Putative ABC transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter, putative

Species:

Leishmania mexicana

UniProt:

E9B0R2_LEIMU

TriTrypDb:

LmxM.29.1330

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0R2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0005215	transporter activity	1	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140657	ATP-dependent activity	1	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.528
CLV_NRD_NRD_1	27	29	PF00675	0.428
CLV_NRD_NRD_1	53	55	PF00675	0.367
CLV_PCSK_KEX2_1	148	150	PF00082	0.621
CLV_PCSK_KEX2_1	273	275	PF00082	0.426
CLV_PCSK_KEX2_1	337	339	PF00082	0.328
CLV_PCSK_KEX2_1	52	54	PF00082	0.380
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.621
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.426
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.292
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.391
CLV_PCSK_SKI1_1	222	226	PF00082	0.396
CLV_PCSK_SKI1_1	237	241	PF00082	0.305
CLV_PCSK_SKI1_1	258	262	PF00082	0.321
CLV_PCSK_SKI1_1	303	307	PF00082	0.399
CLV_PCSK_SKI1_1	317	321	PF00082	0.123
CLV_PCSK_SKI1_1	380	384	PF00082	0.390
CLV_Separin_Metazoa	87	91	PF03568	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DEG_SPOP_SBC_1	171	175	PF00917	0.716
DOC_MAPK_gen_1	273	281	PF00069	0.426
DOC_MAPK_gen_1	28	38	PF00069	0.305
DOC_MAPK_gen_1	312	322	PF00069	0.340
DOC_MAPK_gen_1	337	345	PF00069	0.321
DOC_MAPK_MEF2A_6	31	40	PF00069	0.328
DOC_MAPK_MEF2A_6	315	324	PF00069	0.346
DOC_MAPK_MEF2A_6	337	345	PF00069	0.312
DOC_MAPK_NFAT4_5	338	346	PF00069	0.321
DOC_PP1_RVXF_1	122	129	PF00149	0.537
DOC_PP2B_LxvP_1	134	137	PF13499	0.471
DOC_USP7_MATH_1	160	164	PF00917	0.715
DOC_USP7_MATH_1	283	287	PF00917	0.356
DOC_USP7_MATH_1	434	438	PF00917	0.435
DOC_USP7_UBL2_3	129	133	PF12436	0.461
DOC_WW_Pin1_4	18	23	PF00397	0.552
DOC_WW_Pin1_4	184	189	PF00397	0.729
DOC_WW_Pin1_4	192	197	PF00397	0.640
LIG_14-3-3_CanoR_1	366	370	PF00244	0.427
LIG_14-3-3_CanoR_1	380	385	PF00244	0.285
LIG_14-3-3_CanoR_1	416	423	PF00244	0.531
LIG_14-3-3_CanoR_1	82	86	PF00244	0.407
LIG_Clathr_ClatBox_1	117	121	PF01394	0.515
LIG_CSL_BTD_1	5	8	PF09270	0.544
LIG_DLG_GKlike_1	264	271	PF00625	0.411
LIG_EH1_1	82	90	PF00400	0.350
LIG_eIF4E_1	364	370	PF01652	0.513
LIG_FHA_1	102	108	PF00498	0.389
LIG_FHA_1	113	119	PF00498	0.398
LIG_FHA_1	133	139	PF00498	0.219
LIG_FHA_1	356	362	PF00498	0.378
LIG_FHA_1	64	70	PF00498	0.498
LIG_FHA_2	203	209	PF00498	0.511
LIG_FHA_2	357	363	PF00498	0.426
LIG_FHA_2	73	79	PF00498	0.374
LIG_FHA_2	82	88	PF00498	0.394
LIG_GBD_Chelix_1	32	40	PF00786	0.397
LIG_HP1_1	350	354	PF01393	0.340
LIG_LIR_Gen_1	223	233	PF02991	0.390
LIG_LIR_Gen_1	290	300	PF02991	0.377
LIG_LIR_Gen_1	395	404	PF02991	0.358
LIG_LIR_Nem_3	127	131	PF02991	0.406
LIG_LIR_Nem_3	223	228	PF02991	0.418
LIG_LIR_Nem_3	229	233	PF02991	0.344
LIG_LIR_Nem_3	290	295	PF02991	0.391
LIG_LIR_Nem_3	388	394	PF02991	0.377
LIG_LIR_Nem_3	395	400	PF02991	0.387
LIG_NRBOX	341	347	PF00104	0.363
LIG_OCRL_FandH_1	260	272	PF00620	0.403
LIG_PDZ_Class_3	436	441	PF00595	0.471
LIG_PTB_Apo_2	224	231	PF02174	0.391
LIG_REV1ctd_RIR_1	258	268	PF16727	0.363
LIG_SH2_SRC	374	377	PF00017	0.436
LIG_SH2_STAP1	102	106	PF00017	0.374
LIG_SH2_STAP1	141	145	PF00017	0.511
LIG_SH2_STAP1	276	280	PF00017	0.356
LIG_SH2_STAP1	374	378	PF00017	0.380
LIG_SH2_STAP1	386	390	PF00017	0.306
LIG_SH2_STAT3	141	144	PF00017	0.508
LIG_SH2_STAT3	199	202	PF00017	0.427
LIG_SH2_STAT5	68	71	PF00017	0.354
LIG_SH3_3	156	162	PF00018	0.729
LIG_SH3_3	16	22	PF00018	0.494
LIG_SH3_3	2	8	PF00018	0.539
LIG_SH3_5	137	141	PF00018	0.534
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.400
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.356
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.422
LIG_SUMO_SIM_par_1	318	323	PF11976	0.391
LIG_SUMO_SIM_par_1	347	356	PF11976	0.305
LIG_SUMO_SIM_par_1	399	405	PF11976	0.409
LIG_SUMO_SIM_par_1	430	437	PF11976	0.347
LIG_TRAF2_1	205	208	PF00917	0.560
LIG_TYR_ITIM	219	224	PF00017	0.404
LIG_UBA3_1	251	258	PF00899	0.321
LIG_UBA3_1	341	349	PF00899	0.321
MOD_CK1_1	165	171	PF00069	0.691
MOD_CK1_1	173	179	PF00069	0.732
MOD_CK1_1	187	193	PF00069	0.646
MOD_CK2_1	202	208	PF00069	0.598
MOD_CK2_1	308	314	PF00069	0.449
MOD_CK2_1	329	335	PF00069	0.305
MOD_CK2_1	45	51	PF00069	0.420
MOD_CK2_1	81	87	PF00069	0.556
MOD_Cter_Amidation	146	149	PF01082	0.306
MOD_Cter_Amidation	271	274	PF01082	0.426
MOD_DYRK1A_RPxSP_1	18	22	PF00069	0.647
MOD_GlcNHglycan	168	171	PF01048	0.720
MOD_GlcNHglycan	176	179	PF01048	0.733
MOD_GlcNHglycan	189	192	PF01048	0.687
MOD_GlcNHglycan	331	334	PF01048	0.308
MOD_GSK3_1	162	169	PF00069	0.657
MOD_GSK3_1	170	177	PF00069	0.652
MOD_GSK3_1	243	250	PF00069	0.351
MOD_GSK3_1	380	387	PF00069	0.384
MOD_N-GLC_1	226	231	PF02516	0.418
MOD_N-GLC_1	243	248	PF02516	0.185
MOD_NEK2_1	308	313	PF00069	0.455
MOD_NEK2_1	38	43	PF00069	0.414
MOD_NEK2_1	404	409	PF00069	0.392
MOD_PKA_2	166	172	PF00069	0.455
MOD_PKA_2	27	33	PF00069	0.551
MOD_PKA_2	365	371	PF00069	0.404
MOD_PKA_2	38	44	PF00069	0.532
MOD_PKA_2	415	421	PF00069	0.533
MOD_PKA_2	81	87	PF00069	0.410
MOD_Plk_1	226	232	PF00069	0.379
MOD_Plk_1	374	380	PF00069	0.517
MOD_Plk_1	404	410	PF00069	0.510
MOD_Plk_2-3	356	362	PF00069	0.408
MOD_Plk_2-3	45	51	PF00069	0.471
MOD_Plk_2-3	72	78	PF00069	0.387
MOD_Plk_2-3	81	87	PF00069	0.394
MOD_Plk_4	195	201	PF00069	0.696
MOD_Plk_4	247	253	PF00069	0.305
MOD_Plk_4	266	272	PF00069	0.305
MOD_Plk_4	365	371	PF00069	0.370
MOD_Plk_4	380	386	PF00069	0.311
MOD_Plk_4	428	434	PF00069	0.361
MOD_Plk_4	63	69	PF00069	0.478
MOD_Plk_4	81	87	PF00069	0.356
MOD_ProDKin_1	18	24	PF00069	0.542
MOD_ProDKin_1	184	190	PF00069	0.726
MOD_ProDKin_1	192	198	PF00069	0.637
MOD_SUMO_rev_2	121	131	PF00179	0.475
MOD_SUMO_rev_2	21	30	PF00179	0.602
MOD_SUMO_rev_2	332	339	PF00179	0.276
TRG_ENDOCYTIC_2	221	224	PF00928	0.412
TRG_ENDOCYTIC_2	276	279	PF00928	0.321
TRG_ER_diArg_1	53	55	PF00400	0.342
TRG_NES_CRM1_1	314	327	PF08389	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VFI8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	79%
A0A0N1I8R4	Leptomonas seymouri	71%	84%
A0A0S4J6G0	Bodo saltans	52%	85%
A0A1X0P1Z8	Trypanosomatidae	55%	86%
A0A3R7K7R6	Trypanosoma rangeli	56%	88%
A0A3S7X391	Leishmania donovani	91%	100%
A4HI85	Leishmania braziliensis	81%	100%
A4I5G4	Leishmania infantum	91%	100%
C9ZQV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	85%
P0A9W3	Escherichia coli (strain K12)	26%	79%
P0A9W4	Escherichia coli O157:H7	26%	79%
P0A9W5	Shigella flexneri	26%	79%
P45127	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	79%
Q4Q7H1	Leishmania major	92%	100%
Q6GDC0	Staphylococcus aureus (strain MRSA252)	22%	77%
Q87G35	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	24%	76%
Q8PSR0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	22%	75%
V5BPK8	Trypanosoma cruzi	58%	94%