Flavoprotein domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantothenoylcysteine decarboxylase, putative

Species:

Leishmania mexicana

UniProt:

E9B0S8_LEIMU

TriTrypDb:

LmxM.29.1540

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0071513	phosphopantothenoylcysteine decarboxylase complex	3	1
GO:1902494	catalytic complex	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0S8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015937	coenzyme A biosynthetic process	7	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033866	nucleoside bisphosphate biosynthetic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0000166	nucleotide binding	3	1
GO:0004633	phosphopantothenoylcysteine decarboxylase activity	5	3
GO:0005488	binding	1	1
GO:0010181	FMN binding	4	1
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	3
GO:0016831	carboxy-lyase activity	4	3
GO:0032553	ribonucleotide binding	3	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	297	299	PF00675	0.557
CLV_NRD_NRD_1	306	308	PF00675	0.609
CLV_NRD_NRD_1	62	64	PF00675	0.386
CLV_NRD_NRD_1	99	101	PF00675	0.351
CLV_PCSK_KEX2_1	263	265	PF00082	0.404
CLV_PCSK_KEX2_1	296	298	PF00082	0.566
CLV_PCSK_KEX2_1	306	308	PF00082	0.661
CLV_PCSK_KEX2_1	62	64	PF00082	0.431
CLV_PCSK_KEX2_1	99	101	PF00082	0.351
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.404
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.566
CLV_PCSK_PC7_1	293	299	PF00082	0.545
CLV_PCSK_SKI1_1	117	121	PF00082	0.439
CLV_PCSK_SKI1_1	55	59	PF00082	0.339
DEG_SPOP_SBC_1	222	226	PF00917	0.646
DOC_MAPK_DCC_7	242	250	PF00069	0.507
DOC_MAPK_gen_1	99	107	PF00069	0.347
DOC_MAPK_MEF2A_6	16	24	PF00069	0.425
DOC_MAPK_MEF2A_6	242	250	PF00069	0.527
DOC_USP7_MATH_1	194	198	PF00917	0.763
DOC_USP7_MATH_1	222	226	PF00917	0.724
DOC_USP7_MATH_1	228	232	PF00917	0.703
DOC_USP7_MATH_1	64	68	PF00917	0.361
DOC_USP7_MATH_1	72	76	PF00917	0.414
DOC_WW_Pin1_4	192	197	PF00397	0.628
LIG_14-3-3_CanoR_1	174	183	PF00244	0.619
LIG_14-3-3_CanoR_1	286	290	PF00244	0.454
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BIR_III_1	1	5	PF00653	0.549
LIG_BIR_III_3	1	5	PF00653	0.737
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.315
LIG_eIF4E_1	17	23	PF01652	0.492
LIG_FHA_1	215	221	PF00498	0.661
LIG_FHA_1	25	31	PF00498	0.326
LIG_FHA_1	260	266	PF00498	0.421
LIG_FHA_1	286	292	PF00498	0.411
LIG_FHA_1	312	318	PF00498	0.642
LIG_FHA_1	33	39	PF00498	0.335
LIG_FHA_2	247	253	PF00498	0.518
LIG_GBD_Chelix_1	118	126	PF00786	0.375
LIG_GBD_Chelix_1	281	289	PF00786	0.496
LIG_LIR_Apic_2	149	155	PF02991	0.315
LIG_LIR_Apic_2	166	171	PF02991	0.315
LIG_LIR_Gen_1	252	260	PF02991	0.388
LIG_LIR_LC3C_4	103	106	PF02991	0.431
LIG_LIR_Nem_3	14	20	PF02991	0.559
LIG_LIR_Nem_3	252	258	PF02991	0.438
LIG_LYPXL_yS_3	17	20	PF13949	0.517
LIG_Pex14_2	300	304	PF04695	0.343
LIG_PTB_Apo_2	181	188	PF02174	0.460
LIG_SH2_CRK	255	259	PF00017	0.476
LIG_SH2_STAT5	168	171	PF00017	0.477
LIG_SH2_STAT5	284	287	PF00017	0.391
LIG_SH3_3	103	109	PF00018	0.315
LIG_SH3_3	241	247	PF00018	0.616
LIG_SH3_3	254	260	PF00018	0.335
LIG_SH3_3	314	320	PF00018	0.715
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.375
LIG_SUMO_SIM_par_1	21	27	PF11976	0.315
LIG_SUMO_SIM_par_1	246	253	PF11976	0.519
LIG_SxIP_EBH_1	63	77	PF03271	0.431
LIG_TRAF2_1	12	15	PF00917	0.608
LIG_TRAF2_1	277	280	PF00917	0.455
LIG_TRAF2_1	320	323	PF00917	0.801
LIG_WW_2	244	247	PF00397	0.546
MOD_CDC14_SPxK_1	195	198	PF00782	0.635
MOD_CDK_SPxK_1	192	198	PF00069	0.631
MOD_CK1_1	175	181	PF00069	0.517
MOD_CK1_1	192	198	PF00069	0.627
MOD_CK1_1	221	227	PF00069	0.714
MOD_CK1_1	3	9	PF00069	0.761
MOD_CK1_1	75	81	PF00069	0.410
MOD_CK2_1	246	252	PF00069	0.577
MOD_CK2_1	274	280	PF00069	0.524
MOD_CMANNOS	83	86	PF00535	0.315
MOD_GlcNHglycan	203	206	PF01048	0.710
MOD_GlcNHglycan	220	223	PF01048	0.733
MOD_GlcNHglycan	225	228	PF01048	0.633
MOD_GSK3_1	192	199	PF00069	0.762
MOD_GSK3_1	214	221	PF00069	0.760
MOD_GSK3_1	223	230	PF00069	0.756
MOD_GSK3_1	246	253	PF00069	0.517
MOD_GSK3_1	6	13	PF00069	0.648
MOD_N-GLC_1	183	188	PF02516	0.487
MOD_N-GLC_1	214	219	PF02516	0.654
MOD_NEK2_1	126	131	PF00069	0.425
MOD_NEK2_1	24	29	PF00069	0.388
MOD_NEK2_1	250	255	PF00069	0.555
MOD_OFUCOSY	169	176	PF10250	0.538
MOD_PIKK_1	311	317	PF00454	0.656
MOD_PK_1	16	22	PF00069	0.431
MOD_PKA_2	250	256	PF00069	0.486
MOD_PKA_2	285	291	PF00069	0.447
MOD_Plk_1	183	189	PF00069	0.464
MOD_Plk_4	126	132	PF00069	0.410
MOD_Plk_4	250	256	PF00069	0.509
MOD_Plk_4	6	12	PF00069	0.438
MOD_Plk_4	72	78	PF00069	0.458
MOD_ProDKin_1	192	198	PF00069	0.631
MOD_SUMO_rev_2	13	18	PF00179	0.552
MOD_SUMO_rev_2	79	89	PF00179	0.208
TRG_ENDOCYTIC_2	17	20	PF00928	0.517
TRG_ENDOCYTIC_2	255	258	PF00928	0.520
TRG_ER_diArg_1	61	63	PF00400	0.431
TRG_ER_diArg_1	98	100	PF00400	0.315
TRG_NES_CRM1_1	279	295	PF08389	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGH1	Leptomonas seymouri	61%	100%
A0A3Q8IBY6	Leishmania donovani	90%	100%
A0A3R7KRR4	Trypanosoma rangeli	52%	100%
A4HI99	Leishmania braziliensis	76%	100%
A4I5I3	Leishmania infantum	90%	100%
C9ZQW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
O51752	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	22%	83%
Q4Q7F0	Leishmania major	87%	99%
V5B8Z6	Trypanosoma cruzi	50%	100%