Prefoldin subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin subunit

Gene product:

prefoldin subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B0L2_LEIMU

TriTrypDb:

LmxM.29.0830

Length:

146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0L2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051082	unfolded protein binding	3	11
GO:0044183	protein folding chaperone	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.374
CLV_NRD_NRD_1	51	53	PF00675	0.315
CLV_PCSK_KEX2_1	122	124	PF00082	0.376
CLV_PCSK_KEX2_1	47	49	PF00082	0.303
CLV_PCSK_KEX2_1	51	53	PF00082	0.311
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.299
CLV_PCSK_SKI1_1	129	133	PF00082	0.640
CLV_PCSK_SKI1_1	20	24	PF00082	0.645
CLV_PCSK_SKI1_1	42	46	PF00082	0.387
DEG_APCC_DBOX_1	128	136	PF00400	0.642
DOC_MAPK_gen_1	107	115	PF00069	0.512
DOC_MAPK_gen_1	47	57	PF00069	0.549
DOC_USP7_MATH_1	137	141	PF00917	0.725
DOC_USP7_MATH_1	98	102	PF00917	0.521
LIG_14-3-3_CanoR_1	109	115	PF00244	0.535
LIG_14-3-3_CanoR_1	42	47	PF00244	0.509
LIG_14-3-3_CanoR_1	52	58	PF00244	0.482
LIG_14-3-3_CterR_2	141	146	PF00244	0.730
LIG_Actin_WH2_2	32	49	PF00022	0.586
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_FHA_1	108	114	PF00498	0.528
LIG_FHA_1	39	45	PF00498	0.546
LIG_FHA_2	19	25	PF00498	0.694
LIG_FHA_2	54	60	PF00498	0.548
LIG_SH2_CRK	70	74	PF00017	0.548
LIG_TRAF2_1	124	127	PF00917	0.699
LIG_TYR_ITIM	68	73	PF00017	0.548
MOD_CK1_1	101	107	PF00069	0.521
MOD_CK1_1	2	8	PF00069	0.660
MOD_CK2_1	18	24	PF00069	0.690
MOD_CK2_1	53	59	PF00069	0.492
MOD_GSK3_1	28	35	PF00069	0.586
MOD_GSK3_1	38	45	PF00069	0.554
MOD_GSK3_1	98	105	PF00069	0.544
MOD_N-GLC_1	2	7	PF02516	0.714
MOD_NEK2_1	32	37	PF00069	0.505
MOD_PIKK_1	139	145	PF00454	0.648
MOD_PKA_2	101	107	PF00069	0.513
MOD_PKA_2	108	114	PF00069	0.518
MOD_PKA_2	32	38	PF00069	0.504
MOD_Plk_1	18	24	PF00069	0.690
MOD_Plk_1	98	104	PF00069	0.521
MOD_SUMO_for_1	115	118	PF00179	0.512
TRG_ENDOCYTIC_2	70	73	PF00928	0.492
TRG_ER_diArg_1	121	123	PF00400	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDG9	Bodo saltans	46%	100%
A0A1X0P260	Trypanosomatidae	51%	100%
A0A3S7X344	Leishmania donovani	96%	100%
A0A422P4U7	Trypanosoma rangeli	50%	100%
A4HI39	Leishmania braziliensis	89%	100%
A4I5B6	Leishmania infantum	96%	100%
C6K3X3	Leptomonas seymouri	86%	100%
C9ZQP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4Q7M0	Leishmania major	95%	100%