Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0M5_LEIMU

TriTrypDb:

LmxM.29.0960

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0M5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.628
CLV_NRD_NRD_1	190	192	PF00675	0.807
CLV_NRD_NRD_1	41	43	PF00675	0.836
CLV_NRD_NRD_1	65	67	PF00675	0.661
CLV_NRD_NRD_1	89	91	PF00675	0.637
CLV_PCSK_KEX2_1	190	192	PF00082	0.733
CLV_PCSK_KEX2_1	43	45	PF00082	0.844
CLV_PCSK_KEX2_1	89	91	PF00082	0.637
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.854
CLV_PCSK_SKI1_1	394	398	PF00082	0.663
CLV_PCSK_SKI1_1	444	448	PF00082	0.596
DEG_APCC_DBOX_1	115	123	PF00400	0.620
DEG_Nend_UBRbox_3	1	3	PF02207	0.593
DOC_CDC14_PxL_1	265	273	PF14671	0.752
DOC_CKS1_1	239	244	PF01111	0.622
DOC_CKS1_1	75	80	PF01111	0.795
DOC_CYCLIN_yClb1_LxF_4	397	403	PF00134	0.666
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.700
DOC_MAPK_DCC_7	71	81	PF00069	0.572
DOC_PP2B_LxvP_1	149	152	PF13499	0.772
DOC_PP4_FxxP_1	110	113	PF00568	0.527
DOC_PP4_FxxP_1	402	405	PF00568	0.668
DOC_PP4_FxxP_1	408	411	PF00568	0.582
DOC_PP4_MxPP_1	115	118	PF00568	0.508
DOC_USP7_MATH_1	16	20	PF00917	0.582
DOC_USP7_MATH_1	305	309	PF00917	0.719
DOC_WW_Pin1_4	238	243	PF00397	0.828
DOC_WW_Pin1_4	272	277	PF00397	0.653
DOC_WW_Pin1_4	325	330	PF00397	0.817
DOC_WW_Pin1_4	4	9	PF00397	0.768
DOC_WW_Pin1_4	49	54	PF00397	0.742
DOC_WW_Pin1_4	74	79	PF00397	0.788
DOC_WW_Pin1_4	94	99	PF00397	0.509
LIG_14-3-3_CanoR_1	159	166	PF00244	0.815
LIG_14-3-3_CanoR_1	254	259	PF00244	0.464
LIG_14-3-3_CanoR_1	298	303	PF00244	0.734
LIG_14-3-3_CanoR_1	359	365	PF00244	0.787
LIG_Clathr_ClatBox_1	400	404	PF01394	0.664
LIG_CtBP_PxDLS_1	46	50	PF00389	0.760
LIG_FHA_1	176	182	PF00498	0.744
LIG_FHA_1	281	287	PF00498	0.672
LIG_FHA_1	289	295	PF00498	0.665
LIG_FHA_1	395	401	PF00498	0.660
LIG_FHA_1	55	61	PF00498	0.644
LIG_FHA_2	102	108	PF00498	0.744
LIG_FHA_2	258	264	PF00498	0.729
LIG_FHA_2	422	428	PF00498	0.655
LIG_HCF-1_HBM_1	418	421	PF13415	0.572
LIG_LIR_Apic_2	107	113	PF02991	0.530
LIG_LIR_Apic_2	72	78	PF02991	0.780
LIG_LIR_Gen_1	253	264	PF02991	0.605
LIG_LIR_Nem_3	253	259	PF02991	0.619
LIG_LIR_Nem_3	260	265	PF02991	0.562
LIG_PDZ_Class_1	444	449	PF00595	0.700
LIG_Pex14_2	392	396	PF04695	0.562
LIG_SH2_STAP1	252	256	PF00017	0.578
LIG_SH3_1	273	279	PF00018	0.692
LIG_SH3_3	114	120	PF00018	0.556
LIG_SH3_3	236	242	PF00018	0.798
LIG_SH3_3	264	270	PF00018	0.617
LIG_SH3_3	273	279	PF00018	0.577
LIG_SH3_3	347	353	PF00018	0.688
LIG_SH3_3	400	406	PF00018	0.667
LIG_SH3_3	5	11	PF00018	0.730
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.615
LIG_SUMO_SIM_par_1	410	415	PF11976	0.690
LIG_TRAF2_1	141	144	PF00917	0.727
LIG_TRAF2_1	433	436	PF00917	0.587
LIG_WW_2	117	120	PF00397	0.507
MOD_CDK_SPK_2	272	277	PF00069	0.773
MOD_CDK_SPK_2	54	59	PF00069	0.535
MOD_CDK_SPxK_1	74	80	PF00069	0.791
MOD_CK1_1	105	111	PF00069	0.691
MOD_CK1_1	158	164	PF00069	0.637
MOD_CK1_1	211	217	PF00069	0.717
MOD_CK1_1	257	263	PF00069	0.591
MOD_CK1_1	280	286	PF00069	0.702
MOD_CK1_1	288	294	PF00069	0.726
MOD_CK1_1	297	303	PF00069	0.507
MOD_CK1_1	316	322	PF00069	0.643
MOD_CK1_1	328	334	PF00069	0.585
MOD_CK1_1	355	361	PF00069	0.639
MOD_CK1_1	388	394	PF00069	0.589
MOD_CK1_1	4	10	PF00069	0.600
MOD_CK1_1	52	58	PF00069	0.655
MOD_CK2_1	138	144	PF00069	0.743
MOD_CK2_1	151	157	PF00069	0.575
MOD_CK2_1	183	189	PF00069	0.741
MOD_CK2_1	316	322	PF00069	0.744
MOD_CK2_1	430	436	PF00069	0.593
MOD_GlcNHglycan	160	163	PF01048	0.671
MOD_GlcNHglycan	18	21	PF01048	0.795
MOD_GlcNHglycan	210	213	PF01048	0.727
MOD_GlcNHglycan	3	6	PF01048	0.616
MOD_GlcNHglycan	30	33	PF01048	0.629
MOD_GlcNHglycan	385	390	PF01048	0.574
MOD_GSK3_1	130	137	PF00069	0.721
MOD_GSK3_1	151	158	PF00069	0.579
MOD_GSK3_1	195	202	PF00069	0.750
MOD_GSK3_1	207	214	PF00069	0.827
MOD_GSK3_1	248	255	PF00069	0.609
MOD_GSK3_1	290	297	PF00069	0.726
MOD_GSK3_1	324	331	PF00069	0.709
MOD_GSK3_1	355	362	PF00069	0.754
MOD_GSK3_1	90	97	PF00069	0.762
MOD_GSK3_1	98	105	PF00069	0.644
MOD_N-GLC_1	1	6	PF02516	0.583
MOD_N-GLC_1	105	110	PF02516	0.747
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	169	174	PF00069	0.515
MOD_NEK2_1	271	276	PF00069	0.748
MOD_NEK2_1	28	33	PF00069	0.656
MOD_NEK2_1	296	301	PF00069	0.617
MOD_NEK2_1	324	329	PF00069	0.720
MOD_NEK2_1	69	74	PF00069	0.678
MOD_NEK2_2	290	295	PF00069	0.506
MOD_PIKK_1	151	157	PF00454	0.498
MOD_PIKK_1	280	286	PF00454	0.719
MOD_PIKK_1	52	58	PF00454	0.753
MOD_PK_1	254	260	PF00069	0.486
MOD_PK_1	298	304	PF00069	0.618
MOD_PKA_2	158	164	PF00069	0.816
MOD_PKA_2	297	303	PF00069	0.716
MOD_Plk_1	105	111	PF00069	0.747
MOD_Plk_1	248	254	PF00069	0.703
MOD_Plk_2-3	430	436	PF00069	0.593
MOD_Plk_4	105	111	PF00069	0.708
MOD_Plk_4	130	136	PF00069	0.792
MOD_Plk_4	18	24	PF00069	0.744
MOD_Plk_4	277	283	PF00069	0.689
MOD_Plk_4	421	427	PF00069	0.614
MOD_ProDKin_1	238	244	PF00069	0.825
MOD_ProDKin_1	272	278	PF00069	0.657
MOD_ProDKin_1	325	331	PF00069	0.818
MOD_ProDKin_1	4	10	PF00069	0.769
MOD_ProDKin_1	49	55	PF00069	0.740
MOD_ProDKin_1	74	80	PF00069	0.791
MOD_ProDKin_1	94	100	PF00069	0.507
MOD_SUMO_rev_2	435	443	PF00179	0.673
MOD_SUMO_rev_2	61	69	PF00179	0.762
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.754
TRG_ER_diArg_1	42	45	PF00400	0.631
TRG_ER_diArg_1	71	74	PF00400	0.641
TRG_NLS_MonoExtC_3	41	46	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.837
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ5	Leptomonas seymouri	30%	100%
A0A3Q8IRU8	Leishmania donovani	84%	76%
A4HI51	Leishmania braziliensis	65%	100%
A4I5C7	Leishmania infantum	84%	100%
Q4Q7K7	Leishmania major	83%	100%