DUF4139 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0M2_LEIMU

TriTrypDb:

LmxM.29.0930

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B0M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0M2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016829	lyase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.424
CLV_NRD_NRD_1	319	321	PF00675	0.363
CLV_NRD_NRD_1	461	463	PF00675	0.289
CLV_PCSK_KEX2_1	166	168	PF00082	0.456
CLV_PCSK_KEX2_1	186	188	PF00082	0.409
CLV_PCSK_KEX2_1	318	320	PF00082	0.426
CLV_PCSK_KEX2_1	461	463	PF00082	0.314
CLV_PCSK_KEX2_1	557	559	PF00082	0.373
CLV_PCSK_KEX2_1	98	100	PF00082	0.534
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.437
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.421
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.589
CLV_PCSK_PC7_1	457	463	PF00082	0.319
CLV_PCSK_SKI1_1	209	213	PF00082	0.465
DEG_SPOP_SBC_1	470	474	PF00917	0.269
DOC_CKS1_1	570	575	PF01111	0.473
DOC_CYCLIN_yClb1_LxF_4	386	391	PF00134	0.395
DOC_MAPK_gen_1	318	327	PF00069	0.173
DOC_MAPK_gen_1	554	564	PF00069	0.472
DOC_MAPK_MEF2A_6	396	403	PF00069	0.395
DOC_PP1_RVXF_1	386	392	PF00149	0.395
DOC_PP4_FxxP_1	24	27	PF00568	0.380
DOC_PP4_FxxP_1	489	492	PF00568	0.215
DOC_USP7_MATH_1	158	162	PF00917	0.458
DOC_USP7_MATH_1	32	36	PF00917	0.493
DOC_USP7_MATH_1	417	421	PF00917	0.322
DOC_USP7_MATH_1	490	494	PF00917	0.460
DOC_USP7_UBL2_3	94	98	PF12436	0.502
DOC_WW_Pin1_4	239	244	PF00397	0.338
DOC_WW_Pin1_4	286	291	PF00397	0.318
DOC_WW_Pin1_4	435	440	PF00397	0.367
DOC_WW_Pin1_4	569	574	PF00397	0.554
DOC_WW_Pin1_4	73	78	PF00397	0.443
LIG_14-3-3_CanoR_1	123	128	PF00244	0.345
LIG_14-3-3_CanoR_1	19	25	PF00244	0.278
LIG_14-3-3_CanoR_1	276	284	PF00244	0.372
LIG_14-3-3_CanoR_1	296	306	PF00244	0.288
LIG_14-3-3_CanoR_1	3	7	PF00244	0.486
LIG_APCC_ABBA_1	13	18	PF00400	0.416
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BRCT_BRCA1_1	419	423	PF00533	0.371
LIG_deltaCOP1_diTrp_1	44	51	PF00928	0.536
LIG_deltaCOP1_diTrp_1	545	550	PF00928	0.399
LIG_FHA_1	213	219	PF00498	0.474
LIG_FHA_1	224	230	PF00498	0.513
LIG_FHA_1	279	285	PF00498	0.329
LIG_FHA_1	450	456	PF00498	0.352
LIG_FHA_1	496	502	PF00498	0.371
LIG_FHA_1	51	57	PF00498	0.389
LIG_FHA_1	534	540	PF00498	0.416
LIG_FHA_1	541	547	PF00498	0.445
LIG_FHA_2	266	272	PF00498	0.303
LIG_FHA_2	409	415	PF00498	0.439
LIG_FHA_2	536	542	PF00498	0.373
LIG_Integrin_RGD_1	133	135	PF01839	0.521
LIG_LIR_Apic_2	23	27	PF02991	0.380
LIG_LIR_Apic_2	359	364	PF02991	0.439
LIG_LIR_Apic_2	487	492	PF02991	0.215
LIG_LIR_Gen_1	269	279	PF02991	0.296
LIG_LIR_Gen_1	411	419	PF02991	0.367
LIG_LIR_Gen_1	48	58	PF02991	0.441
LIG_LIR_LC3C_4	213	218	PF02991	0.520
LIG_LIR_Nem_3	269	275	PF02991	0.289
LIG_LIR_Nem_3	411	416	PF02991	0.367
LIG_LIR_Nem_3	44	49	PF02991	0.416
LIG_LIR_Nem_3	50	54	PF02991	0.436
LIG_MYND_1	291	295	PF01753	0.439
LIG_Pex14_1	241	245	PF04695	0.322
LIG_Pex14_2	560	564	PF04695	0.312
LIG_REV1ctd_RIR_1	160	171	PF16727	0.536
LIG_SH2_CRK	361	365	PF00017	0.395
LIG_SH2_NCK_1	361	365	PF00017	0.395
LIG_SH2_SRC	251	254	PF00017	0.258
LIG_SH2_SRC	361	364	PF00017	0.395
LIG_SH2_STAP1	245	249	PF00017	0.341
LIG_SH2_STAP1	260	264	PF00017	0.311
LIG_SH2_STAP1	413	417	PF00017	0.269
LIG_SH2_STAP1	482	486	PF00017	0.338
LIG_SH2_STAT5	484	487	PF00017	0.364
LIG_SH3_3	289	295	PF00018	0.416
LIG_SH3_3	300	306	PF00018	0.381
LIG_SH3_3	336	342	PF00018	0.409
LIG_SH3_3	389	395	PF00018	0.374
LIG_SH3_3	567	573	PF00018	0.519
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.402
LIG_SUMO_SIM_anti_2	253	261	PF11976	0.308
LIG_SUMO_SIM_anti_2	35	41	PF11976	0.410
LIG_SUMO_SIM_anti_2	512	518	PF11976	0.303
LIG_SUMO_SIM_par_1	173	179	PF11976	0.459
LIG_SUMO_SIM_par_1	228	233	PF11976	0.439
LIG_SUMO_SIM_par_1	35	41	PF11976	0.451
LIG_SUMO_SIM_par_1	497	503	PF11976	0.324
LIG_SUMO_SIM_par_1	535	543	PF11976	0.430
LIG_TRAF2_1	106	109	PF00917	0.516
LIG_TRAF2_1	113	116	PF00917	0.553
LIG_TRAF2_1	439	442	PF00917	0.395
LIG_TYR_ITSM	409	416	PF00017	0.311
LIG_WRC_WIRS_1	124	129	PF05994	0.341
LIG_WRC_WIRS_1	159	164	PF05994	0.544
MOD_CDC14_SPxK_1	76	79	PF00782	0.448
MOD_CDK_SPxK_1	73	79	PF00069	0.447
MOD_CK1_1	2	8	PF00069	0.466
MOD_CK1_1	280	286	PF00069	0.323
MOD_CK1_1	298	304	PF00069	0.378
MOD_CK1_1	332	338	PF00069	0.444
MOD_CK1_1	356	362	PF00069	0.311
MOD_CK1_1	446	452	PF00069	0.336
MOD_CK1_1	465	471	PF00069	0.183
MOD_CK1_1	473	479	PF00069	0.334
MOD_CK2_1	207	213	PF00069	0.512
MOD_CK2_1	251	257	PF00069	0.470
MOD_CK2_1	408	414	PF00069	0.428
MOD_CK2_1	435	441	PF00069	0.368
MOD_CK2_1	535	541	PF00069	0.381
MOD_CMANNOS	294	297	PF00535	0.439
MOD_GlcNHglycan	129	132	PF01048	0.583
MOD_GlcNHglycan	141	144	PF01048	0.664
MOD_GlcNHglycan	201	204	PF01048	0.568
MOD_GlcNHglycan	209	212	PF01048	0.532
MOD_GlcNHglycan	223	226	PF01048	0.544
MOD_GlcNHglycan	236	239	PF01048	0.476
MOD_GlcNHglycan	24	27	PF01048	0.525
MOD_GlcNHglycan	260	263	PF01048	0.451
MOD_GlcNHglycan	32	35	PF01048	0.426
MOD_GlcNHglycan	403	406	PF01048	0.439
MOD_GlcNHglycan	492	495	PF01048	0.436
MOD_GSK3_1	123	130	PF00069	0.388
MOD_GSK3_1	158	165	PF00069	0.514
MOD_GSK3_1	230	237	PF00069	0.351
MOD_GSK3_1	352	359	PF00069	0.319
MOD_GSK3_1	449	456	PF00069	0.398
MOD_GSK3_1	462	469	PF00069	0.341
MOD_N-GLC_1	356	361	PF02516	0.408
MOD_N-GLC_1	408	413	PF02516	0.335
MOD_N-GLC_1	429	434	PF02516	0.393
MOD_N-GLC_1	73	78	PF02516	0.443
MOD_N-GLC_2	528	530	PF02516	0.415
MOD_NEK2_1	114	119	PF00069	0.425
MOD_NEK2_1	127	132	PF00069	0.572
MOD_NEK2_1	162	167	PF00069	0.502
MOD_NEK2_1	212	217	PF00069	0.444
MOD_NEK2_1	22	27	PF00069	0.459
MOD_NEK2_1	277	282	PF00069	0.341
MOD_NEK2_1	326	331	PF00069	0.330
MOD_NEK2_1	403	408	PF00069	0.424
MOD_NEK2_1	443	448	PF00069	0.323
MOD_NEK2_1	471	476	PF00069	0.321
MOD_NEK2_2	158	163	PF00069	0.426
MOD_NEK2_2	365	370	PF00069	0.295
MOD_PIKK_1	429	435	PF00454	0.415
MOD_PIKK_1	473	479	PF00454	0.361
MOD_PKA_2	193	199	PF00069	0.502
MOD_PKA_2	2	8	PF00069	0.528
MOD_PKA_2	277	283	PF00069	0.376
MOD_PKA_2	295	301	PF00069	0.378
MOD_PKA_2	381	387	PF00069	0.379
MOD_PKA_2	78	84	PF00069	0.558
MOD_PKB_1	276	284	PF00069	0.439
MOD_Plk_1	212	218	PF00069	0.435
MOD_Plk_1	230	236	PF00069	0.351
MOD_Plk_1	356	362	PF00069	0.389
MOD_Plk_1	429	435	PF00069	0.368
MOD_Plk_1	443	449	PF00069	0.385
MOD_Plk_1	465	471	PF00069	0.415
MOD_Plk_2-3	535	541	PF00069	0.475
MOD_Plk_4	11	17	PF00069	0.386
MOD_Plk_4	123	129	PF00069	0.551
MOD_Plk_4	158	164	PF00069	0.450
MOD_Plk_4	2	8	PF00069	0.433
MOD_Plk_4	212	218	PF00069	0.428
MOD_Plk_4	32	38	PF00069	0.560
MOD_Plk_4	356	362	PF00069	0.456
MOD_Plk_4	424	430	PF00069	0.297
MOD_Plk_4	466	472	PF00069	0.459
MOD_Plk_4	495	501	PF00069	0.336
MOD_ProDKin_1	239	245	PF00069	0.338
MOD_ProDKin_1	286	292	PF00069	0.318
MOD_ProDKin_1	435	441	PF00069	0.367
MOD_ProDKin_1	569	575	PF00069	0.562
MOD_ProDKin_1	73	79	PF00069	0.447
MOD_SUMO_for_1	532	535	PF00179	0.258
MOD_SUMO_for_1	553	556	PF00179	0.215
MOD_SUMO_for_1	8	11	PF00179	0.393
TRG_ENDOCYTIC_2	413	416	PF00928	0.338
TRG_ER_diArg_1	275	278	PF00400	0.418
TRG_ER_diArg_1	318	320	PF00400	0.433
TRG_ER_diArg_1	388	391	PF00400	0.411
TRG_ER_diArg_1	460	462	PF00400	0.319
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W3	Leptomonas seymouri	23%	92%
A0A0N1IA86	Leptomonas seymouri	59%	100%
A0A0S4JNB4	Bodo saltans	30%	100%
A0A0S4KK03	Bodo saltans	27%	95%
A0A1X0P222	Trypanosomatidae	30%	94%
A0A3Q8IFG9	Leishmania donovani	25%	90%
A0A3Q8IHT6	Leishmania donovani	92%	100%
A0A422P4V3	Trypanosoma rangeli	31%	100%
A4HHL0	Leishmania braziliensis	25%	100%
A4HI48	Leishmania braziliensis	80%	100%
A4I4S0	Leishmania infantum	24%	90%
A4I5C4	Leishmania infantum	92%	100%
C9ZQQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZUB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	83%
E9AE72	Leishmania major	26%	100%
E9ALL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q7L0	Leishmania major	90%	100%
V5DQS5	Trypanosoma cruzi	32%	100%