Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B0R9_LEIMU

TriTrypDb:

LmxM.29.1400

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	17
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	17
GO:0043228	non-membrane-bounded organelle	3	17
GO:0043229	intracellular organelle	3	17
GO:0043232	intracellular non-membrane-bounded organelle	4	17
GO:0110165	cellular anatomical entity	1	17
GO:1990904	ribonucleoprotein complex	2	17
GO:0005730	nucleolus	5	5
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9B0R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0R9

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.500
CLV_C14_Caspase3-7	417	421	PF00656	0.338
CLV_NRD_NRD_1	270	272	PF00675	0.342
CLV_PCSK_KEX2_1	270	272	PF00082	0.342
CLV_PCSK_KEX2_1	388	390	PF00082	0.402
CLV_PCSK_KEX2_1	464	466	PF00082	0.457
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.402
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.444
CLV_PCSK_SKI1_1	245	249	PF00082	0.489
CLV_PCSK_SKI1_1	428	432	PF00082	0.396
CLV_PCSK_SKI1_1	529	533	PF00082	0.408
DEG_SPOP_SBC_1	319	323	PF00917	0.461
DOC_ANK_TNKS_1	127	134	PF00023	0.517
DOC_CYCLIN_yCln2_LP_2	196	199	PF00134	0.304
DOC_PP2B_LxvP_1	196	199	PF13499	0.304
DOC_PP4_FxxP_1	10	13	PF00568	0.588
DOC_PP4_FxxP_1	532	535	PF00568	0.379
DOC_USP7_MATH_1	185	189	PF00917	0.432
DOC_USP7_MATH_1	220	224	PF00917	0.698
DOC_USP7_MATH_1	319	323	PF00917	0.465
DOC_USP7_MATH_1	450	454	PF00917	0.307
DOC_USP7_MATH_1	49	53	PF00917	0.598
DOC_USP7_MATH_1	533	537	PF00917	0.352
DOC_USP7_MATH_1	94	98	PF00917	0.685
DOC_WW_Pin1_4	131	136	PF00397	0.565
DOC_WW_Pin1_4	146	151	PF00397	0.634
DOC_WW_Pin1_4	158	163	PF00397	0.585
DOC_WW_Pin1_4	34	39	PF00397	0.766
DOC_WW_Pin1_4	445	450	PF00397	0.348
DOC_WW_Pin1_4	531	536	PF00397	0.358
DOC_WW_Pin1_4	57	62	PF00397	0.565
DOC_WW_Pin1_4	89	94	PF00397	0.751
LIG_14-3-3_CanoR_1	138	143	PF00244	0.725
LIG_14-3-3_CanoR_1	166	172	PF00244	0.506
LIG_14-3-3_CanoR_1	17	25	PF00244	0.610
LIG_14-3-3_CanoR_1	265	273	PF00244	0.542
LIG_14-3-3_CanoR_1	313	319	PF00244	0.379
LIG_14-3-3_CanoR_1	422	431	PF00244	0.478
LIG_14-3-3_CanoR_1	50	54	PF00244	0.616
LIG_14-3-3_CanoR_1	55	61	PF00244	0.588
LIG_14-3-3_CanoR_1	91	97	PF00244	0.577
LIG_APCC_ABBA_1	406	411	PF00400	0.439
LIG_BIR_III_4	420	424	PF00653	0.386
LIG_BRCT_BRCA1_1	6	10	PF00533	0.554
LIG_Clathr_ClatBox_1	190	194	PF01394	0.323
LIG_deltaCOP1_diTrp_1	259	266	PF00928	0.447
LIG_FHA_1	132	138	PF00498	0.570
LIG_FHA_1	256	262	PF00498	0.480
LIG_FHA_1	300	306	PF00498	0.462
LIG_FHA_1	325	331	PF00498	0.481
LIG_FHA_1	358	364	PF00498	0.532
LIG_FHA_1	368	374	PF00498	0.520
LIG_FHA_1	512	518	PF00498	0.542
LIG_FHA_1	62	68	PF00498	0.601
LIG_FHA_2	241	247	PF00498	0.456
LIG_FHA_2	415	421	PF00498	0.333
LIG_FHA_2	478	484	PF00498	0.303
LIG_Integrin_isoDGR_2	504	506	PF01839	0.453
LIG_LIR_Apic_2	169	175	PF02991	0.607
LIG_LIR_Apic_2	530	535	PF02991	0.375
LIG_LIR_Apic_2	7	13	PF02991	0.581
LIG_LIR_Gen_1	353	363	PF02991	0.450
LIG_LIR_Nem_3	119	125	PF02991	0.663
LIG_LIR_Nem_3	353	358	PF02991	0.450
LIG_PCNA_PIPBox_1	244	253	PF02747	0.471
LIG_PCNA_yPIPBox_3	412	422	PF02747	0.273
LIG_PTAP_UEV_1	24	29	PF05743	0.520
LIG_SH2_CRK	122	126	PF00017	0.531
LIG_SH2_STAP1	324	328	PF00017	0.447
LIG_SH2_STAP1	489	493	PF00017	0.518
LIG_SH2_STAP1	519	523	PF00017	0.333
LIG_SH2_STAT5	251	254	PF00017	0.415
LIG_SH3_1	172	178	PF00018	0.525
LIG_SH3_3	172	178	PF00018	0.466
LIG_SH3_3	192	198	PF00018	0.251
LIG_SH3_3	22	28	PF00018	0.546
LIG_SH3_3	449	455	PF00018	0.394
LIG_SH3_3	77	83	PF00018	0.665
LIG_SH3_4	428	435	PF00018	0.415
LIG_SUMO_SIM_par_1	414	420	PF11976	0.263
LIG_SUMO_SIM_par_1	453	459	PF11976	0.389
LIG_UBA3_1	517	522	PF00899	0.315
LIG_WRC_WIRS_1	440	445	PF05994	0.460
MOD_CDK_SPxxK_3	131	138	PF00069	0.554
MOD_CDK_SPxxK_3	146	153	PF00069	0.625
MOD_CK1_1	124	130	PF00069	0.805
MOD_CK1_1	141	147	PF00069	0.528
MOD_CK1_1	167	173	PF00069	0.526
MOD_CK1_1	20	26	PF00069	0.517
MOD_CK1_1	249	255	PF00069	0.336
MOD_CK1_1	92	98	PF00069	0.693
MOD_CK2_1	167	173	PF00069	0.569
MOD_CK2_1	240	246	PF00069	0.431
MOD_CK2_1	303	309	PF00069	0.295
MOD_CK2_1	353	359	PF00069	0.255
MOD_DYRK1A_RPxSP_1	445	449	PF00069	0.329
MOD_DYRK1A_RPxSP_1	57	61	PF00069	0.544
MOD_GlcNHglycan	103	106	PF01048	0.525
MOD_GlcNHglycan	145	148	PF01048	0.604
MOD_GlcNHglycan	220	223	PF01048	0.508
MOD_GlcNHglycan	230	233	PF01048	0.284
MOD_GlcNHglycan	273	276	PF01048	0.321
MOD_GlcNHglycan	345	348	PF01048	0.437
MOD_GlcNHglycan	363	366	PF01048	0.298
MOD_GlcNHglycan	425	428	PF01048	0.617
MOD_GlcNHglycan	452	455	PF01048	0.426
MOD_GlcNHglycan	499	502	PF01048	0.368
MOD_GlcNHglycan	6	9	PF01048	0.576
MOD_GlcNHglycan	96	99	PF01048	0.619
MOD_GSK3_1	15	22	PF00069	0.702
MOD_GSK3_1	161	168	PF00069	0.516
MOD_GSK3_1	179	186	PF00069	0.326
MOD_GSK3_1	251	258	PF00069	0.313
MOD_GSK3_1	26	33	PF00069	0.615
MOD_GSK3_1	299	306	PF00069	0.311
MOD_GSK3_1	314	321	PF00069	0.395
MOD_GSK3_1	353	360	PF00069	0.424
MOD_GSK3_1	493	500	PF00069	0.483
MOD_GSK3_1	57	64	PF00069	0.735
MOD_GSK3_1	81	88	PF00069	0.726
MOD_N-GLC_1	15	20	PF02516	0.528
MOD_N-GLC_2	240	242	PF02516	0.505
MOD_NEK2_1	121	126	PF00069	0.736
MOD_NEK2_1	165	170	PF00069	0.535
MOD_NEK2_1	299	304	PF00069	0.328
MOD_NEK2_1	318	323	PF00069	0.268
MOD_NEK2_1	383	388	PF00069	0.522
MOD_NEK2_1	456	461	PF00069	0.478
MOD_NEK2_1	497	502	PF00069	0.345
MOD_NEK2_1	56	61	PF00069	0.669
MOD_NEK2_1	85	90	PF00069	0.780
MOD_NEK2_2	324	329	PF00069	0.335
MOD_PIKK_1	303	309	PF00454	0.316
MOD_PIKK_1	350	356	PF00454	0.375
MOD_PK_1	138	144	PF00069	0.479
MOD_PKA_2	165	171	PF00069	0.520
MOD_PKA_2	31	37	PF00069	0.646
MOD_PKA_2	49	55	PF00069	0.807
MOD_PKA_2	56	62	PF00069	0.835
MOD_Plk_1	324	330	PF00069	0.316
MOD_Plk_2-3	477	483	PF00069	0.307
MOD_Plk_4	167	173	PF00069	0.546
MOD_Plk_4	246	252	PF00069	0.463
MOD_Plk_4	414	420	PF00069	0.377
MOD_Plk_4	439	445	PF00069	0.469
MOD_Plk_4	493	499	PF00069	0.449
MOD_Plk_4	533	539	PF00069	0.340
MOD_Plk_4	81	87	PF00069	0.750
MOD_ProDKin_1	131	137	PF00069	0.567
MOD_ProDKin_1	146	152	PF00069	0.627
MOD_ProDKin_1	158	164	PF00069	0.584
MOD_ProDKin_1	34	40	PF00069	0.766
MOD_ProDKin_1	445	451	PF00069	0.344
MOD_ProDKin_1	531	537	PF00069	0.356
MOD_ProDKin_1	57	63	PF00069	0.564
MOD_ProDKin_1	89	95	PF00069	0.750
MOD_SUMO_rev_2	274	281	PF00179	0.275
MOD_SUMO_rev_2	516	523	PF00179	0.326
TRG_DiLeu_BaEn_1	513	518	PF01217	0.350
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.332
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.413
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.510
TRG_ENDOCYTIC_2	122	125	PF00928	0.740
TRG_ER_diArg_1	270	272	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	23%	100%
A0A0N1IMQ0	Leptomonas seymouri	68%	100%
A0A1X0P1V8	Trypanosomatidae	55%	100%
A0A3Q8IGC4	Leishmania donovani	24%	100%
A0A3Q8IHW0	Leishmania donovani	92%	100%
A0A3R7MF36	Trypanosoma rangeli	51%	100%
A0A3S7WR72	Leishmania donovani	25%	100%
A4H666	Leishmania braziliensis	23%	100%
A4HI91	Leishmania braziliensis	80%	100%
A4HUJ0	Leishmania infantum	25%	100%
A4I135	Leishmania infantum	24%	100%
A4I5H1	Leishmania infantum	92%	100%
C9ZQV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q7G4	Leishmania major	91%	100%
Q4QAA4	Leishmania major	24%	100%
Q4QHD6	Leishmania major	25%	100%
V5BYY0	Trypanosoma cruzi	51%	100%