Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0R3_LEIMU

TriTrypDb:

LmxM.29.1340

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0R3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.675
CLV_C14_Caspase3-7	78	82	PF00656	0.726
CLV_NRD_NRD_1	169	171	PF00675	0.652
CLV_NRD_NRD_1	44	46	PF00675	0.615
CLV_PCSK_KEX2_1	104	106	PF00082	0.482
CLV_PCSK_KEX2_1	168	170	PF00082	0.635
CLV_PCSK_KEX2_1	44	46	PF00082	0.555
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.601
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.635
CLV_PCSK_PC7_1	164	170	PF00082	0.641
CLV_PCSK_SKI1_1	152	156	PF00082	0.506
DEG_APCC_DBOX_1	151	159	PF00400	0.600
DEG_SCF_FBW7_1	284	291	PF00400	0.509
DEG_SPOP_SBC_1	67	71	PF00917	0.582
DOC_CKS1_1	283	288	PF01111	0.512
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.481
DOC_MAPK_gen_1	52	59	PF00069	0.417
DOC_PP4_FxxP_1	227	230	PF00568	0.703
DOC_USP7_MATH_1	19	23	PF00917	0.507
DOC_USP7_MATH_1	231	235	PF00917	0.719
DOC_USP7_MATH_1	250	254	PF00917	0.541
DOC_USP7_MATH_1	272	276	PF00917	0.701
DOC_USP7_MATH_1	67	71	PF00917	0.680
DOC_USP7_MATH_1	9	13	PF00917	0.637
DOC_WW_Pin1_4	178	183	PF00397	0.678
DOC_WW_Pin1_4	263	268	PF00397	0.726
DOC_WW_Pin1_4	282	287	PF00397	0.698
LIG_14-3-3_CanoR_1	224	230	PF00244	0.747
LIG_FHA_1	134	140	PF00498	0.654
LIG_FHA_2	104	110	PF00498	0.583
LIG_LIR_Apic_2	225	230	PF02991	0.704
LIG_LIR_Gen_1	35	46	PF02991	0.531
LIG_LIR_Nem_3	35	41	PF02991	0.560
LIG_NRP_CendR_1	315	318	PF00754	0.706
LIG_RPA_C_Fungi	93	105	PF08784	0.390
LIG_SH2_CRK	38	42	PF00017	0.316
LIG_SH2_STAP1	38	42	PF00017	0.566
LIG_SH2_STAT5	27	30	PF00017	0.485
LIG_SH3_3	237	243	PF00018	0.722
LIG_SH3_3	290	296	PF00018	0.686
LIG_TRAF2_1	106	109	PF00917	0.575
LIG_WW_2	240	243	PF00397	0.575
MOD_CDK_SPK_2	263	268	PF00069	0.727
MOD_CK1_1	253	259	PF00069	0.747
MOD_CK1_1	266	272	PF00069	0.711
MOD_CK1_1	70	76	PF00069	0.646
MOD_CK2_1	208	214	PF00069	0.771
MOD_CK2_1	97	103	PF00069	0.535
MOD_Cter_Amidation	312	315	PF01082	0.611
MOD_GlcNHglycan	244	247	PF01048	0.732
MOD_GlcNHglycan	252	255	PF01048	0.673
MOD_GlcNHglycan	256	259	PF01048	0.673
MOD_GlcNHglycan	268	271	PF01048	0.732
MOD_GlcNHglycan	273	277	PF01048	0.721
MOD_GlcNHglycan	308	311	PF01048	0.613
MOD_GlcNHglycan	99	102	PF01048	0.544
MOD_GSK3_1	127	134	PF00069	0.649
MOD_GSK3_1	250	257	PF00069	0.737
MOD_GSK3_1	284	291	PF00069	0.552
MOD_GSK3_1	63	70	PF00069	0.523
MOD_N-GLC_1	32	37	PF02516	0.550
MOD_NEK2_1	306	311	PF00069	0.664
MOD_NEK2_1	32	37	PF00069	0.533
MOD_NEK2_1	68	73	PF00069	0.649
MOD_PIKK_1	103	109	PF00454	0.534
MOD_PIKK_1	137	143	PF00454	0.531
MOD_PKA_2	225	231	PF00069	0.793
MOD_PKA_2	306	312	PF00069	0.673
MOD_PKA_2	97	103	PF00069	0.671
MOD_Plk_1	222	228	PF00069	0.705
MOD_Plk_2-3	210	216	PF00069	0.764
MOD_ProDKin_1	178	184	PF00069	0.678
MOD_ProDKin_1	263	269	PF00069	0.726
MOD_ProDKin_1	282	288	PF00069	0.698
MOD_SUMO_for_1	175	178	PF00179	0.746
TRG_DiLeu_BaEn_1	109	114	PF01217	0.577
TRG_ENDOCYTIC_2	38	41	PF00928	0.562
TRG_ER_diArg_1	224	227	PF00400	0.712
TRG_ER_diArg_1	44	47	PF00400	0.640
TRG_ER_diArg_1	54	57	PF00400	0.546
TRG_ER_diLys_1	314	318	PF00400	0.720
TRG_NLS_MonoCore_2	167	172	PF00514	0.649
TRG_NLS_MonoExtC_3	167	173	PF00514	0.648
TRG_NLS_MonoExtC_3	313	318	PF00514	0.730
TRG_NLS_MonoExtN_4	166	172	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU5	Leptomonas seymouri	50%	100%
A0A3S7X3H3	Leishmania donovani	85%	100%
A0A422N7B9	Trypanosoma rangeli	32%	100%
A4HI86	Leishmania braziliensis	67%	100%
A4I5G5	Leishmania infantum	85%	100%
C9ZQV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q7H0	Leishmania major	82%	100%
V5BYY3	Trypanosoma cruzi	32%	79%