Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0P3_LEIMU

TriTrypDb:

LmxM.29.1140

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B0P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0P3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.492
CLV_PCSK_KEX2_1	133	135	PF00082	0.493
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.493
CLV_PCSK_SKI1_1	137	141	PF00082	0.338
DEG_Nend_UBRbox_1	1	4	PF02207	0.593
DOC_CYCLIN_RxL_1	149	158	PF00134	0.513
DOC_MAPK_gen_1	133	144	PF00069	0.677
DOC_MAPK_gen_1	2	11	PF00069	0.563
DOC_MAPK_MEF2A_6	137	146	PF00069	0.494
DOC_MAPK_MEF2A_6	4	13	PF00069	0.557
DOC_PP1_RVXF_1	135	142	PF00149	0.686
DOC_PP1_RVXF_1	150	157	PF00149	0.353
DOC_USP7_MATH_1	51	55	PF00917	0.507
DOC_WW_Pin1_4	63	68	PF00397	0.569
DOC_WW_Pin1_4	98	103	PF00397	0.757
LIG_14-3-3_CanoR_1	2	7	PF00244	0.566
LIG_BRCT_BRCA1_1	94	98	PF00533	0.544
LIG_DLG_GKlike_1	2	9	PF00625	0.564
LIG_FHA_1	103	109	PF00498	0.670
LIG_FHA_1	122	128	PF00498	0.568
LIG_FHA_1	32	38	PF00498	0.411
LIG_FHA_1	64	70	PF00498	0.501
LIG_FHA_1	81	87	PF00498	0.353
LIG_LIR_Gen_1	71	81	PF02991	0.411
LIG_LIR_LC3C_4	41	44	PF02991	0.418
LIG_LIR_LC3C_4	8	11	PF02991	0.673
LIG_LIR_Nem_3	155	159	PF02991	0.524
LIG_LIR_Nem_3	27	32	PF02991	0.563
LIG_LIR_Nem_3	71	76	PF02991	0.411
LIG_LIR_Nem_3	88	94	PF02991	0.601
LIG_NRP_CendR_1	177	180	PF00754	0.571
LIG_Pex14_2	153	157	PF04695	0.389
LIG_Rb_pABgroove_1	7	15	PF01858	0.672
LIG_SH2_CRK	91	95	PF00017	0.763
LIG_SH2_STAT5	107	110	PF00017	0.673
LIG_SH2_STAT5	24	27	PF00017	0.758
LIG_SH3_3	113	119	PF00018	0.560
LIG_SH3_3	96	102	PF00018	0.741
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.513
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.669
LIG_SUMO_SIM_par_1	33	38	PF11976	0.478
LIG_SUMO_SIM_par_1	8	15	PF11976	0.690
LIG_SUMO_SIM_par_1	82	88	PF11976	0.506
LIG_TYR_ITIM	89	94	PF00017	0.706
LIG_WRC_WIRS_1	153	158	PF05994	0.411
LIG_WRC_WIRS_1	70	75	PF05994	0.411
MOD_CDK_SPK_2	98	103	PF00069	0.757
MOD_CK1_1	155	161	PF00069	0.513
MOD_CK1_1	38	44	PF00069	0.513
MOD_CK1_1	53	59	PF00069	0.546
MOD_CK1_1	72	78	PF00069	0.306
MOD_CK1_1	80	86	PF00069	0.418
MOD_CK2_1	2	8	PF00069	0.700
MOD_CK2_1	98	104	PF00069	0.755
MOD_CMANNOS	167	170	PF00535	0.694
MOD_GlcNHglycan	53	56	PF01048	0.705
MOD_GlcNHglycan	58	61	PF01048	0.706
MOD_GlcNHglycan	94	97	PF01048	0.380
MOD_GSK3_1	31	38	PF00069	0.448
MOD_GSK3_1	49	56	PF00069	0.430
MOD_GSK3_1	68	75	PF00069	0.225
MOD_GSK3_1	98	105	PF00069	0.679
MOD_NEK2_1	12	17	PF00069	0.705
MOD_NEK2_1	140	145	PF00069	0.451
MOD_NEK2_1	50	55	PF00069	0.532
MOD_NEK2_1	62	67	PF00069	0.518
MOD_NEK2_1	68	73	PF00069	0.379
MOD_NEK2_1	85	90	PF00069	0.388
MOD_NEK2_2	168	173	PF00069	0.565
MOD_PIKK_1	12	18	PF00454	0.759
MOD_PKA_2	102	108	PF00069	0.720
MOD_Plk_1	121	127	PF00069	0.745
MOD_Plk_4	152	158	PF00069	0.397
MOD_Plk_4	161	167	PF00069	0.411
MOD_Plk_4	18	24	PF00069	0.730
MOD_Plk_4	38	44	PF00069	0.195
MOD_Plk_4	77	83	PF00069	0.444
MOD_Plk_4	85	91	PF00069	0.360
MOD_ProDKin_1	63	69	PF00069	0.566
MOD_ProDKin_1	98	104	PF00069	0.755
TRG_DiLeu_BaEn_2	148	154	PF01217	0.389
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.495
TRG_ENDOCYTIC_2	91	94	PF00928	0.761
TRG_ER_diArg_1	1	4	PF00400	0.576
TRG_NES_CRM1_1	16	27	PF08389	0.660
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	4	8	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Z6	Leptomonas seymouri	57%	100%
A0A3S7X3F8	Leishmania donovani	89%	98%
A4HI68	Leishmania braziliensis	76%	100%
A4I5E5	Leishmania infantum	89%	98%
Q4Q7I9	Leishmania major	89%	100%