PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0T2_LEIMU

TriTrypDb:

LmxM.29.1580

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.524
CLV_C14_Caspase3-7	687	691	PF00656	0.635
CLV_NRD_NRD_1	152	154	PF00675	0.761
CLV_NRD_NRD_1	176	178	PF00675	0.803
CLV_NRD_NRD_1	301	303	PF00675	0.634
CLV_NRD_NRD_1	640	642	PF00675	0.676
CLV_NRD_NRD_1	769	771	PF00675	0.768
CLV_NRD_NRD_1	786	788	PF00675	0.497
CLV_PCSK_KEX2_1	301	303	PF00082	0.634
CLV_PCSK_KEX2_1	527	529	PF00082	0.687
CLV_PCSK_KEX2_1	640	642	PF00082	0.689
CLV_PCSK_KEX2_1	768	770	PF00082	0.822
CLV_PCSK_KEX2_1	786	788	PF00082	0.446
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.687
CLV_PCSK_SKI1_1	301	305	PF00082	0.563
CLV_PCSK_SKI1_1	327	331	PF00082	0.667
CLV_PCSK_SKI1_1	378	382	PF00082	0.653
CLV_PCSK_SKI1_1	714	718	PF00082	0.539
CLV_PCSK_SKI1_1	8	12	PF00082	0.518
CLV_PCSK_SKI1_1	839	843	PF00082	0.574
CLV_PCSK_SKI1_1	86	90	PF00082	0.505
DEG_SIAH_1	415	423	PF03145	0.638
DEG_SPOP_SBC_1	707	711	PF00917	0.578
DEG_SPOP_SBC_1	762	766	PF00917	0.500
DOC_ANK_TNKS_1	527	534	PF00023	0.404
DOC_CYCLIN_RxL_1	295	307	PF00134	0.520
DOC_CYCLIN_RxL_1	319	330	PF00134	0.764
DOC_CYCLIN_RxL_1	833	843	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.658
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	834	840	PF00134	0.577
DOC_MAPK_gen_1	48	56	PF00069	0.627
DOC_MAPK_gen_1	786	796	PF00069	0.517
DOC_MAPK_MEF2A_6	352	361	PF00069	0.600
DOC_MAPK_MEF2A_6	747	754	PF00069	0.494
DOC_MAPK_MEF2A_6	789	797	PF00069	0.533
DOC_MAPK_MEF2A_6	803	811	PF00069	0.502
DOC_MAPK_MEF2A_6	833	842	PF00069	0.539
DOC_SPAK_OSR1_1	282	286	PF12202	0.500
DOC_USP7_MATH_1	106	110	PF00917	0.707
DOC_USP7_MATH_1	173	177	PF00917	0.814
DOC_USP7_MATH_1	182	186	PF00917	0.763
DOC_USP7_MATH_1	306	310	PF00917	0.676
DOC_USP7_MATH_1	320	324	PF00917	0.563
DOC_USP7_MATH_1	625	629	PF00917	0.502
DOC_USP7_MATH_1	689	693	PF00917	0.691
DOC_USP7_MATH_1	707	711	PF00917	0.484
DOC_USP7_MATH_1	763	767	PF00917	0.684
DOC_USP7_MATH_1	824	828	PF00917	0.538
DOC_USP7_MATH_2	656	662	PF00917	0.591
DOC_WW_Pin1_4	1	6	PF00397	0.747
DOC_WW_Pin1_4	132	137	PF00397	0.827
DOC_WW_Pin1_4	180	185	PF00397	0.797
DOC_WW_Pin1_4	261	266	PF00397	0.556
DOC_WW_Pin1_4	476	481	PF00397	0.482
LIG_14-3-3_CanoR_1	177	184	PF00244	0.560
LIG_14-3-3_CanoR_1	203	207	PF00244	0.491
LIG_14-3-3_CanoR_1	295	300	PF00244	0.512
LIG_14-3-3_CanoR_1	327	334	PF00244	0.637
LIG_14-3-3_CanoR_1	36	40	PF00244	0.447
LIG_14-3-3_CanoR_1	425	431	PF00244	0.528
LIG_14-3-3_CanoR_1	714	723	PF00244	0.511
LIG_14-3-3_CanoR_1	773	782	PF00244	0.650
LIG_Actin_WH2_2	312	329	PF00022	0.463
LIG_Actin_WH2_2	70	88	PF00022	0.501
LIG_AP2alpha_2	57	59	PF02296	0.648
LIG_APCC_ABBA_1	380	385	PF00400	0.651
LIG_APCC_ABBA_1	809	814	PF00400	0.473
LIG_APCC_ABBAyCdc20_2	301	307	PF00400	0.545
LIG_BIR_III_2	181	185	PF00653	0.552
LIG_Clathr_ClatBox_1	754	758	PF01394	0.497
LIG_deltaCOP1_diTrp_1	20	23	PF00928	0.561
LIG_deltaCOP1_diTrp_1	221	228	PF00928	0.565
LIG_deltaCOP1_diTrp_1	270	275	PF00928	0.573
LIG_deltaCOP1_diTrp_1	307	312	PF00928	0.561
LIG_deltaCOP1_diTrp_1	366	373	PF00928	0.639
LIG_deltaCOP1_diTrp_1	472	477	PF00928	0.502
LIG_deltaCOP1_diTrp_1	637	646	PF00928	0.564
LIG_deltaCOP1_diTrp_1	94	100	PF00928	0.311
LIG_FHA_1	100	106	PF00498	0.558
LIG_FHA_1	203	209	PF00498	0.728
LIG_FHA_1	388	394	PF00498	0.719
LIG_FHA_1	537	543	PF00498	0.499
LIG_FHA_1	611	617	PF00498	0.493
LIG_FHA_1	72	78	PF00498	0.493
LIG_FHA_1	806	812	PF00498	0.453
LIG_FHA_1	87	93	PF00498	0.508
LIG_FHA_2	166	172	PF00498	0.792
LIG_FHA_2	328	334	PF00498	0.711
LIG_FHA_2	573	579	PF00498	0.620
LIG_FHA_2	673	679	PF00498	0.813
LIG_GBD_Chelix_1	11	19	PF00786	0.562
LIG_HCF-1_HBM_1	26	29	PF13415	0.415
LIG_Integrin_RGD_1	158	160	PF01839	0.766
LIG_LIR_Apic_2	475	480	PF02991	0.471
LIG_LIR_Gen_1	307	316	PF02991	0.601
LIG_LIR_Gen_1	331	341	PF02991	0.611
LIG_LIR_Gen_1	532	542	PF02991	0.492
LIG_LIR_Gen_1	551	560	PF02991	0.541
LIG_LIR_Gen_1	814	823	PF02991	0.601
LIG_LIR_Nem_3	20	24	PF02991	0.546
LIG_LIR_Nem_3	26	32	PF02991	0.464
LIG_LIR_Nem_3	270	275	PF02991	0.515
LIG_LIR_Nem_3	281	287	PF02991	0.506
LIG_LIR_Nem_3	307	313	PF02991	0.605
LIG_LIR_Nem_3	331	337	PF02991	0.584
LIG_LIR_Nem_3	354	358	PF02991	0.360
LIG_LIR_Nem_3	47	53	PF02991	0.615
LIG_LIR_Nem_3	532	538	PF02991	0.428
LIG_LIR_Nem_3	551	556	PF02991	0.480
LIG_LIR_Nem_3	643	649	PF02991	0.644
LIG_LIR_Nem_3	814	818	PF02991	0.589
LIG_PAM2_1	371	383	PF00658	0.581
LIG_Pex14_1	21	25	PF04695	0.539
LIG_Pex14_1	228	232	PF04695	0.508
LIG_Pex14_1	96	100	PF04695	0.304
LIG_Pex14_2	10	14	PF04695	0.486
LIG_SH2_CRK	466	470	PF00017	0.626
LIG_SH2_SRC	412	415	PF00017	0.748
LIG_SH2_SRC	466	469	PF00017	0.636
LIG_SH2_STAP1	25	29	PF00017	0.469
LIG_SH2_STAP1	553	557	PF00017	0.464
LIG_SH2_STAP1	93	97	PF00017	0.587
LIG_SH2_STAT5	256	259	PF00017	0.546
LIG_SH2_STAT5	29	32	PF00017	0.439
LIG_SH2_STAT5	297	300	PF00017	0.570
LIG_SH2_STAT5	360	363	PF00017	0.550
LIG_SH2_STAT5	71	74	PF00017	0.461
LIG_SH2_STAT5	753	756	PF00017	0.488
LIG_SH2_STAT5	815	818	PF00017	0.511
LIG_SH3_3	100	106	PF00018	0.558
LIG_SH3_3	133	139	PF00018	0.787
LIG_SH3_3	432	438	PF00018	0.527
LIG_SH3_3	507	513	PF00018	0.434
LIG_SH3_3	740	746	PF00018	0.566
LIG_SH3_3	757	763	PF00018	0.650
LIG_SUMO_SIM_anti_2	209	216	PF11976	0.465
LIG_SUMO_SIM_anti_2	613	618	PF11976	0.485
LIG_SUMO_SIM_par_1	101	111	PF11976	0.615
LIG_SUMO_SIM_par_1	209	216	PF11976	0.568
LIG_SUMO_SIM_par_1	394	399	PF11976	0.675
LIG_SUMO_SIM_par_1	753	758	PF11976	0.563
LIG_TRAF2_1	289	292	PF00917	0.514
LIG_TRAF2_1	411	414	PF00917	0.755
LIG_TYR_ITIM	285	290	PF00017	0.595
LIG_UBA3_1	213	220	PF00899	0.495
LIG_WRC_WIRS_1	347	352	PF05994	0.527
LIG_WRC_WIRS_1	53	58	PF05994	0.543
MOD_CDK_SPxK_1	132	138	PF00069	0.552
MOD_CDK_SPxxK_3	1	8	PF00069	0.736
MOD_CK1_1	107	113	PF00069	0.784
MOD_CK1_1	123	129	PF00069	0.587
MOD_CK1_1	167	173	PF00069	0.720
MOD_CK1_1	176	182	PF00069	0.795
MOD_CK1_1	245	251	PF00069	0.563
MOD_CK1_1	386	392	PF00069	0.627
MOD_CK1_1	571	577	PF00069	0.623
MOD_CK1_1	709	715	PF00069	0.481
MOD_CK2_1	10	16	PF00069	0.576
MOD_CK2_1	165	171	PF00069	0.794
MOD_CK2_1	213	219	PF00069	0.498
MOD_CK2_1	246	252	PF00069	0.561
MOD_CK2_1	286	292	PF00069	0.507
MOD_CK2_1	571	577	PF00069	0.642
MOD_CK2_1	672	678	PF00069	0.815
MOD_CK2_1	824	830	PF00069	0.681
MOD_CMANNOS	474	477	PF00535	0.499
MOD_Cter_Amidation	766	769	PF01082	0.762
MOD_GlcNHglycan	110	113	PF01048	0.709
MOD_GlcNHglycan	140	143	PF01048	0.738
MOD_GlcNHglycan	171	174	PF01048	0.725
MOD_GlcNHglycan	184	187	PF01048	0.547
MOD_GlcNHglycan	245	248	PF01048	0.554
MOD_GlcNHglycan	330	333	PF01048	0.601
MOD_GlcNHglycan	342	345	PF01048	0.437
MOD_GlcNHglycan	461	464	PF01048	0.717
MOD_GlcNHglycan	521	524	PF01048	0.608
MOD_GlcNHglycan	675	678	PF01048	0.810
MOD_GlcNHglycan	765	768	PF01048	0.669
MOD_GlcNHglycan	775	778	PF01048	0.645
MOD_GSK3_1	104	111	PF00069	0.660
MOD_GSK3_1	119	126	PF00069	0.721
MOD_GSK3_1	163	170	PF00069	0.746
MOD_GSK3_1	172	179	PF00069	0.782
MOD_GSK3_1	202	209	PF00069	0.653
MOD_GSK3_1	242	249	PF00069	0.522
MOD_GSK3_1	328	335	PF00069	0.607
MOD_GSK3_1	342	349	PF00069	0.435
MOD_GSK3_1	383	390	PF00069	0.731
MOD_GSK3_1	392	399	PF00069	0.548
MOD_GSK3_1	468	475	PF00069	0.647
MOD_GSK3_1	568	575	PF00069	0.732
MOD_GSK3_1	702	709	PF00069	0.584
MOD_GSK3_1	769	776	PF00069	0.656
MOD_N-GLC_2	670	672	PF02516	0.756
MOD_NEK2_1	10	15	PF00069	0.478
MOD_NEK2_1	213	218	PF00069	0.440
MOD_NEK2_1	273	278	PF00069	0.507
MOD_NEK2_1	32	37	PF00069	0.476
MOD_NEK2_1	396	401	PF00069	0.696
MOD_NEK2_1	536	541	PF00069	0.477
MOD_NEK2_1	701	706	PF00069	0.644
MOD_NEK2_1	708	713	PF00069	0.740
MOD_NEK2_2	320	325	PF00069	0.766
MOD_NEK2_2	59	64	PF00069	0.561
MOD_PIKK_1	165	171	PF00454	0.833
MOD_PIKK_1	691	697	PF00454	0.659
MOD_PIKK_1	741	747	PF00454	0.582
MOD_PK_1	124	130	PF00069	0.670
MOD_PK_1	286	292	PF00069	0.507
MOD_PKA_1	640	646	PF00069	0.688
MOD_PKA_1	769	775	PF00069	0.768
MOD_PKA_2	123	129	PF00069	0.562
MOD_PKA_2	137	143	PF00069	0.565
MOD_PKA_2	152	158	PF00069	0.490
MOD_PKA_2	176	182	PF00069	0.564
MOD_PKA_2	202	208	PF00069	0.483
MOD_PKA_2	224	230	PF00069	0.648
MOD_PKA_2	243	249	PF00069	0.518
MOD_PKA_2	35	41	PF00069	0.462
MOD_PKA_2	584	590	PF00069	0.427
MOD_PKA_2	59	65	PF00069	0.557
MOD_PKA_2	640	646	PF00069	0.688
MOD_PKA_2	673	679	PF00069	0.797
MOD_PKA_2	769	775	PF00069	0.768
MOD_PKB_1	325	333	PF00069	0.661
MOD_Plk_1	124	130	PF00069	0.823
MOD_Plk_1	187	193	PF00069	0.564
MOD_Plk_1	306	312	PF00069	0.563
MOD_Plk_1	701	707	PF00069	0.700
MOD_Plk_2-3	573	579	PF00069	0.579
MOD_Plk_2-3	79	85	PF00069	0.611
MOD_Plk_4	10	16	PF00069	0.476
MOD_Plk_4	213	219	PF00069	0.459
MOD_Plk_4	342	348	PF00069	0.502
MOD_Plk_4	49	55	PF00069	0.629
MOD_Plk_4	610	616	PF00069	0.505
MOD_Plk_4	92	98	PF00069	0.564
MOD_Plk_4	99	105	PF00069	0.517
MOD_ProDKin_1	1	7	PF00069	0.744
MOD_ProDKin_1	132	138	PF00069	0.829
MOD_ProDKin_1	180	186	PF00069	0.796
MOD_ProDKin_1	261	267	PF00069	0.566
MOD_ProDKin_1	476	482	PF00069	0.484
MOD_SUMO_rev_2	13	19	PF00179	0.461
MOD_SUMO_rev_2	42	50	PF00179	0.635
MOD_SUMO_rev_2	744	752	PF00179	0.641
TRG_DiLeu_BaEn_1	237	242	PF01217	0.497
TRG_DiLeu_BaEn_2	25	31	PF01217	0.459
TRG_DiLeu_BaEn_2	791	797	PF01217	0.545
TRG_DiLeu_BaEn_4	581	587	PF01217	0.665
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.518
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.353
TRG_ENDOCYTIC_2	232	235	PF00928	0.460
TRG_ENDOCYTIC_2	287	290	PF00928	0.604
TRG_ENDOCYTIC_2	29	32	PF00928	0.439
TRG_ENDOCYTIC_2	334	337	PF00928	0.618
TRG_ENDOCYTIC_2	553	556	PF00928	0.461
TRG_ENDOCYTIC_2	815	818	PF00928	0.511
TRG_ER_diArg_1	301	303	PF00400	0.571
TRG_ER_diArg_1	324	327	PF00400	0.676
TRG_ER_diArg_1	546	549	PF00400	0.547
TRG_ER_diArg_1	583	586	PF00400	0.669
TRG_ER_diArg_1	639	641	PF00400	0.662
TRG_ER_diArg_1	768	770	PF00400	0.776
TRG_ER_diArg_1	786	789	PF00400	0.501
TRG_NES_CRM1_1	718	732	PF08389	0.366
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	839	843	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V2	Leptomonas seymouri	58%	96%
A0A3S7X3F2	Leishmania donovani	90%	100%
A4HIA3	Leishmania braziliensis	77%	100%
A4I5I7	Leishmania infantum	90%	100%
Q4Q7E6	Leishmania major	88%	100%