ER membrane protein complex subunit 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0T3_LEIMU

TriTrypDb:

LmxM.29.1590

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B0T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	307	309	PF00675	0.631
CLV_NRD_NRD_1	356	358	PF00675	0.465
CLV_PCSK_KEX2_1	342	344	PF00082	0.389
CLV_PCSK_KEX2_1	356	358	PF00082	0.382
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.395
CLV_PCSK_SKI1_1	264	268	PF00082	0.613
CLV_PCSK_SKI1_1	303	307	PF00082	0.670
DEG_APCC_DBOX_1	148	156	PF00400	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DOC_CKS1_1	298	303	PF01111	0.371
DOC_MAPK_gen_1	308	315	PF00069	0.415
DOC_MAPK_gen_1	71	78	PF00069	0.291
DOC_MAPK_JIP1_4	149	155	PF00069	0.362
DOC_MAPK_MEF2A_6	318	326	PF00069	0.269
DOC_PP2B_LxvP_1	24	27	PF13499	0.506
DOC_PP2B_LxvP_1	362	365	PF13499	0.623
DOC_USP7_MATH_1	222	226	PF00917	0.444
DOC_USP7_MATH_1	237	241	PF00917	0.511
DOC_USP7_MATH_1	299	303	PF00917	0.465
DOC_WW_Pin1_4	297	302	PF00397	0.355
DOC_WW_Pin1_4	40	45	PF00397	0.368
LIG_14-3-3_CanoR_1	107	112	PF00244	0.319
LIG_14-3-3_CanoR_1	264	271	PF00244	0.335
LIG_14-3-3_CanoR_1	4	12	PF00244	0.383
LIG_14-3-3_CanoR_1	71	77	PF00244	0.391
LIG_BRCT_BRCA1_1	62	66	PF00533	0.348
LIG_BRCT_BRCA1_1	74	78	PF00533	0.302
LIG_Clathr_ClatBox_1	152	156	PF01394	0.332
LIG_eIF4E_1	173	179	PF01652	0.401
LIG_FHA_1	152	158	PF00498	0.280
LIG_FHA_1	166	172	PF00498	0.352
LIG_FHA_1	274	280	PF00498	0.458
LIG_FHA_2	228	234	PF00498	0.472
LIG_FHA_2	265	271	PF00498	0.387
LIG_FHA_2	286	292	PF00498	0.397
LIG_LIR_Apic_2	170	175	PF02991	0.338
LIG_LIR_Gen_1	43	54	PF02991	0.303
LIG_LIR_Nem_3	43	49	PF02991	0.354
LIG_Pex14_1	294	298	PF04695	0.315
LIG_Pex14_2	46	50	PF04695	0.428
LIG_SH2_CRK	298	302	PF00017	0.336
LIG_SH2_NCK_1	298	302	PF00017	0.365
LIG_SH2_PTP2	319	322	PF00017	0.233
LIG_SH2_SRC	173	176	PF00017	0.395
LIG_SH2_STAT5	173	176	PF00017	0.395
LIG_SH2_STAT5	319	322	PF00017	0.317
LIG_SH3_3	272	278	PF00018	0.336
LIG_UBA3_1	86	93	PF00899	0.366
MOD_CDK_SPxK_1	297	303	PF00069	0.336
MOD_CK1_1	117	123	PF00069	0.468
MOD_CK1_1	151	157	PF00069	0.248
MOD_CK1_1	238	244	PF00069	0.591
MOD_CK1_1	335	341	PF00069	0.531
MOD_CK1_1	57	63	PF00069	0.316
MOD_CK2_1	134	140	PF00069	0.501
MOD_CK2_1	264	270	PF00069	0.314
MOD_CK2_1	285	291	PF00069	0.426
MOD_Cter_Amidation	131	134	PF01082	0.571
MOD_Cter_Amidation	144	147	PF01082	0.511
MOD_Cter_Amidation	339	342	PF01082	0.408
MOD_GlcNHglycan	116	119	PF01048	0.625
MOD_GlcNHglycan	190	194	PF01048	0.639
MOD_GlcNHglycan	195	198	PF01048	0.599
MOD_GlcNHglycan	21	24	PF01048	0.623
MOD_GlcNHglycan	225	228	PF01048	0.592
MOD_GlcNHglycan	250	254	PF01048	0.739
MOD_GlcNHglycan	270	274	PF01048	0.573
MOD_GlcNHglycan	334	337	PF01048	0.389
MOD_GlcNHglycan	37	40	PF01048	0.719
MOD_GlcNHglycan	62	65	PF01048	0.513
MOD_GSK3_1	189	196	PF00069	0.388
MOD_GSK3_1	223	230	PF00069	0.382
MOD_GSK3_1	235	242	PF00069	0.514
MOD_GSK3_1	249	256	PF00069	0.392
MOD_GSK3_1	269	276	PF00069	0.245
MOD_GSK3_1	297	304	PF00069	0.351
MOD_GSK3_1	35	42	PF00069	0.514
MOD_GSK3_1	50	57	PF00069	0.260
MOD_GSK3_1	93	100	PF00069	0.400
MOD_N-GLC_1	66	71	PF02516	0.503
MOD_NEK2_1	119	124	PF00069	0.378
MOD_NEK2_1	127	132	PF00069	0.391
MOD_NEK2_1	165	170	PF00069	0.353
MOD_NEK2_1	19	24	PF00069	0.406
MOD_NEK2_1	50	55	PF00069	0.332
MOD_NEK2_1	59	64	PF00069	0.301
MOD_NEK2_1	66	71	PF00069	0.328
MOD_NEK2_1	72	77	PF00069	0.376
MOD_NEK2_2	167	172	PF00069	0.362
MOD_NEK2_2	301	306	PF00069	0.418
MOD_PIKK_1	57	63	PF00454	0.394
MOD_PIKK_1	93	99	PF00454	0.392
MOD_PK_1	107	113	PF00069	0.245
MOD_PK_1	239	245	PF00069	0.483
MOD_PKA_1	134	140	PF00069	0.512
MOD_PKA_2	148	154	PF00069	0.394
MOD_PKA_2	159	165	PF00069	0.415
MOD_PKA_2	3	9	PF00069	0.556
MOD_PKA_2	370	376	PF00069	0.662
MOD_PKA_2	72	78	PF00069	0.321
MOD_Plk_1	66	72	PF00069	0.303
MOD_Plk_2-3	202	208	PF00069	0.399
MOD_Plk_4	148	154	PF00069	0.309
MOD_Plk_4	167	173	PF00069	0.218
MOD_Plk_4	301	307	PF00069	0.416
MOD_Plk_4	54	60	PF00069	0.307
MOD_Plk_4	97	103	PF00069	0.393
MOD_ProDKin_1	297	303	PF00069	0.363
MOD_ProDKin_1	40	46	PF00069	0.356
MOD_SUMO_for_1	360	363	PF00179	0.637
MOD_SUMO_rev_2	110	117	PF00179	0.329
MOD_SUMO_rev_2	349	354	PF00179	0.620
MOD_SUMO_rev_2	85	95	PF00179	0.413
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.624
TRG_ENDOCYTIC_2	319	322	PF00928	0.432
TRG_ER_diArg_1	70	73	PF00400	0.317
TRG_ER_diLys_1	374	377	PF00400	0.611
TRG_NLS_Bipartite_1	133	150	PF00514	0.323
TRG_NLS_MonoExtC_3	145	150	PF00514	0.263
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH7	Leptomonas seymouri	52%	98%
A0A1X0P321	Trypanosomatidae	30%	100%
A0A3S7X3C2	Leishmania donovani	85%	99%
A0A422P4W9	Trypanosoma rangeli	30%	100%
A4HIA4	Leishmania braziliensis	66%	97%
A4I5I8	Leishmania infantum	85%	99%
C9ZQS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q7E5	Leishmania major	84%	100%
V5BPM9	Trypanosoma cruzi	31%	100%