PseudoU_synth_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania mexicana

UniProt:

E9B0S6_LEIMU

TriTrypDb:

LmxM.29.1520

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0S6

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0009982	pseudouridine synthase activity	4	7
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.412
CLV_NRD_NRD_1	128	130	PF00675	0.359
CLV_NRD_NRD_1	212	214	PF00675	0.315
CLV_NRD_NRD_1	240	242	PF00675	0.212
CLV_NRD_NRD_1	332	334	PF00675	0.346
CLV_NRD_NRD_1	378	380	PF00675	0.627
CLV_NRD_NRD_1	410	412	PF00675	0.574
CLV_NRD_NRD_1	49	51	PF00675	0.329
CLV_NRD_NRD_1	89	91	PF00675	0.335
CLV_PCSK_KEX2_1	128	130	PF00082	0.359
CLV_PCSK_KEX2_1	212	214	PF00082	0.315
CLV_PCSK_KEX2_1	289	291	PF00082	0.418
CLV_PCSK_KEX2_1	332	334	PF00082	0.346
CLV_PCSK_KEX2_1	378	380	PF00082	0.526
CLV_PCSK_KEX2_1	408	410	PF00082	0.527
CLV_PCSK_KEX2_1	49	51	PF00082	0.346
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.418
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.527
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.346
CLV_PCSK_PC7_1	208	214	PF00082	0.315
CLV_PCSK_SKI1_1	175	179	PF00082	0.418
CLV_PCSK_SKI1_1	217	221	PF00082	0.224
CLV_PCSK_SKI1_1	279	283	PF00082	0.418
CLV_PCSK_SKI1_1	29	33	PF00082	0.367
CLV_PCSK_SKI1_1	34	38	PF00082	0.411
CLV_PCSK_SKI1_1	386	390	PF00082	0.459
CLV_PCSK_SKI1_1	402	406	PF00082	0.541
CLV_PCSK_SKI1_1	411	415	PF00082	0.580
CLV_PCSK_SKI1_1	52	56	PF00082	0.346
DEG_Nend_Nbox_1	1	3	PF02207	0.430
DEG_ODPH_VHL_1	326	338	PF01847	0.618
DEG_SPOP_SBC_1	367	371	PF00917	0.479
DOC_CYCLIN_RxL_1	383	392	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.412
DOC_MAPK_DCC_7	195	205	PF00069	0.412
DOC_MAPK_gen_1	332	338	PF00069	0.546
DOC_MAPK_gen_1	406	416	PF00069	0.585
DOC_MAPK_gen_1	46	56	PF00069	0.612
DOC_MAPK_gen_1	87	96	PF00069	0.531
DOC_MAPK_MEF2A_6	249	257	PF00069	0.482
DOC_PP1_RVXF_1	339	346	PF00149	0.601
DOC_PP1_RVXF_1	50	57	PF00149	0.546
DOC_PP2B_LxvP_1	293	296	PF13499	0.545
DOC_PP2B_LxvP_1	325	328	PF13499	0.618
DOC_PP2B_LxvP_1	365	368	PF13499	0.441
DOC_PP2B_LxvP_1	387	390	PF13499	0.494
DOC_USP7_MATH_1	108	112	PF00917	0.468
DOC_USP7_MATH_1	127	131	PF00917	0.569
DOC_USP7_MATH_1	155	159	PF00917	0.585
DOC_USP7_MATH_1	191	195	PF00917	0.453
DOC_USP7_MATH_1	248	252	PF00917	0.545
DOC_USP7_MATH_1	275	279	PF00917	0.565
DOC_USP7_MATH_1	281	285	PF00917	0.525
DOC_USP7_UBL2_3	245	249	PF12436	0.412
DOC_USP7_UBL2_3	48	52	PF12436	0.559
DOC_WW_Pin1_4	310	315	PF00397	0.578
DOC_WW_Pin1_4	391	396	PF00397	0.698
LIG_14-3-3_CanoR_1	128	133	PF00244	0.542
LIG_14-3-3_CanoR_1	180	189	PF00244	0.538
LIG_14-3-3_CanoR_1	217	227	PF00244	0.500
LIG_BRCT_BRCA1_1	265	269	PF00533	0.449
LIG_BRCT_BRCA1_1	436	440	PF00533	0.655
LIG_deltaCOP1_diTrp_1	430	434	PF00928	0.534
LIG_FHA_1	219	225	PF00498	0.589
LIG_FHA_1	280	286	PF00498	0.546
LIG_FHA_1	320	326	PF00498	0.544
LIG_FHA_1	372	378	PF00498	0.456
LIG_FHA_1	392	398	PF00498	0.580
LIG_FHA_1	430	436	PF00498	0.643
LIG_FHA_1	62	68	PF00498	0.546
LIG_FHA_2	182	188	PF00498	0.559
LIG_FHA_2	262	268	PF00498	0.546
LIG_FHA_2	439	445	PF00498	0.631
LIG_LIR_Gen_1	161	166	PF02991	0.427
LIG_LIR_Gen_1	183	192	PF02991	0.548
LIG_LIR_Gen_1	430	438	PF02991	0.540
LIG_LIR_Nem_3	161	165	PF02991	0.446
LIG_LIR_Nem_3	183	189	PF02991	0.548
LIG_LIR_Nem_3	237	243	PF02991	0.549
LIG_LIR_Nem_3	430	434	PF02991	0.534
LIG_LIR_Nem_3	437	443	PF02991	0.588
LIG_PCNA_PIPBox_1	86	95	PF02747	0.618
LIG_SH2_CRK	240	244	PF00017	0.546
LIG_SH2_PTP2	93	96	PF00017	0.546
LIG_SH2_SRC	381	384	PF00017	0.454
LIG_SH2_STAT3	176	179	PF00017	0.486
LIG_SH2_STAT5	176	179	PF00017	0.527
LIG_SH2_STAT5	292	295	PF00017	0.618
LIG_SH2_STAT5	353	356	PF00017	0.496
LIG_SH2_STAT5	381	384	PF00017	0.430
LIG_SH2_STAT5	93	96	PF00017	0.528
LIG_SH3_3	1	7	PF00018	0.380
LIG_SH3_3	252	258	PF00018	0.546
LIG_SH3_3	361	367	PF00018	0.535
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.543
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.555
LIG_TYR_ITIM	238	243	PF00017	0.618
LIG_UBA3_1	285	289	PF00899	0.546
MOD_CDK_SPK_2	391	396	PF00069	0.504
MOD_CK1_1	111	117	PF00069	0.544
MOD_CK1_1	119	125	PF00069	0.596
MOD_CK1_1	131	137	PF00069	0.459
MOD_CK1_1	154	160	PF00069	0.533
MOD_CK1_1	211	217	PF00069	0.618
MOD_CK1_1	218	224	PF00069	0.536
MOD_CK1_1	244	250	PF00069	0.534
MOD_CK1_1	424	430	PF00069	0.499
MOD_CK2_1	181	187	PF00069	0.532
MOD_CK2_1	261	267	PF00069	0.546
MOD_CK2_1	424	430	PF00069	0.736
MOD_Cter_Amidation	330	333	PF01082	0.346
MOD_GlcNHglycan	109	113	PF01048	0.307
MOD_GlcNHglycan	153	156	PF01048	0.340
MOD_GlcNHglycan	157	160	PF01048	0.340
MOD_GlcNHglycan	213	216	PF01048	0.315
MOD_GlcNHglycan	424	427	PF01048	0.710
MOD_GlcNHglycan	64	67	PF01048	0.346
MOD_GSK3_1	116	123	PF00069	0.554
MOD_GSK3_1	127	134	PF00069	0.453
MOD_GSK3_1	151	158	PF00069	0.559
MOD_GSK3_1	211	218	PF00069	0.609
MOD_GSK3_1	244	251	PF00069	0.515
MOD_GSK3_1	271	278	PF00069	0.559
MOD_GSK3_1	310	317	PF00069	0.583
MOD_GSK3_1	348	355	PF00069	0.424
MOD_GSK3_1	367	374	PF00069	0.773
MOD_GSK3_1	420	427	PF00069	0.692
MOD_GSK3_1	434	441	PF00069	0.428
MOD_N-GLC_2	137	139	PF02516	0.418
MOD_NEK2_1	2	7	PF00069	0.618
MOD_NEK2_1	243	248	PF00069	0.559
MOD_NEK2_1	271	276	PF00069	0.443
MOD_NEK2_1	288	293	PF00069	0.571
MOD_NEK2_1	37	42	PF00069	0.446
MOD_NEK2_1	62	67	PF00069	0.552
MOD_NEK2_2	14	19	PF00069	0.559
MOD_NEK2_2	145	150	PF00069	0.412
MOD_PKA_1	128	134	PF00069	0.559
MOD_PKA_1	241	247	PF00069	0.412
MOD_PKA_2	127	133	PF00069	0.534
MOD_PKA_2	211	217	PF00069	0.556
MOD_Plk_1	14	20	PF00069	0.559
MOD_Plk_4	14	20	PF00069	0.518
MOD_Plk_4	201	207	PF00069	0.576
MOD_Plk_4	22	28	PF00069	0.457
MOD_Plk_4	248	254	PF00069	0.592
MOD_Plk_4	281	287	PF00069	0.546
MOD_Plk_4	319	325	PF00069	0.546
MOD_Plk_4	348	354	PF00069	0.372
MOD_Plk_4	368	374	PF00069	0.543
MOD_ProDKin_1	310	316	PF00069	0.578
MOD_ProDKin_1	391	397	PF00069	0.699
MOD_SUMO_rev_2	119	127	PF00179	0.559
TRG_DiLeu_BaEn_2	429	435	PF01217	0.549
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.482
TRG_ENDOCYTIC_2	240	243	PF00928	0.546
TRG_ENDOCYTIC_2	93	96	PF00928	0.504
TRG_ER_diArg_1	377	379	PF00400	0.664
TRG_ER_diArg_1	409	411	PF00400	0.544
TRG_NLS_MonoCore_2	405	410	PF00514	0.588
TRG_NLS_MonoCore_2	48	53	PF00514	0.545
TRG_NLS_MonoExtC_3	405	410	PF00514	0.588
TRG_NLS_MonoExtN_4	406	411	PF00514	0.585
TRG_NLS_MonoExtN_4	46	53	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P976	Leptomonas seymouri	50%	100%
A0A3S7X3F6	Leishmania donovani	86%	100%
A4HI97	Leishmania braziliensis	71%	100%
A4I5I1	Leishmania infantum	86%	100%
Q4Q7F2	Leishmania major	82%	100%