Putative calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0Q3_LEIMU

TriTrypDb:

LmxM.29.1240

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B0Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Q3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005509	calcium ion binding	5	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.498
CLV_C14_Caspase3-7	412	416	PF00656	0.475
CLV_NRD_NRD_1	126	128	PF00675	0.505
CLV_NRD_NRD_1	21	23	PF00675	0.599
CLV_NRD_NRD_1	352	354	PF00675	0.555
CLV_NRD_NRD_1	360	362	PF00675	0.528
CLV_NRD_NRD_1	442	444	PF00675	0.409
CLV_NRD_NRD_1	9	11	PF00675	0.531
CLV_NRD_NRD_1	96	98	PF00675	0.582
CLV_PCSK_FUR_1	7	11	PF00082	0.521
CLV_PCSK_KEX2_1	125	127	PF00082	0.504
CLV_PCSK_KEX2_1	21	23	PF00082	0.602
CLV_PCSK_KEX2_1	265	267	PF00082	0.429
CLV_PCSK_KEX2_1	360	362	PF00082	0.434
CLV_PCSK_KEX2_1	57	59	PF00082	0.505
CLV_PCSK_KEX2_1	9	11	PF00082	0.534
CLV_PCSK_KEX2_1	95	97	PF00082	0.589
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.429
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.505
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.530
CLV_PCSK_PC7_1	7	13	PF00082	0.523
CLV_PCSK_SKI1_1	127	131	PF00082	0.635
CLV_PCSK_SKI1_1	173	177	PF00082	0.389
CLV_PCSK_SKI1_1	265	269	PF00082	0.509
CLV_PCSK_SKI1_1	361	365	PF00082	0.502
CLV_PCSK_SKI1_1	389	393	PF00082	0.449
CLV_PCSK_SKI1_1	445	449	PF00082	0.496
CLV_PCSK_SKI1_1	489	493	PF00082	0.393
DEG_APCC_DBOX_1	388	396	PF00400	0.433
DEG_Nend_UBRbox_2	1	3	PF02207	0.526
DOC_MAPK_gen_1	150	159	PF00069	0.433
DOC_MAPK_gen_1	265	272	PF00069	0.545
DOC_MAPK_gen_1	443	450	PF00069	0.490
DOC_MAPK_gen_1	489	497	PF00069	0.392
DOC_MAPK_RevD_3	82	97	PF00069	0.445
DOC_PP1_SILK_1	531	536	PF00149	0.445
DOC_PP2B_LxvP_1	253	256	PF13499	0.570
DOC_PP2B_LxvP_1	305	308	PF13499	0.620
DOC_PP2B_PxIxI_1	340	346	PF00149	0.500
DOC_SPAK_OSR1_1	266	270	PF12202	0.507
DOC_USP7_MATH_1	20	24	PF00917	0.598
DOC_USP7_MATH_1	223	227	PF00917	0.639
DOC_USP7_MATH_1	26	30	PF00917	0.551
DOC_USP7_MATH_1	62	66	PF00917	0.473
DOC_USP7_UBL2_3	535	539	PF12436	0.435
DOC_WW_Pin1_4	316	321	PF00397	0.393
LIG_14-3-3_CanoR_1	12	20	PF00244	0.530
LIG_14-3-3_CanoR_1	126	136	PF00244	0.581
LIG_14-3-3_CanoR_1	25	33	PF00244	0.497
LIG_14-3-3_CanoR_1	353	362	PF00244	0.508
LIG_14-3-3_CanoR_1	384	392	PF00244	0.357
LIG_APCC_ABBA_1	507	512	PF00400	0.402
LIG_BIR_III_4	415	419	PF00653	0.421
LIG_BRCT_BRCA1_1	374	378	PF00533	0.412
LIG_EH1_1	244	252	PF00400	0.507
LIG_eIF4E_1	68	74	PF01652	0.463
LIG_FHA_1	236	242	PF00498	0.557
LIG_FHA_1	279	285	PF00498	0.592
LIG_FHA_1	535	541	PF00498	0.515
LIG_FHA_2	110	116	PF00498	0.602
LIG_FHA_2	32	38	PF00498	0.500
LIG_FHA_2	410	416	PF00498	0.465
LIG_FHA_2	461	467	PF00498	0.459
LIG_Integrin_RGD_1	153	155	PF01839	0.486
LIG_LIR_Apic_2	212	217	PF02991	0.485
LIG_LIR_Apic_2	536	541	PF02991	0.504
LIG_LIR_Gen_1	143	151	PF02991	0.497
LIG_LIR_Gen_1	155	164	PF02991	0.406
LIG_LIR_Gen_1	400	411	PF02991	0.486
LIG_LIR_Gen_1	427	435	PF02991	0.383
LIG_LIR_Gen_1	449	456	PF02991	0.420
LIG_LIR_Nem_3	143	148	PF02991	0.522
LIG_LIR_Nem_3	155	159	PF02991	0.409
LIG_LIR_Nem_3	400	406	PF02991	0.485
LIG_LIR_Nem_3	427	431	PF02991	0.420
LIG_LIR_Nem_3	449	454	PF02991	0.416
LIG_LIR_Nem_3	511	516	PF02991	0.442
LIG_LIR_Nem_3	527	533	PF02991	0.359
LIG_Pex14_1	183	187	PF04695	0.442
LIG_Pex14_1	543	547	PF04695	0.575
LIG_Pex14_2	494	498	PF04695	0.400
LIG_PTB_Apo_2	194	201	PF02174	0.533
LIG_PTB_Phospho_1	194	200	PF10480	0.531
LIG_Rb_LxCxE_1	72	92	PF01857	0.432
LIG_SH2_CRK	517	521	PF00017	0.456
LIG_SH2_GRB2like	516	519	PF00017	0.392
LIG_SH2_SRC	332	335	PF00017	0.478
LIG_SH2_STAP1	145	149	PF00017	0.595
LIG_SH2_STAP1	422	426	PF00017	0.408
LIG_SH2_STAP1	428	432	PF00017	0.375
LIG_SH2_STAP1	510	514	PF00017	0.432
LIG_SH2_STAT5	156	159	PF00017	0.497
LIG_SH2_STAT5	174	177	PF00017	0.392
LIG_SH2_STAT5	187	190	PF00017	0.406
LIG_SH2_STAT5	200	203	PF00017	0.447
LIG_SH2_STAT5	214	217	PF00017	0.409
LIG_SH2_STAT5	240	243	PF00017	0.539
LIG_SH2_STAT5	332	335	PF00017	0.409
LIG_SH2_STAT5	434	437	PF00017	0.399
LIG_SH2_STAT5	510	513	PF00017	0.527
LIG_SH3_1	204	210	PF00018	0.483
LIG_SH3_3	204	210	PF00018	0.511
LIG_SH3_3	249	255	PF00018	0.533
LIG_SH3_3	411	417	PF00018	0.592
LIG_SUMO_SIM_par_1	268	273	PF11976	0.502
LIG_SUMO_SIM_par_1	475	482	PF11976	0.513
LIG_SUMO_SIM_par_1	86	92	PF11976	0.453
LIG_TRAF2_1	34	37	PF00917	0.501
LIG_TRAF2_1	407	410	PF00917	0.524
LIG_TRAF2_1	417	420	PF00917	0.639
LIG_TRAF2_1	421	424	PF00917	0.534
LIG_TRFH_1	282	286	PF08558	0.564
LIG_TRFH_1	505	509	PF08558	0.407
MOD_CK1_1	101	107	PF00069	0.583
MOD_CK1_1	143	149	PF00069	0.603
MOD_CK1_1	226	232	PF00069	0.556
MOD_CK1_1	69	75	PF00069	0.460
MOD_CK1_1	89	95	PF00069	0.491
MOD_CK2_1	31	37	PF00069	0.498
MOD_CK2_1	39	45	PF00069	0.504
MOD_Cter_Amidation	358	361	PF01082	0.472
MOD_Cter_Amidation	7	10	PF01082	0.522
MOD_GlcNHglycan	164	167	PF01048	0.517
MOD_GlcNHglycan	22	25	PF01048	0.536
MOD_GlcNHglycan	225	228	PF01048	0.618
MOD_GlcNHglycan	233	236	PF01048	0.717
MOD_GlcNHglycan	39	42	PF01048	0.608
MOD_GlcNHglycan	403	406	PF01048	0.337
MOD_GlcNHglycan	440	443	PF01048	0.332
MOD_GlcNHglycan	520	523	PF01048	0.395
MOD_GlcNHglycan	68	71	PF01048	0.440
MOD_GSK3_1	101	108	PF00069	0.528
MOD_GSK3_1	130	137	PF00069	0.600
MOD_GSK3_1	231	238	PF00069	0.727
MOD_GSK3_1	268	275	PF00069	0.429
MOD_GSK3_1	276	283	PF00069	0.465
MOD_GSK3_1	297	304	PF00069	0.679
MOD_GSK3_1	62	69	PF00069	0.489
MOD_LATS_1	103	109	PF00433	0.494
MOD_LATS_1	276	282	PF00433	0.568
MOD_N-GLC_1	12	17	PF02516	0.521
MOD_N-GLC_1	235	240	PF02516	0.615
MOD_N-GLC_1	290	295	PF02516	0.574
MOD_N-GLC_1	460	465	PF02516	0.470
MOD_N-GLC_1	541	546	PF02516	0.567
MOD_NEK2_1	140	145	PF00069	0.545
MOD_NEK2_1	290	295	PF00069	0.618
MOD_NEK2_1	301	306	PF00069	0.557
MOD_NEK2_1	385	390	PF00069	0.516
MOD_NEK2_1	534	539	PF00069	0.503
MOD_NEK2_1	66	71	PF00069	0.468
MOD_NEK2_1	88	93	PF00069	0.464
MOD_NEK2_2	460	465	PF00069	0.470
MOD_NEK2_2	541	546	PF00069	0.541
MOD_PIKK_1	168	174	PF00454	0.471
MOD_PK_1	134	140	PF00069	0.492
MOD_PK_1	268	274	PF00069	0.507
MOD_PKA_1	134	140	PF00069	0.489
MOD_PKA_1	353	359	PF00069	0.591
MOD_PKA_2	101	107	PF00069	0.543
MOD_PKA_2	168	174	PF00069	0.510
MOD_PKA_2	20	26	PF00069	0.541
MOD_PKA_2	372	378	PF00069	0.382
MOD_PKA_2	383	389	PF00069	0.455
MOD_PKB_1	10	18	PF00069	0.521
MOD_PKB_1	125	133	PF00069	0.511
MOD_Plk_1	118	124	PF00069	0.496
MOD_Plk_1	140	146	PF00069	0.537
MOD_Plk_1	235	241	PF00069	0.607
MOD_Plk_1	272	278	PF00069	0.435
MOD_Plk_1	290	296	PF00069	0.561
MOD_Plk_1	409	415	PF00069	0.593
MOD_Plk_1	460	466	PF00069	0.569
MOD_Plk_1	541	547	PF00069	0.553
MOD_Plk_2-3	409	415	PF00069	0.378
MOD_Plk_4	140	146	PF00069	0.537
MOD_Plk_4	236	242	PF00069	0.497
MOD_Plk_4	297	303	PF00069	0.696
MOD_Plk_4	398	404	PF00069	0.434
MOD_Plk_4	62	68	PF00069	0.480
MOD_Plk_4	69	75	PF00069	0.442
MOD_ProDKin_1	316	322	PF00069	0.390
MOD_SUMO_rev_2	40	50	PF00179	0.514
TRG_DiLeu_BaEn_3	189	195	PF01217	0.477
TRG_ENDOCYTIC_2	145	148	PF00928	0.516
TRG_ENDOCYTIC_2	156	159	PF00928	0.403
TRG_ENDOCYTIC_2	200	203	PF00928	0.540
TRG_ENDOCYTIC_2	428	431	PF00928	0.419
TRG_ENDOCYTIC_2	510	513	PF00928	0.452
TRG_ENDOCYTIC_2	517	520	PF00928	0.448
TRG_ER_diArg_1	125	127	PF00400	0.517
TRG_ER_diArg_1	20	22	PF00400	0.537
TRG_ER_diArg_1	360	362	PF00400	0.528
TRG_ER_diArg_1	95	97	PF00400	0.471
TRG_NLS_MonoCore_2	8	13	PF00514	0.523
TRG_NLS_MonoExtC_3	9	14	PF00514	0.525
TRG_NLS_MonoExtN_4	7	14	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBZ1	Leptomonas seymouri	77%	100%
A0A3Q8IBX6	Leishmania donovani	88%	100%
A0A422P525	Trypanosoma rangeli	50%	100%
A4HI76	Leishmania braziliensis	87%	100%
A4I676	Leishmania infantum	89%	100%
Q4Q7I0	Leishmania major	80%	99%
V5BU66	Trypanosoma cruzi	50%	100%