Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0M1_LEIMU

TriTrypDb:

LmxM.29.0920

Length:

937

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0M1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.719
CLV_MEL_PAP_1	538	544	PF00089	0.533
CLV_NRD_NRD_1	3	5	PF00675	0.589
CLV_NRD_NRD_1	623	625	PF00675	0.543
CLV_NRD_NRD_1	748	750	PF00675	0.680
CLV_NRD_NRD_1	876	878	PF00675	0.559
CLV_PCSK_KEX2_1	3	5	PF00082	0.589
CLV_PCSK_KEX2_1	320	322	PF00082	0.513
CLV_PCSK_KEX2_1	48	50	PF00082	0.615
CLV_PCSK_KEX2_1	623	625	PF00082	0.543
CLV_PCSK_KEX2_1	748	750	PF00082	0.636
CLV_PCSK_KEX2_1	927	929	PF00082	0.542
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.513
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.542
CLV_PCSK_PC1ET2_1	927	929	PF00082	0.542
CLV_PCSK_PC7_1	619	625	PF00082	0.524
CLV_PCSK_SKI1_1	33	37	PF00082	0.337
CLV_PCSK_SKI1_1	332	336	PF00082	0.576
CLV_PCSK_SKI1_1	619	623	PF00082	0.532
CLV_PCSK_SKI1_1	699	703	PF00082	0.503
CLV_PCSK_SKI1_1	861	865	PF00082	0.512
CLV_PCSK_SKI1_1	877	881	PF00082	0.567
CLV_PCSK_SKI1_1	910	914	PF00082	0.483
DEG_APCC_DBOX_1	860	868	PF00400	0.522
DEG_MDM2_SWIB_1	828	836	PF02201	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DEG_SPOP_SBC_1	377	381	PF00917	0.467
DEG_SPOP_SBC_1	505	509	PF00917	0.759
DEG_SPOP_SBC_1	54	58	PF00917	0.661
DOC_CYCLIN_RxL_1	858	868	PF00134	0.517
DOC_MAPK_gen_1	320	326	PF00069	0.459
DOC_PP1_RVXF_1	864	870	PF00149	0.446
DOC_PP2B_LxvP_1	172	175	PF13499	0.594
DOC_USP7_MATH_1	233	237	PF00917	0.767
DOC_USP7_MATH_1	345	349	PF00917	0.687
DOC_USP7_MATH_1	370	374	PF00917	0.742
DOC_USP7_MATH_1	376	380	PF00917	0.682
DOC_USP7_MATH_1	505	509	PF00917	0.699
DOC_USP7_MATH_1	512	516	PF00917	0.620
DOC_USP7_MATH_1	53	57	PF00917	0.725
DOC_USP7_MATH_1	631	635	PF00917	0.640
DOC_USP7_MATH_1	691	695	PF00917	0.540
DOC_USP7_MATH_1	732	736	PF00917	0.656
DOC_USP7_MATH_1	8	12	PF00917	0.530
DOC_USP7_UBL2_3	568	572	PF12436	0.714
DOC_USP7_UBL2_3	910	914	PF12436	0.464
DOC_WW_Pin1_4	238	243	PF00397	0.738
DOC_WW_Pin1_4	571	576	PF00397	0.816
DOC_WW_Pin1_4	589	594	PF00397	0.515
DOC_WW_Pin1_4	661	666	PF00397	0.608
DOC_WW_Pin1_4	730	735	PF00397	0.707
DOC_WW_Pin1_4	789	794	PF00397	0.660
DOC_WW_Pin1_4	797	802	PF00397	0.703
DOC_WW_Pin1_4	81	86	PF00397	0.596
LIG_14-3-3_CanoR_1	246	252	PF00244	0.632
LIG_14-3-3_CanoR_1	267	271	PF00244	0.529
LIG_14-3-3_CanoR_1	3	7	PF00244	0.600
LIG_14-3-3_CanoR_1	321	327	PF00244	0.488
LIG_14-3-3_CanoR_1	38	46	PF00244	0.581
LIG_14-3-3_CanoR_1	406	411	PF00244	0.519
LIG_14-3-3_CanoR_1	476	480	PF00244	0.586
LIG_14-3-3_CanoR_1	541	550	PF00244	0.493
LIG_14-3-3_CanoR_1	613	622	PF00244	0.471
LIG_14-3-3_CanoR_1	637	647	PF00244	0.505
LIG_14-3-3_CanoR_1	749	755	PF00244	0.624
LIG_14-3-3_CanoR_1	877	885	PF00244	0.571
LIG_Actin_WH2_2	532	550	PF00022	0.586
LIG_Actin_WH2_2	608	625	PF00022	0.574
LIG_BIR_III_4	190	194	PF00653	0.453
LIG_BRCT_BRCA1_1	408	412	PF00533	0.568
LIG_BRCT_BRCA1_1	640	644	PF00533	0.620
LIG_CaM_IQ_9	461	477	PF13499	0.563
LIG_eIF4E_1	126	132	PF01652	0.535
LIG_eIF4E_1	441	447	PF01652	0.509
LIG_eIF4E_1	90	96	PF01652	0.548
LIG_FHA_1	103	109	PF00498	0.566
LIG_FHA_1	154	160	PF00498	0.536
LIG_FHA_1	321	327	PF00498	0.498
LIG_FHA_1	380	386	PF00498	0.633
LIG_FHA_1	459	465	PF00498	0.485
LIG_FHA_1	485	491	PF00498	0.426
LIG_FHA_1	590	596	PF00498	0.705
LIG_FHA_1	607	613	PF00498	0.322
LIG_FHA_1	837	843	PF00498	0.554
LIG_FHA_2	155	161	PF00498	0.607
LIG_FHA_2	199	205	PF00498	0.621
LIG_FHA_2	286	292	PF00498	0.507
LIG_FHA_2	299	305	PF00498	0.476
LIG_FHA_2	344	350	PF00498	0.686
LIG_FHA_2	544	550	PF00498	0.601
LIG_FHA_2	612	618	PF00498	0.575
LIG_FHA_2	924	930	PF00498	0.645
LIG_GBD_Chelix_1	859	867	PF00786	0.467
LIG_IBAR_NPY_1	775	777	PF08397	0.538
LIG_Integrin_isoDGR_2	635	637	PF01839	0.624
LIG_LIR_Gen_1	160	169	PF02991	0.445
LIG_LIR_Gen_1	288	296	PF02991	0.415
LIG_LIR_Gen_1	641	650	PF02991	0.580
LIG_LIR_Gen_1	720	729	PF02991	0.626
LIG_LIR_Gen_1	826	836	PF02991	0.444
LIG_LIR_Gen_1	853	864	PF02991	0.411
LIG_LIR_Gen_1	883	893	PF02991	0.429
LIG_LIR_LC3C_4	421	425	PF02991	0.283
LIG_LIR_Nem_3	304	309	PF02991	0.566
LIG_LIR_Nem_3	311	316	PF02991	0.400
LIG_LIR_Nem_3	672	677	PF02991	0.572
LIG_LIR_Nem_3	720	724	PF02991	0.580
LIG_LIR_Nem_3	771	777	PF02991	0.573
LIG_LIR_Nem_3	826	831	PF02991	0.411
LIG_LIR_Nem_3	853	859	PF02991	0.394
LIG_LIR_Nem_3	883	888	PF02991	0.507
LIG_LIR_Nem_3	894	900	PF02991	0.414
LIG_MYND_1	661	665	PF01753	0.708
LIG_NRBOX	253	259	PF00104	0.415
LIG_PCNA_yPIPBox_3	16	28	PF02747	0.626
LIG_Pex14_1	279	283	PF04695	0.489
LIG_Pex14_2	309	313	PF04695	0.536
LIG_Pex14_2	828	832	PF04695	0.415
LIG_SH2_CRK	885	889	PF00017	0.597
LIG_SH2_NCK_1	77	81	PF00017	0.702
LIG_SH2_SRC	677	680	PF00017	0.485
LIG_SH2_SRC	77	80	PF00017	0.674
LIG_SH2_STAP1	162	166	PF00017	0.443
LIG_SH2_STAP1	607	611	PF00017	0.474
LIG_SH2_STAP1	885	889	PF00017	0.495
LIG_SH2_STAP1	90	94	PF00017	0.514
LIG_SH2_STAT3	607	610	PF00017	0.524
LIG_SH2_STAT5	114	117	PF00017	0.524
LIG_SH2_STAT5	12	15	PF00017	0.578
LIG_SH2_STAT5	525	528	PF00017	0.526
LIG_SH2_STAT5	677	680	PF00017	0.485
LIG_SH2_STAT5	767	770	PF00017	0.677
LIG_SH2_STAT5	849	852	PF00017	0.415
LIG_SH2_STAT5	885	888	PF00017	0.508
LIG_SH3_1	655	661	PF00018	0.656
LIG_SH3_2	244	249	PF14604	0.577
LIG_SH3_3	227	233	PF00018	0.511
LIG_SH3_3	241	247	PF00018	0.596
LIG_SH3_3	405	411	PF00018	0.555
LIG_SH3_3	547	553	PF00018	0.594
LIG_SH3_3	582	588	PF00018	0.761
LIG_SH3_3	590	596	PF00018	0.670
LIG_SH3_3	655	661	PF00018	0.623
LIG_SH3_3	770	776	PF00018	0.597
LIG_Sin3_3	618	625	PF02671	0.550
LIG_SUMO_SIM_anti_2	331	338	PF11976	0.553
LIG_SUMO_SIM_par_1	600	605	PF11976	0.615
LIG_SUMO_SIM_par_1	84	91	PF11976	0.507
LIG_TRAF2_1	42	45	PF00917	0.611
LIG_TRAF2_1	497	500	PF00917	0.609
LIG_UBA3_1	384	390	PF00899	0.260
LIG_WRC_WIRS_1	132	137	PF05994	0.549
LIG_WRC_WIRS_1	96	101	PF05994	0.561
LIG_WW_3	246	250	PF00397	0.531
LIG_WW_3	656	660	PF00397	0.627
MOD_CK1_1	102	108	PF00069	0.597
MOD_CK1_1	154	160	PF00069	0.615
MOD_CK1_1	236	242	PF00069	0.794
MOD_CK1_1	262	268	PF00069	0.561
MOD_CK1_1	294	300	PF00069	0.550
MOD_CK1_1	379	385	PF00069	0.655
MOD_CK1_1	504	510	PF00069	0.655
MOD_CK1_1	540	546	PF00069	0.514
MOD_CK1_1	566	572	PF00069	0.629
MOD_CK1_1	574	580	PF00069	0.804
MOD_CK1_1	583	589	PF00069	0.672
MOD_CK1_1	65	71	PF00069	0.683
MOD_CK1_1	694	700	PF00069	0.604
MOD_CK1_1	733	739	PF00069	0.649
MOD_CK1_1	841	847	PF00069	0.596
MOD_CK2_1	154	160	PF00069	0.619
MOD_CK2_1	198	204	PF00069	0.544
MOD_CK2_1	209	215	PF00069	0.439
MOD_CK2_1	343	349	PF00069	0.672
MOD_CK2_1	500	506	PF00069	0.745
MOD_CK2_1	602	608	PF00069	0.502
MOD_CK2_1	611	617	PF00069	0.428
MOD_CK2_1	736	742	PF00069	0.673
MOD_CK2_1	85	91	PF00069	0.524
MOD_CK2_1	923	929	PF00069	0.576
MOD_GlcNHglycan	107	111	PF01048	0.544
MOD_GlcNHglycan	153	156	PF01048	0.552
MOD_GlcNHglycan	249	252	PF01048	0.522
MOD_GlcNHglycan	39	42	PF01048	0.512
MOD_GlcNHglycan	503	506	PF01048	0.746
MOD_GlcNHglycan	51	54	PF01048	0.566
MOD_GlcNHglycan	514	517	PF01048	0.614
MOD_GlcNHglycan	542	545	PF01048	0.586
MOD_GlcNHglycan	576	579	PF01048	0.721
MOD_GlcNHglycan	689	692	PF01048	0.549
MOD_GlcNHglycan	730	733	PF01048	0.685
MOD_GlcNHglycan	759	762	PF01048	0.725
MOD_GlcNHglycan	770	773	PF01048	0.655
MOD_GlcNHglycan	793	796	PF01048	0.568
MOD_GSK3_1	127	134	PF00069	0.570
MOD_GSK3_1	151	158	PF00069	0.550
MOD_GSK3_1	200	207	PF00069	0.636
MOD_GSK3_1	234	241	PF00069	0.781
MOD_GSK3_1	261	268	PF00069	0.590
MOD_GSK3_1	291	298	PF00069	0.491
MOD_GSK3_1	376	383	PF00069	0.712
MOD_GSK3_1	402	409	PF00069	0.592
MOD_GSK3_1	431	438	PF00069	0.460
MOD_GSK3_1	448	455	PF00069	0.546
MOD_GSK3_1	49	56	PF00069	0.613
MOD_GSK3_1	500	507	PF00069	0.710
MOD_GSK3_1	514	521	PF00069	0.571
MOD_GSK3_1	563	570	PF00069	0.697
MOD_GSK3_1	576	583	PF00069	0.698
MOD_GSK3_1	602	609	PF00069	0.542
MOD_GSK3_1	65	72	PF00069	0.698
MOD_GSK3_1	687	694	PF00069	0.624
MOD_GSK3_1	728	735	PF00069	0.649
MOD_GSK3_1	750	757	PF00069	0.675
MOD_GSK3_1	783	790	PF00069	0.691
MOD_GSK3_1	791	798	PF00069	0.676
MOD_GSK3_1	81	88	PF00069	0.477
MOD_GSK3_1	837	844	PF00069	0.476
MOD_GSK3_1	873	880	PF00069	0.553
MOD_GSK3_1	95	102	PF00069	0.457
MOD_N-GLC_1	629	634	PF02516	0.575
MOD_N-GLC_1	883	888	PF02516	0.519
MOD_N-GLC_2	785	787	PF02516	0.756
MOD_NEK2_1	108	113	PF00069	0.459
MOD_NEK2_1	131	136	PF00069	0.549
MOD_NEK2_1	151	156	PF00069	0.610
MOD_NEK2_1	2	7	PF00069	0.541
MOD_NEK2_1	384	389	PF00069	0.429
MOD_NEK2_1	392	397	PF00069	0.425
MOD_NEK2_1	431	436	PF00069	0.627
MOD_NEK2_1	452	457	PF00069	0.466
MOD_NEK2_1	484	489	PF00069	0.714
MOD_NEK2_1	490	495	PF00069	0.752
MOD_NEK2_1	511	516	PF00069	0.768
MOD_NEK2_1	611	616	PF00069	0.544
MOD_NEK2_1	687	692	PF00069	0.541
MOD_NEK2_1	69	74	PF00069	0.602
MOD_NEK2_1	728	733	PF00069	0.593
MOD_NEK2_1	743	748	PF00069	0.530
MOD_NEK2_1	768	773	PF00069	0.633
MOD_NEK2_1	836	841	PF00069	0.547
MOD_NEK2_1	95	100	PF00069	0.481
MOD_NEK2_2	525	530	PF00069	0.627
MOD_PIKK_1	102	108	PF00454	0.575
MOD_PIKK_1	606	612	PF00454	0.613
MOD_PIKK_1	639	645	PF00454	0.562
MOD_PIKK_1	736	742	PF00454	0.673
MOD_PIKK_1	795	801	PF00454	0.763
MOD_PIKK_1	877	883	PF00454	0.568
MOD_PK_1	838	844	PF00069	0.614
MOD_PKA_1	320	326	PF00069	0.374
MOD_PKA_1	48	54	PF00069	0.564
MOD_PKA_1	877	883	PF00069	0.568
MOD_PKA_2	2	8	PF00069	0.590
MOD_PKA_2	266	272	PF00069	0.549
MOD_PKA_2	320	326	PF00069	0.483
MOD_PKA_2	37	43	PF00069	0.535
MOD_PKA_2	370	376	PF00069	0.790
MOD_PKA_2	475	481	PF00069	0.614
MOD_PKA_2	48	54	PF00069	0.540
MOD_PKA_2	490	496	PF00069	0.678
MOD_PKA_2	540	546	PF00069	0.504
MOD_PKA_2	639	645	PF00069	0.494
MOD_PKA_2	680	686	PF00069	0.541
MOD_PKA_2	691	697	PF00069	0.453
MOD_PKA_2	750	756	PF00069	0.630
MOD_PKA_2	918	924	PF00069	0.633
MOD_Plk_1	121	127	PF00069	0.563
MOD_Plk_1	629	635	PF00069	0.437
MOD_Plk_1	681	687	PF00069	0.535
MOD_Plk_1	883	889	PF00069	0.471
MOD_Plk_1	891	897	PF00069	0.432
MOD_Plk_4	127	133	PF00069	0.466
MOD_Plk_4	253	259	PF00069	0.415
MOD_Plk_4	291	297	PF00069	0.519
MOD_Plk_4	308	314	PF00069	0.342
MOD_Plk_4	380	386	PF00069	0.507
MOD_Plk_4	424	430	PF00069	0.485
MOD_Plk_4	448	454	PF00069	0.512
MOD_Plk_4	534	540	PF00069	0.478
MOD_Plk_4	8	14	PF00069	0.513
MOD_Plk_4	85	91	PF00069	0.569
MOD_Plk_4	883	889	PF00069	0.467
MOD_Plk_4	892	898	PF00069	0.428
MOD_Plk_4	95	101	PF00069	0.449
MOD_ProDKin_1	238	244	PF00069	0.737
MOD_ProDKin_1	571	577	PF00069	0.815
MOD_ProDKin_1	589	595	PF00069	0.510
MOD_ProDKin_1	661	667	PF00069	0.602
MOD_ProDKin_1	730	736	PF00069	0.708
MOD_ProDKin_1	789	795	PF00069	0.657
MOD_ProDKin_1	797	803	PF00069	0.700
MOD_ProDKin_1	81	87	PF00069	0.577
TRG_DiLeu_BaEn_1	331	336	PF01217	0.579
TRG_DiLeu_BaEn_1	91	96	PF01217	0.446
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.619
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.572
TRG_ENDOCYTIC_2	162	165	PF00928	0.446
TRG_ENDOCYTIC_2	885	888	PF00928	0.485
TRG_ER_diArg_1	2	4	PF00400	0.636
TRG_ER_diArg_1	360	363	PF00400	0.502
TRG_ER_diArg_1	622	624	PF00400	0.617
TRG_ER_diArg_1	747	749	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	766	770	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	898	902	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M8	Leptomonas seymouri	58%	100%
A0A0S4JAN9	Bodo saltans	29%	100%
A0A1X0P2C0	Trypanosomatidae	36%	100%
A0A3Q8IEP4	Leishmania donovani	94%	100%
A0A422P4V0	Trypanosoma rangeli	36%	100%
A4HI47	Leishmania braziliensis	82%	99%
A4I5C3	Leishmania infantum	94%	100%
Q4Q7L1	Leishmania major	93%	100%
V5BU87	Trypanosoma cruzi	37%	100%