Succinate dehydrogenase assembly factor 2, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flavinator of succinate dehydrogenase, putative

Species:

Leishmania mexicana

UniProt:

E9B0N6_LEIMU

TriTrypDb:

LmxM.29.1070

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B0N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0N6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	7
GO:0006121	mitochondrial electron transport, succinate to ubiquinone	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009060	aerobic respiration	6	7
GO:0009987	cellular process	1	7
GO:0015980	energy derivation by oxidation of organic compounds	4	7
GO:0018293	protein-FAD linkage	5	7
GO:0019538	protein metabolic process	3	7
GO:0019646	aerobic electron transport chain	6	7
GO:0022900	electron transport chain	4	7
GO:0022904	respiratory electron transport chain	5	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0045333	cellular respiration	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0006099	tricarboxylic acid cycle	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0034552	respiratory chain complex II assembly	6	1
GO:0034553	mitochondrial respiratory chain complex II assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.510
CLV_NRD_NRD_1	149	151	PF00675	0.291
CLV_NRD_NRD_1	221	223	PF00675	0.306
CLV_PCSK_KEX2_1	147	149	PF00082	0.435
CLV_PCSK_KEX2_1	221	223	PF00082	0.310
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.395
CLV_PCSK_SKI1_1	222	226	PF00082	0.325
CLV_PCSK_SKI1_1	75	79	PF00082	0.509
DEG_APCC_DBOX_1	171	179	PF00400	0.460
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DEG_SPOP_SBC_1	53	57	PF00917	0.436
DOC_CKS1_1	102	107	PF01111	0.543
DOC_MAPK_gen_1	156	165	PF00069	0.502
DOC_MAPK_MEF2A_6	158	167	PF00069	0.460
DOC_USP7_MATH_1	108	112	PF00917	0.621
DOC_USP7_MATH_1	140	144	PF00917	0.518
DOC_USP7_MATH_1	53	57	PF00917	0.557
DOC_USP7_MATH_1	79	83	PF00917	0.419
DOC_WW_Pin1_4	101	106	PF00397	0.650
DOC_WW_Pin1_4	75	80	PF00397	0.519
DOC_WW_Pin1_4	91	96	PF00397	0.529
LIG_14-3-3_CanoR_1	4	8	PF00244	0.434
LIG_AP2alpha_2	52	54	PF02296	0.450
LIG_BRCT_BRCA1_1	194	198	PF00533	0.460
LIG_BRCT_BRCA1_1	67	71	PF00533	0.534
LIG_FHA_1	227	233	PF00498	0.533
LIG_FHA_1	53	59	PF00498	0.632
LIG_FHA_2	59	65	PF00498	0.604
LIG_FHA_2	76	82	PF00498	0.576
LIG_LIR_Gen_1	184	193	PF02991	0.459
LIG_LIR_Gen_1	68	79	PF02991	0.556
LIG_LIR_Nem_3	164	170	PF02991	0.498
LIG_LIR_Nem_3	184	189	PF02991	0.468
LIG_LIR_Nem_3	195	201	PF02991	0.509
LIG_LIR_Nem_3	68	74	PF02991	0.523
LIG_PCNA_PIPBox_1	163	172	PF02747	0.502
LIG_Pex14_2	67	71	PF04695	0.536
LIG_RPA_C_Fungi	4	16	PF08784	0.512
LIG_SH2_CRK	186	190	PF00017	0.296
LIG_SH2_STAP1	186	190	PF00017	0.296
LIG_SH3_3	134	140	PF00018	0.514
LIG_SH3_3	202	208	PF00018	0.450
LIG_SH3_3	96	102	PF00018	0.603
MOD_CDK_SPK_2	75	80	PF00069	0.519
MOD_CDK_SPK_2	95	100	PF00069	0.445
MOD_CK1_1	29	35	PF00069	0.663
MOD_CK1_1	39	45	PF00069	0.685
MOD_CK2_1	108	114	PF00069	0.620
MOD_CK2_1	58	64	PF00069	0.603
MOD_CK2_1	75	81	PF00069	0.632
MOD_GlcNHglycan	28	31	PF01048	0.607
MOD_GlcNHglycan	38	41	PF01048	0.608
MOD_GlcNHglycan	44	48	PF01048	0.633
MOD_GSK3_1	104	111	PF00069	0.698
MOD_GSK3_1	174	181	PF00069	0.313
MOD_GSK3_1	21	28	PF00069	0.660
MOD_GSK3_1	36	43	PF00069	0.685
MOD_GSK3_1	54	61	PF00069	0.488
MOD_GSK3_1	75	82	PF00069	0.604
MOD_GSK3_1	87	94	PF00069	0.614
MOD_NEK2_1	132	137	PF00069	0.499
MOD_NEK2_1	178	183	PF00069	0.313
MOD_NEK2_1	21	26	PF00069	0.569
MOD_NEK2_1	3	8	PF00069	0.594
MOD_NEK2_1	54	59	PF00069	0.505
MOD_PIKK_1	31	37	PF00454	0.610
MOD_PKA_2	132	138	PF00069	0.476
MOD_PKA_2	3	9	PF00069	0.437
MOD_Plk_1	178	184	PF00069	0.313
MOD_Plk_4	178	184	PF00069	0.310
MOD_Plk_4	185	191	PF00069	0.252
MOD_ProDKin_1	101	107	PF00069	0.649
MOD_ProDKin_1	75	81	PF00069	0.517
MOD_ProDKin_1	91	97	PF00069	0.529
MOD_SUMO_for_1	224	227	PF00179	0.393
MOD_SUMO_rev_2	134	143	PF00179	0.434
TRG_DiLeu_BaEn_1	185	190	PF01217	0.355
TRG_DiLeu_BaEn_1	227	232	PF01217	0.472
TRG_DiLeu_BaEn_2	218	224	PF01217	0.355
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.296
TRG_ENDOCYTIC_2	157	160	PF00928	0.296
TRG_ENDOCYTIC_2	186	189	PF00928	0.296
TRG_ER_diArg_1	148	150	PF00400	0.296
TRG_ER_diArg_1	220	222	PF00400	0.365
TRG_NES_CRM1_1	192	206	PF08389	0.355
TRG_NLS_MonoCore_2	146	151	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P987	Leptomonas seymouri	68%	100%
A0A3S7X377	Leishmania donovani	89%	100%
A4HI62	Leishmania braziliensis	79%	100%
A4I5D8	Leishmania infantum	88%	100%
Q4Q7J6	Leishmania major	82%	99%
V5BU78	Trypanosoma cruzi	37%	100%