Putative surface protein amastin

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface protein amastin, putative

Species:

Leishmania mexicana

UniProt:

E9B0L4_LEIMU

TriTrypDb:

LmxM.29.0850

Length:

198

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 71
NetGPI	no	yes: 0, no: 76

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	68
GO:0110165	cellular anatomical entity	1	68

Expansion

Sequence features

E9B0L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0L4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.313
CLV_PCSK_SKI1_1	81	85	PF00082	0.591
DOC_CYCLIN_RxL_1	78	88	PF00134	0.253
DOC_MAPK_gen_1	113	121	PF00069	0.583
DOC_MAPK_gen_1	7	14	PF00069	0.562
DOC_MAPK_MEF2A_6	113	121	PF00069	0.574
DOC_MAPK_MEF2A_6	7	16	PF00069	0.585
DOC_USP7_MATH_1	163	167	PF00917	0.394
LIG_BRCT_BRCA1_1	86	90	PF00533	0.322
LIG_EH1_1	90	98	PF00400	0.432
LIG_FHA_1	147	153	PF00498	0.380
LIG_FHA_1	185	191	PF00498	0.418
LIG_GBD_Chelix_1	92	100	PF00786	0.454
LIG_LIR_Nem_3	87	93	PF02991	0.307
LIG_NRBOX	116	122	PF00104	0.526
LIG_Pex14_1	140	144	PF04695	0.380
LIG_SH2_CRK	164	168	PF00017	0.250
LIG_SH2_STAT5	108	111	PF00017	0.362
LIG_SH2_STAT5	144	147	PF00017	0.341
LIG_SH2_STAT5	91	94	PF00017	0.431
LIG_SUMO_SIM_par_1	119	125	PF11976	0.344
LIG_TYR_ITIM	162	167	PF00017	0.238
LIG_WRC_WIRS_1	96	101	PF05994	0.431
MOD_CK1_1	49	55	PF00069	0.374
MOD_CK1_1	98	104	PF00069	0.391
MOD_GlcNHglycan	104	107	PF01048	0.422
MOD_GlcNHglycan	174	177	PF01048	0.545
MOD_GlcNHglycan	28	31	PF01048	0.436
MOD_GlcNHglycan	42	45	PF01048	0.576
MOD_GSK3_1	12	19	PF00069	0.486
MOD_GSK3_1	168	175	PF00069	0.259
MOD_GSK3_1	26	33	PF00069	0.422
MOD_GSK3_1	42	49	PF00069	0.370
MOD_GSK3_1	98	105	PF00069	0.369
MOD_N-GLC_1	152	157	PF02516	0.600
MOD_N-GLC_1	40	45	PF02516	0.487
MOD_N-GLC_2	143	145	PF02516	0.590
MOD_N-GLC_2	61	63	PF02516	0.581
MOD_NEK2_1	16	21	PF00069	0.408
MOD_NEK2_1	168	173	PF00069	0.334
MOD_NEK2_1	25	30	PF00069	0.398
MOD_NEK2_2	146	151	PF00069	0.423
MOD_PIKK_1	184	190	PF00454	0.265
MOD_PIKK_1	30	36	PF00454	0.467
MOD_PK_1	71	77	PF00069	0.258
MOD_PKA_2	168	174	PF00069	0.421
MOD_PKA_2	70	76	PF00069	0.417
MOD_Plk_4	12	18	PF00069	0.331
MOD_Plk_4	163	169	PF00069	0.263
MOD_Plk_4	95	101	PF00069	0.381
TRG_ENDOCYTIC_2	164	167	PF00928	0.376
TRG_ER_diArg_1	35	38	PF00400	0.332
TRG_ER_diArg_1	6	9	PF00400	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	29%	100%
A0A0N0P547	Leptomonas seymouri	23%	100%
A0A0N0P993	Leptomonas seymouri	27%	88%
A0A0N1I0E5	Leptomonas seymouri	25%	100%
A0A0N1PAD5	Leptomonas seymouri	26%	79%
A0A0N1PDH0	Leptomonas seymouri	27%	98%
A0A0S4J784	Bodo saltans	23%	89%
A0A1X0NQ58	Trypanosomatidae	28%	100%
A0A1X0NUH1	Trypanosomatidae	24%	87%
A0A1X0NX02	Trypanosomatidae	26%	100%
A0A1X0P2R3	Trypanosomatidae	28%	94%
A0A1X0P988	Trypanosomatidae	28%	100%
A0A381MTN2	Leishmania infantum	25%	100%
A0A3Q8ID16	Leishmania donovani	25%	100%
A0A3Q8IEC2	Leishmania donovani	23%	100%
A0A3Q8IEI1	Leishmania donovani	26%	100%
A0A3Q8IFI8	Leishmania donovani	93%	100%
A0A3Q8IL03	Leishmania donovani	22%	100%
A0A3Q8IMR4	Leishmania donovani	23%	100%
A0A3Q8IUR5	Leishmania donovani	25%	100%
A0A3S5H666	Leishmania donovani	25%	100%
A0A3S5H7D2	Leishmania donovani	26%	100%
A0A3S7WQA8	Leishmania donovani	24%	100%
A0A3S7X357	Leishmania donovani	27%	89%
A0A3S7X381	Leishmania donovani	94%	100%
A0A3S7X7E5	Leishmania donovani	28%	79%
A0A3S7X7W2	Leishmania donovani	26%	94%
A0A3S7X7Y0	Leishmania donovani	24%	100%
A4H5G0	Leishmania braziliensis	24%	100%
A4H7D7	Leishmania braziliensis	24%	100%
A4HAM2	Leishmania braziliensis	25%	100%
A4HAM4	Leishmania braziliensis	25%	100%
A4HAR1	Leishmania braziliensis	24%	100%
A4HAZ8	Leishmania braziliensis	26%	100%
A4HBJ1	Leishmania braziliensis	25%	100%
A4HDI3	Leishmania braziliensis	26%	82%
A4HDL3	Leishmania braziliensis	28%	100%
A4HI41	Leishmania braziliensis	77%	100%
A4HI43	Leishmania braziliensis	24%	100%
A4HTM3	Leishmania infantum	23%	100%
A4HTM4	Leishmania infantum	25%	100%
A4HTM5	Leishmania infantum	24%	100%
A4I0W4	Leishmania infantum	26%	100%
A4I0W5	Leishmania infantum	25%	100%
A4I5B8	Leishmania infantum	93%	100%
A4I5B9	Leishmania infantum	27%	89%
A4I9X0	Leishmania infantum	26%	94%
A4IA59	Leishmania infantum	25%	76%
A4IAM2	Leishmania infantum	26%	100%
C6K3X5	Leptomonas seymouri	59%	99%
C6K3X9	Leptomonas seymouri	26%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AG83	Leishmania infantum	23%	99%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	91%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	99%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	97%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	89%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q309	Leishmania major	26%	98%
Q4Q317	Leishmania major	24%	98%
Q4Q3A8	Leishmania major	24%	100%
Q4Q7L6	Leishmania major	28%	100%
Q4Q7L7	Leishmania major	91%	98%
Q4Q7L8	Leishmania major	92%	98%
Q4QAK4	Leishmania major	23%	100%
Q4QAK5	Leishmania major	25%	100%
Q4QAK6	Leishmania major	26%	88%
Q4QAK7	Leishmania major	23%	100%
Q4QI84	Leishmania major	29%	88%
Q4QI86	Leishmania major	26%	88%
Q4QI87	Leishmania major	25%	99%
Q4QI88	Leishmania major	24%	98%