991	0.538
LIG_LIR_Gen_1	365	374	PF02991	0.630
LIG_LIR_Gen_1	81	90	PF02991	0.538
LIG_LIR_Nem_3	109	114	PF02991	0.539
LIG_LIR_Nem_3	188	193	PF02991	0.621
LIG_LIR_Nem_3	202	208	PF02991	0.634
LIG_LIR_Nem_3	28	32	PF02991	0.508
LIG_LIR_Nem_3	365	371	PF02991	0.625
LIG_LIR_Nem_3	526	532	PF02991	0.348
LIG_LIR_Nem_3	81	87	PF02991	0.542
LIG_LYPXL_yS_3	29	32	PF13949	0.546
LIG_MYND_1	206	210	PF01753	0.690
LIG_MYND_1	30	34	PF01753	0.402
LIG_NRBOX	312	318	PF00104	0.591
LIG_PCNA_yPIPBox_3	226	237	PF02747	0.439
LIG_Rb_pABgroove_1	350	358	PF01858	0.535
LIG_SH2_CRK	84	88	PF00017	0.490
LIG_SH2_GRB2like	166	169	PF00017	0.560
LIG_SH2_SRC	351	354	PF00017	0.572
LIG_SH2_STAT3	11	14	PF00017	0.541
LIG_SH2_STAT5	18	21	PF00017	0.412
LIG_SH2_STAT5	351	354	PF00017	0.554
LIG_SH2_STAT5	358	361	PF00017	0.575
LIG_SH3_3	24	30	PF00018	0.577
LIG_SH3_3	322	328	PF00018	0.653
LIG_SH3_3	484	490	PF00018	0.672
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.574
LIG_SUMO_SIM_par_1	124	131	PF11976	0.400
LIG_SUMO_SIM_par_1	235	241	PF11976	0.547
LIG_TRAF2_1	444	447	PF00917	0.739
LIG_TRAF2_1	515	518	PF00917	0.598
LIG_TYR_ITIM	82	87	PF00017	0.478
LIG_UBA3_1	294	301	PF00899	0.485
LIG_UBA3_1	355	361	PF00899	0.534
MOD_CDK_SPxxK_3	238	245	PF00069	0.518
MOD_CK1_1	103	109	PF00069	0.461
MOD_CK1_1	149	155	PF00069	0.462
MOD_CK1_1	196	202	PF00069	0.634
MOD_CK1_1	381	387	PF00069	0.762
MOD_CK1_1	431	437	PF00069	0.728
MOD_CK1_1	454	460	PF00069	0.719
MOD_CK1_1	461	467	PF00069	0.655
MOD_CK1_1	470	476	PF00069	0.616
MOD_CK1_1	481	487	PF00069	0.416
MOD_CK1_1	499	505	PF00069	0.471
MOD_CK1_1	60	66	PF00069	0.728
MOD_CK2_1	103	109	PF00069	0.502
MOD_CK2_1	215	221	PF00069	0.752
MOD_CK2_1	261	267	PF00069	0.510
MOD_CK2_1	391	397	PF00069	0.647
MOD_CK2_1	441	447	PF00069	0.816
MOD_CK2_1	469	475	PF00069	0.683
MOD_CK2_1	512	518	PF00069	0.534
MOD_GlcNHglycan	1	4	PF01048	0.633
MOD_GlcNHglycan	133	136	PF01048	0.517
MOD_GlcNHglycan	221	225	PF01048	0.634
MOD_GlcNHglycan	230	233	PF01048	0.690
MOD_GlcNHglycan	285	288	PF01048	0.674
MOD_GlcNHglycan	329	332	PF01048	0.773
MOD_GlcNHglycan	407	410	PF01048	0.821
MOD_GlcNHglycan	412	415	PF01048	0.729
MOD_GlcNHglycan	464	467	PF01048	0.730
MOD_GlcNHglycan	54	58	PF01048	0.745
MOD_GlcNHglycan	59	62	PF01048	0.736
MOD_GlcNHglycan	67	70	PF01048	0.561
MOD_GSK3_1	160	167	PF00069	0.576
MOD_GSK3_1	193	200	PF00069	0.559
MOD_GSK3_1	215	222	PF00069	0.561
MOD_GSK3_1	323	330	PF00069	0.695
MOD_GSK3_1	378	385	PF00069	0.656
MOD_GSK3_1	401	408	PF00069	0.742
MOD_GSK3_1	429	436	PF00069	0.724
MOD_GSK3_1	451	458	PF00069	0.695
MOD_GSK3_1	460	467	PF00069	0.638
MOD_GSK3_1	470	477	PF00069	0.526
MOD_GSK3_1	519	526	PF00069	0.356
MOD_GSK3_1	53	60	PF00069	0.683
MOD_GSK3_1	61	68	PF00069	0.652
MOD_GSK3_1	99	106	PF00069	0.504
MOD_N-GLC_1	522	527	PF02516	0.557
MOD_NEK2_1	101	106	PF00069	0.492
MOD_NEK2_1	128	133	PF00069	0.449
MOD_NEK2_1	228	233	PF00069	0.681
MOD_NEK2_1	275	280	PF00069	0.655
MOD_NEK2_1	382	387	PF00069	0.761
MOD_NEK2_1	496	501	PF00069	0.507
MOD_NEK2_2	61	66	PF00069	0.484
MOD_PIKK_1	261	267	PF00454	0.505
MOD_PIKK_1	384	390	PF00454	0.627
MOD_PIKK_1	478	484	PF00454	0.555
MOD_PKA_1	378	384	PF00069	0.688
MOD_PKA_2	164	170	PF00069	0.618
MOD_PKA_2	399	405	PF00069	0.837
MOD_PKA_2	434	440	PF00069	0.702
MOD_PKA_2	502	508	PF00069	0.597
MOD_PKA_2	519	525	PF00069	0.389
MOD_PKB_1	288	296	PF00069	0.679
MOD_PKB_1	376	384	PF00069	0.729
MOD_Plk_1	109	115	PF00069	0.531
MOD_Plk_1	474	480	PF00069	0.718
MOD_Plk_4	14	20	PF00069	0.376
MOD_Plk_4	290	296	PF00069	0.646
MOD_Plk_4	474	480	PF00069	0.753
MOD_Plk_4	496	502	PF00069	0.529
MOD_ProDKin_1	238	244	PF00069	0.583
MOD_ProDKin_1	324	330	PF00069	0.756
MOD_ProDKin_1	481	487	PF00069	0.626
TRG_DiLeu_BaEn_1	38	43	PF01217	0.561
TRG_DiLeu_BaEn_4	109	115	PF01217	0.531
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.601
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.492
TRG_DiLeu_LyEn_5	38	43	PF01217	0.561
TRG_ENDOCYTIC_2	257	260	PF00928	0.466
TRG_ENDOCYTIC_2	29	32	PF00928	0.546
TRG_ENDOCYTIC_2	84	87	PF00928	0.487
TRG_ER_diArg_1	123	125	PF00400	0.504
TRG_ER_diArg_1	375	378	PF00400	0.670
TRG_NES_CRM1_1	175	189	PF08389	0.550
TRG_NLS_Bipartite_1	361	382	PF00514	0.692
TRG_NLS_MonoExtN_4	375	382	PF00514	0.723
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P973	Leptomonas seymouri	46%	100%
A0A3Q8IFL5	Leishmania donovani	89%	100%
A0A3R7NW81	Trypanosoma rangeli	24%	100%
A4HIA5	Leishmania braziliensis	75%	100%
A4I5I9	Leishmania infantum	90%	100%
Q4Q7E4	Leishmania major	89%	100%
V5BZ01	Trypanosoma cruzi	26%	100%