Transmembrane protein 107

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0P7_LEIMU

TriTrypDb:

LmxM.29.1180

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9B0P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0P7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.420
CLV_PCSK_KEX2_1	12	14	PF00082	0.420
CLV_PCSK_SKI1_1	28	32	PF00082	0.280
CLV_PCSK_SKI1_1	75	79	PF00082	0.480
DOC_CYCLIN_RxL_1	97	107	PF00134	0.480
DOC_MAPK_gen_1	55	64	PF00069	0.169
DOC_MAPK_MEF2A_6	12	21	PF00069	0.652
DOC_PP1_RVXF_1	98	105	PF00149	0.480
DOC_SPAK_OSR1_1	103	107	PF12202	0.480
LIG_14-3-3_CanoR_1	12	17	PF00244	0.669
LIG_14-3-3_CanoR_1	58	63	PF00244	0.350
LIG_Actin_WH2_2	89	105	PF00022	0.386
LIG_FHA_1	127	133	PF00498	0.356
LIG_FHA_1	82	88	PF00498	0.476
LIG_FHA_2	145	151	PF00498	0.293
LIG_LIR_Gen_1	68	77	PF02991	0.301
LIG_LIR_Gen_1	84	93	PF02991	0.182
LIG_LIR_Nem_3	15	21	PF02991	0.601
LIG_LIR_Nem_3	68	74	PF02991	0.250
LIG_LIR_Nem_3	84	89	PF02991	0.210
LIG_Pex14_1	136	140	PF04695	0.210
LIG_Pex14_1	39	43	PF04695	0.331
LIG_SH2_NCK_1	66	70	PF00017	0.169
LIG_SH2_PTP2	71	74	PF00017	0.280
LIG_SH2_SRC	66	69	PF00017	0.169
LIG_SH2_STAT5	140	143	PF00017	0.254
LIG_SH2_STAT5	18	21	PF00017	0.639
LIG_SH2_STAT5	71	74	PF00017	0.284
LIG_SH3_3	14	20	PF00018	0.687
LIG_SH3_3	27	33	PF00018	0.535
LIG_Sin3_3	117	124	PF02671	0.178
LIG_SUMO_SIM_par_1	1	7	PF11976	0.565
LIG_SUMO_SIM_par_1	119	125	PF11976	0.386
MOD_CK1_1	157	163	PF00069	0.503
MOD_CK2_1	144	150	PF00069	0.293
MOD_CK2_1	157	163	PF00069	0.449
MOD_GlcNHglycan	159	162	PF01048	0.257
MOD_GSK3_1	122	129	PF00069	0.409
MOD_GSK3_1	140	147	PF00069	0.386
MOD_GSK3_1	150	157	PF00069	0.386
MOD_N-GLC_2	79	81	PF02516	0.331
MOD_NEK2_1	110	115	PF00069	0.367
MOD_NEK2_1	122	127	PF00069	0.265
MOD_NEK2_1	154	159	PF00069	0.374
MOD_NEK2_1	82	87	PF00069	0.290
MOD_PIKK_1	47	53	PF00454	0.255
MOD_PKA_1	12	18	PF00069	0.652
MOD_PKA_2	12	18	PF00069	0.610
MOD_PKA_2	57	63	PF00069	0.333
MOD_Plk_4	154	160	PF00069	0.411
MOD_Plk_4	42	48	PF00069	0.482
MOD_Plk_4	82	88	PF00069	0.269
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.656
TRG_ENDOCYTIC_2	18	21	PF00928	0.706
TRG_ENDOCYTIC_2	71	74	PF00928	0.300
TRG_ER_diArg_1	11	13	PF00400	0.620
TRG_NES_CRM1_1	54	68	PF08389	0.169

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KEE0	Bodo saltans	38%	100%
A0A1X0P1Z3	Trypanosomatidae	49%	100%
A0A3R7MXG9	Trypanosoma rangeli	52%	100%
A0A3S7X379	Leishmania donovani	90%	100%
A4I5E9	Leishmania infantum	90%	100%
C9ZQT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q7I5	Leishmania major	89%	100%