Autophagy protein 5 (ATG5)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 5

Species:

Leishmania mexicana

UniProt:

E9B0M7_LEIMU

TriTrypDb:

LmxM.29.0980

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0M7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	423	425	PF00675	0.552
CLV_PCSK_KEX2_1	423	425	PF00082	0.546
CLV_PCSK_SKI1_1	225	229	PF00082	0.728
CLV_PCSK_SKI1_1	357	361	PF00082	0.666
CLV_PCSK_SKI1_1	452	456	PF00082	0.534
CLV_PCSK_SKI1_1	7	11	PF00082	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.471
DEG_SPOP_SBC_1	69	73	PF00917	0.448
DOC_CDC14_PxL_1	300	308	PF14671	0.489
DOC_CKS1_1	227	232	PF01111	0.529
DOC_CKS1_1	436	441	PF01111	0.724
DOC_CYCLIN_RxL_1	222	229	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.498
DOC_MAPK_gen_1	398	408	PF00069	0.596
DOC_MAPK_MEF2A_6	264	273	PF00069	0.609
DOC_MAPK_MEF2A_6	401	408	PF00069	0.604
DOC_MAPK_MEF2A_6	452	460	PF00069	0.528
DOC_PP1_RVXF_1	237	243	PF00149	0.577
DOC_PP1_RVXF_1	421	428	PF00149	0.537
DOC_PP4_FxxP_1	211	214	PF00568	0.619
DOC_PP4_FxxP_1	301	304	PF00568	0.475
DOC_SPAK_OSR1_1	426	430	PF12202	0.581
DOC_USP7_MATH_1	250	254	PF00917	0.663
DOC_USP7_MATH_1	317	321	PF00917	0.607
DOC_USP7_MATH_1	327	331	PF00917	0.690
DOC_USP7_MATH_1	412	416	PF00917	0.646
DOC_USP7_MATH_1	69	73	PF00917	0.484
DOC_USP7_UBL2_3	127	131	PF12436	0.446
DOC_WW_Pin1_4	197	202	PF00397	0.621
DOC_WW_Pin1_4	210	215	PF00397	0.718
DOC_WW_Pin1_4	226	231	PF00397	0.410
DOC_WW_Pin1_4	31	36	PF00397	0.421
DOC_WW_Pin1_4	370	375	PF00397	0.586
DOC_WW_Pin1_4	415	420	PF00397	0.581
DOC_WW_Pin1_4	435	440	PF00397	0.621
DOC_WW_Pin1_4	65	70	PF00397	0.557
LIG_14-3-3_CanoR_1	264	271	PF00244	0.691
LIG_BRCT_BRCA1_1	205	209	PF00533	0.583
LIG_CtBP_PxDLS_1	89	93	PF00389	0.396
LIG_FHA_1	106	112	PF00498	0.595
LIG_FHA_1	22	28	PF00498	0.480
LIG_FHA_1	358	364	PF00498	0.565
LIG_FHA_2	274	280	PF00498	0.714
LIG_FHA_2	371	377	PF00498	0.578
LIG_LIR_Apic_2	37	41	PF02991	0.432
LIG_LIR_Gen_1	218	228	PF02991	0.549
LIG_LIR_Gen_1	338	349	PF02991	0.530
LIG_LIR_Nem_3	135	141	PF02991	0.464
LIG_LIR_Nem_3	218	223	PF02991	0.542
LIG_LIR_Nem_3	25	31	PF02991	0.383
LIG_LIR_Nem_3	254	260	PF02991	0.599
LIG_LIR_Nem_3	338	344	PF02991	0.526
LIG_NRBOX	223	229	PF00104	0.583
LIG_PCNA_yPIPBox_3	221	231	PF02747	0.499
LIG_PDZ_Class_2	455	460	PF00595	0.591
LIG_PTB_Apo_2	189	196	PF02174	0.618
LIG_PTB_Phospho_1	189	195	PF10480	0.616
LIG_SH2_CRK	134	138	PF00017	0.464
LIG_SH2_CRK	205	209	PF00017	0.738
LIG_SH2_CRK	220	224	PF00017	0.440
LIG_SH2_CRK	341	345	PF00017	0.597
LIG_SH2_GRB2like	112	115	PF00017	0.440
LIG_SH2_GRB2like	48	51	PF00017	0.427
LIG_SH2_NCK_1	205	209	PF00017	0.596
LIG_SH2_NCK_1	352	356	PF00017	0.625
LIG_SH2_SRC	352	355	PF00017	0.553
LIG_SH2_STAP1	134	138	PF00017	0.464
LIG_SH2_STAP1	16	20	PF00017	0.481
LIG_SH2_STAT5	112	115	PF00017	0.440
LIG_SH2_STAT5	134	137	PF00017	0.466
LIG_SH2_STAT5	141	144	PF00017	0.431
LIG_SH2_STAT5	215	218	PF00017	0.579
LIG_SH2_STAT5	236	239	PF00017	0.514
LIG_SH2_STAT5	257	260	PF00017	0.558
LIG_SH2_STAT5	48	51	PF00017	0.427
LIG_SH3_3	371	377	PF00018	0.578
LIG_SUMO_SIM_par_1	87	93	PF11976	0.439
LIG_TRAF2_1	167	170	PF00917	0.549
LIG_TYR_ITIM	113	118	PF00017	0.435
LIG_WRC_WIRS_1	388	393	PF05994	0.412
LIG_WRPW_2	13	16	PF00400	0.534
LIG_WRPW_2	161	164	PF00400	0.516
LIG_WW_3	354	358	PF00397	0.637
MOD_CDK_SPK_2	226	231	PF00069	0.502
MOD_CK1_1	197	203	PF00069	0.660
MOD_CK1_1	322	328	PF00069	0.623
MOD_CK1_1	415	421	PF00069	0.555
MOD_CK1_1	64	70	PF00069	0.592
MOD_CK1_1	84	90	PF00069	0.424
MOD_CK2_1	27	33	PF00069	0.299
MOD_CK2_1	273	279	PF00069	0.716
MOD_CK2_1	332	338	PF00069	0.595
MOD_CK2_1	370	376	PF00069	0.650
MOD_CK2_1	438	444	PF00069	0.544
MOD_CMANNOS	380	383	PF00535	0.515
MOD_GlcNHglycan	149	152	PF01048	0.540
MOD_GlcNHglycan	182	185	PF01048	0.585
MOD_GlcNHglycan	205	208	PF01048	0.597
MOD_GlcNHglycan	254	257	PF01048	0.586
MOD_GlcNHglycan	265	268	PF01048	0.565
MOD_GlcNHglycan	273	276	PF01048	0.559
MOD_GlcNHglycan	321	324	PF01048	0.627
MOD_GlcNHglycan	329	332	PF01048	0.628
MOD_GlcNHglycan	414	417	PF01048	0.557
MOD_GlcNHglycan	61	64	PF01048	0.553
MOD_GlcNHglycan	72	75	PF01048	0.483
MOD_GSK3_1	193	200	PF00069	0.676
MOD_GSK3_1	27	34	PF00069	0.403
MOD_GSK3_1	271	278	PF00069	0.704
MOD_GSK3_1	315	322	PF00069	0.650
MOD_GSK3_1	434	441	PF00069	0.610
MOD_GSK3_1	59	66	PF00069	0.485
MOD_GSK3_1	77	84	PF00069	0.558
MOD_GSK3_1	97	104	PF00069	0.399
MOD_N-GLC_1	139	144	PF02516	0.413
MOD_N-GLC_2	420	422	PF02516	0.470
MOD_N-GLC_2	50	52	PF02516	0.426
MOD_NEK2_1	105	110	PF00069	0.540
MOD_NEK2_1	182	187	PF00069	0.669
MOD_NEK2_1	209	214	PF00069	0.577
MOD_NEK2_1	271	276	PF00069	0.695
MOD_NEK2_1	344	349	PF00069	0.552
MOD_NEK2_1	369	374	PF00069	0.650
MOD_NEK2_1	387	392	PF00069	0.388
MOD_NEK2_1	61	66	PF00069	0.559
MOD_NEK2_1	77	82	PF00069	0.475
MOD_NEK2_1	90	95	PF00069	0.406
MOD_NEK2_2	139	144	PF00069	0.449
MOD_PIKK_1	22	28	PF00454	0.416
MOD_PKA_2	263	269	PF00069	0.534
MOD_Plk_1	139	145	PF00069	0.417
MOD_Plk_1	22	28	PF00069	0.416
MOD_Plk_1	337	343	PF00069	0.584
MOD_Plk_1	90	96	PF00069	0.389
MOD_Plk_4	132	138	PF00069	0.595
MOD_Plk_4	139	145	PF00069	0.457
MOD_Plk_4	34	40	PF00069	0.486
MOD_Plk_4	387	393	PF00069	0.447
MOD_Plk_4	438	444	PF00069	0.544
MOD_Plk_4	81	87	PF00069	0.604
MOD_ProDKin_1	197	203	PF00069	0.620
MOD_ProDKin_1	210	216	PF00069	0.714
MOD_ProDKin_1	226	232	PF00069	0.414
MOD_ProDKin_1	31	37	PF00069	0.420
MOD_ProDKin_1	370	376	PF00069	0.585
MOD_ProDKin_1	415	421	PF00069	0.579
MOD_ProDKin_1	435	441	PF00069	0.622
MOD_ProDKin_1	65	71	PF00069	0.556
MOD_SUMO_rev_2	119	129	PF00179	0.513
TRG_DiLeu_BaEn_1	219	224	PF01217	0.571
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.599
TRG_ENDOCYTIC_2	115	118	PF00928	0.436
TRG_ENDOCYTIC_2	134	137	PF00928	0.466
TRG_ENDOCYTIC_2	161	164	PF00928	0.516
TRG_ENDOCYTIC_2	220	223	PF00928	0.505
TRG_ENDOCYTIC_2	341	344	PF00928	0.512
TRG_ER_diArg_1	423	426	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W7	Leptomonas seymouri	56%	86%
A0A3S7X356	Leishmania donovani	94%	100%
A4HI53	Leishmania braziliensis	83%	100%
A4I5C9	Leishmania infantum	95%	100%
Q4Q7K5	Leishmania major	93%	100%