Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0Q7_LEIMU

TriTrypDb:

LmxM.29.1270

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.649
CLV_C14_Caspase3-7	558	562	PF00656	0.478
CLV_C14_Caspase3-7	596	600	PF00656	0.714
CLV_NRD_NRD_1	15	17	PF00675	0.472
CLV_NRD_NRD_1	209	211	PF00675	0.638
CLV_NRD_NRD_1	343	345	PF00675	0.494
CLV_NRD_NRD_1	385	387	PF00675	0.441
CLV_NRD_NRD_1	401	403	PF00675	0.533
CLV_NRD_NRD_1	658	660	PF00675	0.617
CLV_NRD_NRD_1	680	682	PF00675	0.592
CLV_PCSK_KEX2_1	15	17	PF00082	0.512
CLV_PCSK_KEX2_1	209	211	PF00082	0.697
CLV_PCSK_KEX2_1	343	345	PF00082	0.494
CLV_PCSK_KEX2_1	384	386	PF00082	0.436
CLV_PCSK_KEX2_1	401	403	PF00082	0.287
CLV_PCSK_KEX2_1	657	659	PF00082	0.609
CLV_PCSK_KEX2_1	680	682	PF00082	0.592
CLV_PCSK_SKI1_1	15	19	PF00082	0.443
CLV_PCSK_SKI1_1	230	234	PF00082	0.607
CLV_PCSK_SKI1_1	261	265	PF00082	0.597
CLV_PCSK_SKI1_1	300	304	PF00082	0.465
CLV_PCSK_SKI1_1	370	374	PF00082	0.422
CLV_PCSK_SKI1_1	385	389	PF00082	0.432
CLV_PCSK_SKI1_1	402	406	PF00082	0.282
CLV_PCSK_SKI1_1	606	610	PF00082	0.512
CLV_PCSK_SKI1_1	635	639	PF00082	0.525
CLV_Separin_Metazoa	180	184	PF03568	0.419
CLV_Separin_Metazoa	666	670	PF03568	0.600
DEG_APCC_DBOX_1	136	144	PF00400	0.422
DEG_APCC_DBOX_1	267	275	PF00400	0.513
DEG_APCC_DBOX_1	401	409	PF00400	0.417
DEG_APCC_DBOX_1	515	523	PF00400	0.575
DOC_CYCLIN_RxL_1	297	305	PF00134	0.450
DOC_CYCLIN_RxL_1	432	442	PF00134	0.417
DOC_MAPK_gen_1	696	704	PF00069	0.372
DOC_MAPK_MEF2A_6	696	704	PF00069	0.372
DOC_PP2B_LxvP_1	25	28	PF13499	0.446
DOC_PP2B_LxvP_1	48	51	PF13499	0.442
DOC_USP7_MATH_1	194	198	PF00917	0.736
DOC_USP7_MATH_1	506	510	PF00917	0.561
DOC_USP7_MATH_1	56	60	PF00917	0.472
DOC_WW_Pin1_4	210	215	PF00397	0.730
DOC_WW_Pin1_4	222	227	PF00397	0.685
DOC_WW_Pin1_4	235	240	PF00397	0.789
DOC_WW_Pin1_4	26	31	PF00397	0.572
DOC_WW_Pin1_4	307	312	PF00397	0.508
DOC_WW_Pin1_4	597	602	PF00397	0.669
DOC_WW_Pin1_4	668	673	PF00397	0.683
LIG_14-3-3_CanoR_1	137	146	PF00244	0.350
LIG_14-3-3_CanoR_1	261	266	PF00244	0.583
LIG_14-3-3_CanoR_1	385	395	PF00244	0.550
LIG_14-3-3_CanoR_1	530	540	PF00244	0.485
LIG_14-3-3_CanoR_1	606	611	PF00244	0.555
LIG_Actin_WH2_2	33	49	PF00022	0.466
LIG_Actin_WH2_2	432	449	PF00022	0.321
LIG_APCC_ABBA_1	591	596	PF00400	0.524
LIG_BRCT_BRCA1_1	217	221	PF00533	0.762
LIG_CaM_IQ_9	278	294	PF13499	0.510
LIG_EH1_1	42	50	PF00400	0.413
LIG_EH1_1	83	91	PF00400	0.344
LIG_eIF4E_1	632	638	PF01652	0.557
LIG_FHA_1	108	114	PF00498	0.467
LIG_FHA_1	139	145	PF00498	0.419
LIG_FHA_1	262	268	PF00498	0.534
LIG_FHA_1	354	360	PF00498	0.473
LIG_FHA_1	532	538	PF00498	0.555
LIG_FHA_1	571	577	PF00498	0.626
LIG_FHA_1	671	677	PF00498	0.553
LIG_FHA_1	688	694	PF00498	0.540
LIG_FHA_2	387	393	PF00498	0.410
LIG_FHA_2	425	431	PF00498	0.473
LIG_FHA_2	508	514	PF00498	0.585
LIG_FHA_2	533	539	PF00498	0.583
LIG_FHA_2	55	61	PF00498	0.570
LIG_FHA_2	572	578	PF00498	0.553
LIG_LIR_Gen_1	31	41	PF02991	0.353
LIG_LIR_LC3C_4	147	152	PF02991	0.274
LIG_LIR_Nem_3	296	302	PF02991	0.421
LIG_LIR_Nem_3	31	36	PF02991	0.372
LIG_LIR_Nem_3	633	637	PF02991	0.537
LIG_NRBOX	624	630	PF00104	0.549
LIG_PCNA_yPIPBox_3	164	178	PF02747	0.498
LIG_PCNA_yPIPBox_3	489	502	PF02747	0.477
LIG_PCNA_yPIPBox_3	620	629	PF02747	0.337
LIG_PCNA_yPIPBox_3	678	692	PF02747	0.585
LIG_PDZ_Class_2	699	704	PF00595	0.382
LIG_PTB_Apo_2	259	266	PF02174	0.536
LIG_PTB_Phospho_1	259	265	PF10480	0.535
LIG_SH2_CRK	299	303	PF00017	0.455
LIG_SH2_CRK	634	638	PF00017	0.482
LIG_SH2_STAP1	96	100	PF00017	0.455
LIG_SH3_3	20	26	PF00018	0.496
LIG_SH3_3	595	601	PF00018	0.747
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.286
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.425
LIG_SUMO_SIM_anti_2	577	582	PF11976	0.522
LIG_SUMO_SIM_anti_2	662	669	PF11976	0.606
LIG_SUMO_SIM_par_1	149	154	PF11976	0.328
LIG_SUMO_SIM_par_1	434	440	PF11976	0.516
LIG_SUMO_SIM_par_1	468	474	PF11976	0.563
LIG_TRAF2_1	167	170	PF00917	0.485
LIG_TRAF2_1	2	5	PF00917	0.503
LIG_TRAF2_1	252	255	PF00917	0.611
LIG_TRAF2_1	389	392	PF00917	0.435
LIG_TRAF2_1	582	585	PF00917	0.586
LIG_TRFH_1	185	189	PF08558	0.468
LIG_TRFH_1	235	239	PF08558	0.475
MOD_CDK_SPxxK_3	597	604	PF00069	0.587
MOD_CK1_1	202	208	PF00069	0.616
MOD_CK1_1	238	244	PF00069	0.649
MOD_CK1_1	364	370	PF00069	0.318
MOD_CK1_1	460	466	PF00069	0.545
MOD_CK1_1	571	577	PF00069	0.594
MOD_CK1_1	579	585	PF00069	0.698
MOD_CK1_1	59	65	PF00069	0.641
MOD_CK1_1	674	680	PF00069	0.511
MOD_CK2_1	386	392	PF00069	0.435
MOD_CK2_1	424	430	PF00069	0.584
MOD_CK2_1	532	538	PF00069	0.532
MOD_CK2_1	54	60	PF00069	0.562
MOD_CK2_1	579	585	PF00069	0.738
MOD_DYRK1A_RPxSP_1	210	214	PF00069	0.476
MOD_GlcNHglycan	105	108	PF01048	0.380
MOD_GlcNHglycan	126	131	PF01048	0.633
MOD_GlcNHglycan	153	156	PF01048	0.367
MOD_GlcNHglycan	201	204	PF01048	0.609
MOD_GlcNHglycan	218	221	PF01048	0.773
MOD_GlcNHglycan	316	319	PF01048	0.662
MOD_GlcNHglycan	332	335	PF01048	0.639
MOD_GlcNHglycan	549	552	PF01048	0.552
MOD_GlcNHglycan	570	573	PF01048	0.705
MOD_GSK3_1	103	110	PF00069	0.498
MOD_GSK3_1	158	165	PF00069	0.518
MOD_GSK3_1	222	229	PF00069	0.540
MOD_GSK3_1	309	316	PF00069	0.711
MOD_GSK3_1	332	339	PF00069	0.603
MOD_GSK3_1	360	367	PF00069	0.530
MOD_GSK3_1	456	463	PF00069	0.654
MOD_GSK3_1	50	57	PF00069	0.560
MOD_GSK3_1	507	514	PF00069	0.589
MOD_GSK3_1	59	66	PF00069	0.708
MOD_GSK3_1	670	677	PF00069	0.607
MOD_N-GLC_1	261	266	PF02516	0.493
MOD_N-GLC_1	457	462	PF02516	0.562
MOD_N-GLC_1	463	468	PF02516	0.519
MOD_N-GLC_1	511	516	PF02516	0.582
MOD_N-GLC_2	85	87	PF02516	0.396
MOD_NEK2_1	101	106	PF00069	0.561
MOD_NEK2_1	216	221	PF00069	0.576
MOD_NEK2_1	313	318	PF00069	0.670
MOD_NEK2_1	457	462	PF00069	0.554
MOD_NEK2_1	547	552	PF00069	0.658
MOD_NEK2_1	630	635	PF00069	0.472
MOD_NEK2_1	687	692	PF00069	0.525
MOD_PIKK_1	107	113	PF00454	0.528
MOD_PIKK_1	138	144	PF00454	0.376
MOD_PIKK_1	31	37	PF00454	0.502
MOD_PIKK_1	361	367	PF00454	0.491
MOD_PIKK_1	424	430	PF00454	0.514
MOD_PKA_2	285	291	PF00069	0.365
MOD_PKA_2	483	489	PF00069	0.569
MOD_PKB_1	384	392	PF00069	0.549
MOD_PKB_1	604	612	PF00069	0.513
MOD_Plk_1	261	267	PF00069	0.531
MOD_Plk_1	348	354	PF00069	0.464
MOD_Plk_1	457	463	PF00069	0.505
MOD_Plk_1	511	517	PF00069	0.580
MOD_Plk_1	576	582	PF00069	0.656
MOD_Plk_2-3	584	590	PF00069	0.591
MOD_Plk_4	309	315	PF00069	0.399
MOD_Plk_4	336	342	PF00069	0.493
MOD_Plk_4	576	582	PF00069	0.656
MOD_Plk_4	624	630	PF00069	0.439
MOD_Plk_4	641	647	PF00069	0.447
MOD_Plk_4	66	72	PF00069	0.417
MOD_Plk_4	671	677	PF00069	0.579
MOD_Plk_4	687	693	PF00069	0.577
MOD_ProDKin_1	210	216	PF00069	0.731
MOD_ProDKin_1	222	228	PF00069	0.682
MOD_ProDKin_1	235	241	PF00069	0.781
MOD_ProDKin_1	26	32	PF00069	0.567
MOD_ProDKin_1	307	313	PF00069	0.514
MOD_ProDKin_1	597	603	PF00069	0.671
MOD_ProDKin_1	668	674	PF00069	0.679
MOD_SUMO_for_1	396	399	PF00179	0.543
MOD_SUMO_rev_2	161	166	PF00179	0.418
MOD_SUMO_rev_2	270	276	PF00179	0.397
MOD_SUMO_rev_2	288	294	PF00179	0.423
TRG_DiLeu_BaEn_3	662	668	PF01217	0.543
TRG_DiLeu_BaEn_4	584	590	PF01217	0.591
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.504
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.544
TRG_ENDOCYTIC_2	299	302	PF00928	0.433
TRG_ENDOCYTIC_2	634	637	PF00928	0.482
TRG_ER_diArg_1	14	16	PF00400	0.471
TRG_ER_diArg_1	208	210	PF00400	0.496
TRG_ER_diArg_1	383	386	PF00400	0.488
TRG_ER_diArg_1	657	659	PF00400	0.653
TRG_NES_CRM1_1	413	426	PF08389	0.561
TRG_NES_CRM1_1	430	444	PF08389	0.313
TRG_Pf-PMV_PEXEL_1	300	305	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	635	640	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P981	Leptomonas seymouri	57%	95%
A0A1X0P283	Trypanosomatidae	29%	100%
A0A3Q8IFR6	Leishmania donovani	91%	100%
A0A3R7NW91	Trypanosoma rangeli	31%	100%
A4HI80	Leishmania braziliensis	77%	100%
A4I5F9	Leishmania infantum	91%	100%
Q4Q7H6	Leishmania major	90%	100%
V5DQP9	Trypanosoma cruzi	32%	100%