Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B0M9_LEIMU

TriTrypDb:

LmxM.29.1000

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0M9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.683
CLV_C14_Caspase3-7	380	384	PF00656	0.411
CLV_C14_Caspase3-7	465	469	PF00656	0.598
CLV_C14_Caspase3-7	479	483	PF00656	0.567
CLV_NRD_NRD_1	292	294	PF00675	0.567
CLV_NRD_NRD_1	302	304	PF00675	0.267
CLV_NRD_NRD_1	393	395	PF00675	0.443
CLV_NRD_NRD_1	429	431	PF00675	0.443
CLV_NRD_NRD_1	452	454	PF00675	0.662
CLV_PCSK_FUR_1	290	294	PF00082	0.589
CLV_PCSK_FUR_1	450	454	PF00082	0.566
CLV_PCSK_KEX2_1	290	292	PF00082	0.577
CLV_PCSK_KEX2_1	393	395	PF00082	0.440
CLV_PCSK_KEX2_1	412	414	PF00082	0.199
CLV_PCSK_KEX2_1	429	431	PF00082	0.449
CLV_PCSK_KEX2_1	452	454	PF00082	0.662
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.424
CLV_PCSK_SKI1_1	174	178	PF00082	0.270
CLV_PCSK_SKI1_1	216	220	PF00082	0.244
CLV_PCSK_SKI1_1	292	296	PF00082	0.555
DEG_COP1_1	153	161	PF00400	0.412
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DEG_SPOP_SBC_1	137	141	PF00917	0.540
DEG_SPOP_SBC_1	180	184	PF00917	0.513
DOC_CYCLIN_RxL_1	184	193	PF00134	0.513
DOC_MAPK_gen_1	216	225	PF00069	0.457
DOC_MAPK_gen_1	228	236	PF00069	0.444
DOC_MAPK_gen_1	290	296	PF00069	0.565
DOC_MAPK_JIP1_4	20	26	PF00069	0.515
DOC_MAPK_MEF2A_6	369	378	PF00069	0.377
DOC_MAPK_MEF2A_6	46	55	PF00069	0.479
DOC_PP1_RVXF_1	185	192	PF00149	0.486
DOC_PP1_RVXF_1	373	379	PF00149	0.419
DOC_PP4_FxxP_1	511	514	PF00568	0.642
DOC_USP7_MATH_1	136	140	PF00917	0.484
DOC_USP7_MATH_1	166	170	PF00917	0.551
DOC_USP7_MATH_1	180	184	PF00917	0.421
DOC_USP7_MATH_1	268	272	PF00917	0.711
DOC_USP7_MATH_1	31	35	PF00917	0.373
DOC_USP7_MATH_1	498	502	PF00917	0.404
DOC_USP7_MATH_1	545	549	PF00917	0.718
DOC_USP7_MATH_1	555	559	PF00917	0.629
DOC_USP7_MATH_1	567	571	PF00917	0.711
DOC_USP7_MATH_1	9	13	PF00917	0.616
DOC_USP7_UBL2_3	58	62	PF12436	0.444
DOC_WW_Pin1_4	314	319	PF00397	0.313
LIG_14-3-3_CanoR_1	291	297	PF00244	0.529
LIG_14-3-3_CanoR_1	429	434	PF00244	0.230
LIG_14-3-3_CanoR_1	522	530	PF00244	0.609
LIG_Actin_WH2_2	33	48	PF00022	0.470
LIG_APCC_ABBA_1	414	419	PF00400	0.489
LIG_APCC_ABBA_1	508	513	PF00400	0.528
LIG_APCC_ABBAyCdc20_2	413	419	PF00400	0.320
LIG_BIR_III_4	381	385	PF00653	0.320
LIG_BRCT_BRCA1_1	6	10	PF00533	0.477
LIG_Clathr_ClatBox_1	233	237	PF01394	0.444
LIG_deltaCOP1_diTrp_1	323	333	PF00928	0.343
LIG_EH_1	527	531	PF12763	0.517
LIG_FHA_1	152	158	PF00498	0.412
LIG_FHA_1	196	202	PF00498	0.446
LIG_FHA_1	236	242	PF00498	0.519
LIG_FHA_1	563	569	PF00498	0.718
LIG_FHA_2	351	357	PF00498	0.374
LIG_FHA_2	460	466	PF00498	0.692
LIG_FXI_DFP_1	233	237	PF00024	0.244
LIG_LIR_Apic_2	312	318	PF02991	0.283
LIG_LIR_Gen_1	190	199	PF02991	0.471
LIG_LIR_Gen_1	337	348	PF02991	0.192
LIG_LIR_Gen_1	353	362	PF02991	0.321
LIG_LIR_Gen_1	504	514	PF02991	0.513
LIG_LIR_Gen_1	527	534	PF02991	0.483
LIG_LIR_Nem_3	101	107	PF02991	0.508
LIG_LIR_Nem_3	190	194	PF02991	0.471
LIG_LIR_Nem_3	337	343	PF02991	0.192
LIG_LIR_Nem_3	346	352	PF02991	0.299
LIG_LIR_Nem_3	353	358	PF02991	0.481
LIG_LIR_Nem_3	371	376	PF02991	0.247
LIG_LIR_Nem_3	432	437	PF02991	0.343
LIG_LIR_Nem_3	504	509	PF02991	0.463
LIG_LIR_Nem_3	513	519	PF02991	0.431
LIG_LIR_Nem_3	527	533	PF02991	0.583
LIG_LIR_Nem_3	600	606	PF02991	0.523
LIG_PCNA_yPIPBox_3	62	75	PF02747	0.544
LIG_Pex14_2	105	109	PF04695	0.508
LIG_Pex14_2	530	534	PF04695	0.676
LIG_REV1ctd_RIR_1	531	539	PF16727	0.453
LIG_SH2_CRK	506	510	PF00017	0.493
LIG_SH2_NCK_1	340	344	PF00017	0.343
LIG_SH2_PTP2	315	318	PF00017	0.299
LIG_SH2_STAP1	340	344	PF00017	0.355
LIG_SH2_STAP1	516	520	PF00017	0.495
LIG_SH2_STAT3	121	124	PF00017	0.508
LIG_SH2_STAT5	104	107	PF00017	0.384
LIG_SH2_STAT5	121	124	PF00017	0.440
LIG_SH2_STAT5	315	318	PF00017	0.299
LIG_SH2_STAT5	366	369	PF00017	0.407
LIG_SH2_STAT5	519	522	PF00017	0.509
LIG_SH2_STAT5	594	597	PF00017	0.650
LIG_SH2_STAT5	602	605	PF00017	0.645
LIG_SH2_STAT5	606	609	PF00017	0.650
LIG_SH2_STAT5	89	92	PF00017	0.494
LIG_SH3_3	242	248	PF00018	0.599
LIG_SH3_3	251	257	PF00018	0.575
LIG_SH3_3	48	54	PF00018	0.491
LIG_SUMO_SIM_par_1	201	206	PF11976	0.532
LIG_SUMO_SIM_par_1	564	570	PF11976	0.481
LIG_SxIP_EBH_1	174	185	PF03271	0.508
LIG_TRAF2_1	441	444	PF00917	0.395
LIG_TYR_ITIM	338	343	PF00017	0.318
LIG_WRC_WIRS_1	446	451	PF05994	0.549
MOD_CK1_1	12	18	PF00069	0.442
MOD_CK1_1	139	145	PF00069	0.562
MOD_CK1_1	164	170	PF00069	0.552
MOD_CK1_1	327	333	PF00069	0.283
MOD_CK1_1	350	356	PF00069	0.424
MOD_CK1_1	456	462	PF00069	0.684
MOD_CK1_1	463	469	PF00069	0.652
MOD_CK1_1	478	484	PF00069	0.595
MOD_CK1_1	501	507	PF00069	0.472
MOD_CK2_1	350	356	PF00069	0.424
MOD_CK2_1	362	368	PF00069	0.436
MOD_CK2_1	459	465	PF00069	0.533
MOD_CK2_1	567	573	PF00069	0.688
MOD_CK2_1	96	102	PF00069	0.428
MOD_Cter_Amidation	391	394	PF01082	0.239
MOD_GlcNHglycan	11	14	PF01048	0.510
MOD_GlcNHglycan	165	169	PF01048	0.347
MOD_GlcNHglycan	33	36	PF01048	0.272
MOD_GlcNHglycan	349	352	PF01048	0.368
MOD_GlcNHglycan	455	458	PF01048	0.608
MOD_GlcNHglycan	462	465	PF01048	0.652
MOD_GlcNHglycan	484	487	PF01048	0.552
MOD_GlcNHglycan	497	501	PF01048	0.525
MOD_GlcNHglycan	557	560	PF01048	0.606
MOD_GlcNHglycan	597	600	PF01048	0.691
MOD_GSK3_1	166	173	PF00069	0.495
MOD_GSK3_1	175	182	PF00069	0.429
MOD_GSK3_1	294	301	PF00069	0.620
MOD_GSK3_1	305	312	PF00069	0.474
MOD_GSK3_1	31	38	PF00069	0.461
MOD_GSK3_1	456	463	PF00069	0.629
MOD_GSK3_1	474	481	PF00069	0.751
MOD_N-GLC_2	605	607	PF02516	0.448
MOD_NEK2_1	294	299	PF00069	0.519
MOD_NEK2_1	309	314	PF00069	0.317
MOD_NEK2_1	423	428	PF00069	0.439
MOD_NEK2_1	592	597	PF00069	0.646
MOD_NEK2_1	93	98	PF00069	0.444
MOD_PIKK_1	294	300	PF00454	0.683
MOD_PIKK_1	35	41	PF00454	0.505
MOD_PIKK_1	350	356	PF00454	0.396
MOD_PIKK_1	4	10	PF00454	0.641
MOD_PK_1	70	76	PF00069	0.544
MOD_PKA_1	292	298	PF00069	0.539
MOD_PKA_1	303	309	PF00069	0.231
MOD_PKA_1	429	435	PF00069	0.240
MOD_PKA_2	292	298	PF00069	0.530
MOD_PKA_2	429	435	PF00069	0.400
MOD_PKA_2	521	527	PF00069	0.603
MOD_PKB_1	290	298	PF00069	0.712
MOD_Plk_1	423	429	PF00069	0.412
MOD_Plk_1	467	473	PF00069	0.484
MOD_Plk_2-3	573	579	PF00069	0.699
MOD_Plk_4	334	340	PF00069	0.192
MOD_Plk_4	362	368	PF00069	0.333
MOD_Plk_4	429	435	PF00069	0.278
MOD_Plk_4	573	579	PF00069	0.748
MOD_Plk_4	70	76	PF00069	0.544
MOD_ProDKin_1	314	320	PF00069	0.313
MOD_SUMO_for_1	218	221	PF00179	0.444
MOD_SUMO_rev_2	317	327	PF00179	0.424
MOD_SUMO_rev_2	377	386	PF00179	0.172
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.470
TRG_ENDOCYTIC_2	104	107	PF00928	0.444
TRG_ENDOCYTIC_2	340	343	PF00928	0.299
TRG_ENDOCYTIC_2	506	509	PF00928	0.482
TRG_ER_diArg_1	290	293	PF00400	0.644
TRG_ER_diArg_1	393	395	PF00400	0.427
TRG_ER_diArg_1	428	430	PF00400	0.544
TRG_ER_diArg_1	449	452	PF00400	0.586
TRG_NES_CRM1_1	193	206	PF08389	0.532
TRG_NES_CRM1_1	346	359	PF08389	0.239
TRG_NLS_Bipartite_1	290	307	PF00514	0.485
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI5	Leptomonas seymouri	55%	98%
A0A0S4IZ51	Bodo saltans	39%	100%
A0A1X0P290	Trypanosomatidae	45%	100%
A0A3S7X363	Leishmania donovani	90%	100%
A0A422P4X7	Trypanosoma rangeli	39%	100%
A4HI55	Leishmania braziliensis	76%	100%
A4I5D1	Leishmania infantum	90%	100%
C9ZQR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q7K3	Leishmania major	88%	100%
V5BU83	Trypanosoma cruzi	42%	100%