Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinate dehydrogenase subunit 7

Species:

Leishmania mexicana

UniProt:

E9B0N3_LEIMU

TriTrypDb:

LmxM.29.1040

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 5
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005749	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	4	1
GO:0032991	protein-containing complex	1	1
GO:0045257	succinate dehydrogenase complex (ubiquinone)	5	1
GO:0045281	succinate dehydrogenase complex	4	1
GO:0045283	fumarate reductase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

E9B0N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.648
CLV_NRD_NRD_1	154	156	PF00675	0.584
CLV_NRD_NRD_1	2	4	PF00675	0.578
CLV_NRD_NRD_1	247	249	PF00675	0.660
CLV_PCSK_KEX2_1	2	4	PF00082	0.578
CLV_PCSK_KEX2_1	242	244	PF00082	0.562
CLV_PCSK_KEX2_1	247	249	PF00082	0.588
CLV_PCSK_KEX2_1	56	58	PF00082	0.575
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.562
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.575
CLV_PCSK_PC7_1	243	249	PF00082	0.647
CLV_PCSK_SKI1_1	137	141	PF00082	0.619
CLV_PCSK_SKI1_1	161	165	PF00082	0.564
CLV_PCSK_SKI1_1	243	247	PF00082	0.644
CLV_PCSK_SKI1_1	56	60	PF00082	0.568
CLV_PCSK_SKI1_1	88	92	PF00082	0.651
DEG_APCC_DBOX_1	87	95	PF00400	0.695
DEG_MDM2_SWIB_1	110	118	PF02201	0.585
DEG_Nend_UBRbox_1	1	4	PF02207	0.579
DEG_SPOP_SBC_1	26	30	PF00917	0.698
DOC_CYCLIN_RxL_1	82	95	PF00134	0.659
DOC_MAPK_HePTP_8	216	228	PF00069	0.668
DOC_MAPK_MEF2A_6	219	228	PF00069	0.610
DOC_PP1_RVXF_1	159	166	PF00149	0.650
DOC_USP7_MATH_1	204	208	PF00917	0.601
DOC_USP7_MATH_1	227	231	PF00917	0.690
DOC_USP7_MATH_1	25	29	PF00917	0.619
DOC_USP7_UBL2_3	146	150	PF12436	0.566
LIG_14-3-3_CanoR_1	117	122	PF00244	0.585
LIG_14-3-3_CanoR_1	34	44	PF00244	0.648
LIG_14-3-3_CanoR_1	57	64	PF00244	0.614
LIG_BRCT_BRCA1_1	65	69	PF00533	0.601
LIG_DLG_GKlike_1	117	124	PF00625	0.646
LIG_eIF4E_1	159	165	PF01652	0.616
LIG_FHA_1	244	250	PF00498	0.691
LIG_LIR_Apic_2	68	73	PF02991	0.621
LIG_LIR_Gen_1	171	182	PF02991	0.551
LIG_LIR_Nem_3	108	113	PF02991	0.550
LIG_LIR_Nem_3	122	128	PF02991	0.527
LIG_LIR_Nem_3	171	177	PF02991	0.546
LIG_LIR_Nem_3	38	43	PF02991	0.572
LIG_LIR_Nem_3	62	67	PF02991	0.567
LIG_LIR_Nem_3	68	72	PF02991	0.565
LIG_MYND_3	221	225	PF01753	0.666
LIG_Pex14_1	106	110	PF04695	0.560
LIG_Pex14_2	110	114	PF04695	0.563
LIG_PTB_Apo_2	159	166	PF02174	0.658
LIG_SH2_CRK	125	129	PF00017	0.581
LIG_SH2_CRK	136	140	PF00017	0.584
LIG_SH2_CRK	174	178	PF00017	0.558
LIG_SH2_NCK_1	174	178	PF00017	0.586
LIG_SH2_STAP1	174	178	PF00017	0.553
LIG_SH2_STAT3	182	185	PF00017	0.618
LIG_SH2_STAT5	129	132	PF00017	0.588
LIG_SH2_STAT5	138	141	PF00017	0.594
LIG_SH2_STAT5	159	162	PF00017	0.536
LIG_SH2_STAT5	174	177	PF00017	0.554
LIG_SH2_STAT5	183	186	PF00017	0.580
LIG_SH2_STAT5	197	200	PF00017	0.485
LIG_SH2_STAT5	37	40	PF00017	0.616
LIG_SH2_STAT5	89	92	PF00017	0.588
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.630
LIG_TYR_ITAM	122	139	PF00017	0.610
LIG_UBA3_1	153	161	PF00899	0.666
LIG_WRC_WIRS_1	205	210	PF05994	0.547
LIG_WRC_WIRS_1	64	69	PF05994	0.587
MOD_CK1_1	14	20	PF00069	0.737
MOD_CK2_1	102	108	PF00069	0.538
MOD_CK2_1	116	122	PF00069	0.576
MOD_CK2_1	57	63	PF00069	0.600
MOD_CK2_1	89	95	PF00069	0.608
MOD_Cter_Amidation	208	211	PF01082	0.672
MOD_Cter_Amidation	240	243	PF01082	0.673
MOD_GlcNHglycan	13	16	PF01048	0.669
MOD_GlcNHglycan	8	11	PF01048	0.666
MOD_GSK3_1	14	21	PF00069	0.710
MOD_GSK3_1	35	42	PF00069	0.570
MOD_GSK3_1	59	66	PF00069	0.575
MOD_N-GLC_1	102	107	PF02516	0.468
MOD_N-GLC_1	141	146	PF02516	0.574
MOD_N-GLC_1	50	55	PF02516	0.603
MOD_NEK2_1	102	107	PF00069	0.577
MOD_NEK2_1	124	129	PF00069	0.561
MOD_NEK2_1	35	40	PF00069	0.671
MOD_NEK2_2	227	232	PF00069	0.693
MOD_PIKK_1	57	63	PF00454	0.652
MOD_PKA_1	56	62	PF00069	0.578
MOD_PKA_2	116	122	PF00069	0.495
MOD_PKA_2	56	62	PF00069	0.559
MOD_PKB_1	115	123	PF00069	0.644
MOD_Plk_1	102	108	PF00069	0.412
MOD_Plk_1	50	56	PF00069	0.623
MOD_Plk_2-3	63	69	PF00069	0.698
MOD_Plk_4	109	115	PF00069	0.585
MOD_Plk_4	124	130	PF00069	0.524
MOD_Plk_4	50	56	PF00069	0.612
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.587
TRG_ENDOCYTIC_2	125	128	PF00928	0.565
TRG_ENDOCYTIC_2	136	139	PF00928	0.544
TRG_ENDOCYTIC_2	174	177	PF00928	0.554
TRG_ENDOCYTIC_2	64	67	PF00928	0.571
TRG_ER_diArg_1	1	3	PF00400	0.584
TRG_ER_diArg_1	247	249	PF00400	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB7	Leptomonas seymouri	80%	100%
A0A0S4J0Y6	Bodo saltans	47%	100%
A0A1X0P208	Trypanosomatidae	56%	100%
A0A3R7MXF5	Trypanosoma rangeli	58%	100%
A0A3S7X3E5	Leishmania donovani	95%	100%
A4HI59	Leishmania braziliensis	84%	100%
A4I5D5	Leishmania infantum	96%	100%
C9ZQR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
Q4Q7J9	Leishmania major	96%	100%