DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania mexicana

UniProt:

E9B0N2_LEIMU

TriTrypDb:

LmxM.29.1030

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0N2

PDB structure(s): 7am2_BS

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0044183	protein folding chaperone	1	1
GO:0051082	unfolded protein binding	3	1
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.610
CLV_C14_Caspase3-7	394	398	PF00656	0.618
CLV_MEL_PAP_1	113	119	PF00089	0.415
CLV_NRD_NRD_1	115	117	PF00675	0.398
CLV_NRD_NRD_1	130	132	PF00675	0.288
CLV_NRD_NRD_1	142	144	PF00675	0.681
CLV_NRD_NRD_1	183	185	PF00675	0.775
CLV_NRD_NRD_1	204	206	PF00675	0.583
CLV_NRD_NRD_1	239	241	PF00675	0.516
CLV_NRD_NRD_1	48	50	PF00675	0.743
CLV_PCSK_FUR_1	237	241	PF00082	0.517
CLV_PCSK_KEX2_1	115	117	PF00082	0.372
CLV_PCSK_KEX2_1	129	131	PF00082	0.217
CLV_PCSK_KEX2_1	142	144	PF00082	0.681
CLV_PCSK_KEX2_1	182	184	PF00082	0.764
CLV_PCSK_KEX2_1	204	206	PF00082	0.596
CLV_PCSK_KEX2_1	237	239	PF00082	0.499
CLV_PCSK_KEX2_1	48	50	PF00082	0.743
CLV_PCSK_SKI1_1	17	21	PF00082	0.588
CLV_Separin_Metazoa	385	389	PF03568	0.339
DEG_Nend_UBRbox_1	1	4	PF02207	0.625
DEG_SPOP_SBC_1	191	195	PF00917	0.754
DEG_SPOP_SBC_1	369	373	PF00917	0.477
DEG_SPOP_SBC_1	63	67	PF00917	0.698
DOC_ANK_TNKS_1	254	261	PF00023	0.542
DOC_CKS1_1	350	355	PF01111	0.504
DOC_PP1_SILK_1	311	316	PF00149	0.642
DOC_USP7_MATH_1	174	178	PF00917	0.757
DOC_USP7_MATH_1	262	266	PF00917	0.721
DOC_USP7_MATH_1	62	66	PF00917	0.621
DOC_WW_Pin1_4	166	171	PF00397	0.787
DOC_WW_Pin1_4	19	24	PF00397	0.548
DOC_WW_Pin1_4	269	274	PF00397	0.746
DOC_WW_Pin1_4	349	354	PF00397	0.499
DOC_WW_Pin1_4	396	401	PF00397	0.680
DOC_WW_Pin1_4	79	84	PF00397	0.395
LIG_14-3-3_CanoR_1	115	124	PF00244	0.297
LIG_14-3-3_CanoR_1	403	408	PF00244	0.592
LIG_Actin_WH2_2	30	47	PF00022	0.422
LIG_AP2alpha_1	219	223	PF02296	0.488
LIG_BIR_III_2	80	84	PF00653	0.407
LIG_BRCT_BRCA1_1	195	199	PF00533	0.630
LIG_BRCT_BRCA1_1	34	38	PF00533	0.497
LIG_DLG_GKlike_1	403	411	PF00625	0.594
LIG_FHA_1	409	415	PF00498	0.597
LIG_FHA_1	64	70	PF00498	0.570
LIG_FHA_2	106	112	PF00498	0.176
LIG_FHA_2	225	231	PF00498	0.516
LIG_FHA_2	294	300	PF00498	0.518
LIG_FHA_2	350	356	PF00498	0.485
LIG_FHA_2	392	398	PF00498	0.664
LIG_FHA_2	80	86	PF00498	0.276
LIG_Integrin_RGD_1	212	214	PF01839	0.443
LIG_LIR_Apic_2	426	430	PF02991	0.448
LIG_LIR_Gen_1	118	128	PF02991	0.297
LIG_LIR_Nem_3	111	117	PF02991	0.286
LIG_LIR_Nem_3	118	124	PF02991	0.313
LIG_LIR_Nem_3	333	338	PF02991	0.459
LIG_Pex14_2	219	223	PF04695	0.396
LIG_SH2_CRK	206	210	PF00017	0.637
LIG_SH2_CRK	427	431	PF00017	0.459
LIG_SH2_CRK	72	76	PF00017	0.276
LIG_SH2_CRK	90	94	PF00017	0.407
LIG_SH2_SRC	384	387	PF00017	0.628
LIG_SH2_SRC	395	398	PF00017	0.579
LIG_SH2_SRC	413	416	PF00017	0.593
LIG_SH2_STAT5	413	416	PF00017	0.610
LIG_SH3_3	270	276	PF00018	0.549
LIG_SH3_3	317	323	PF00018	0.590
LIG_SH3_3	325	331	PF00018	0.484
LIG_SH3_3	334	340	PF00018	0.358
LIG_SH3_3	342	348	PF00018	0.421
LIG_SH3_3	350	356	PF00018	0.469
LIG_TRAF2_1	82	85	PF00917	0.295
LIG_WRPW_2	338	341	PF00400	0.441
MOD_CDK_SPxxK_3	396	403	PF00069	0.602
MOD_CK1_1	177	183	PF00069	0.813
MOD_CK1_1	189	195	PF00069	0.680
MOD_CK1_1	264	270	PF00069	0.801
MOD_CK1_1	371	377	PF00069	0.627
MOD_CK1_1	402	408	PF00069	0.456
MOD_CK1_1	51	57	PF00069	0.622
MOD_CK2_1	105	111	PF00069	0.176
MOD_CK2_1	224	230	PF00069	0.572
MOD_CK2_1	293	299	PF00069	0.544
MOD_CK2_1	349	355	PF00069	0.473
MOD_CK2_1	79	85	PF00069	0.282
MOD_DYRK1A_RPxSP_1	166	170	PF00069	0.649
MOD_GlcNHglycan	147	150	PF01048	0.741
MOD_GlcNHglycan	156	159	PF01048	0.670
MOD_GlcNHglycan	179	182	PF01048	0.777
MOD_GlcNHglycan	30	33	PF01048	0.605
MOD_GlcNHglycan	53	56	PF01048	0.596
MOD_GlcNHglycan	59	62	PF01048	0.550
MOD_GSK3_1	13	20	PF00069	0.582
MOD_GSK3_1	150	157	PF00069	0.666
MOD_GSK3_1	162	169	PF00069	0.749
MOD_GSK3_1	185	192	PF00069	0.734
MOD_GSK3_1	21	28	PF00069	0.600
MOD_GSK3_1	261	268	PF00069	0.780
MOD_GSK3_1	361	368	PF00069	0.623
MOD_GSK3_1	371	378	PF00069	0.565
MOD_GSK3_1	399	406	PF00069	0.542
MOD_GSK3_1	40	47	PF00069	0.484
MOD_NEK2_1	13	18	PF00069	0.441
MOD_NEK2_1	44	49	PF00069	0.576
MOD_NEK2_2	40	45	PF00069	0.471
MOD_PIKK_1	361	367	PF00454	0.668
MOD_PKA_1	115	121	PF00069	0.433
MOD_PKA_1	184	190	PF00069	0.736
MOD_PKA_1	48	54	PF00069	0.717
MOD_PKA_2	115	121	PF00069	0.433
MOD_PKA_2	174	180	PF00069	0.744
MOD_PKA_2	402	408	PF00069	0.402
MOD_PKA_2	48	54	PF00069	0.719
MOD_PKB_1	182	190	PF00069	0.812
MOD_Plk_1	365	371	PF00069	0.656
MOD_Plk_1	40	46	PF00069	0.428
MOD_Plk_2-3	224	230	PF00069	0.523
MOD_Plk_4	32	38	PF00069	0.530
MOD_ProDKin_1	166	172	PF00069	0.788
MOD_ProDKin_1	19	25	PF00069	0.550
MOD_ProDKin_1	269	275	PF00069	0.743
MOD_ProDKin_1	349	355	PF00069	0.502
MOD_ProDKin_1	396	402	PF00069	0.676
MOD_ProDKin_1	79	85	PF00069	0.395
MOD_SUMO_rev_2	221	228	PF00179	0.449
MOD_SUMO_rev_2	80	89	PF00179	0.327
TRG_ENDOCYTIC_2	121	124	PF00928	0.297
TRG_ENDOCYTIC_2	335	338	PF00928	0.465
TRG_ENDOCYTIC_2	72	75	PF00928	0.276
TRG_ENDOCYTIC_2	90	93	PF00928	0.407
TRG_ER_diArg_1	114	116	PF00400	0.433
TRG_ER_diArg_1	128	131	PF00400	0.441
TRG_ER_diArg_1	182	184	PF00400	0.698
TRG_ER_diArg_1	204	206	PF00400	0.597
TRG_ER_diArg_1	237	240	PF00400	0.511
TRG_ER_diArg_1	48	50	PF00400	0.735
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S6	Leptomonas seymouri	61%	100%
A0A0S4JEE6	Bodo saltans	32%	100%
A0A1X0P2B2	Trypanosomatidae	36%	100%
A0A3Q8IFJ9	Leishmania donovani	89%	100%
A0A3R7P4U9	Trypanosoma rangeli	37%	100%
A4HI58	Leishmania braziliensis	82%	99%
A4I5D4	Leishmania infantum	89%	100%
C9ZQR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q7K0	Leishmania major	87%	100%
V5BPN3	Trypanosoma cruzi	35%	100%