Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone-binding protein RBBP4 or subunit C of CAF1 complex/WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B0M4_LEIMU

TriTrypDb:

LmxM.29.0950

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

E9B0M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0M4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.744
CLV_C14_Caspase3-7	166	170	PF00656	0.551
CLV_C14_Caspase3-7	385	389	PF00656	0.463
CLV_C14_Caspase3-7	477	481	PF00656	0.524
CLV_C14_Caspase3-7	7	11	PF00656	0.694
CLV_NRD_NRD_1	132	134	PF00675	0.739
CLV_NRD_NRD_1	178	180	PF00675	0.719
CLV_NRD_NRD_1	201	203	PF00675	0.638
CLV_NRD_NRD_1	395	397	PF00675	0.540
CLV_NRD_NRD_1	50	52	PF00675	0.609
CLV_NRD_NRD_1	533	535	PF00675	0.486
CLV_NRD_NRD_1	77	79	PF00675	0.710
CLV_PCSK_FUR_1	198	202	PF00082	0.510
CLV_PCSK_FUR_1	48	52	PF00082	0.583
CLV_PCSK_KEX2_1	132	134	PF00082	0.736
CLV_PCSK_KEX2_1	178	180	PF00082	0.719
CLV_PCSK_KEX2_1	200	202	PF00082	0.647
CLV_PCSK_KEX2_1	325	327	PF00082	0.587
CLV_PCSK_KEX2_1	395	397	PF00082	0.540
CLV_PCSK_KEX2_1	50	52	PF00082	0.609
CLV_PCSK_KEX2_1	533	535	PF00082	0.486
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.587
CLV_PCSK_SKI1_1	547	551	PF00082	0.376
CLV_PCSK_SKI1_1	570	574	PF00082	0.514
CLV_PCSK_SKI1_1	634	638	PF00082	0.394
DEG_APCC_DBOX_1	569	577	PF00400	0.526
DEG_APCC_DBOX_1	633	641	PF00400	0.393
DEG_MDM2_SWIB_1	399	406	PF02201	0.447
DEG_SPOP_SBC_1	492	496	PF00917	0.491
DOC_CYCLIN_RxL_1	212	222	PF00134	0.657
DOC_PP1_RVXF_1	568	575	PF00149	0.425
DOC_PP2B_LxvP_1	590	593	PF13499	0.596
DOC_PP4_FxxP_1	17	20	PF00568	0.722
DOC_PP4_FxxP_1	254	257	PF00568	0.524
DOC_USP7_MATH_1	106	110	PF00917	0.640
DOC_USP7_MATH_1	168	172	PF00917	0.545
DOC_USP7_MATH_1	475	479	PF00917	0.524
DOC_USP7_MATH_1	492	496	PF00917	0.514
DOC_USP7_MATH_1	500	504	PF00917	0.447
DOC_USP7_MATH_1	523	527	PF00917	0.463
DOC_USP7_MATH_1	593	597	PF00917	0.455
DOC_WW_Pin1_4	110	115	PF00397	0.814
DOC_WW_Pin1_4	18	23	PF00397	0.716
DOC_WW_Pin1_4	552	557	PF00397	0.440
LIG_14-3-3_CanoR_1	39	49	PF00244	0.671
LIG_14-3-3_CanoR_1	489	497	PF00244	0.512
LIG_14-3-3_CanoR_1	533	538	PF00244	0.487
LIG_14-3-3_CanoR_1	605	611	PF00244	0.442
LIG_BIR_III_2	58	62	PF00653	0.537
LIG_BIR_III_4	140	144	PF00653	0.744
LIG_deltaCOP1_diTrp_1	240	248	PF00928	0.483
LIG_FHA_1	234	240	PF00498	0.524
LIG_FHA_1	241	247	PF00498	0.524
LIG_FHA_1	35	41	PF00498	0.682
LIG_FHA_1	354	360	PF00498	0.391
LIG_FHA_1	428	434	PF00498	0.633
LIG_FHA_1	446	452	PF00498	0.338
LIG_FHA_1	534	540	PF00498	0.373
LIG_FHA_1	558	564	PF00498	0.446
LIG_FHA_1	578	584	PF00498	0.289
LIG_FHA_1	625	631	PF00498	0.550
LIG_FHA_2	291	297	PF00498	0.551
LIG_FHA_2	376	382	PF00498	0.546
LIG_FHA_2	383	389	PF00498	0.527
LIG_FHA_2	75	81	PF00498	0.767
LIG_LIR_Apic_2	251	257	PF02991	0.524
LIG_LIR_Gen_1	262	272	PF02991	0.524
LIG_LIR_Gen_1	402	411	PF02991	0.451
LIG_LIR_Gen_1	594	603	PF02991	0.462
LIG_LIR_Nem_3	240	244	PF02991	0.483
LIG_LIR_Nem_3	262	268	PF02991	0.524
LIG_LIR_Nem_3	296	302	PF02991	0.579
LIG_LIR_Nem_3	365	370	PF02991	0.362
LIG_LIR_Nem_3	402	406	PF02991	0.451
LIG_LIR_Nem_3	416	422	PF02991	0.376
LIG_LIR_Nem_3	594	600	PF02991	0.561
LIG_LIR_Nem_3	642	646	PF02991	0.559
LIG_Pex14_1	540	544	PF04695	0.465
LIG_Pex14_2	186	190	PF04695	0.490
LIG_Pex14_2	399	403	PF04695	0.435
LIG_RPA_C_Fungi	196	208	PF08784	0.487
LIG_SH2_CRK	371	375	PF00017	0.455
LIG_SH2_CRK	633	637	PF00017	0.541
LIG_SH2_GRB2like	419	422	PF00017	0.425
LIG_SH2_STAP1	261	265	PF00017	0.389
LIG_SH2_STAT3	261	264	PF00017	0.389
LIG_SH2_STAT5	233	236	PF00017	0.475
LIG_SH2_STAT5	261	264	PF00017	0.389
LIG_SH2_STAT5	265	268	PF00017	0.389
LIG_SH2_STAT5	419	422	PF00017	0.438
LIG_SH3_2	22	27	PF14604	0.756
LIG_SH3_3	19	25	PF00018	0.752
LIG_SH3_3	236	242	PF00018	0.389
LIG_SH3_3	284	290	PF00018	0.389
LIG_SH3_3	59	65	PF00018	0.751
LIG_SH3_3	629	635	PF00018	0.432
LIG_SH3_5	257	261	PF00018	0.389
LIG_SUMO_SIM_par_1	242	247	PF11976	0.491
LIG_SUMO_SIM_par_1	355	363	PF11976	0.426
LIG_SUMO_SIM_par_1	429	435	PF11976	0.693
LIG_SUMO_SIM_par_1	559	564	PF11976	0.526
LIG_TRAF2_1	123	126	PF00917	0.742
LIG_TYR_ITIM	263	268	PF00017	0.389
LIG_TYR_ITIM	420	425	PF00017	0.424
MOD_CK1_1	222	228	PF00069	0.316
MOD_CK1_1	402	408	PF00069	0.417
MOD_CK1_1	491	497	PF00069	0.509
MOD_CK1_1	503	509	PF00069	0.449
MOD_CK1_1	610	616	PF00069	0.543
MOD_CK1_1	623	629	PF00069	0.391
MOD_CK1_1	95	101	PF00069	0.725
MOD_CK2_1	375	381	PF00069	0.513
MOD_CK2_1	441	447	PF00069	0.589
MOD_CK2_1	611	617	PF00069	0.591
MOD_CK2_1	74	80	PF00069	0.697
MOD_Cter_Amidation	323	326	PF01082	0.605
MOD_GlcNHglycan	108	111	PF01048	0.742
MOD_GlcNHglycan	165	168	PF01048	0.629
MOD_GlcNHglycan	175	178	PF01048	0.703
MOD_GlcNHglycan	190	193	PF01048	0.617
MOD_GlcNHglycan	275	278	PF01048	0.406
MOD_GlcNHglycan	31	34	PF01048	0.770
MOD_GlcNHglycan	364	367	PF01048	0.373
MOD_GlcNHglycan	412	415	PF01048	0.382
MOD_GlcNHglycan	435	439	PF01048	0.642
MOD_GlcNHglycan	443	446	PF01048	0.413
MOD_GlcNHglycan	490	493	PF01048	0.536
MOD_GlcNHglycan	498	501	PF01048	0.498
MOD_GlcNHglycan	502	505	PF01048	0.495
MOD_GlcNHglycan	622	625	PF01048	0.534
MOD_GSK3_1	106	113	PF00069	0.720
MOD_GSK3_1	188	195	PF00069	0.692
MOD_GSK3_1	34	41	PF00069	0.704
MOD_GSK3_1	423	430	PF00069	0.434
MOD_GSK3_1	441	448	PF00069	0.555
MOD_GSK3_1	488	495	PF00069	0.518
MOD_GSK3_1	496	503	PF00069	0.490
MOD_GSK3_1	557	564	PF00069	0.386
MOD_GSK3_1	607	614	PF00069	0.465
MOD_GSK3_1	620	627	PF00069	0.308
MOD_GSK3_1	92	99	PF00069	0.808
MOD_LATS_1	545	551	PF00433	0.383
MOD_N-GLC_1	4	9	PF02516	0.633
MOD_N-GLC_1	611	616	PF02516	0.517
MOD_N-GLC_2	173	175	PF02516	0.546
MOD_NEK2_1	399	404	PF00069	0.433
MOD_NEK2_1	410	415	PF00069	0.415
MOD_NEK2_1	473	478	PF00069	0.389
MOD_NEK2_1	557	562	PF00069	0.562
MOD_NEK2_1	576	581	PF00069	0.276
MOD_PIKK_1	20	26	PF00454	0.657
MOD_PIKK_1	267	273	PF00454	0.389
MOD_PIKK_1	375	381	PF00454	0.545
MOD_PIKK_1	40	46	PF00454	0.584
MOD_PIKK_1	445	451	PF00454	0.505
MOD_PIKK_1	466	472	PF00454	0.389
MOD_PKA_1	533	539	PF00069	0.375
MOD_PKA_2	38	44	PF00069	0.591
MOD_PKA_2	427	433	PF00069	0.565
MOD_PKA_2	488	494	PF00069	0.500
MOD_PKA_2	532	538	PF00069	0.482
MOD_PKA_2	604	610	PF00069	0.445
MOD_PKA_2	72	78	PF00069	0.517
MOD_PKA_2	92	98	PF00069	0.497
MOD_PKB_1	200	208	PF00069	0.775
MOD_Plk_1	259	265	PF00069	0.389
MOD_Plk_1	336	342	PF00069	0.423
MOD_Plk_1	4	10	PF00069	0.660
MOD_Plk_1	434	440	PF00069	0.645
MOD_Plk_1	593	599	PF00069	0.453
MOD_Plk_1	607	613	PF00069	0.444
MOD_Plk_4	369	375	PF00069	0.253
MOD_Plk_4	557	563	PF00069	0.387
MOD_Plk_4	593	599	PF00069	0.453
MOD_ProDKin_1	110	116	PF00069	0.815
MOD_ProDKin_1	18	24	PF00069	0.718
MOD_ProDKin_1	552	558	PF00069	0.444
MOD_SUMO_rev_2	222	230	PF00179	0.491
MOD_SUMO_rev_2	53	62	PF00179	0.727
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.374
TRG_DiLeu_BaLyEn_6	632	637	PF01217	0.375
TRG_ENDOCYTIC_2	265	268	PF00928	0.389
TRG_ENDOCYTIC_2	371	374	PF00928	0.425
TRG_ENDOCYTIC_2	422	425	PF00928	0.374
TRG_ENDOCYTIC_2	633	636	PF00928	0.442
TRG_ER_diArg_1	198	201	PF00400	0.652
TRG_ER_diArg_1	48	51	PF00400	0.587
TRG_ER_diArg_1	532	534	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W9	Leptomonas seymouri	59%	97%
A0A3S7X390	Leishmania donovani	90%	100%
A0A3S7X6T4	Leishmania donovani	23%	100%
A4HI50	Leishmania braziliensis	74%	100%
A4HLQ3	Leishmania braziliensis	23%	100%
A4I5C6	Leishmania infantum	90%	100%
A4I953	Leishmania infantum	23%	91%
E9B428	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O22607	Arabidopsis thaliana	22%	100%
P0CS36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	31%	100%
P0CS37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	31%	100%
Q4Q3Z6	Leishmania major	23%	100%
Q4Q7K8	Leishmania major	88%	100%
Q9SU78	Arabidopsis thaliana	23%	100%