Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein kinase RIO2, putative

Species:

Leishmania mexicana

UniProt:

E9B0R5_LEIMU

TriTrypDb:

LmxM.29.1360

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B0R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0R5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.520
CLV_NRD_NRD_1	212	214	PF00675	0.253
CLV_NRD_NRD_1	277	279	PF00675	0.219
CLV_NRD_NRD_1	294	296	PF00675	0.397
CLV_NRD_NRD_1	310	312	PF00675	0.448
CLV_NRD_NRD_1	412	414	PF00675	0.541
CLV_NRD_NRD_1	443	445	PF00675	0.502
CLV_NRD_NRD_1	448	450	PF00675	0.506
CLV_NRD_NRD_1	49	51	PF00675	0.219
CLV_PCSK_FUR_1	410	414	PF00082	0.599
CLV_PCSK_KEX2_1	212	214	PF00082	0.230
CLV_PCSK_KEX2_1	277	279	PF00082	0.219
CLV_PCSK_KEX2_1	412	414	PF00082	0.536
CLV_PCSK_KEX2_1	448	450	PF00082	0.523
CLV_PCSK_KEX2_1	51	53	PF00082	0.227
CLV_PCSK_KEX2_1	89	91	PF00082	0.219
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.227
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.244
CLV_PCSK_PC7_1	444	450	PF00082	0.526
CLV_PCSK_PC7_1	85	91	PF00082	0.244
CLV_PCSK_SKI1_1	18	22	PF00082	0.227
CLV_PCSK_SKI1_1	185	189	PF00082	0.244
CLV_PCSK_SKI1_1	212	216	PF00082	0.320
CLV_PCSK_SKI1_1	277	281	PF00082	0.230
CLV_PCSK_SKI1_1	319	323	PF00082	0.603
CLV_PCSK_SKI1_1	474	478	PF00082	0.483
DEG_APCC_DBOX_1	211	219	PF00400	0.444
DEG_APCC_DBOX_1	49	57	PF00400	0.419
DOC_MAPK_gen_1	209	219	PF00069	0.434
DOC_MAPK_MEF2A_6	212	221	PF00069	0.420
DOC_MAPK_NFAT4_5	212	220	PF00069	0.430
DOC_PP4_FxxP_1	175	178	PF00568	0.430
DOC_SPAK_OSR1_1	278	282	PF12202	0.430
DOC_USP7_MATH_1	258	262	PF00917	0.520
DOC_USP7_UBL2_3	465	469	PF12436	0.478
LIG_14-3-3_CanoR_1	128	132	PF00244	0.419
LIG_14-3-3_CanoR_1	157	166	PF00244	0.503
LIG_14-3-3_CanoR_1	18	27	PF00244	0.419
LIG_14-3-3_CanoR_1	474	484	PF00244	0.639
LIG_BRCT_BRCA1_1	260	264	PF00533	0.510
LIG_BRCT_BRCA1_1	305	309	PF00533	0.450
LIG_CSL_BTD_1	284	287	PF09270	0.526
LIG_FHA_1	33	39	PF00498	0.419
LIG_FHA_2	19	25	PF00498	0.419
LIG_FHA_2	65	71	PF00498	0.419
LIG_Integrin_isoDGR_2	143	145	PF01839	0.287
LIG_LIR_Apic_2	172	178	PF02991	0.430
LIG_LIR_Gen_1	163	171	PF02991	0.422
LIG_LIR_Gen_1	230	238	PF02991	0.434
LIG_LIR_Gen_1	371	379	PF02991	0.568
LIG_LIR_Gen_1	80	87	PF02991	0.432
LIG_LIR_Nem_3	130	134	PF02991	0.436
LIG_LIR_Nem_3	14	20	PF02991	0.428
LIG_LIR_Nem_3	150	155	PF02991	0.420
LIG_LIR_Nem_3	230	234	PF02991	0.434
LIG_LIR_Nem_3	283	289	PF02991	0.385
LIG_LIR_Nem_3	371	375	PF02991	0.564
LIG_LIR_Nem_3	67	72	PF02991	0.419
LIG_LIR_Nem_3	80	84	PF02991	0.458
LIG_NRBOX	52	58	PF00104	0.419
LIG_PALB2_WD40_1	281	289	PF16756	0.508
LIG_PCNA_yPIPBox_3	311	321	PF02747	0.405
LIG_Pex14_2	275	279	PF04695	0.445
LIG_Rb_pABgroove_1	165	173	PF01858	0.430
LIG_REV1ctd_RIR_1	272	282	PF16727	0.419
LIG_SH2_CRK	79	83	PF00017	0.419
LIG_SH2_SRC	171	174	PF00017	0.442
LIG_SH2_STAP1	418	422	PF00017	0.608
LIG_SH2_STAP1	72	76	PF00017	0.443
LIG_SH2_STAP1	79	83	PF00017	0.433
LIG_SH2_STAT5	154	157	PF00017	0.436
LIG_SH2_STAT5	81	84	PF00017	0.473
LIG_SH3_3	174	180	PF00018	0.419
LIG_SH3_4	179	186	PF00018	0.444
LIG_SUMO_SIM_anti_2	105	114	PF11976	0.360
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.330
LIG_SUMO_SIM_par_1	105	114	PF11976	0.342
LIG_SUMO_SIM_par_1	243	248	PF11976	0.419
LIG_TRAF2_1	384	387	PF00917	0.630
MOD_CK1_1	130	136	PF00069	0.419
MOD_CK1_1	342	348	PF00069	0.657
MOD_CK1_1	354	360	PF00069	0.714
MOD_CK2_1	157	163	PF00069	0.520
MOD_CK2_1	18	24	PF00069	0.419
MOD_CK2_1	328	334	PF00069	0.593
MOD_CK2_1	381	387	PF00069	0.751
MOD_GlcNHglycan	223	226	PF01048	0.292
MOD_GlcNHglycan	305	308	PF01048	0.464
MOD_GlcNHglycan	375	378	PF01048	0.794
MOD_GlcNHglycan	420	423	PF01048	0.709
MOD_GSK3_1	153	160	PF00069	0.483
MOD_GSK3_1	281	288	PF00069	0.495
MOD_GSK3_1	303	310	PF00069	0.431
MOD_GSK3_1	85	92	PF00069	0.464
MOD_N-GLC_1	199	204	PF02516	0.267
MOD_N-GLC_1	258	263	PF02516	0.320
MOD_N-GLC_1	351	356	PF02516	0.758
MOD_NEK2_1	153	158	PF00069	0.419
MOD_NEK2_1	221	226	PF00069	0.492
MOD_NEK2_1	4	9	PF00069	0.357
MOD_NEK2_1	476	481	PF00069	0.634
MOD_NEK2_2	127	132	PF00069	0.419
MOD_PIKK_1	157	163	PF00454	0.520
MOD_PIKK_1	334	340	PF00454	0.703
MOD_PIKK_1	351	357	PF00454	0.616
MOD_PKA_1	89	95	PF00069	0.492
MOD_PKA_2	127	133	PF00069	0.419
MOD_PKA_2	339	345	PF00069	0.669
MOD_PKA_2	89	95	PF00069	0.492
MOD_Plk_1	162	168	PF00069	0.462
MOD_Plk_1	281	287	PF00069	0.516
MOD_Plk_1	4	10	PF00069	0.364
MOD_Plk_1	64	70	PF00069	0.425
MOD_Plk_2-3	389	395	PF00069	0.660
MOD_Plk_4	148	154	PF00069	0.419
MOD_Plk_4	162	168	PF00069	0.419
MOD_Plk_4	193	199	PF00069	0.444
MOD_Plk_4	281	287	PF00069	0.378
MOD_Plk_4	4	10	PF00069	0.364
MOD_Plk_4	64	70	PF00069	0.464
MOD_SUMO_rev_2	426	434	PF00179	0.366
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.578
TRG_ENDOCYTIC_2	164	167	PF00928	0.486
TRG_ENDOCYTIC_2	79	82	PF00928	0.419
TRG_ER_diArg_1	211	213	PF00400	0.444
TRG_ER_diArg_1	277	279	PF00400	0.419
TRG_ER_diArg_1	447	449	PF00400	0.515
TRG_ER_diArg_1	50	53	PF00400	0.419
TRG_NES_CRM1_1	269	282	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V8	Leptomonas seymouri	83%	100%
A0A0S4J6X4	Bodo saltans	60%	100%
A0A1X0P272	Trypanosomatidae	57%	100%
A0A3R7N743	Trypanosoma rangeli	65%	97%
A0A3S7X3A2	Leishmania donovani	96%	100%
A4HI88	Leishmania braziliensis	88%	100%
A4I5G7	Leishmania infantum	96%	100%
C9ZQV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
P40160	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q4Q7G8	Leishmania major	96%	100%
Q922Q2	Mus musculus	22%	86%
Q95Q34	Caenorhabditis elegans	47%	92%
Q9BVS4	Homo sapiens	43%	88%
Q9CQS5	Mus musculus	49%	89%
Q9P7W5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
V5B903	Trypanosoma cruzi	68%	100%