G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania mexicana

UniProt:

E9B0L3_LEIMU

TriTrypDb:

LmxM.29.0840

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0L3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	3
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0005525	GTP binding	5	5
GO:0017076	purine nucleotide binding	4	5
GO:0019001	guanyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032561	guanyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097367	carbohydrate derivative binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	556	560	PF00656	0.647
CLV_C14_Caspase3-7	852	856	PF00656	0.676
CLV_NRD_NRD_1	136	138	PF00675	0.600
CLV_NRD_NRD_1	194	196	PF00675	0.653
CLV_NRD_NRD_1	233	235	PF00675	0.585
CLV_NRD_NRD_1	379	381	PF00675	0.556
CLV_NRD_NRD_1	464	466	PF00675	0.397
CLV_NRD_NRD_1	511	513	PF00675	0.610
CLV_NRD_NRD_1	550	552	PF00675	0.564
CLV_NRD_NRD_1	671	673	PF00675	0.432
CLV_NRD_NRD_1	675	677	PF00675	0.426
CLV_NRD_NRD_1	782	784	PF00675	0.442
CLV_NRD_NRD_1	832	834	PF00675	0.591
CLV_NRD_NRD_1	840	842	PF00675	0.588
CLV_PCSK_FUR_1	779	783	PF00082	0.509
CLV_PCSK_KEX2_1	135	137	PF00082	0.609
CLV_PCSK_KEX2_1	379	381	PF00082	0.569
CLV_PCSK_KEX2_1	464	466	PF00082	0.397
CLV_PCSK_KEX2_1	490	492	PF00082	0.477
CLV_PCSK_KEX2_1	511	513	PF00082	0.610
CLV_PCSK_KEX2_1	671	673	PF00082	0.432
CLV_PCSK_KEX2_1	781	783	PF00082	0.473
CLV_PCSK_KEX2_1	832	834	PF00082	0.596
CLV_PCSK_KEX2_1	839	841	PF00082	0.579
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.727
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.477
CLV_PCSK_PC1ET2_1	839	841	PF00082	0.665
CLV_PCSK_SKI1_1	234	238	PF00082	0.593
CLV_PCSK_SKI1_1	361	365	PF00082	0.549
CLV_PCSK_SKI1_1	393	397	PF00082	0.540
CLV_PCSK_SKI1_1	564	568	PF00082	0.524
CLV_PCSK_SKI1_1	594	598	PF00082	0.559
CLV_PCSK_SKI1_1	662	666	PF00082	0.514
CLV_PCSK_SKI1_1	708	712	PF00082	0.393
CLV_PCSK_SKI1_1	80	84	PF00082	0.774
CLV_PCSK_SKI1_1	827	831	PF00082	0.410
CLV_PCSK_SKI1_1	840	844	PF00082	0.659
CLV_Separin_Metazoa	822	826	PF03568	0.419
DEG_APCC_DBOX_1	661	669	PF00400	0.588
DEG_APCC_DBOX_1	707	715	PF00400	0.410
DOC_CKS1_1	570	575	PF01111	0.492
DOC_CKS1_1	650	655	PF01111	0.437
DOC_CKS1_1	869	874	PF01111	0.639
DOC_CYCLIN_RxL_1	106	117	PF00134	0.657
DOC_CYCLIN_RxL_1	658	666	PF00134	0.511
DOC_CYCLIN_RxL_1	704	716	PF00134	0.476
DOC_MAPK_gen_1	204	211	PF00069	0.573
DOC_MAPK_gen_1	393	403	PF00069	0.422
DOC_MAPK_gen_1	464	472	PF00069	0.390
DOC_MAPK_gen_1	590	598	PF00069	0.594
DOC_MAPK_gen_1	781	790	PF00069	0.400
DOC_MAPK_MEF2A_6	396	405	PF00069	0.400
DOC_MAPK_MEF2A_6	464	472	PF00069	0.404
DOC_PP1_RVXF_1	233	240	PF00149	0.592
DOC_PP1_RVXF_1	562	569	PF00149	0.645
DOC_PP1_RVXF_1	706	713	PF00149	0.518
DOC_PP2B_LxvP_1	540	543	PF13499	0.531
DOC_PP2B_LxvP_1	685	688	PF13499	0.547
DOC_PP2B_LxvP_1	742	745	PF13499	0.399
DOC_PP4_FxxP_1	271	274	PF00568	0.478
DOC_PP4_FxxP_1	474	477	PF00568	0.402
DOC_PP4_FxxP_1	678	681	PF00568	0.504
DOC_PP4_FxxP_1	68	71	PF00568	0.630
DOC_SPAK_OSR1_1	218	222	PF12202	0.582
DOC_USP7_MATH_1	57	61	PF00917	0.722
DOC_USP7_MATH_1	64	68	PF00917	0.745
DOC_USP7_MATH_1	82	86	PF00917	0.713
DOC_USP7_MATH_1	874	878	PF00917	0.735
DOC_USP7_MATH_1	882	886	PF00917	0.766
DOC_USP7_MATH_1	91	95	PF00917	0.694
DOC_USP7_UBL2_3	231	235	PF12436	0.663
DOC_USP7_UBL2_3	590	594	PF12436	0.566
DOC_WW_Pin1_4	174	179	PF00397	0.653
DOC_WW_Pin1_4	187	192	PF00397	0.769
DOC_WW_Pin1_4	356	361	PF00397	0.609
DOC_WW_Pin1_4	569	574	PF00397	0.497
DOC_WW_Pin1_4	615	620	PF00397	0.558
DOC_WW_Pin1_4	649	654	PF00397	0.438
DOC_WW_Pin1_4	868	873	PF00397	0.709
DOC_WW_Pin1_4	97	102	PF00397	0.655
LIG_14-3-3_CanoR_1	380	386	PF00244	0.532
LIG_14-3-3_CanoR_1	440	445	PF00244	0.500
LIG_14-3-3_CanoR_1	612	616	PF00244	0.531
LIG_14-3-3_CanoR_1	628	636	PF00244	0.674
LIG_14-3-3_CanoR_1	662	668	PF00244	0.512
LIG_14-3-3_CanoR_1	671	675	PF00244	0.368
LIG_14-3-3_CanoR_1	765	773	PF00244	0.439
LIG_14-3-3_CanoR_1	809	814	PF00244	0.396
LIG_14-3-3_CanoR_1	840	847	PF00244	0.633
LIG_14-3-3_CanoR_1	864	869	PF00244	0.664
LIG_14-3-3_CanoR_1	896	905	PF00244	0.650
LIG_BIR_III_4	294	298	PF00653	0.534
LIG_BIR_III_4	559	563	PF00653	0.678
LIG_BRCT_BRCA1_1	729	733	PF00533	0.411
LIG_BRCT_BRCA1_1	770	774	PF00533	0.450
LIG_BRCT_BRCA1_1	901	905	PF00533	0.608
LIG_Clathr_ClatBox_1	166	170	PF01394	0.648
LIG_Clathr_ClatBox_1	751	755	PF01394	0.642
LIG_deltaCOP1_diTrp_1	341	346	PF00928	0.534
LIG_eIF4E_1	417	423	PF01652	0.428
LIG_eIF4E_1	650	656	PF01652	0.560
LIG_FHA_1	387	393	PF00498	0.481
LIG_FHA_1	494	500	PF00498	0.496
LIG_FHA_1	517	523	PF00498	0.455
LIG_FHA_1	603	609	PF00498	0.616
LIG_FHA_1	650	656	PF00498	0.444
LIG_FHA_1	689	695	PF00498	0.402
LIG_FHA_2	346	352	PF00498	0.474
LIG_FHA_2	554	560	PF00498	0.622
LIG_FXI_DFP_1	408	412	PF00024	0.395
LIG_LIR_Apic_2	269	274	PF02991	0.511
LIG_LIR_Apic_2	414	420	PF02991	0.416
LIG_LIR_Apic_2	647	653	PF02991	0.535
LIG_LIR_Apic_2	67	71	PF02991	0.628
LIG_LIR_Gen_1	341	347	PF02991	0.521
LIG_LIR_Gen_1	350	360	PF02991	0.480
LIG_LIR_Gen_1	747	754	PF02991	0.637
LIG_LIR_Gen_1	902	912	PF02991	0.568
LIG_LIR_Nem_3	293	299	PF02991	0.453
LIG_LIR_Nem_3	341	346	PF02991	0.534
LIG_LIR_Nem_3	350	355	PF02991	0.462
LIG_LIR_Nem_3	519	524	PF02991	0.398
LIG_LIR_Nem_3	747	751	PF02991	0.612
LIG_LIR_Nem_3	771	777	PF02991	0.453
LIG_LIR_Nem_3	902	908	PF02991	0.585
LIG_MYND_1	653	657	PF01753	0.439
LIG_NRBOX	663	669	PF00104	0.507
LIG_PALB2_WD40_1	28	36	PF16756	0.485
LIG_PCNA_PIPBox_1	325	334	PF02747	0.486
LIG_PCNA_yPIPBox_3	478	491	PF02747	0.551
LIG_PTB_Apo_2	438	445	PF02174	0.476
LIG_SH2_CRK	207	211	PF00017	0.580
LIG_SH2_CRK	417	421	PF00017	0.440
LIG_SH2_CRK	571	575	PF00017	0.492
LIG_SH2_CRK	650	654	PF00017	0.559
LIG_SH2_NCK_1	417	421	PF00017	0.440
LIG_SH2_NCK_1	571	575	PF00017	0.492
LIG_SH2_NCK_1	650	654	PF00017	0.559
LIG_SH2_PTP2	298	301	PF00017	0.579
LIG_SH2_STAP1	321	325	PF00017	0.462
LIG_SH2_STAP1	748	752	PF00017	0.622
LIG_SH2_STAT3	307	310	PF00017	0.579
LIG_SH2_STAT3	541	544	PF00017	0.667
LIG_SH2_STAT3	715	718	PF00017	0.409
LIG_SH2_STAT5	298	301	PF00017	0.432
LIG_SH2_STAT5	307	310	PF00017	0.459
LIG_SH2_STAT5	462	465	PF00017	0.416
LIG_SH2_STAT5	520	523	PF00017	0.396
LIG_SH2_STAT5	541	544	PF00017	0.558
LIG_SH2_STAT5	555	558	PF00017	0.500
LIG_SH2_STAT5	571	574	PF00017	0.489
LIG_SH2_STAT5	648	651	PF00017	0.488
LIG_SH2_STAT5	715	718	PF00017	0.393
LIG_SH2_STAT5	772	775	PF00017	0.433
LIG_SH2_STAT5	789	792	PF00017	0.377
LIG_SH3_3	270	276	PF00018	0.589
LIG_SH3_3	510	516	PF00018	0.580
LIG_SH3_3	539	545	PF00018	0.531
LIG_SH3_3	633	639	PF00018	0.484
LIG_SH3_3	700	706	PF00018	0.499
LIG_SH3_3	797	803	PF00018	0.444
LIG_SH3_3	817	823	PF00018	0.222
LIG_SH3_3	866	872	PF00018	0.735
LIG_SH3_3	889	895	PF00018	0.706
LIG_SUMO_SIM_anti_2	663	669	PF11976	0.475
LIG_SUMO_SIM_par_1	163	170	PF11976	0.595
LIG_SUMO_SIM_par_1	401	407	PF11976	0.354
LIG_SxIP_EBH_1	98	109	PF03271	0.462
LIG_TRAF2_1	348	351	PF00917	0.487
LIG_TRFH_1	684	688	PF08558	0.400
LIG_WRC_WIRS_1	65	70	PF05994	0.633
LIG_WW_3	36	40	PF00397	0.466
LIG_WW_3	705	709	PF00397	0.524
LIG_WW_3	762	766	PF00397	0.505
MOD_CDK_SPK_2	187	192	PF00069	0.672
MOD_CDK_SPK_2	356	361	PF00069	0.609
MOD_CK1_1	663	669	PF00069	0.458
MOD_CK1_1	858	864	PF00069	0.627
MOD_CK1_1	86	92	PF00069	0.768
MOD_CK1_1	885	891	PF00069	0.732
MOD_CK1_1	899	905	PF00069	0.528
MOD_CK2_1	345	351	PF00069	0.485
MOD_CK2_1	497	503	PF00069	0.484
MOD_CK2_1	874	880	PF00069	0.736
MOD_Cter_Amidation	377	380	PF01082	0.555
MOD_Cter_Amidation	561	564	PF01082	0.479
MOD_GlcNHglycan	3	6	PF01048	0.663
MOD_GlcNHglycan	383	386	PF01048	0.518
MOD_GlcNHglycan	487	490	PF01048	0.397
MOD_GlcNHglycan	499	502	PF01048	0.391
MOD_GlcNHglycan	59	62	PF01048	0.643
MOD_GlcNHglycan	631	634	PF01048	0.606
MOD_GlcNHglycan	758	761	PF01048	0.625
MOD_GlcNHglycan	866	869	PF01048	0.728
MOD_GlcNHglycan	876	879	PF01048	0.756
MOD_GlcNHglycan	89	92	PF01048	0.710
MOD_GlcNHglycan	898	901	PF01048	0.653
MOD_GSK3_1	117	124	PF00069	0.611
MOD_GSK3_1	493	500	PF00069	0.502
MOD_GSK3_1	53	60	PF00069	0.604
MOD_GSK3_1	590	597	PF00069	0.560
MOD_GSK3_1	611	618	PF00069	0.695
MOD_GSK3_1	764	771	PF00069	0.470
MOD_GSK3_1	794	801	PF00069	0.484
MOD_GSK3_1	82	89	PF00069	0.755
MOD_GSK3_1	849	856	PF00069	0.680
MOD_GSK3_1	864	871	PF00069	0.528
MOD_GSK3_1	97	104	PF00069	0.689
MOD_LATS_1	588	594	PF00433	0.574
MOD_LATS_1	894	900	PF00433	0.762
MOD_N-GLC_1	199	204	PF02516	0.644
MOD_N-GLC_1	289	294	PF02516	0.610
MOD_N-GLC_1	440	445	PF02516	0.477
MOD_NEK2_1	107	112	PF00069	0.718
MOD_NEK2_1	596	601	PF00069	0.555
MOD_NEK2_1	629	634	PF00069	0.527
MOD_NEK2_1	670	675	PF00069	0.413
MOD_NEK2_1	713	718	PF00069	0.386
MOD_NEK2_1	766	771	PF00069	0.449
MOD_NEK2_1	793	798	PF00069	0.504
MOD_NEK2_2	688	693	PF00069	0.361
MOD_NEK2_2	882	887	PF00069	0.745
MOD_PIKK_1	345	351	PF00454	0.475
MOD_PIKK_1	642	648	PF00454	0.594
MOD_PIKK_1	714	720	PF00454	0.409
MOD_PK_1	449	455	PF00069	0.655
MOD_PKA_1	135	141	PF00069	0.731
MOD_PKA_1	590	596	PF00069	0.582
MOD_PKA_1	840	846	PF00069	0.631
MOD_PKA_2	135	141	PF00069	0.603
MOD_PKA_2	611	617	PF00069	0.545
MOD_PKA_2	627	633	PF00069	0.610
MOD_PKA_2	670	676	PF00069	0.417
MOD_PKA_2	764	770	PF00069	0.447
MOD_PKA_2	840	846	PF00069	0.631
MOD_Plk_1	440	446	PF00069	0.475
MOD_Plk_1	449	455	PF00069	0.524
MOD_Plk_1	660	666	PF00069	0.322
MOD_Plk_1	882	888	PF00069	0.758
MOD_Plk_2-3	849	855	PF00069	0.726
MOD_Plk_4	142	148	PF00069	0.581
MOD_Plk_4	259	265	PF00069	0.611
MOD_Plk_4	411	417	PF00069	0.386
MOD_Plk_4	458	464	PF00069	0.487
MOD_Plk_4	516	522	PF00069	0.419
MOD_Plk_4	528	534	PF00069	0.402
MOD_Plk_4	644	650	PF00069	0.583
MOD_Plk_4	663	669	PF00069	0.300
MOD_Plk_4	688	694	PF00069	0.374
MOD_Plk_4	858	864	PF00069	0.627
MOD_ProDKin_1	174	180	PF00069	0.657
MOD_ProDKin_1	187	193	PF00069	0.764
MOD_ProDKin_1	356	362	PF00069	0.605
MOD_ProDKin_1	569	575	PF00069	0.500
MOD_ProDKin_1	615	621	PF00069	0.554
MOD_ProDKin_1	649	655	PF00069	0.437
MOD_ProDKin_1	868	874	PF00069	0.710
MOD_ProDKin_1	97	103	PF00069	0.655
MOD_SUMO_for_1	622	625	PF00179	0.733
MOD_SUMO_rev_2	230	237	PF00179	0.592
MOD_SUMO_rev_2	252	262	PF00179	0.658
MOD_SUMO_rev_2	583	593	PF00179	0.606
TRG_DiLeu_BaEn_3	341	347	PF01217	0.521
TRG_DiLeu_BaEn_4	164	170	PF01217	0.684
TRG_DiLeu_BaLyEn_6	861	866	PF01217	0.671
TRG_ENDOCYTIC_2	207	210	PF00928	0.593
TRG_ENDOCYTIC_2	748	751	PF00928	0.616
TRG_ER_diArg_1	136	139	PF00400	0.629
TRG_ER_diArg_1	439	442	PF00400	0.449
TRG_ER_diArg_1	463	465	PF00400	0.397
TRG_ER_diArg_1	510	512	PF00400	0.605
TRG_ER_diArg_1	584	587	PF00400	0.712
TRG_ER_diArg_1	670	672	PF00400	0.442
TRG_ER_diArg_1	779	782	PF00400	0.479
TRG_ER_diArg_1	808	811	PF00400	0.391
TRG_ER_diArg_1	840	842	PF00400	0.605
TRG_NES_CRM1_1	199	215	PF08389	0.604
TRG_NLS_MonoExtC_3	134	139	PF00514	0.717
TRG_NLS_MonoExtN_4	836	843	PF00514	0.647
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAV8	Bodo saltans	55%	100%
A0A1X0P214	Trypanosomatidae	64%	95%
A0A3Q8IFP9	Leishmania donovani	94%	100%
A0A3R7N4Q1	Trypanosoma rangeli	67%	99%
A4HI40	Leishmania braziliensis	88%	100%
A4I5B7	Leishmania infantum	94%	100%
C6K3X4	Leptomonas seymouri	72%	90%
C9ZQP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
Q4Q7L9	Leishmania major	94%	100%
V5BU91	Trypanosoma cruzi	63%	100%