AAA_28 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B0Q1_LEIMU

TriTrypDb:

LmxM.29.1220

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.506
CLV_C14_Caspase3-7	433	437	PF00656	0.439
CLV_C14_Caspase3-7	451	455	PF00656	0.408
CLV_C14_Caspase3-7	548	552	PF00656	0.531
CLV_C14_Caspase3-7	560	564	PF00656	0.535
CLV_C14_Caspase3-7	883	887	PF00656	0.554
CLV_NRD_NRD_1	127	129	PF00675	0.835
CLV_NRD_NRD_1	152	154	PF00675	0.555
CLV_NRD_NRD_1	199	201	PF00675	0.842
CLV_NRD_NRD_1	513	515	PF00675	0.537
CLV_NRD_NRD_1	798	800	PF00675	0.699
CLV_NRD_NRD_1	820	822	PF00675	0.721
CLV_NRD_NRD_1	92	94	PF00675	0.851
CLV_PCSK_KEX2_1	152	154	PF00082	0.576
CLV_PCSK_KEX2_1	199	201	PF00082	0.842
CLV_PCSK_KEX2_1	513	515	PF00082	0.487
CLV_PCSK_KEX2_1	546	548	PF00082	0.490
CLV_PCSK_KEX2_1	780	782	PF00082	0.609
CLV_PCSK_KEX2_1	798	800	PF00082	0.588
CLV_PCSK_KEX2_1	820	822	PF00082	0.721
CLV_PCSK_KEX2_1	92	94	PF00082	0.851
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.490
CLV_PCSK_PC1ET2_1	780	782	PF00082	0.601
CLV_PCSK_PC7_1	542	548	PF00082	0.487
CLV_PCSK_SKI1_1	153	157	PF00082	0.718
CLV_Separin_Metazoa	409	413	PF03568	0.384
DEG_APCC_DBOX_1	819	827	PF00400	0.715
DEG_APCC_KENBOX_2	128	132	PF00400	0.545
DEG_COP1_1	663	672	PF00400	0.515
DEG_ODPH_VHL_1	651	664	PF01847	0.501
DEG_SCF_FBW7_1	755	761	PF00400	0.815
DEG_SPOP_SBC_1	40	44	PF00917	0.736
DEG_SPOP_SBC_1	888	892	PF00917	0.633
DOC_ANK_TNKS_1	546	553	PF00023	0.519
DOC_CKS1_1	755	760	PF01111	0.712
DOC_CKS1_1	872	877	PF01111	0.713
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.408
DOC_MAPK_DCC_7	820	828	PF00069	0.689
DOC_MAPK_gen_1	301	309	PF00069	0.581
DOC_MAPK_gen_1	513	521	PF00069	0.537
DOC_MAPK_gen_1	820	828	PF00069	0.689
DOC_MAPK_MEF2A_6	693	700	PF00069	0.544
DOC_MAPK_RevD_3	807	821	PF00069	0.513
DOC_PP2B_LxvP_1	357	360	PF13499	0.509
DOC_PP2B_LxvP_1	692	695	PF13499	0.667
DOC_PP2B_LxvP_1	809	812	PF13499	0.661
DOC_PP2B_LxvP_1	815	818	PF13499	0.696
DOC_PP2B_PxIxI_1	385	391	PF00149	0.303
DOC_USP7_MATH_1	123	127	PF00917	0.565
DOC_USP7_MATH_1	18	22	PF00917	0.715
DOC_USP7_MATH_1	242	246	PF00917	0.660
DOC_USP7_MATH_1	29	33	PF00917	0.580
DOC_USP7_MATH_1	290	294	PF00917	0.567
DOC_USP7_MATH_1	315	319	PF00917	0.408
DOC_USP7_MATH_1	380	384	PF00917	0.509
DOC_USP7_MATH_1	456	460	PF00917	0.408
DOC_USP7_MATH_1	520	524	PF00917	0.594
DOC_USP7_MATH_1	550	554	PF00917	0.549
DOC_USP7_MATH_1	568	572	PF00917	0.638
DOC_USP7_MATH_1	705	709	PF00917	0.549
DOC_USP7_MATH_1	803	807	PF00917	0.711
DOC_USP7_MATH_1	837	841	PF00917	0.746
DOC_USP7_MATH_1	919	923	PF00917	0.680
DOC_USP7_MATH_1	924	928	PF00917	0.522
DOC_USP7_UBL2_3	125	129	PF12436	0.830
DOC_WW_Pin1_4	191	196	PF00397	0.729
DOC_WW_Pin1_4	224	229	PF00397	0.729
DOC_WW_Pin1_4	275	280	PF00397	0.611
DOC_WW_Pin1_4	41	46	PF00397	0.678
DOC_WW_Pin1_4	597	602	PF00397	0.807
DOC_WW_Pin1_4	754	759	PF00397	0.712
DOC_WW_Pin1_4	839	844	PF00397	0.670
DOC_WW_Pin1_4	871	876	PF00397	0.664
DOC_WW_Pin1_4	920	925	PF00397	0.730
LIG_14-3-3_CanoR_1	200	206	PF00244	0.744
LIG_14-3-3_CanoR_1	399	407	PF00244	0.408
LIG_14-3-3_CanoR_1	457	463	PF00244	0.366
LIG_14-3-3_CanoR_1	588	592	PF00244	0.700
LIG_14-3-3_CanoR_1	611	617	PF00244	0.551
LIG_14-3-3_CanoR_1	634	640	PF00244	0.481
LIG_14-3-3_CanoR_1	659	665	PF00244	0.480
LIG_14-3-3_CanoR_1	68	76	PF00244	0.603
LIG_14-3-3_CanoR_1	877	881	PF00244	0.576
LIG_APCC_ABBA_1	694	699	PF00400	0.536
LIG_APCC_ABBA_1	856	861	PF00400	0.614
LIG_BIR_III_4	154	158	PF00653	0.702
LIG_BIR_III_4	253	257	PF00653	0.625
LIG_BRCT_BRCA1_1	263	267	PF00533	0.697
LIG_BRCT_BRCA1_1	478	482	PF00533	0.408
LIG_BRCT_BRCA1_1	725	729	PF00533	0.591
LIG_FHA_1	11	17	PF00498	0.703
LIG_FHA_1	132	138	PF00498	0.753
LIG_FHA_1	187	193	PF00498	0.728
LIG_FHA_1	342	348	PF00498	0.408
LIG_FHA_1	385	391	PF00498	0.356
LIG_FHA_1	415	421	PF00498	0.384
LIG_FHA_1	456	462	PF00498	0.303
LIG_FHA_1	506	512	PF00498	0.609
LIG_FHA_1	528	534	PF00498	0.511
LIG_FHA_1	634	640	PF00498	0.433
LIG_FHA_1	646	652	PF00498	0.449
LIG_FHA_1	659	665	PF00498	0.452
LIG_FHA_1	709	715	PF00498	0.534
LIG_FHA_1	718	724	PF00498	0.584
LIG_FHA_1	745	751	PF00498	0.697
LIG_FHA_1	759	765	PF00498	0.732
LIG_FHA_1	795	801	PF00498	0.583
LIG_FHA_1	828	834	PF00498	0.697
LIG_FHA_1	846	852	PF00498	0.821
LIG_FHA_1	99	105	PF00498	0.784
LIG_FHA_2	431	437	PF00498	0.509
LIG_FHA_2	478	484	PF00498	0.408
LIG_FHA_2	625	631	PF00498	0.625
LIG_IRF3_LxIS_1	828	834	PF10401	0.726
LIG_LIR_Gen_1	404	414	PF02991	0.390
LIG_LIR_Gen_1	423	432	PF02991	0.408
LIG_LIR_Gen_1	527	533	PF02991	0.458
LIG_LIR_Nem_3	264	270	PF02991	0.752
LIG_LIR_Nem_3	373	379	PF02991	0.374
LIG_LIR_Nem_3	404	410	PF02991	0.390
LIG_LIR_Nem_3	423	428	PF02991	0.408
LIG_LIR_Nem_3	439	444	PF02991	0.349
LIG_LIR_Nem_3	508	512	PF02991	0.446
LIG_LIR_Nem_3	523	529	PF02991	0.407
LIG_LIR_Nem_3	614	620	PF02991	0.659
LIG_LIR_Nem_3	726	732	PF02991	0.590
LIG_Pex14_2	729	733	PF04695	0.564
LIG_REV1ctd_RIR_1	555	563	PF16727	0.515
LIG_SH2_CRK	270	274	PF00017	0.609
LIG_SH2_CRK	425	429	PF00017	0.408
LIG_SH2_CRK	529	533	PF00017	0.455
LIG_SH2_CRK	617	621	PF00017	0.537
LIG_SH2_CRK	724	728	PF00017	0.553
LIG_SH2_STAP1	377	381	PF00017	0.408
LIG_SH2_STAP1	425	429	PF00017	0.353
LIG_SH2_STAP1	529	533	PF00017	0.455
LIG_SH2_STAP1	724	728	PF00017	0.553
LIG_SH2_STAT5	467	470	PF00017	0.408
LIG_SH2_STAT5	510	513	PF00017	0.502
LIG_SH2_STAT5	526	529	PF00017	0.488
LIG_SH2_STAT5	724	727	PF00017	0.601
LIG_SH3_3	12	18	PF00018	0.568
LIG_SH3_3	133	139	PF00018	0.728
LIG_SH3_3	189	195	PF00018	0.727
LIG_SH3_3	227	233	PF00018	0.711
LIG_SH3_3	252	258	PF00018	0.784
LIG_SH3_3	465	471	PF00018	0.509
LIG_SH3_3	501	507	PF00018	0.590
LIG_SH3_3	53	59	PF00018	0.708
LIG_SH3_3	588	594	PF00018	0.727
LIG_SH3_3	752	758	PF00018	0.704
LIG_SH3_3	810	816	PF00018	0.694
LIG_SH3_3	869	875	PF00018	0.710
LIG_SUMO_SIM_anti_2	416	423	PF11976	0.384
LIG_SUMO_SIM_par_1	186	194	PF11976	0.705
LIG_SUMO_SIM_par_1	343	348	PF11976	0.408
LIG_SUMO_SIM_par_1	386	392	PF11976	0.408
LIG_SUMO_SIM_par_1	660	666	PF11976	0.524
LIG_SUMO_SIM_par_1	824	830	PF11976	0.662
LIG_TRAF2_1	31	34	PF00917	0.772
LIG_TRAF2_1	672	675	PF00917	0.745
LIG_TRAF2_1	881	884	PF00917	0.743
LIG_TYR_ITSM	266	273	PF00017	0.654
LIG_TYR_ITSM	525	532	PF00017	0.464
LIG_UBA3_1	320	327	PF00899	0.408
LIG_WW_2	813	816	PF00397	0.769
LIG_WW_3	573	577	PF00397	0.750
MOD_CDK_SPK_2	754	759	PF00069	0.712
MOD_CDK_SPK_2	839	844	PF00069	0.636
MOD_CDK_SPxK_1	871	877	PF00069	0.586
MOD_CDK_SPxxK_3	758	765	PF00069	0.743
MOD_CK1_1	143	149	PF00069	0.714
MOD_CK1_1	201	207	PF00069	0.813
MOD_CK1_1	21	27	PF00069	0.757
MOD_CK1_1	223	229	PF00069	0.741
MOD_CK1_1	265	271	PF00069	0.668
MOD_CK1_1	536	542	PF00069	0.639
MOD_CK1_1	579	585	PF00069	0.740
MOD_CK1_1	586	592	PF00069	0.781
MOD_CK1_1	597	603	PF00069	0.700
MOD_CK1_1	708	714	PF00069	0.542
MOD_CK1_1	753	759	PF00069	0.714
MOD_CK1_1	876	882	PF00069	0.729
MOD_CK2_1	191	197	PF00069	0.815
MOD_CK2_1	28	34	PF00069	0.673
MOD_CK2_1	477	483	PF00069	0.408
MOD_CK2_1	610	616	PF00069	0.499
MOD_CK2_1	624	630	PF00069	0.635
MOD_CK2_1	713	719	PF00069	0.543
MOD_CK2_1	862	868	PF00069	0.662
MOD_Cter_Amidation	150	153	PF01082	0.517
MOD_Cter_Amidation	197	200	PF01082	0.833
MOD_DYRK1A_RPxSP_1	275	279	PF00069	0.606
MOD_GlcNHglycan	101	104	PF01048	0.759
MOD_GlcNHglycan	20	23	PF01048	0.751
MOD_GlcNHglycan	200	203	PF01048	0.748
MOD_GlcNHglycan	222	225	PF01048	0.835
MOD_GlcNHglycan	240	243	PF01048	0.499
MOD_GlcNHglycan	275	278	PF01048	0.554
MOD_GlcNHglycan	321	324	PF01048	0.408
MOD_GlcNHglycan	522	525	PF01048	0.543
MOD_GlcNHglycan	565	568	PF01048	0.560
MOD_GlcNHglycan	582	585	PF01048	0.811
MOD_GlcNHglycan	607	610	PF01048	0.618
MOD_GlcNHglycan	792	795	PF01048	0.654
MOD_GlcNHglycan	833	836	PF01048	0.710
MOD_GlcNHglycan	839	842	PF01048	0.730
MOD_GSK3_1	200	207	PF00069	0.744
MOD_GSK3_1	220	227	PF00069	0.584
MOD_GSK3_1	238	245	PF00069	0.659
MOD_GSK3_1	261	268	PF00069	0.724
MOD_GSK3_1	315	322	PF00069	0.408
MOD_GSK3_1	341	348	PF00069	0.397
MOD_GSK3_1	380	387	PF00069	0.358
MOD_GSK3_1	388	395	PF00069	0.365
MOD_GSK3_1	520	527	PF00069	0.496
MOD_GSK3_1	563	570	PF00069	0.664
MOD_GSK3_1	575	582	PF00069	0.675
MOD_GSK3_1	583	590	PF00069	0.814
MOD_GSK3_1	705	712	PF00069	0.546
MOD_GSK3_1	713	720	PF00069	0.555
MOD_GSK3_1	750	757	PF00069	0.712
MOD_GSK3_1	763	770	PF00069	0.635
MOD_GSK3_1	790	797	PF00069	0.725
MOD_GSK3_1	827	834	PF00069	0.684
MOD_GSK3_1	919	926	PF00069	0.757
MOD_GSK3_1	99	106	PF00069	0.806
MOD_N-GLC_1	477	482	PF02516	0.408
MOD_N-GLC_1	919	924	PF02516	0.520
MOD_NEK2_1	220	225	PF00069	0.748
MOD_NEK2_1	262	267	PF00069	0.779
MOD_NEK2_1	345	350	PF00069	0.383
MOD_NEK2_1	365	370	PF00069	0.180
MOD_NEK2_1	476	481	PF00069	0.353
MOD_NEK2_1	533	538	PF00069	0.542
MOD_NEK2_1	557	562	PF00069	0.513
MOD_NEK2_1	587	592	PF00069	0.701
MOD_NEK2_1	633	638	PF00069	0.510
MOD_NEK2_1	709	714	PF00069	0.534
MOD_NEK2_1	71	76	PF00069	0.755
MOD_NEK2_1	723	728	PF00069	0.618
MOD_NEK2_1	751	756	PF00069	0.820
MOD_NEK2_1	831	836	PF00069	0.738
MOD_NEK2_1	860	865	PF00069	0.716
MOD_NEK2_2	242	247	PF00069	0.581
MOD_NEK2_2	4	9	PF00069	0.764
MOD_NEK2_2	803	808	PF00069	0.712
MOD_NEK2_2	924	929	PF00069	0.527
MOD_NMyristoyl	1	7	PF02799	0.641
MOD_PIKK_1	365	371	PF00454	0.408
MOD_PIKK_1	491	497	PF00454	0.513
MOD_PIKK_1	533	539	PF00454	0.545
MOD_PIKK_1	71	77	PF00454	0.698
MOD_PKA_2	131	137	PF00069	0.630
MOD_PKA_2	198	204	PF00069	0.747
MOD_PKA_2	392	398	PF00069	0.408
MOD_PKA_2	456	462	PF00069	0.366
MOD_PKA_2	575	581	PF00069	0.771
MOD_PKA_2	587	593	PF00069	0.639
MOD_PKA_2	610	616	PF00069	0.556
MOD_PKA_2	633	639	PF00069	0.399
MOD_PKA_2	658	664	PF00069	0.519
MOD_PKA_2	69	75	PF00069	0.759
MOD_PKA_2	876	882	PF00069	0.575
MOD_Plk_1	186	192	PF00069	0.679
MOD_Plk_1	355	361	PF00069	0.434
MOD_Plk_1	477	483	PF00069	0.361
MOD_Plk_1	645	651	PF00069	0.435
MOD_Plk_1	781	787	PF00069	0.646
MOD_Plk_1	803	809	PF00069	0.718
MOD_Plk_1	861	867	PF00069	0.807
MOD_Plk_2-3	392	398	PF00069	0.408
MOD_Plk_2-3	862	868	PF00069	0.632
MOD_Plk_4	140	146	PF00069	0.734
MOD_Plk_4	316	322	PF00069	0.408
MOD_Plk_4	341	347	PF00069	0.408
MOD_Plk_4	384	390	PF00069	0.408
MOD_Plk_4	505	511	PF00069	0.523
MOD_Plk_4	528	534	PF00069	0.490
MOD_Plk_4	646	652	PF00069	0.489
MOD_Plk_4	709	715	PF00069	0.486
MOD_Plk_4	803	809	PF00069	0.712
MOD_Plk_4	909	915	PF00069	0.720
MOD_ProDKin_1	191	197	PF00069	0.732
MOD_ProDKin_1	224	230	PF00069	0.727
MOD_ProDKin_1	275	281	PF00069	0.618
MOD_ProDKin_1	41	47	PF00069	0.681
MOD_ProDKin_1	597	603	PF00069	0.800
MOD_ProDKin_1	754	760	PF00069	0.713
MOD_ProDKin_1	839	845	PF00069	0.669
MOD_ProDKin_1	871	877	PF00069	0.665
MOD_ProDKin_1	920	926	PF00069	0.730
MOD_SUMO_for_1	545	548	PF00179	0.474
MOD_SUMO_for_1	672	675	PF00179	0.663
MOD_SUMO_for_1	843	846	PF00179	0.616
MOD_SUMO_rev_2	477	486	PF00179	0.408
TRG_DiLeu_BaEn_1	341	346	PF01217	0.408
TRG_DiLeu_BaEn_2	803	809	PF01217	0.732
TRG_DiLeu_BaEn_4	439	445	PF01217	0.408
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.708
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.408
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.507
TRG_ENDOCYTIC_2	270	273	PF00928	0.613
TRG_ENDOCYTIC_2	286	289	PF00928	0.633
TRG_ENDOCYTIC_2	425	428	PF00928	0.408
TRG_ENDOCYTIC_2	450	453	PF00928	0.408
TRG_ENDOCYTIC_2	509	512	PF00928	0.589
TRG_ENDOCYTIC_2	529	532	PF00928	0.251
TRG_ENDOCYTIC_2	617	620	PF00928	0.540
TRG_ENDOCYTIC_2	724	727	PF00928	0.551
TRG_ER_diArg_1	512	514	PF00400	0.531
TRG_ER_diArg_1	67	70	PF00400	0.760
TRG_ER_diArg_1	798	800	PF00400	0.699
TRG_ER_diArg_1	92	94	PF00400	0.851
TRG_NES_CRM1_1	361	374	PF08389	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3L1	Leptomonas seymouri	54%	100%
A0A3Q8IRW3	Leishmania donovani	89%	100%
A4HI74	Leishmania braziliensis	72%	100%
A4I5F3	Leishmania infantum	89%	100%