Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative papain-like cysteine peptidase (DUF1796), putative

Species:

Leishmania mexicana

UniProt:

E9B0T1_LEIMU

TriTrypDb:

LmxM.29.1570

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0T1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.166
CLV_C14_Caspase3-7	253	257	PF00656	0.514
CLV_C14_Caspase3-7	319	323	PF00656	0.593
CLV_NRD_NRD_1	146	148	PF00675	0.321
CLV_NRD_NRD_1	241	243	PF00675	0.426
CLV_NRD_NRD_1	307	309	PF00675	0.617
CLV_PCSK_KEX2_1	145	147	PF00082	0.366
CLV_PCSK_KEX2_1	241	243	PF00082	0.587
CLV_PCSK_KEX2_1	398	400	PF00082	0.470
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.428
CLV_PCSK_SKI1_1	169	173	PF00082	0.446
CLV_PCSK_SKI1_1	207	211	PF00082	0.439
CLV_PCSK_SKI1_1	287	291	PF00082	0.370
CLV_PCSK_SKI1_1	409	413	PF00082	0.434
DEG_Nend_Nbox_1	1	3	PF02207	0.297
DEG_SCF_FBW7_1	245	252	PF00400	0.461
DEG_SCF_FBW7_2	311	317	PF00400	0.411
DEG_SPOP_SBC_1	249	253	PF00917	0.535
DEG_SPOP_SBC_1	65	69	PF00917	0.166
DOC_CKS1_1	311	316	PF01111	0.406
DOC_CYCLIN_RxL_1	406	414	PF00134	0.547
DOC_MAPK_DCC_7	110	119	PF00069	0.166
DOC_MAPK_gen_1	197	206	PF00069	0.377
DOC_PIKK_1	368	375	PF02985	0.353
DOC_PP1_RVXF_1	167	174	PF00149	0.399
DOC_USP7_MATH_1	226	230	PF00917	0.526
DOC_USP7_MATH_1	247	251	PF00917	0.674
DOC_USP7_MATH_1	25	29	PF00917	0.394
DOC_USP7_MATH_1	64	68	PF00917	0.258
DOC_USP7_MATH_1	89	93	PF00917	0.321
DOC_WW_Pin1_4	153	158	PF00397	0.425
DOC_WW_Pin1_4	230	235	PF00397	0.494
DOC_WW_Pin1_4	245	250	PF00397	0.673
DOC_WW_Pin1_4	310	315	PF00397	0.553
DOC_WW_Pin1_4	53	58	PF00397	0.259
DOC_WW_Pin1_4	96	101	PF00397	0.424
LIG_14-3-3_CanoR_1	169	174	PF00244	0.339
LIG_14-3-3_CanoR_1	3	8	PF00244	0.313
LIG_14-3-3_CanoR_1	35	39	PF00244	0.315
LIG_14-3-3_CanoR_1	93	100	PF00244	0.168
LIG_14-3-3_CterR_2	409	414	PF00244	0.536
LIG_APCC_ABBA_1	312	317	PF00400	0.416
LIG_BIR_III_4	256	260	PF00653	0.492
LIG_BRCT_BRCA1_1	27	31	PF00533	0.291
LIG_FHA_1	206	212	PF00498	0.336
LIG_FHA_1	217	223	PF00498	0.463
LIG_FHA_1	54	60	PF00498	0.258
LIG_FHA_2	129	135	PF00498	0.351
LIG_LIR_Gen_1	276	285	PF02991	0.429
LIG_LIR_Gen_1	28	38	PF02991	0.466
LIG_LIR_Gen_1	313	321	PF02991	0.557
LIG_LIR_Gen_1	403	412	PF02991	0.522
LIG_LIR_LC3C_4	208	212	PF02991	0.439
LIG_LIR_Nem_3	276	281	PF02991	0.437
LIG_LIR_Nem_3	28	34	PF02991	0.399
LIG_LIR_Nem_3	313	318	PF02991	0.551
LIG_LIR_Nem_3	37	41	PF02991	0.343
LIG_LIR_Nem_3	403	408	PF02991	0.491
LIG_NRBOX	407	413	PF00104	0.530
LIG_Pex14_2	334	338	PF04695	0.421
LIG_REV1ctd_RIR_1	77	86	PF16727	0.166
LIG_SH2_CRK	278	282	PF00017	0.458
LIG_SH2_GRB2like	304	307	PF00017	0.273
LIG_SH2_SRC	304	307	PF00017	0.364
LIG_SH2_STAP1	301	305	PF00017	0.384
LIG_SH2_STAT5	304	307	PF00017	0.398
LIG_SH2_STAT5	315	318	PF00017	0.553
LIG_SH2_STAT5	87	90	PF00017	0.291
LIG_SH3_1	308	314	PF00018	0.463
LIG_SH3_1	54	60	PF00018	0.208
LIG_SH3_3	110	116	PF00018	0.213
LIG_SH3_3	308	314	PF00018	0.558
LIG_SH3_3	54	60	PF00018	0.301
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.325
LIG_SUMO_SIM_par_1	208	214	PF11976	0.384
LIG_SUMO_SIM_par_1	39	45	PF11976	0.291
LIG_TRAF2_1	163	166	PF00917	0.469
LIG_TRAF2_1	182	185	PF00917	0.315
LIG_TRAF2_1	24	27	PF00917	0.350
LIG_TRAF2_1	81	84	PF00917	0.291
LIG_UBA3_1	281	290	PF00899	0.383
MOD_CK1_1	156	162	PF00069	0.208
MOD_CK1_1	250	256	PF00069	0.764
MOD_CK1_1	336	342	PF00069	0.565
MOD_CK1_1	69	75	PF00069	0.210
MOD_CK1_1	92	98	PF00069	0.285
MOD_GlcNHglycan	158	161	PF01048	0.350
MOD_GlcNHglycan	252	255	PF01048	0.561
MOD_GlcNHglycan	261	264	PF01048	0.532
MOD_GlcNHglycan	338	341	PF01048	0.570
MOD_GlcNHglycan	356	359	PF01048	0.609
MOD_GlcNHglycan	60	63	PF01048	0.457
MOD_GlcNHglycan	68	71	PF01048	0.490
MOD_GlcNHglycan	95	98	PF01048	0.297
MOD_GSK3_1	11	18	PF00069	0.295
MOD_GSK3_1	169	176	PF00069	0.336
MOD_GSK3_1	226	233	PF00069	0.480
MOD_GSK3_1	245	252	PF00069	0.605
MOD_GSK3_1	255	262	PF00069	0.676
MOD_GSK3_1	277	284	PF00069	0.553
MOD_GSK3_1	290	297	PF00069	0.448
MOD_GSK3_1	300	307	PF00069	0.480
MOD_GSK3_1	329	336	PF00069	0.481
MOD_GSK3_1	49	56	PF00069	0.268
MOD_GSK3_1	65	72	PF00069	0.171
MOD_GSK3_1	89	96	PF00069	0.333
MOD_N-GLC_1	135	140	PF02516	0.468
MOD_NEK2_1	122	127	PF00069	0.384
MOD_NEK2_1	15	20	PF00069	0.325
MOD_NEK2_1	173	178	PF00069	0.306
MOD_NEK2_1	294	299	PF00069	0.451
MOD_NEK2_1	334	339	PF00069	0.606
MOD_NEK2_1	49	54	PF00069	0.373
MOD_NEK2_2	164	169	PF00069	0.166
MOD_PIKK_1	122	128	PF00454	0.388
MOD_PKA_2	327	333	PF00069	0.522
MOD_PKA_2	34	40	PF00069	0.297
MOD_PKA_2	89	95	PF00069	0.226
MOD_Plk_1	25	31	PF00069	0.461
MOD_Plk_1	294	300	PF00069	0.477
MOD_Plk_1	316	322	PF00069	0.539
MOD_Plk_2-3	266	272	PF00069	0.508
MOD_Plk_4	11	17	PF00069	0.312
MOD_Plk_4	169	175	PF00069	0.315
MOD_Plk_4	266	272	PF00069	0.541
MOD_Plk_4	277	283	PF00069	0.460
MOD_Plk_4	300	306	PF00069	0.532
MOD_ProDKin_1	153	159	PF00069	0.425
MOD_ProDKin_1	230	236	PF00069	0.484
MOD_ProDKin_1	245	251	PF00069	0.681
MOD_ProDKin_1	310	316	PF00069	0.411
MOD_ProDKin_1	53	59	PF00069	0.259
MOD_ProDKin_1	96	102	PF00069	0.424
MOD_SUMO_for_1	81	84	PF00179	0.208
TRG_DiLeu_BaEn_1	266	271	PF01217	0.452
TRG_DiLeu_BaEn_4	184	190	PF01217	0.430
TRG_ENDOCYTIC_2	278	281	PF00928	0.394
TRG_ENDOCYTIC_2	315	318	PF00928	0.474
TRG_ENDOCYTIC_2	77	80	PF00928	0.189
TRG_ER_diArg_1	144	147	PF00400	0.392
TRG_ER_diArg_1	201	204	PF00400	0.258
TRG_ER_diArg_1	240	242	PF00400	0.402
TRG_Pf-PMV_PEXEL_1	409	414	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L5	Leptomonas seymouri	30%	100%
A0A0S4JE30	Bodo saltans	38%	100%
A0A0S4JK16	Bodo saltans	30%	95%
A0A1X0NVQ6	Trypanosomatidae	30%	100%
A0A1X0P1X9	Trypanosomatidae	41%	100%
A0A3Q8IFT0	Leishmania donovani	91%	100%
A0A3R7KWZ0	Trypanosoma rangeli	29%	100%
A0A3R7KYN0	Trypanosoma rangeli	43%	100%
A0A3S7WTN3	Leishmania donovani	28%	100%
A4H8A5	Leishmania braziliensis	28%	84%
A4HIA2	Leishmania braziliensis	84%	100%
A4HWM5	Leishmania infantum	29%	100%
A4I5I6	Leishmania infantum	91%	100%
C9ZXR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	89%
Q4Q7E7	Leishmania major	93%	100%
Q4QF43	Leishmania major	29%	89%
V5BPI9	Trypanosoma cruzi	41%	100%
V5BUE5	Trypanosoma cruzi	29%	100%