Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B0P6_LEIMU

TriTrypDb:

LmxM.29.1170

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B0P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0P6

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016417	S-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	8
GO:0019707	protein-cysteine S-acyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.585
CLV_NRD_NRD_1	236	238	PF00675	0.572
CLV_NRD_NRD_1	326	328	PF00675	0.465
CLV_NRD_NRD_1	405	407	PF00675	0.497
CLV_NRD_NRD_1	643	645	PF00675	0.432
CLV_PCSK_KEX2_1	20	22	PF00082	0.579
CLV_PCSK_KEX2_1	236	238	PF00082	0.522
CLV_PCSK_KEX2_1	325	327	PF00082	0.460
CLV_PCSK_KEX2_1	405	407	PF00082	0.502
CLV_PCSK_KEX2_1	63	65	PF00082	0.605
CLV_PCSK_KEX2_1	676	678	PF00082	0.489
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.579
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.519
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.489
CLV_PCSK_SKI1_1	185	189	PF00082	0.516
CLV_PCSK_SKI1_1	326	330	PF00082	0.467
CLV_PCSK_SKI1_1	422	426	PF00082	0.579
CLV_PCSK_SKI1_1	562	566	PF00082	0.341
CLV_Separin_Metazoa	668	672	PF03568	0.738
DEG_APCC_DBOX_1	324	332	PF00400	0.698
DEG_APCC_KENBOX_2	180	184	PF00400	0.796
DEG_COP1_1	431	440	PF00400	0.701
DEG_SCF_FBW7_1	41	48	PF00400	0.710
DOC_CKS1_1	42	47	PF01111	0.847
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.656
DOC_MAPK_FxFP_2	548	551	PF00069	0.429
DOC_MAPK_gen_1	526	536	PF00069	0.362
DOC_MAPK_gen_1	571	580	PF00069	0.494
DOC_MAPK_MEF2A_6	529	538	PF00069	0.319
DOC_PP1_RVXF_1	574	581	PF00149	0.503
DOC_PP1_RVXF_1	630	636	PF00149	0.652
DOC_PP2B_LxvP_1	435	438	PF13499	0.683
DOC_PP2B_LxvP_1	637	640	PF13499	0.652
DOC_PP4_FxxP_1	317	320	PF00568	0.617
DOC_PP4_FxxP_1	548	551	PF00568	0.429
DOC_USP7_MATH_1	170	174	PF00917	0.712
DOC_USP7_MATH_1	24	28	PF00917	0.697
DOC_USP7_MATH_1	290	294	PF00917	0.362
DOC_USP7_MATH_1	387	391	PF00917	0.657
DOC_USP7_MATH_1	45	49	PF00917	0.828
DOC_USP7_MATH_1	65	69	PF00917	0.615
DOC_USP7_MATH_1	72	76	PF00917	0.802
DOC_USP7_MATH_1	82	86	PF00917	0.725
DOC_USP7_MATH_2	13	19	PF00917	0.692
DOC_USP7_UBL2_3	181	185	PF12436	0.735
DOC_USP7_UBL2_3	571	575	PF12436	0.520
DOC_USP7_UBL2_3	642	646	PF12436	0.501
DOC_WW_Pin1_4	41	46	PF00397	0.796
DOC_WW_Pin1_4	48	53	PF00397	0.830
DOC_WW_Pin1_4	9	14	PF00397	0.744
LIG_14-3-3_CanoR_1	33	42	PF00244	0.727
LIG_14-3-3_CanoR_1	405	410	PF00244	0.741
LIG_14-3-3_CanoR_1	429	437	PF00244	0.758
LIG_14-3-3_CanoR_1	514	518	PF00244	0.347
LIG_14-3-3_CanoR_1	562	570	PF00244	0.547
LIG_BIR_II_1	1	5	PF00653	0.814
LIG_BRCT_BRCA1_1	240	244	PF00533	0.774
LIG_BRCT_BRCA1_1	492	496	PF00533	0.500
LIG_BRCT_BRCA1_1	576	580	PF00533	0.662
LIG_deltaCOP1_diTrp_1	292	302	PF00928	0.358
LIG_eIF4E_1	489	495	PF01652	0.429
LIG_FHA_1	169	175	PF00498	0.795
LIG_FHA_1	447	453	PF00498	0.499
LIG_FHA_1	519	525	PF00498	0.373
LIG_FHA_2	163	169	PF00498	0.621
LIG_FHA_2	195	201	PF00498	0.613
LIG_FHA_2	563	569	PF00498	0.513
LIG_GBD_Chelix_1	299	307	PF00786	0.418
LIG_Integrin_RGD_1	105	107	PF01839	0.429
LIG_Integrin_RGD_1	334	336	PF01839	0.570
LIG_LIR_Apic_2	516	520	PF02991	0.347
LIG_LIR_Gen_1	292	303	PF02991	0.344
LIG_LIR_Gen_1	493	504	PF02991	0.500
LIG_LIR_Nem_3	292	298	PF02991	0.423
LIG_LIR_Nem_3	439	445	PF02991	0.666
LIG_LIR_Nem_3	493	499	PF02991	0.467
LIG_LIR_Nem_3	541	545	PF02991	0.409
LIG_LIR_Nem_3	577	583	PF02991	0.663
LIG_LIR_Nem_3	616	622	PF02991	0.634
LIG_LIR_Nem_3	8	14	PF02991	0.772
LIG_LYPXL_S_1	280	284	PF13949	0.429
LIG_MLH1_MIPbox_1	492	496	PF16413	0.500
LIG_MLH1_MIPbox_1	576	580	PF16413	0.662
LIG_MYND_3	437	441	PF01753	0.659
LIG_PCNA_PIPBox_1	409	418	PF02747	0.656
LIG_Pex14_1	269	273	PF04695	0.429
LIG_Pex14_2	442	446	PF04695	0.646
LIG_Pex14_2	491	495	PF04695	0.500
LIG_PTB_Apo_2	132	139	PF02174	0.625
LIG_PTB_Phospho_1	132	138	PF10480	0.626
LIG_SH2_CRK	275	279	PF00017	0.429
LIG_SH2_CRK	503	507	PF00017	0.429
LIG_SH2_CRK	532	536	PF00017	0.355
LIG_SH2_CRK	592	596	PF00017	0.619
LIG_SH2_GRB2like	592	595	PF00017	0.654
LIG_SH2_NCK_1	11	15	PF00017	0.771
LIG_SH2_SRC	517	520	PF00017	0.380
LIG_SH2_SRC	530	533	PF00017	0.258
LIG_SH2_SRC	592	595	PF00017	0.654
LIG_SH2_STAP1	383	387	PF00017	0.764
LIG_SH2_STAP1	503	507	PF00017	0.500
LIG_SH2_STAP1	596	600	PF00017	0.612
LIG_SH2_STAP1	91	95	PF00017	0.759
LIG_SH2_STAT5	202	205	PF00017	0.534
LIG_SH2_STAT5	383	386	PF00017	0.765
LIG_SH2_STAT5	415	418	PF00017	0.734
LIG_SH2_STAT5	489	492	PF00017	0.399
LIG_SH2_STAT5	517	520	PF00017	0.340
LIG_SH2_STAT5	530	533	PF00017	0.281
LIG_SH2_STAT5	539	542	PF00017	0.431
LIG_SH2_STAT5	579	582	PF00017	0.659
LIG_SH3_3	130	136	PF00018	0.726
LIG_SH3_3	227	233	PF00018	0.720
LIG_SH3_3	260	266	PF00018	0.641
LIG_SH3_3	337	343	PF00018	0.663
LIG_SH3_3	36	42	PF00018	0.827
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.440
LIG_SxIP_EBH_1	185	199	PF03271	0.740
LIG_TRAF2_1	198	201	PF00917	0.643
LIG_TRAF2_1	605	608	PF00917	0.705
LIG_TRAF2_1	95	98	PF00917	0.691
LIG_TYR_ITIM	501	506	PF00017	0.429
LIG_UBA3_1	636	642	PF00899	0.415
LIG_WRC_WIRS_1	539	544	PF05994	0.429
MOD_CK1_1	145	151	PF00069	0.697
MOD_CK1_1	2	8	PF00069	0.644
MOD_CK1_1	23	29	PF00069	0.804
MOD_CK1_1	305	311	PF00069	0.376
MOD_CK1_1	371	377	PF00069	0.728
MOD_CK1_1	381	387	PF00069	0.699
MOD_CK1_1	48	54	PF00069	0.779
MOD_CK2_1	172	178	PF00069	0.712
MOD_CK2_1	194	200	PF00069	0.557
MOD_CK2_1	2	8	PF00069	0.576
MOD_CK2_1	562	568	PF00069	0.369
MOD_CK2_1	82	88	PF00069	0.788
MOD_CK2_1	9	15	PF00069	0.637
MOD_GlcNHglycan	144	147	PF01048	0.787
MOD_GlcNHglycan	150	153	PF01048	0.642
MOD_GlcNHglycan	174	177	PF01048	0.747
MOD_GlcNHglycan	22	25	PF01048	0.808
MOD_GlcNHglycan	26	29	PF01048	0.789
MOD_GlcNHglycan	292	295	PF01048	0.578
MOD_GlcNHglycan	304	307	PF01048	0.407
MOD_GlcNHglycan	370	373	PF01048	0.725
MOD_GlcNHglycan	380	383	PF01048	0.599
MOD_GlcNHglycan	389	392	PF01048	0.532
MOD_GlcNHglycan	47	50	PF01048	0.817
MOD_GlcNHglycan	88	91	PF01048	0.765
MOD_GSK3_1	140	147	PF00069	0.699
MOD_GSK3_1	148	155	PF00069	0.737
MOD_GSK3_1	168	175	PF00069	0.737
MOD_GSK3_1	20	27	PF00069	0.837
MOD_GSK3_1	228	235	PF00069	0.607
MOD_GSK3_1	404	411	PF00069	0.685
MOD_GSK3_1	41	48	PF00069	0.789
MOD_GSK3_1	72	79	PF00069	0.721
MOD_GSK3_1	82	89	PF00069	0.744
MOD_N-GLC_1	329	334	PF02516	0.649
MOD_N-GLC_1	45	50	PF02516	0.755
MOD_N-GLC_2	479	481	PF02516	0.487
MOD_NEK2_1	188	193	PF00069	0.617
MOD_NEK2_1	238	243	PF00069	0.659
MOD_NEK2_1	446	451	PF00069	0.412
MOD_NEK2_1	490	495	PF00069	0.376
MOD_NEK2_1	86	91	PF00069	0.731
MOD_NEK2_2	574	579	PF00069	0.354
MOD_NEK2_2	82	87	PF00069	0.633
MOD_PIKK_1	33	39	PF00454	0.667
MOD_PIKK_1	584	590	PF00454	0.601
MOD_PIKK_1	65	71	PF00454	0.658
MOD_PIKK_1	76	82	PF00454	0.563
MOD_PKA_1	113	119	PF00069	0.550
MOD_PKA_1	20	26	PF00069	0.745
MOD_PKA_1	405	411	PF00069	0.609
MOD_PKA_2	20	26	PF00069	0.828
MOD_PKA_2	32	38	PF00069	0.653
MOD_PKA_2	404	410	PF00069	0.691
MOD_PKA_2	428	434	PF00069	0.718
MOD_PKA_2	513	519	PF00069	0.418
MOD_PKA_2	86	92	PF00069	0.793
MOD_Plk_4	305	311	PF00069	0.433
MOD_Plk_4	397	403	PF00069	0.608
MOD_Plk_4	405	411	PF00069	0.690
MOD_Plk_4	490	496	PF00069	0.429
MOD_Plk_4	513	519	PF00069	0.418
MOD_Plk_4	574	580	PF00069	0.556
MOD_ProDKin_1	41	47	PF00069	0.766
MOD_ProDKin_1	48	54	PF00069	0.814
MOD_ProDKin_1	9	15	PF00069	0.692
MOD_SUMO_rev_2	219	227	PF00179	0.654
MOD_SUMO_rev_2	629	633	PF00179	0.513
TRG_ENDOCYTIC_2	11	14	PF00928	0.731
TRG_ENDOCYTIC_2	275	278	PF00928	0.429
TRG_ENDOCYTIC_2	281	284	PF00928	0.429
TRG_ENDOCYTIC_2	487	490	PF00928	0.376
TRG_ENDOCYTIC_2	503	506	PF00928	0.376
TRG_ENDOCYTIC_2	539	542	PF00928	0.389
TRG_ENDOCYTIC_2	592	595	PF00928	0.511
TRG_ENDOCYTIC_2	596	599	PF00928	0.482
TRG_ENDOCYTIC_2	619	622	PF00928	0.527
TRG_ER_diArg_1	236	238	PF00400	0.733
TRG_ER_diArg_1	324	327	PF00400	0.571
TRG_ER_diArg_1	456	459	PF00400	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P984	Leptomonas seymouri	63%	96%
A0A1X0P316	Trypanosomatidae	33%	100%
A0A3Q8IHU7	Leishmania donovani	89%	100%
A4HI71	Leishmania braziliensis	78%	100%
A4I5E8	Leishmania infantum	89%	100%
Q4Q7I6	Leishmania major	89%	100%