RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9B0Q2_LEIMU

TriTrypDb:

LmxM.29.1230

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Q2

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072344	rescue of stalled ribosome	6	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006807	nitrogen compound metabolic process	2	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0005488	binding	1	5
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0061630	ubiquitin protein ligase activity	5	11
GO:0061659	ubiquitin-like protein ligase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.612
CLV_NRD_NRD_1	360	362	PF00675	0.721
CLV_NRD_NRD_1	546	548	PF00675	0.613
CLV_NRD_NRD_1	705	707	PF00675	0.725
CLV_NRD_NRD_1	73	75	PF00675	0.447
CLV_PCSK_KEX2_1	103	105	PF00082	0.612
CLV_PCSK_KEX2_1	213	215	PF00082	0.604
CLV_PCSK_KEX2_1	360	362	PF00082	0.719
CLV_PCSK_KEX2_1	705	707	PF00082	0.722
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.604
CLV_PCSK_SKI1_1	104	108	PF00082	0.564
CLV_PCSK_SKI1_1	173	177	PF00082	0.406
CLV_PCSK_SKI1_1	75	79	PF00082	0.480
DEG_APCC_KENBOX_2	351	355	PF00400	0.795
DEG_SPOP_SBC_1	182	186	PF00917	0.321
DEG_SPOP_SBC_1	404	408	PF00917	0.712
DEG_SPOP_SBC_1	422	426	PF00917	0.579
DEG_SPOP_SBC_1	634	638	PF00917	0.770
DOC_CKS1_1	669	674	PF01111	0.707
DOC_MAPK_gen_1	74	82	PF00069	0.408
DOC_PP1_RVXF_1	297	303	PF00149	0.599
DOC_PP4_FxxP_1	131	134	PF00568	0.321
DOC_PP4_FxxP_1	497	500	PF00568	0.563
DOC_USP7_MATH_1	134	138	PF00917	0.551
DOC_USP7_MATH_1	182	186	PF00917	0.419
DOC_USP7_MATH_1	319	323	PF00917	0.693
DOC_USP7_MATH_1	325	329	PF00917	0.680
DOC_USP7_MATH_1	405	409	PF00917	0.700
DOC_USP7_MATH_1	423	427	PF00917	0.710
DOC_USP7_MATH_1	567	571	PF00917	0.672
DOC_USP7_MATH_1	626	630	PF00917	0.779
DOC_USP7_MATH_1	635	639	PF00917	0.724
DOC_USP7_MATH_1	642	646	PF00917	0.689
DOC_USP7_MATH_1	661	665	PF00917	0.509
DOC_WW_Pin1_4	115	120	PF00397	0.517
DOC_WW_Pin1_4	22	27	PF00397	0.654
DOC_WW_Pin1_4	300	305	PF00397	0.642
DOC_WW_Pin1_4	461	466	PF00397	0.609
DOC_WW_Pin1_4	578	583	PF00397	0.783
DOC_WW_Pin1_4	584	589	PF00397	0.715
DOC_WW_Pin1_4	668	673	PF00397	0.765
DOC_WW_Pin1_4	678	683	PF00397	0.727
LIG_14-3-3_CanoR_1	103	112	PF00244	0.578
LIG_14-3-3_CanoR_1	200	204	PF00244	0.589
LIG_14-3-3_CanoR_1	240	246	PF00244	0.552
LIG_14-3-3_CanoR_1	419	423	PF00244	0.728
LIG_14-3-3_CanoR_1	463	469	PF00244	0.536
LIG_14-3-3_CanoR_1	61	66	PF00244	0.447
LIG_Actin_WH2_2	98	115	PF00022	0.596
LIG_AP2alpha_2	145	147	PF02296	0.536
LIG_APCC_ABBA_1	24	29	PF00400	0.618
LIG_BIR_II_1	1	5	PF00653	0.748
LIG_BRCT_BRCA1_1	387	391	PF00533	0.544
LIG_BRCT_BRCA1_1	424	428	PF00533	0.724
LIG_eIF4E_1	219	225	PF01652	0.428
LIG_EVH1_2	207	211	PF00568	0.498
LIG_FHA_1	130	136	PF00498	0.530
LIG_FHA_1	232	238	PF00498	0.449
LIG_FHA_1	393	399	PF00498	0.595
LIG_FHA_1	511	517	PF00498	0.452
LIG_FHA_1	533	539	PF00498	0.632
LIG_FHA_1	668	674	PF00498	0.604
LIG_FHA_1	82	88	PF00498	0.470
LIG_FHA_2	555	561	PF00498	0.354
LIG_LIR_Apic_2	130	134	PF02991	0.393
LIG_LIR_Apic_2	495	500	PF02991	0.558
LIG_LIR_Gen_1	145	153	PF02991	0.494
LIG_LIR_Gen_1	162	170	PF02991	0.405
LIG_LIR_Gen_1	336	343	PF02991	0.576
LIG_LIR_Gen_1	425	434	PF02991	0.474
LIG_LIR_Gen_1	467	474	PF02991	0.586
LIG_LIR_Gen_1	486	497	PF02991	0.363
LIG_LIR_Nem_3	162	168	PF02991	0.454
LIG_LIR_Nem_3	244	248	PF02991	0.427
LIG_LIR_Nem_3	336	340	PF02991	0.552
LIG_LIR_Nem_3	388	394	PF02991	0.528
LIG_LIR_Nem_3	425	431	PF02991	0.511
LIG_LIR_Nem_3	467	471	PF02991	0.579
LIG_LIR_Nem_3	485	491	PF02991	0.349
LIG_LIR_Nem_3	693	699	PF02991	0.659
LIG_LRP6_Inhibitor_1	699	705	PF00058	0.710
LIG_NRP_CendR_1	722	723	PF00754	0.763
LIG_PCNA_PIPBox_1	150	159	PF02747	0.422
LIG_PCNA_yPIPBox_3	519	527	PF02747	0.500
LIG_Pex14_2	243	247	PF04695	0.557
LIG_Pex14_2	337	341	PF04695	0.659
LIG_Pex14_2	503	507	PF04695	0.435
LIG_SH2_CRK	489	493	PF00017	0.427
LIG_SH2_STAP1	183	187	PF00017	0.473
LIG_SH2_STAP1	233	237	PF00017	0.532
LIG_SH2_STAP1	27	31	PF00017	0.556
LIG_SH2_STAP1	474	478	PF00017	0.527
LIG_SH2_STAP1	489	493	PF00017	0.519
LIG_SH2_STAT5	165	168	PF00017	0.381
LIG_SH2_STAT5	233	236	PF00017	0.533
LIG_SH2_STAT5	385	388	PF00017	0.595
LIG_SH2_STAT5	474	477	PF00017	0.543
LIG_SH2_STAT5	53	56	PF00017	0.382
LIG_SH3_3	20	26	PF00018	0.449
LIG_SH3_3	370	376	PF00018	0.564
LIG_SH3_3	580	586	PF00018	0.591
LIG_SH3_3	666	672	PF00018	0.744
LIG_SH3_3	676	682	PF00018	0.717
LIG_SH3_3	694	700	PF00018	0.560
LIG_Sin3_3	427	434	PF02671	0.393
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.594
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.536
LIG_SUMO_SIM_par_1	507	513	PF11976	0.419
LIG_TRAF2_1	375	378	PF00917	0.644
LIG_TRAF2_1	522	525	PF00917	0.545
LIG_TRAF2_1	541	544	PF00917	0.456
LIG_TRAF2_1	88	91	PF00917	0.585
LIG_TRAF2_1	95	98	PF00917	0.561
LIG_TRAF2_2	620	625	PF00917	0.760
LIG_TYR_ITIM	163	168	PF00017	0.380
MOD_CDK_SPxxK_3	584	591	PF00069	0.755
MOD_CK1_1	201	207	PF00069	0.547
MOD_CK1_1	25	31	PF00069	0.613
MOD_CK1_1	311	317	PF00069	0.663
MOD_CK1_1	397	403	PF00069	0.682
MOD_CK1_1	421	427	PF00069	0.715
MOD_CK1_1	464	470	PF00069	0.541
MOD_CK1_1	570	576	PF00069	0.752
MOD_CK1_1	659	665	PF00069	0.712
MOD_CK1_1	668	674	PF00069	0.706
MOD_CK2_1	554	560	PF00069	0.563
MOD_CK2_1	85	91	PF00069	0.605
MOD_CK2_1	92	98	PF00069	0.595
MOD_Cter_Amidation	358	361	PF01082	0.702
MOD_GlcNHglycan	1	4	PF01048	0.707
MOD_GlcNHglycan	14	17	PF01048	0.625
MOD_GlcNHglycan	18	21	PF01048	0.551
MOD_GlcNHglycan	309	313	PF01048	0.683
MOD_GlcNHglycan	316	319	PF01048	0.686
MOD_GlcNHglycan	321	324	PF01048	0.600
MOD_GlcNHglycan	387	390	PF01048	0.617
MOD_GlcNHglycan	407	410	PF01048	0.755
MOD_GlcNHglycan	420	423	PF01048	0.490
MOD_GlcNHglycan	425	428	PF01048	0.697
MOD_GlcNHglycan	480	483	PF01048	0.471
MOD_GlcNHglycan	617	620	PF01048	0.758
MOD_GlcNHglycan	628	631	PF01048	0.487
MOD_GlcNHglycan	637	640	PF01048	0.693
MOD_GlcNHglycan	664	667	PF01048	0.700
MOD_GlcNHglycan	675	678	PF01048	0.717
MOD_GlcNHglycan	94	97	PF01048	0.574
MOD_GSK3_1	12	19	PF00069	0.707
MOD_GSK3_1	243	250	PF00069	0.580
MOD_GSK3_1	319	326	PF00069	0.722
MOD_GSK3_1	348	355	PF00069	0.542
MOD_GSK3_1	417	424	PF00069	0.728
MOD_GSK3_1	478	485	PF00069	0.515
MOD_GSK3_1	604	611	PF00069	0.696
MOD_GSK3_1	626	633	PF00069	0.725
MOD_GSK3_1	661	668	PF00069	0.724
MOD_GSK3_1	673	680	PF00069	0.667
MOD_GSK3_1	81	88	PF00069	0.485
MOD_LATS_1	470	476	PF00433	0.501
MOD_N-GLC_1	16	21	PF02516	0.713
MOD_N-GLC_1	577	582	PF02516	0.679
MOD_NEK2_1	243	248	PF00069	0.485
MOD_NEK2_1	394	399	PF00069	0.608
MOD_NEK2_1	478	483	PF00069	0.494
MOD_NEK2_1	613	618	PF00069	0.798
MOD_NEK2_2	51	56	PF00069	0.447
MOD_NEK2_2	642	647	PF00069	0.778
MOD_OFUCOSY	133	138	PF10250	0.542
MOD_OFUCOSY	50	55	PF10250	0.438
MOD_PIKK_1	532	538	PF00454	0.623
MOD_PIKK_1	75	81	PF00454	0.405
MOD_PKA_2	199	205	PF00069	0.567
MOD_PKA_2	418	424	PF00069	0.718
MOD_PKA_2	66	72	PF00069	0.305
MOD_Plk_1	198	204	PF00069	0.543
MOD_Plk_1	692	698	PF00069	0.797
MOD_Plk_1	75	81	PF00069	0.402
MOD_Plk_2-3	269	275	PF00069	0.469
MOD_Plk_4	220	226	PF00069	0.578
MOD_Plk_4	342	348	PF00069	0.458
MOD_ProDKin_1	115	121	PF00069	0.512
MOD_ProDKin_1	22	28	PF00069	0.643
MOD_ProDKin_1	300	306	PF00069	0.643
MOD_ProDKin_1	461	467	PF00069	0.603
MOD_ProDKin_1	578	584	PF00069	0.783
MOD_ProDKin_1	668	674	PF00069	0.767
MOD_ProDKin_1	678	684	PF00069	0.729
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.411
TRG_ENDOCYTIC_2	165	168	PF00928	0.381
TRG_ENDOCYTIC_2	468	471	PF00928	0.591
TRG_ENDOCYTIC_2	488	491	PF00928	0.212
TRG_ER_diArg_1	102	104	PF00400	0.537
TRG_ER_diArg_1	704	706	PF00400	0.768
TRG_NES_CRM1_1	149	162	PF08389	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA72	Leptomonas seymouri	65%	100%
A0A0S4KKN7	Bodo saltans	39%	100%
A0A1X0P1Y0	Trypanosomatidae	42%	100%
A0A3S7X380	Leishmania donovani	93%	100%
A0A422P542	Trypanosoma rangeli	42%	100%
A4HI75	Leishmania braziliensis	83%	100%
A4I5F4	Leishmania infantum	93%	100%
Q4Q7I1	Leishmania major	93%	100%
V5BYZ6	Trypanosoma cruzi	36%	100%