Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0M8_LEIMU

TriTrypDb:

LmxM.29.0990

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.635
CLV_C14_Caspase3-7	395	399	PF00656	0.499
CLV_C14_Caspase3-7	513	517	PF00656	0.479
CLV_NRD_NRD_1	134	136	PF00675	0.515
CLV_NRD_NRD_1	234	236	PF00675	0.618
CLV_NRD_NRD_1	288	290	PF00675	0.658
CLV_NRD_NRD_1	291	293	PF00675	0.641
CLV_NRD_NRD_1	371	373	PF00675	0.530
CLV_NRD_NRD_1	475	477	PF00675	0.392
CLV_NRD_NRD_1	55	57	PF00675	0.626
CLV_PCSK_FUR_1	289	293	PF00082	0.663
CLV_PCSK_KEX2_1	134	136	PF00082	0.515
CLV_PCSK_KEX2_1	234	236	PF00082	0.618
CLV_PCSK_KEX2_1	272	274	PF00082	0.505
CLV_PCSK_KEX2_1	288	290	PF00082	0.607
CLV_PCSK_KEX2_1	291	293	PF00082	0.614
CLV_PCSK_KEX2_1	371	373	PF00082	0.530
CLV_PCSK_KEX2_1	475	477	PF00082	0.392
CLV_PCSK_KEX2_1	55	57	PF00082	0.626
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.505
CLV_PCSK_SKI1_1	174	178	PF00082	0.589
CLV_PCSK_SKI1_1	262	266	PF00082	0.462
CLV_PCSK_SKI1_1	371	375	PF00082	0.477
CLV_PCSK_SKI1_1	41	45	PF00082	0.479
CLV_PCSK_SKI1_1	475	479	PF00082	0.381
DEG_SPOP_SBC_1	11	15	PF00917	0.602
DEG_SPOP_SBC_1	20	24	PF00917	0.618
DEG_SPOP_SBC_1	315	319	PF00917	0.641
DOC_CKS1_1	375	380	PF01111	0.405
DOC_CKS1_1	405	410	PF01111	0.679
DOC_CYCLIN_RxL_1	368	377	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.517
DOC_MAPK_gen_1	134	141	PF00069	0.492
DOC_MAPK_gen_1	172	181	PF00069	0.456
DOC_MAPK_gen_1	288	299	PF00069	0.795
DOC_MAPK_MEF2A_6	28	35	PF00069	0.563
DOC_MAPK_RevD_3	121	135	PF00069	0.474
DOC_PP1_RVXF_1	39	46	PF00149	0.472
DOC_PP2B_LxvP_1	390	393	PF13499	0.405
DOC_PP2B_LxvP_1	484	487	PF13499	0.358
DOC_USP7_MATH_1	11	15	PF00917	0.654
DOC_USP7_MATH_1	303	307	PF00917	0.708
DOC_USP7_MATH_1	315	319	PF00917	0.557
DOC_USP7_MATH_1	344	348	PF00917	0.705
DOC_USP7_MATH_1	364	368	PF00917	0.401
DOC_USP7_MATH_1	487	491	PF00917	0.527
DOC_USP7_MATH_1	536	540	PF00917	0.531
DOC_USP7_MATH_1	549	553	PF00917	0.596
DOC_WW_Pin1_4	180	185	PF00397	0.603
DOC_WW_Pin1_4	238	243	PF00397	0.649
DOC_WW_Pin1_4	297	302	PF00397	0.641
DOC_WW_Pin1_4	306	311	PF00397	0.705
DOC_WW_Pin1_4	33	38	PF00397	0.623
DOC_WW_Pin1_4	340	345	PF00397	0.536
DOC_WW_Pin1_4	374	379	PF00397	0.420
DOC_WW_Pin1_4	404	409	PF00397	0.677
DOC_WW_Pin1_4	7	12	PF00397	0.732
DOC_WW_Pin1_4	94	99	PF00397	0.657
LIG_14-3-3_CanoR_1	174	181	PF00244	0.647
LIG_14-3-3_CanoR_1	234	238	PF00244	0.640
LIG_14-3-3_CanoR_1	291	301	PF00244	0.607
LIG_14-3-3_CanoR_1	520	529	PF00244	0.438
LIG_14-3-3_CanoR_1	65	70	PF00244	0.659
LIG_14-3-3_CanoR_1	75	79	PF00244	0.570
LIG_14-3-3_CanoR_1	91	95	PF00244	0.491
LIG_eIF4E_1	556	562	PF01652	0.524
LIG_FHA_1	21	27	PF00498	0.693
LIG_FHA_1	213	219	PF00498	0.584
LIG_FHA_1	255	261	PF00498	0.519
LIG_FHA_1	318	324	PF00498	0.708
LIG_FHA_1	353	359	PF00498	0.454
LIG_FHA_1	361	367	PF00498	0.532
LIG_FHA_1	505	511	PF00498	0.518
LIG_FHA_1	81	87	PF00498	0.638
LIG_FHA_2	187	193	PF00498	0.572
LIG_FHA_2	246	252	PF00498	0.519
LIG_FHA_2	326	332	PF00498	0.469
LIG_LIR_Apic_2	68	72	PF02991	0.567
LIG_LIR_Gen_1	127	136	PF02991	0.550
LIG_LIR_Gen_1	349	359	PF02991	0.467
LIG_LIR_Gen_1	480	487	PF02991	0.451
LIG_LIR_Nem_3	127	132	PF02991	0.482
LIG_LIR_Nem_3	349	354	PF02991	0.454
LIG_LIR_Nem_3	480	484	PF02991	0.437
LIG_NBox_RRM_1	335	345	PF00076	0.486
LIG_NRBOX	260	266	PF00104	0.461
LIG_NRBOX	353	359	PF00104	0.500
LIG_NRBOX	39	45	PF00104	0.470
LIG_RPA_C_Fungi	167	179	PF08784	0.521
LIG_SH2_CRK	69	73	PF00017	0.520
LIG_SH2_GRB2like	69	72	PF00017	0.781
LIG_SH2_PTP2	481	484	PF00017	0.401
LIG_SH2_SRC	556	559	PF00017	0.502
LIG_SH2_STAT5	481	484	PF00017	0.387
LIG_SH3_2	50	55	PF14604	0.595
LIG_SH3_3	23	29	PF00018	0.562
LIG_SH3_3	304	310	PF00018	0.574
LIG_SH3_3	375	381	PF00018	0.465
LIG_SH3_3	402	408	PF00018	0.598
LIG_SH3_3	47	53	PF00018	0.539
LIG_SH3_3	530	536	PF00018	0.497
LIG_SUMO_SIM_anti_2	192	199	PF11976	0.584
LIG_SUMO_SIM_par_1	224	231	PF11976	0.545
LIG_SUMO_SIM_par_1	31	36	PF11976	0.535
LIG_SUMO_SIM_par_1	372	377	PF11976	0.443
LIG_TRAF2_1	309	312	PF00917	0.616
LIG_TRAF2_2	108	113	PF00917	0.615
LIG_TYR_ITIM	479	484	PF00017	0.397
MOD_CDK_SPK_2	180	185	PF00069	0.544
MOD_CDK_SPK_2	94	99	PF00069	0.516
MOD_CK1_1	10	16	PF00069	0.615
MOD_CK1_1	166	172	PF00069	0.552
MOD_CK1_1	183	189	PF00069	0.523
MOD_CK1_1	199	205	PF00069	0.724
MOD_CK1_1	21	27	PF00069	0.753
MOD_CK1_1	210	216	PF00069	0.602
MOD_CK1_1	306	312	PF00069	0.721
MOD_CK1_1	317	323	PF00069	0.542
MOD_CK1_1	347	353	PF00069	0.521
MOD_CK1_1	362	368	PF00069	0.447
MOD_CK1_1	403	409	PF00069	0.683
MOD_CK1_1	489	495	PF00069	0.534
MOD_CK1_1	503	509	PF00069	0.475
MOD_CK1_1	54	60	PF00069	0.621
MOD_CK1_1	90	96	PF00069	0.760
MOD_CK2_1	186	192	PF00069	0.569
MOD_CK2_1	199	205	PF00069	0.500
MOD_CK2_1	245	251	PF00069	0.533
MOD_CK2_1	306	312	PF00069	0.700
MOD_CK2_1	325	331	PF00069	0.455
MOD_CK2_1	79	85	PF00069	0.601
MOD_DYRK1A_RPxSP_1	404	408	PF00069	0.622
MOD_GlcNHglycan	103	106	PF01048	0.651
MOD_GlcNHglycan	116	119	PF01048	0.482
MOD_GlcNHglycan	14	17	PF01048	0.657
MOD_GlcNHglycan	165	168	PF01048	0.569
MOD_GlcNHglycan	197	201	PF01048	0.771
MOD_GlcNHglycan	212	215	PF01048	0.716
MOD_GlcNHglycan	230	233	PF01048	0.597
MOD_GlcNHglycan	278	281	PF01048	0.641
MOD_GlcNHglycan	294	297	PF01048	0.638
MOD_GlcNHglycan	346	349	PF01048	0.614
MOD_GlcNHglycan	367	370	PF01048	0.525
MOD_GlcNHglycan	491	494	PF01048	0.568
MOD_GlcNHglycan	537	541	PF01048	0.518
MOD_GlcNHglycan	56	59	PF01048	0.613
MOD_GSK3_1	179	186	PF00069	0.499
MOD_GSK3_1	195	202	PF00069	0.674
MOD_GSK3_1	212	219	PF00069	0.549
MOD_GSK3_1	238	245	PF00069	0.650
MOD_GSK3_1	340	347	PF00069	0.488
MOD_GSK3_1	358	365	PF00069	0.511
MOD_GSK3_1	400	407	PF00069	0.648
MOD_GSK3_1	487	494	PF00069	0.532
MOD_GSK3_1	500	507	PF00069	0.483
MOD_GSK3_1	560	567	PF00069	0.360
MOD_GSK3_1	7	14	PF00069	0.622
MOD_GSK3_1	90	97	PF00069	0.658
MOD_LATS_1	290	296	PF00433	0.631
MOD_N-GLC_1	216	221	PF02516	0.420
MOD_N-GLC_1	500	505	PF02516	0.509
MOD_NEK2_1	163	168	PF00069	0.530
MOD_NEK2_1	179	184	PF00069	0.508
MOD_NEK2_1	228	233	PF00069	0.725
MOD_NEK2_1	412	417	PF00069	0.460
MOD_NEK2_1	521	526	PF00069	0.495
MOD_NEK2_2	207	212	PF00069	0.511
MOD_NEK2_2	303	308	PF00069	0.614
MOD_NEK2_2	325	330	PF00069	0.432
MOD_NEK2_2	440	445	PF00069	0.465
MOD_OFUCOSY	485	491	PF10250	0.496
MOD_PIKK_1	216	222	PF00454	0.489
MOD_PIKK_1	233	239	PF00454	0.503
MOD_PIKK_1	504	510	PF00454	0.428
MOD_PKA_2	233	239	PF00069	0.627
MOD_PKA_2	400	406	PF00069	0.611
MOD_PKA_2	54	60	PF00069	0.621
MOD_PKA_2	74	80	PF00069	0.488
MOD_PKA_2	90	96	PF00069	0.494
MOD_PKB_1	172	180	PF00069	0.556
MOD_Plk_1	216	222	PF00069	0.489
MOD_Plk_1	500	506	PF00069	0.507
MOD_Plk_4	183	189	PF00069	0.467
MOD_Plk_4	317	323	PF00069	0.668
MOD_Plk_4	352	358	PF00069	0.546
MOD_Plk_4	440	446	PF00069	0.462
MOD_Plk_4	560	566	PF00069	0.457
MOD_ProDKin_1	180	186	PF00069	0.601
MOD_ProDKin_1	238	244	PF00069	0.650
MOD_ProDKin_1	297	303	PF00069	0.640
MOD_ProDKin_1	306	312	PF00069	0.706
MOD_ProDKin_1	33	39	PF00069	0.616
MOD_ProDKin_1	340	346	PF00069	0.544
MOD_ProDKin_1	374	380	PF00069	0.412
MOD_ProDKin_1	404	410	PF00069	0.677
MOD_ProDKin_1	7	13	PF00069	0.733
MOD_ProDKin_1	94	100	PF00069	0.658
MOD_SUMO_for_1	61	64	PF00179	0.594
TRG_DiLeu_BaEn_2	330	336	PF01217	0.403
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.558
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.373
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.522
TRG_DiLeu_LyEn_5	34	39	PF01217	0.548
TRG_ENDOCYTIC_2	481	484	PF00928	0.438
TRG_ER_diArg_1	121	124	PF00400	0.499
TRG_ER_diArg_1	287	289	PF00400	0.654
TRG_ER_diArg_1	370	372	PF00400	0.520
TRG_ER_diArg_1	474	476	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA3	Leptomonas seymouri	43%	82%
A0A3S7X3A4	Leishmania donovani	88%	99%
A4HI54	Leishmania braziliensis	69%	100%
A4I5D0	Leishmania infantum	88%	99%
Q4Q7K4	Leishmania major	87%	100%