MI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MA3 domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0P4_LEIMU

TriTrypDb:

LmxM.29.1150

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0P4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042274	ribosomal small subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.548
CLV_C14_Caspase3-7	789	793	PF00656	0.687
CLV_C14_Caspase3-7	813	817	PF00656	0.791
CLV_MEL_PAP_1	261	267	PF00089	0.333
CLV_NRD_NRD_1	183	185	PF00675	0.325
CLV_NRD_NRD_1	380	382	PF00675	0.409
CLV_NRD_NRD_1	410	412	PF00675	0.451
CLV_NRD_NRD_1	414	416	PF00675	0.456
CLV_NRD_NRD_1	446	448	PF00675	0.455
CLV_NRD_NRD_1	47	49	PF00675	0.467
CLV_NRD_NRD_1	52	54	PF00675	0.373
CLV_NRD_NRD_1	735	737	PF00675	0.373
CLV_NRD_NRD_1	804	806	PF00675	0.463
CLV_NRD_NRD_1	93	95	PF00675	0.423
CLV_PCSK_KEX2_1	112	114	PF00082	0.496
CLV_PCSK_KEX2_1	183	185	PF00082	0.341
CLV_PCSK_KEX2_1	380	382	PF00082	0.411
CLV_PCSK_KEX2_1	414	416	PF00082	0.407
CLV_PCSK_KEX2_1	446	448	PF00082	0.361
CLV_PCSK_KEX2_1	450	452	PF00082	0.316
CLV_PCSK_KEX2_1	51	53	PF00082	0.376
CLV_PCSK_KEX2_1	545	547	PF00082	0.470
CLV_PCSK_KEX2_1	569	571	PF00082	0.292
CLV_PCSK_KEX2_1	735	737	PF00082	0.373
CLV_PCSK_KEX2_1	753	755	PF00082	0.409
CLV_PCSK_KEX2_1	804	806	PF00082	0.482
CLV_PCSK_KEX2_1	844	846	PF00082	0.258
CLV_PCSK_KEX2_1	95	97	PF00082	0.398
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.520
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.326
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.470
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.292
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.409
CLV_PCSK_PC1ET2_1	844	846	PF00082	0.270
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.406
CLV_PCSK_PC7_1	446	452	PF00082	0.427
CLV_PCSK_PC7_1	48	54	PF00082	0.374
CLV_PCSK_SKI1_1	118	122	PF00082	0.510
CLV_PCSK_SKI1_1	307	311	PF00082	0.470
CLV_PCSK_SKI1_1	363	367	PF00082	0.294
CLV_PCSK_SKI1_1	387	391	PF00082	0.439
CLV_PCSK_SKI1_1	415	419	PF00082	0.402
CLV_PCSK_SKI1_1	447	451	PF00082	0.343
CLV_PCSK_SKI1_1	570	574	PF00082	0.289
CLV_PCSK_SKI1_1	697	701	PF00082	0.241
CLV_PCSK_SKI1_1	702	706	PF00082	0.244
CLV_PCSK_SKI1_1	735	739	PF00082	0.329
CLV_PCSK_SKI1_1	740	744	PF00082	0.323
DEG_APCC_DBOX_1	696	704	PF00400	0.441
DEG_APCC_KENBOX_2	511	515	PF00400	0.672
DEG_Nend_UBRbox_1	1	4	PF02207	0.655
DEG_SPOP_SBC_1	233	237	PF00917	0.576
DEG_SPOP_SBC_1	330	334	PF00917	0.452
DEG_SPOP_SBC_1	819	823	PF00917	0.541
DOC_CYCLIN_RxL_1	304	314	PF00134	0.443
DOC_CYCLIN_RxL_1	446	456	PF00134	0.632
DOC_CYCLIN_RxL_1	631	644	PF00134	0.513
DOC_CYCLIN_RxL_1	678	688	PF00134	0.481
DOC_CYCLIN_RxL_1	732	739	PF00134	0.533
DOC_MAPK_DCC_7	475	483	PF00069	0.617
DOC_MAPK_gen_1	446	454	PF00069	0.561
DOC_MAPK_gen_1	56	64	PF00069	0.649
DOC_MAPK_MEF2A_6	475	483	PF00069	0.617
DOC_MAPK_MEF2A_6	697	705	PF00069	0.454
DOC_PP1_RVXF_1	262	268	PF00149	0.547
DOC_PP1_RVXF_1	634	641	PF00149	0.513
DOC_PP1_RVXF_1	700	706	PF00149	0.477
DOC_PP4_FxxP_1	705	708	PF00568	0.493
DOC_USP7_MATH_1	102	106	PF00917	0.682
DOC_USP7_MATH_1	148	152	PF00917	0.717
DOC_USP7_MATH_1	164	168	PF00917	0.781
DOC_USP7_MATH_1	208	212	PF00917	0.534
DOC_USP7_MATH_1	29	33	PF00917	0.699
DOC_USP7_MATH_1	325	329	PF00917	0.485
DOC_USP7_MATH_1	330	334	PF00917	0.449
DOC_USP7_MATH_1	786	790	PF00917	0.620
DOC_USP7_MATH_1	81	85	PF00917	0.614
DOC_USP7_MATH_1	819	823	PF00917	0.681
DOC_USP7_UBL2_3	108	112	PF12436	0.602
DOC_WW_Pin1_4	169	174	PF00397	0.698
DOC_WW_Pin1_4	27	32	PF00397	0.631
DOC_WW_Pin1_4	334	339	PF00397	0.260
DOC_WW_Pin1_4	365	370	PF00397	0.605
LIG_14-3-3_CanoR_1	2	8	PF00244	0.679
LIG_14-3-3_CanoR_1	212	216	PF00244	0.472
LIG_14-3-3_CanoR_1	264	270	PF00244	0.551
LIG_14-3-3_CanoR_1	380	389	PF00244	0.552
LIG_14-3-3_CanoR_1	414	424	PF00244	0.624
LIG_14-3-3_CanoR_1	446	450	PF00244	0.536
LIG_14-3-3_CanoR_1	451	459	PF00244	0.493
LIG_14-3-3_CanoR_1	563	572	PF00244	0.513
LIG_14-3-3_CanoR_1	574	583	PF00244	0.488
LIG_14-3-3_CanoR_1	63	70	PF00244	0.663
LIG_14-3-3_CanoR_1	711	717	PF00244	0.576
LIG_14-3-3_CanoR_1	809	815	PF00244	0.707
LIG_Actin_WH2_2	295	313	PF00022	0.268
LIG_Actin_WH2_2	350	368	PF00022	0.322
LIG_APCC_ABBA_1	588	593	PF00400	0.477
LIG_BIR_III_2	37	41	PF00653	0.588
LIG_BIR_III_2	420	424	PF00653	0.502
LIG_CaM_IQ_9	87	103	PF13499	0.585
LIG_EH1_1	618	626	PF00400	0.500
LIG_eIF4E_1	619	625	PF01652	0.513
LIG_FAT_LD_1	424	432	PF03623	0.513
LIG_FHA_1	196	202	PF00498	0.535
LIG_FHA_1	235	241	PF00498	0.540
LIG_FHA_1	282	288	PF00498	0.507
LIG_FHA_1	312	318	PF00498	0.414
LIG_FHA_1	453	459	PF00498	0.493
LIG_FHA_1	585	591	PF00498	0.426
LIG_FHA_1	652	658	PF00498	0.438
LIG_FHA_1	689	695	PF00498	0.523
LIG_FHA_1	729	735	PF00498	0.510
LIG_FHA_2	324	330	PF00498	0.486
LIG_FHA_2	368	374	PF00498	0.530
LIG_FHA_2	466	472	PF00498	0.589
LIG_FHA_2	526	532	PF00498	0.647
LIG_FHA_2	576	582	PF00498	0.545
LIG_FHA_2	63	69	PF00498	0.524
LIG_FHA_2	765	771	PF00498	0.508
LIG_FHA_2	795	801	PF00498	0.752
LIG_FHA_2	811	817	PF00498	0.606
LIG_IBAR_NPY_1	617	619	PF08397	0.419
LIG_Integrin_isoDGR_2	514	516	PF01839	0.435
LIG_LIR_Apic_2	517	522	PF02991	0.572
LIG_LIR_Gen_1	392	402	PF02991	0.498
LIG_LIR_Gen_1	463	471	PF02991	0.519
LIG_LIR_Gen_1	584	594	PF02991	0.495
LIG_LIR_Gen_1	597	607	PF02991	0.419
LIG_LIR_Gen_1	641	651	PF02991	0.442
LIG_LIR_Gen_1	739	747	PF02991	0.527
LIG_LIR_Nem_3	239	245	PF02991	0.482
LIG_LIR_Nem_3	392	398	PF02991	0.517
LIG_LIR_Nem_3	463	467	PF02991	0.562
LIG_LIR_Nem_3	571	576	PF02991	0.486
LIG_LIR_Nem_3	584	589	PF02991	0.455
LIG_LIR_Nem_3	593	599	PF02991	0.479
LIG_LIR_Nem_3	613	619	PF02991	0.327
LIG_LIR_Nem_3	641	646	PF02991	0.420
LIG_LIR_Nem_3	739	744	PF02991	0.525
LIG_NRBOX	305	311	PF00104	0.430
LIG_NRBOX	733	739	PF00104	0.566
LIG_OCRL_FandH_1	6	18	PF00620	0.680
LIG_PCNA_yPIPBox_3	647	660	PF02747	0.442
LIG_Pex14_1	755	759	PF04695	0.509
LIG_PTB_Apo_2	614	621	PF02174	0.419
LIG_PTB_Apo_2	669	676	PF02174	0.391
LIG_PTB_Phospho_1	614	620	PF10480	0.419
LIG_PTB_Phospho_1	669	675	PF10480	0.344
LIG_SH2_CRK	850	854	PF00017	0.541
LIG_SH2_GRB2like	659	662	PF00017	0.419
LIG_SH2_NCK_1	760	764	PF00017	0.494
LIG_SH2_PTP2	519	522	PF00017	0.569
LIG_SH2_PTP2	620	623	PF00017	0.500
LIG_SH2_SRC	477	480	PF00017	0.660
LIG_SH2_SRC	519	522	PF00017	0.569
LIG_SH2_SRC	611	614	PF00017	0.344
LIG_SH2_STAP1	760	764	PF00017	0.494
LIG_SH2_STAT3	58	61	PF00017	0.479
LIG_SH2_STAT3	619	622	PF00017	0.419
LIG_SH2_STAT5	292	295	PF00017	0.275
LIG_SH2_STAT5	477	480	PF00017	0.622
LIG_SH2_STAT5	519	522	PF00017	0.569
LIG_SH2_STAT5	596	599	PF00017	0.567
LIG_SH2_STAT5	620	623	PF00017	0.434
LIG_SH2_STAT5	659	662	PF00017	0.419
LIG_SH2_STAT5	745	748	PF00017	0.481
LIG_SH3_1	519	525	PF00018	0.570
LIG_SH3_3	519	525	PF00018	0.622
LIG_Sin3_3	395	402	PF02671	0.571
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.547
LIG_SUMO_SIM_anti_2	284	289	PF11976	0.473
LIG_SUMO_SIM_par_1	193	198	PF11976	0.523
LIG_TRAF2_1	275	278	PF00917	0.567
LIG_TRAF2_1	375	378	PF00917	0.590
LIG_TRAF2_1	436	439	PF00917	0.652
LIG_TRAF2_1	610	613	PF00917	0.454
LIG_TRAF2_1	797	800	PF00917	0.655
LIG_TYR_ITIM	848	853	PF00017	0.533
LIG_WW_3	472	476	PF00397	0.577
MOD_CK1_1	211	217	PF00069	0.535
MOD_CK1_1	328	334	PF00069	0.486
MOD_CK1_1	460	466	PF00069	0.567
MOD_CK1_1	5	11	PF00069	0.780
MOD_CK1_1	523	529	PF00069	0.677
MOD_CK1_1	710	716	PF00069	0.561
MOD_CK1_1	821	827	PF00069	0.586
MOD_CK1_1	831	837	PF00069	0.598
MOD_CK2_1	365	371	PF00069	0.606
MOD_CK2_1	372	378	PF00069	0.595
MOD_CK2_1	465	471	PF00069	0.594
MOD_CK2_1	62	68	PF00069	0.522
MOD_CK2_1	794	800	PF00069	0.730
MOD_Cter_Amidation	110	113	PF01082	0.460
MOD_GlcNHglycan	150	153	PF01048	0.418
MOD_GlcNHglycan	339	342	PF01048	0.364
MOD_GlcNHglycan	382	385	PF01048	0.366
MOD_GlcNHglycan	404	408	PF01048	0.267
MOD_GlcNHglycan	459	462	PF01048	0.364
MOD_GlcNHglycan	494	498	PF01048	0.558
MOD_GlcNHglycan	504	507	PF01048	0.508
MOD_GlcNHglycan	559	562	PF01048	0.377
MOD_GlcNHglycan	628	631	PF01048	0.219
MOD_GlcNHglycan	722	725	PF01048	0.460
MOD_GlcNHglycan	730	734	PF01048	0.411
MOD_GlcNHglycan	764	767	PF01048	0.394
MOD_GlcNHglycan	770	774	PF01048	0.509
MOD_GlcNHglycan	788	791	PF01048	0.351
MOD_GlcNHglycan	794	797	PF01048	0.394
MOD_GlcNHglycan	830	833	PF01048	0.455
MOD_GSK3_1	195	202	PF00069	0.475
MOD_GSK3_1	232	239	PF00069	0.536
MOD_GSK3_1	301	308	PF00069	0.315
MOD_GSK3_1	325	332	PF00069	0.544
MOD_GSK3_1	333	340	PF00069	0.345
MOD_GSK3_1	403	410	PF00069	0.558
MOD_GSK3_1	441	448	PF00069	0.622
MOD_GSK3_1	453	460	PF00069	0.497
MOD_GSK3_1	493	500	PF00069	0.678
MOD_GSK3_1	504	511	PF00069	0.687
MOD_GSK3_1	520	527	PF00069	0.656
MOD_GSK3_1	634	641	PF00069	0.358
MOD_GSK3_1	820	827	PF00069	0.687
MOD_N-GLC_1	387	392	PF02516	0.433
MOD_N-GLC_1	675	680	PF02516	0.337
MOD_N-GLC_1	688	693	PF02516	0.229
MOD_N-GLC_1	749	754	PF02516	0.389
MOD_N-GLC_2	133	135	PF02516	0.549
MOD_NEK2_1	150	155	PF00069	0.695
MOD_NEK2_1	234	239	PF00069	0.549
MOD_NEK2_1	3	8	PF00069	0.808
MOD_NEK2_1	301	306	PF00069	0.277
MOD_NEK2_1	372	377	PF00069	0.555
MOD_NEK2_1	452	457	PF00069	0.518
MOD_NEK2_1	62	67	PF00069	0.565
MOD_NEK2_1	638	643	PF00069	0.413
MOD_NEK2_1	685	690	PF00069	0.509
MOD_NEK2_1	769	774	PF00069	0.642
MOD_NEK2_1	826	831	PF00069	0.614
MOD_PIKK_1	441	447	PF00454	0.620
MOD_PIKK_1	62	68	PF00454	0.589
MOD_PIKK_1	710	716	PF00454	0.574
MOD_PK_1	645	651	PF00069	0.526
MOD_PKA_1	380	386	PF00069	0.563
MOD_PKA_2	128	134	PF00069	0.692
MOD_PKA_2	211	217	PF00069	0.522
MOD_PKA_2	263	269	PF00069	0.546
MOD_PKA_2	380	386	PF00069	0.554
MOD_PKA_2	445	451	PF00069	0.620
MOD_PKA_2	62	68	PF00069	0.662
MOD_PKA_2	710	716	PF00069	0.574
MOD_PKA_2	81	87	PF00069	0.556
MOD_Plk_1	372	378	PF00069	0.643
MOD_Plk_1	675	681	PF00069	0.541
MOD_Plk_1	688	694	PF00069	0.426
MOD_Plk_1	729	735	PF00069	0.541
MOD_Plk_2-3	367	373	PF00069	0.589
MOD_Plk_2-3	530	536	PF00069	0.662
MOD_Plk_4	211	217	PF00069	0.488
MOD_Plk_4	281	287	PF00069	0.531
MOD_Plk_4	301	307	PF00069	0.127
MOD_Plk_4	430	436	PF00069	0.469
MOD_Plk_4	675	681	PF00069	0.587
MOD_Plk_4	810	816	PF00069	0.684
MOD_ProDKin_1	169	175	PF00069	0.690
MOD_ProDKin_1	27	33	PF00069	0.629
MOD_ProDKin_1	334	340	PF00069	0.260
MOD_ProDKin_1	365	371	PF00069	0.606
MOD_SUMO_for_1	544	547	PF00179	0.587
MOD_SUMO_rev_2	43	50	PF00179	0.639
MOD_SUMO_rev_2	554	559	PF00179	0.586
TRG_DiLeu_BaEn_4	554	560	PF01217	0.506
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.359
TRG_DiLeu_BaLyEn_6	699	704	PF01217	0.452
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.569
TRG_ENDOCYTIC_2	596	599	PF00928	0.567
TRG_ENDOCYTIC_2	620	623	PF00928	0.419
TRG_ENDOCYTIC_2	659	662	PF00928	0.419
TRG_ENDOCYTIC_2	760	763	PF00928	0.514
TRG_ENDOCYTIC_2	850	853	PF00928	0.534
TRG_ER_diArg_1	182	184	PF00400	0.528
TRG_ER_diArg_1	51	53	PF00400	0.576
TRG_ER_diArg_1	516	519	PF00400	0.582
TRG_ER_diArg_1	734	736	PF00400	0.572
TRG_ER_diArg_1	803	805	PF00400	0.664
TRG_NLS_MonoExtC_3	410	415	PF00514	0.693
TRG_NLS_MonoExtC_3	93	98	PF00514	0.658
TRG_NLS_MonoExtN_4	409	415	PF00514	0.687
TRG_NLS_MonoExtN_4	92	99	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.294
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	681	686	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	702	706	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W4	Leptomonas seymouri	62%	99%
A0A1X0P271	Trypanosomatidae	38%	100%
A0A3S7X3B0	Leishmania donovani	90%	100%
A0A422P4Z6	Trypanosoma rangeli	40%	100%
A4HI69	Leishmania braziliensis	77%	100%
A4I5E6	Leishmania infantum	91%	100%
C9ZQT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q7I8	Leishmania major	90%	100%
Q5C9Z4	Homo sapiens	23%	100%
V5BPM5	Trypanosoma cruzi	39%	100%