Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0N1_LEIMU

TriTrypDb:

LmxM.29.1020

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0N1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.711
CLV_NRD_NRD_1	138	140	PF00675	0.613
CLV_NRD_NRD_1	246	248	PF00675	0.679
CLV_NRD_NRD_1	389	391	PF00675	0.630
CLV_NRD_NRD_1	438	440	PF00675	0.495
CLV_NRD_NRD_1	54	56	PF00675	0.632
CLV_PCSK_FUR_1	21	25	PF00082	0.680
CLV_PCSK_FUR_1	244	248	PF00082	0.697
CLV_PCSK_FUR_1	39	43	PF00082	0.652
CLV_PCSK_KEX2_1	138	140	PF00082	0.613
CLV_PCSK_KEX2_1	209	211	PF00082	0.593
CLV_PCSK_KEX2_1	23	25	PF00082	0.687
CLV_PCSK_KEX2_1	246	248	PF00082	0.675
CLV_PCSK_KEX2_1	41	43	PF00082	0.650
CLV_PCSK_KEX2_1	438	440	PF00082	0.469
CLV_PCSK_KEX2_1	54	56	PF00082	0.632
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.593
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.687
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.659
CLV_PCSK_PC7_1	19	25	PF00082	0.679
CLV_PCSK_SKI1_1	15	19	PF00082	0.602
CLV_PCSK_SKI1_1	173	177	PF00082	0.596
CLV_PCSK_SKI1_1	323	327	PF00082	0.527
CLV_PCSK_SKI1_1	390	394	PF00082	0.619
CLV_Separin_Metazoa	340	344	PF03568	0.543
CLV_Separin_Metazoa	415	419	PF03568	0.593
DEG_APCC_DBOX_1	172	180	PF00400	0.548
DEG_APCC_DBOX_1	409	417	PF00400	0.496
DEG_APCC_DBOX_1	437	445	PF00400	0.526
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DEG_SPOP_SBC_1	261	265	PF00917	0.636
DEG_SPOP_SBC_1	275	279	PF00917	0.583
DOC_CYCLIN_RxL_1	473	484	PF00134	0.544
DOC_MAPK_DCC_7	438	446	PF00069	0.514
DOC_MAPK_gen_1	390	399	PF00069	0.730
DOC_MAPK_gen_1	438	446	PF00069	0.466
DOC_MAPK_MEF2A_6	438	447	PF00069	0.462
DOC_PP2B_LxvP_1	256	259	PF13499	0.703
DOC_PP2B_LxvP_1	76	79	PF13499	0.567
DOC_PP4_FxxP_1	321	324	PF00568	0.488
DOC_USP7_MATH_1	261	265	PF00917	0.675
DOC_USP7_MATH_1	276	280	PF00917	0.578
DOC_USP7_MATH_1	330	334	PF00917	0.740
DOC_USP7_MATH_1	359	363	PF00917	0.543
DOC_USP7_MATH_1	409	413	PF00917	0.524
DOC_USP7_MATH_1	464	468	PF00917	0.714
DOC_USP7_MATH_1	491	495	PF00917	0.519
DOC_USP7_UBL2_3	373	377	PF12436	0.646
DOC_WW_Pin1_4	199	204	PF00397	0.660
DOC_WW_Pin1_4	257	262	PF00397	0.789
DOC_WW_Pin1_4	263	268	PF00397	0.541
DOC_WW_Pin1_4	326	331	PF00397	0.678
LIG_14-3-3_CanoR_1	11	18	PF00244	0.663
LIG_14-3-3_CanoR_1	223	231	PF00244	0.540
LIG_14-3-3_CanoR_1	3	8	PF00244	0.679
LIG_14-3-3_CanoR_1	302	309	PF00244	0.556
LIG_14-3-3_CanoR_1	323	330	PF00244	0.505
LIG_14-3-3_CanoR_1	358	366	PF00244	0.472
LIG_14-3-3_CanoR_1	375	384	PF00244	0.579
LIG_14-3-3_CanoR_1	407	417	PF00244	0.594
LIG_14-3-3_CanoR_1	42	50	PF00244	0.643
LIG_14-3-3_CanoR_1	438	442	PF00244	0.532
LIG_14-3-3_CanoR_1	460	469	PF00244	0.615
LIG_14-3-3_CanoR_1	476	481	PF00244	0.392
LIG_Actin_WH2_2	112	130	PF00022	0.621
LIG_BIR_III_2	432	436	PF00653	0.635
LIG_BRCT_BRCA1_1	13	17	PF00533	0.679
LIG_BRCT_BRCA1_1	276	280	PF00533	0.710
LIG_BRCT_BRCA1_1	483	487	PF00533	0.499
LIG_Clathr_ClatBox_1	444	448	PF01394	0.474
LIG_CSL_BTD_1	504	507	PF09270	0.490
LIG_deltaCOP1_diTrp_1	503	511	PF00928	0.491
LIG_eIF4E_1	225	231	PF01652	0.543
LIG_EVH1_2	267	271	PF00568	0.786
LIG_FHA_1	122	128	PF00498	0.582
LIG_FHA_1	225	231	PF00498	0.562
LIG_FHA_1	279	285	PF00498	0.708
LIG_FHA_1	376	382	PF00498	0.794
LIG_FHA_1	387	393	PF00498	0.703
LIG_FHA_1	45	51	PF00498	0.773
LIG_FHA_1	451	457	PF00498	0.391
LIG_FHA_2	3	9	PF00498	0.733
LIG_GBD_Chelix_1	157	165	PF00786	0.571
LIG_GBD_Chelix_1	498	506	PF00786	0.348
LIG_IBAR_NPY_1	104	106	PF08397	0.598
LIG_LIR_Apic_2	320	324	PF02991	0.485
LIG_LIR_Apic_2	95	100	PF02991	0.620
LIG_LIR_Gen_1	152	161	PF02991	0.531
LIG_LIR_Gen_1	365	371	PF02991	0.598
LIG_LIR_Gen_1	448	456	PF02991	0.627
LIG_LIR_LC3C_4	126	131	PF02991	0.352
LIG_LIR_Nem_3	152	157	PF02991	0.555
LIG_LIR_Nem_3	365	369	PF02991	0.598
LIG_LIR_Nem_3	448	452	PF02991	0.562
LIG_LIR_Nem_3	484	490	PF02991	0.463
LIG_NRBOX	412	418	PF00104	0.276
LIG_SH2_CRK	40	44	PF00017	0.648
LIG_SH2_CRK	449	453	PF00017	0.590
LIG_SH2_NCK_1	449	453	PF00017	0.590
LIG_SH2_STAT5	421	424	PF00017	0.509
LIG_SH2_STAT5	514	517	PF00017	0.638
LIG_SH3_3	128	134	PF00018	0.443
LIG_SH3_3	145	151	PF00018	0.565
LIG_SH3_3	378	384	PF00018	0.691
LIG_SUMO_SIM_par_1	202	207	PF11976	0.573
LIG_SUMO_SIM_par_1	442	448	PF11976	0.479
LIG_TRAF2_1	88	91	PF00917	0.546
LIG_TYR_ITIM	447	452	PF00017	0.555
LIG_WRC_WIRS_1	4	9	PF05994	0.555
MOD_CK1_1	260	266	PF00069	0.736
MOD_CK1_1	274	280	PF00069	0.695
MOD_CK1_1	283	289	PF00069	0.691
MOD_CK1_1	317	323	PF00069	0.672
MOD_CK1_1	362	368	PF00069	0.655
MOD_CK1_1	376	382	PF00069	0.595
MOD_CK1_1	411	417	PF00069	0.268
MOD_CK1_1	44	50	PF00069	0.759
MOD_CK1_1	450	456	PF00069	0.442
MOD_CK1_1	463	469	PF00069	0.625
MOD_CK1_1	85	91	PF00069	0.570
MOD_CK2_1	343	349	PF00069	0.560
MOD_CK2_1	409	415	PF00069	0.582
MOD_CK2_1	85	91	PF00069	0.570
MOD_Cter_Amidation	207	210	PF01082	0.607
MOD_Cter_Amidation	52	55	PF01082	0.624
MOD_DYRK1A_RPxSP_1	257	261	PF00069	0.702
MOD_GlcNHglycan	165	168	PF01048	0.554
MOD_GlcNHglycan	170	173	PF01048	0.599
MOD_GlcNHglycan	196	199	PF01048	0.574
MOD_GlcNHglycan	273	276	PF01048	0.784
MOD_GlcNHglycan	316	319	PF01048	0.723
MOD_GlcNHglycan	344	348	PF01048	0.541
MOD_GlcNHglycan	361	364	PF01048	0.604
MOD_GlcNHglycan	462	465	PF01048	0.680
MOD_GlcNHglycan	483	486	PF01048	0.552
MOD_GSK3_1	182	189	PF00069	0.471
MOD_GSK3_1	257	264	PF00069	0.691
MOD_GSK3_1	271	278	PF00069	0.674
MOD_GSK3_1	279	286	PF00069	0.639
MOD_GSK3_1	289	296	PF00069	0.545
MOD_GSK3_1	319	326	PF00069	0.644
MOD_GSK3_1	369	376	PF00069	0.655
MOD_GSK3_1	41	48	PF00069	0.706
MOD_GSK3_1	460	467	PF00069	0.658
MOD_N-GLC_1	100	105	PF02516	0.623
MOD_N-GLC_1	121	126	PF02516	0.525
MOD_N-GLC_1	161	166	PF02516	0.283
MOD_NEK2_1	121	126	PF00069	0.525
MOD_NEK2_1	161	166	PF00069	0.543
MOD_NEK2_1	168	173	PF00069	0.574
MOD_NEK2_1	17	22	PF00069	0.594
MOD_NEK2_1	186	191	PF00069	0.465
MOD_NEK2_1	2	7	PF00069	0.656
MOD_NEK2_1	224	229	PF00069	0.577
MOD_NEK2_1	230	235	PF00069	0.636
MOD_NEK2_1	280	285	PF00069	0.734
MOD_NEK2_1	319	324	PF00069	0.654
MOD_NEK2_1	369	374	PF00069	0.765
MOD_NEK2_1	408	413	PF00069	0.584
MOD_NEK2_1	490	495	PF00069	0.528
MOD_NEK2_2	123	128	PF00069	0.369
MOD_NEK2_2	239	244	PF00069	0.552
MOD_PIKK_1	293	299	PF00454	0.766
MOD_PIKK_1	458	464	PF00454	0.716
MOD_PK_1	42	48	PF00069	0.779
MOD_PKA_1	41	47	PF00069	0.645
MOD_PKA_2	10	16	PF00069	0.601
MOD_PKA_2	2	8	PF00069	0.735
MOD_PKA_2	30	36	PF00069	0.658
MOD_PKA_2	409	415	PF00069	0.504
MOD_PKA_2	41	47	PF00069	0.645
MOD_PKA_2	437	443	PF00069	0.518
MOD_PKB_1	458	466	PF00069	0.701
MOD_Plk_1	121	127	PF00069	0.520
MOD_Plk_1	161	167	PF00069	0.287
MOD_Plk_1	186	192	PF00069	0.575
MOD_Plk_1	447	453	PF00069	0.573
MOD_Plk_1	491	497	PF00069	0.512
MOD_Plk_4	115	121	PF00069	0.516
MOD_Plk_4	153	159	PF00069	0.508
MOD_Plk_4	280	286	PF00069	0.682
MOD_Plk_4	295	301	PF00069	0.510
MOD_Plk_4	469	475	PF00069	0.546
MOD_Plk_4	491	497	PF00069	0.512
MOD_ProDKin_1	199	205	PF00069	0.661
MOD_ProDKin_1	257	263	PF00069	0.791
MOD_ProDKin_1	326	332	PF00069	0.678
MOD_SUMO_for_1	235	238	PF00179	0.530
MOD_SUMO_rev_2	111	119	PF00179	0.595
MOD_SUMO_rev_2	328	338	PF00179	0.541
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.568
TRG_ENDOCYTIC_2	40	43	PF00928	0.651
TRG_ENDOCYTIC_2	449	452	PF00928	0.533
TRG_ER_diArg_1	138	140	PF00400	0.603
TRG_ER_diArg_1	18	21	PF00400	0.639
TRG_ER_diArg_1	231	234	PF00400	0.643
TRG_ER_diArg_1	243	246	PF00400	0.718
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGI0	Leptomonas seymouri	48%	93%
A0A1X0P334	Trypanosomatidae	38%	100%
A0A3Q8IFQ7	Leishmania donovani	90%	100%
A4HI57	Leishmania braziliensis	77%	100%
A4I5D3	Leishmania infantum	89%	100%
C9ZQR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q7K1	Leishmania major	88%	100%