Putative GTPase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activating protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0R4_LEIMU

TriTrypDb:

LmxM.29.1350

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0R4

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0003925	G protein activity	2	4
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	457	461	PF00656	0.376
CLV_NRD_NRD_1	124	126	PF00675	0.448
CLV_NRD_NRD_1	349	351	PF00675	0.300
CLV_NRD_NRD_1	533	535	PF00675	0.376
CLV_PCSK_KEX2_1	123	125	PF00082	0.483
CLV_PCSK_KEX2_1	533	535	PF00082	0.376
CLV_PCSK_KEX2_1	600	602	PF00082	0.436
CLV_PCSK_KEX2_1	70	72	PF00082	0.439
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.436
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.416
CLV_PCSK_SKI1_1	18	22	PF00082	0.530
CLV_PCSK_SKI1_1	181	185	PF00082	0.489
CLV_PCSK_SKI1_1	374	378	PF00082	0.316
CLV_PCSK_SKI1_1	513	517	PF00082	0.360
DEG_APCC_DBOX_1	157	165	PF00400	0.616
DEG_MDM2_SWIB_1	502	510	PF02201	0.300
DEG_SCF_FBW7_1	47	54	PF00400	0.574
DEG_SCF_TRCP1_1	149	154	PF00400	0.536
DOC_AGCK_PIF_1	499	504	PF00069	0.360
DOC_CKS1_1	43	48	PF01111	0.618
DOC_CYCLIN_RxL_1	371	380	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.478
DOC_MAPK_gen_1	15	23	PF00069	0.502
DOC_MAPK_gen_1	70	78	PF00069	0.414
DOC_MAPK_HePTP_8	487	499	PF00069	0.328
DOC_MAPK_MEF2A_6	490	499	PF00069	0.328
DOC_PP1_RVXF_1	372	378	PF00149	0.360
DOC_PP1_RVXF_1	85	92	PF00149	0.411
DOC_PP2B_LxvP_1	26	29	PF13499	0.663
DOC_PP2B_LxvP_1	264	267	PF13499	0.588
DOC_PP2B_LxvP_1	395	398	PF13499	0.300
DOC_PP4_FxxP_1	272	275	PF00568	0.523
DOC_USP7_MATH_1	14	18	PF00917	0.709
DOC_USP7_MATH_1	168	172	PF00917	0.490
DOC_USP7_MATH_1	257	261	PF00917	0.674
DOC_USP7_MATH_1	265	269	PF00917	0.630
DOC_USP7_MATH_1	315	319	PF00917	0.601
DOC_USP7_MATH_1	354	358	PF00917	0.344
DOC_USP7_MATH_1	36	40	PF00917	0.626
DOC_USP7_MATH_1	410	414	PF00917	0.336
DOC_USP7_MATH_1	58	62	PF00917	0.536
DOC_USP7_MATH_1	63	67	PF00917	0.523
DOC_USP7_MATH_2	572	578	PF00917	0.438
DOC_USP7_UBL2_3	347	351	PF12436	0.360
DOC_WW_Pin1_4	255	260	PF00397	0.686
DOC_WW_Pin1_4	42	47	PF00397	0.533
LIG_14-3-3_CanoR_1	158	162	PF00244	0.582
LIG_14-3-3_CanoR_1	273	279	PF00244	0.668
LIG_14-3-3_CanoR_1	4	12	PF00244	0.595
LIG_14-3-3_CanoR_1	533	538	PF00244	0.376
LIG_APCC_ABBA_1	495	500	PF00400	0.328
LIG_BIR_III_2	239	243	PF00653	0.697
LIG_BRCT_BRCA1_1	179	183	PF00533	0.485
LIG_BRCT_BRCA1_1	276	280	PF00533	0.551
LIG_BRCT_BRCA1_1	585	589	PF00533	0.405
LIG_deltaCOP1_diTrp_1	101	110	PF00928	0.387
LIG_eIF4E_1	541	547	PF01652	0.300
LIG_FHA_1	1	7	PF00498	0.493
LIG_FHA_1	302	308	PF00498	0.699
LIG_FHA_1	33	39	PF00498	0.623
LIG_FHA_1	409	415	PF00498	0.360
LIG_FHA_1	419	425	PF00498	0.300
LIG_FHA_1	435	441	PF00498	0.243
LIG_FHA_1	449	455	PF00498	0.262
LIG_FHA_1	516	522	PF00498	0.300
LIG_FHA_1	571	577	PF00498	0.427
LIG_FHA_2	455	461	PF00498	0.376
LIG_LIR_Apic_2	270	275	PF02991	0.492
LIG_LIR_Gen_1	140	148	PF02991	0.500
LIG_LIR_Gen_1	422	433	PF02991	0.328
LIG_LIR_Gen_1	559	568	PF02991	0.394
LIG_LIR_LC3C_4	394	397	PF02991	0.360
LIG_LIR_Nem_3	101	106	PF02991	0.316
LIG_LIR_Nem_3	127	131	PF02991	0.361
LIG_LIR_Nem_3	134	139	PF02991	0.421
LIG_LIR_Nem_3	140	144	PF02991	0.510
LIG_LIR_Nem_3	422	428	PF02991	0.328
LIG_LIR_Nem_3	559	564	PF02991	0.424
LIG_Pex14_1	449	453	PF04695	0.360
LIG_Pex14_2	425	429	PF04695	0.328
LIG_Pex14_2	502	506	PF04695	0.300
LIG_SH2_CRK	488	492	PF00017	0.351
LIG_SH2_PTP2	561	564	PF00017	0.393
LIG_SH2_SRC	131	134	PF00017	0.445
LIG_SH2_STAP1	100	104	PF00017	0.374
LIG_SH2_STAP1	420	424	PF00017	0.376
LIG_SH2_STAP1	595	599	PF00017	0.429
LIG_SH2_STAT5	128	131	PF00017	0.354
LIG_SH2_STAT5	362	365	PF00017	0.300
LIG_SH2_STAT5	388	391	PF00017	0.327
LIG_SH2_STAT5	420	423	PF00017	0.360
LIG_SH2_STAT5	453	456	PF00017	0.321
LIG_SH2_STAT5	462	465	PF00017	0.273
LIG_SH2_STAT5	527	530	PF00017	0.300
LIG_SH2_STAT5	541	544	PF00017	0.300
LIG_SH2_STAT5	561	564	PF00017	0.236
LIG_SH3_3	170	176	PF00018	0.625
LIG_SH3_3	25	31	PF00018	0.609
LIG_SH3_3	285	291	PF00018	0.611
LIG_SH3_3	294	300	PF00018	0.713
LIG_SH3_3	40	46	PF00018	0.503
LIG_SH3_3	479	485	PF00018	0.336
LIG_SUMO_SIM_anti_2	559	566	PF11976	0.405
LIG_SxIP_EBH_1	49	58	PF03271	0.454
LIG_TRAF2_1	529	532	PF00917	0.336
LIG_WRC_WIRS_1	38	43	PF05994	0.487
LIG_WW_1	485	488	PF00397	0.360
LIG_WW_2	297	300	PF00397	0.611
MOD_CDK_SPxxK_3	42	49	PF00069	0.652
MOD_CK1_1	194	200	PF00069	0.662
MOD_CK1_1	260	266	PF00069	0.685
MOD_CK1_1	268	274	PF00069	0.721
MOD_CK1_1	318	324	PF00069	0.665
MOD_CK1_1	333	339	PF00069	0.662
MOD_CK1_1	432	438	PF00069	0.328
MOD_CK2_1	410	416	PF00069	0.300
MOD_CK2_1	526	532	PF00069	0.336
MOD_CK2_1	601	607	PF00069	0.532
MOD_GlcNHglycan	149	152	PF01048	0.546
MOD_GlcNHglycan	218	221	PF01048	0.683
MOD_GlcNHglycan	250	253	PF01048	0.592
MOD_GlcNHglycan	267	270	PF01048	0.685
MOD_GlcNHglycan	294	297	PF01048	0.509
MOD_GlcNHglycan	317	320	PF01048	0.701
MOD_GlcNHglycan	332	335	PF01048	0.714
MOD_GlcNHglycan	356	359	PF01048	0.300
MOD_GlcNHglycan	431	434	PF01048	0.371
MOD_GlcNHglycan	6	9	PF01048	0.689
MOD_GlcNHglycan	60	63	PF01048	0.572
MOD_GSK3_1	104	111	PF00069	0.391
MOD_GSK3_1	113	120	PF00069	0.378
MOD_GSK3_1	147	154	PF00069	0.558
MOD_GSK3_1	156	163	PF00069	0.631
MOD_GSK3_1	164	171	PF00069	0.479
MOD_GSK3_1	187	194	PF00069	0.748
MOD_GSK3_1	253	260	PF00069	0.692
MOD_GSK3_1	301	308	PF00069	0.590
MOD_GSK3_1	311	318	PF00069	0.678
MOD_GSK3_1	32	39	PF00069	0.702
MOD_GSK3_1	333	340	PF00069	0.621
MOD_GSK3_1	408	415	PF00069	0.324
MOD_GSK3_1	47	54	PF00069	0.529
MOD_GSK3_1	513	520	PF00069	0.360
MOD_GSK3_1	570	577	PF00069	0.371
MOD_GSK3_1	58	65	PF00069	0.646
MOD_N-GLC_1	460	465	PF02516	0.360
MOD_NEK2_1	104	109	PF00069	0.381
MOD_NEK2_1	147	152	PF00069	0.528
MOD_NEK2_1	280	285	PF00069	0.571
MOD_NEK2_1	305	310	PF00069	0.636
MOD_NEK2_1	332	337	PF00069	0.713
MOD_NEK2_1	377	382	PF00069	0.360
MOD_NEK2_1	454	459	PF00069	0.376
MOD_NEK2_1	515	520	PF00069	0.300
MOD_NEK2_1	6	11	PF00069	0.545
MOD_NEK2_2	595	600	PF00069	0.402
MOD_PIKK_1	168	174	PF00454	0.484
MOD_PIKK_1	241	247	PF00454	0.716
MOD_PIKK_1	434	440	PF00454	0.376
MOD_PIKK_1	515	521	PF00454	0.300
MOD_PIKK_1	549	555	PF00454	0.328
MOD_PK_1	533	539	PF00069	0.376
MOD_PKA_1	533	539	PF00069	0.376
MOD_PKA_1	600	606	PF00069	0.463
MOD_PKA_2	157	163	PF00069	0.583
MOD_PKA_2	354	360	PF00069	0.300
MOD_PKA_2	533	539	PF00069	0.376
MOD_PKA_2	600	606	PF00069	0.511
MOD_Plk_1	168	174	PF00069	0.473
MOD_Plk_1	595	601	PF00069	0.438
MOD_Plk_1	87	93	PF00069	0.411
MOD_Plk_2-3	574	580	PF00069	0.454
MOD_Plk_4	117	123	PF00069	0.415
MOD_Plk_4	206	212	PF00069	0.483
MOD_Plk_4	333	339	PF00069	0.541
MOD_Plk_4	449	455	PF00069	0.311
MOD_Plk_4	468	474	PF00069	0.189
MOD_ProDKin_1	255	261	PF00069	0.688
MOD_ProDKin_1	42	48	PF00069	0.534
TRG_DiLeu_BaEn_2	100	106	PF01217	0.375
TRG_DiLeu_BaEn_2	372	378	PF01217	0.360
TRG_DiLeu_BaLyEn_6	519	524	PF01217	0.360
TRG_ENDOCYTIC_2	136	139	PF00928	0.496
TRG_ENDOCYTIC_2	488	491	PF00928	0.351
TRG_ENDOCYTIC_2	561	564	PF00928	0.402
TRG_ER_diArg_1	122	125	PF00400	0.453
TRG_ER_diArg_1	533	535	PF00400	0.376
TRG_NES_CRM1_1	426	438	PF08389	0.289
TRG_NES_CRM1_1	580	592	PF08389	0.422
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K2	Leptomonas seymouri	55%	82%
A0A3Q8IE73	Leishmania donovani	91%	100%
A4HI87	Leishmania braziliensis	76%	100%
A4I5G6	Leishmania infantum	91%	100%
Q4Q7G9	Leishmania major	90%	100%
V5BU55	Trypanosoma cruzi	41%	100%