Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0K8_LEIMU

TriTrypDb:

LmxM.29.0805

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 4
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B0K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0K8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.722
CLV_NRD_NRD_1	182	184	PF00675	0.443
CLV_PCSK_KEX2_1	193	195	PF00082	0.533
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.528
DEG_Nend_UBRbox_1	1	4	PF02207	0.657
DEG_SCF_FBW7_1	140	145	PF00400	0.363
DEG_SCF_FBW7_1	28	34	PF00400	0.308
DOC_CKS1_1	28	33	PF01111	0.310
DOC_MAPK_gen_1	7	16	PF00069	0.397
DOC_MAPK_MEF2A_6	9	18	PF00069	0.352
DOC_PP1_RVXF_1	73	80	PF00149	0.348
DOC_PP2B_LxvP_1	172	175	PF13499	0.634
DOC_PP2B_LxvP_1	177	180	PF13499	0.637
DOC_PP2B_LxvP_1	25	28	PF13499	0.454
DOC_USP7_MATH_1	104	108	PF00917	0.395
DOC_USP7_MATH_1	142	146	PF00917	0.391
DOC_USP7_MATH_1	26	30	PF00917	0.595
DOC_USP7_MATH_1	73	77	PF00917	0.394
DOC_USP7_MATH_1	85	89	PF00917	0.375
DOC_WW_Pin1_4	117	122	PF00397	0.476
DOC_WW_Pin1_4	138	143	PF00397	0.554
DOC_WW_Pin1_4	192	197	PF00397	0.556
DOC_WW_Pin1_4	27	32	PF00397	0.381
DOC_WW_Pin1_4	81	86	PF00397	0.439
LIG_14-3-3_CanoR_1	75	80	PF00244	0.339
LIG_Actin_WH2_2	95	112	PF00022	0.386
LIG_BRCT_BRCA1_1	75	79	PF00533	0.343
LIG_Clathr_ClatBox_1	99	103	PF01394	0.427
LIG_FHA_1	11	17	PF00498	0.405
LIG_FHA_1	117	123	PF00498	0.430
LIG_FHA_1	32	38	PF00498	0.499
LIG_FHA_1	60	66	PF00498	0.355
LIG_FHA_1	72	78	PF00498	0.355
LIG_FHA_1	90	96	PF00498	0.429
LIG_IRF3_LxIS_1	121	127	PF10401	0.385
LIG_LIR_Gen_1	76	87	PF02991	0.344
LIG_LIR_Nem_3	76	82	PF02991	0.318
LIG_MAD2	167	175	PF02301	0.674
LIG_PCNA_yPIPBox_3	46	58	PF02747	0.335
LIG_SH2_PTP2	52	55	PF00017	0.328
LIG_SH2_STAT5	52	55	PF00017	0.350
LIG_SH3_3	25	31	PF00018	0.446
LIG_SH3_3	90	96	PF00018	0.382
LIG_Sin3_3	149	156	PF02671	0.281
LIG_SUMO_SIM_par_1	167	173	PF11976	0.733
LIG_SUMO_SIM_par_1	90	97	PF11976	0.351
LIG_WRC_WIRS_1	113	118	PF05994	0.315
LIG_WRC_WIRS_1	186	191	PF05994	0.648
MOD_CDK_SPxK_1	192	198	PF00069	0.561
MOD_CK1_1	111	117	PF00069	0.434
MOD_CK1_1	127	133	PF00069	0.308
MOD_CK1_1	147	153	PF00069	0.365
MOD_CK1_1	188	194	PF00069	0.643
MOD_CK2_1	127	133	PF00069	0.415
MOD_GlcNHglycan	146	149	PF01048	0.354
MOD_GlcNHglycan	67	70	PF01048	0.576
MOD_GSK3_1	104	111	PF00069	0.406
MOD_GSK3_1	112	119	PF00069	0.428
MOD_GSK3_1	138	145	PF00069	0.489
MOD_GSK3_1	185	192	PF00069	0.647
MOD_GSK3_1	27	34	PF00069	0.481
MOD_GSK3_1	71	78	PF00069	0.329
MOD_GSK3_1	81	88	PF00069	0.332
MOD_NEK2_1	102	107	PF00069	0.436
MOD_NEK2_1	109	114	PF00069	0.375
MOD_NEK2_1	116	121	PF00069	0.347
MOD_NEK2_1	124	129	PF00069	0.347
MOD_NEK2_1	189	194	PF00069	0.642
MOD_NEK2_1	71	76	PF00069	0.312
MOD_PK_1	167	173	PF00069	0.671
MOD_Plk_1	89	95	PF00069	0.443
MOD_Plk_4	10	16	PF00069	0.410
MOD_Plk_4	104	110	PF00069	0.395
MOD_Plk_4	167	173	PF00069	0.610
MOD_ProDKin_1	117	123	PF00069	0.476
MOD_ProDKin_1	138	144	PF00069	0.551
MOD_ProDKin_1	192	198	PF00069	0.561
MOD_ProDKin_1	27	33	PF00069	0.383
MOD_ProDKin_1	81	87	PF00069	0.434
TRG_ENDOCYTIC_2	52	55	PF00928	0.308
TRG_ER_diArg_1	6	9	PF00400	0.521
TRG_NES_CRM1_1	35	48	PF08389	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM14	Leptomonas seymouri	50%	100%
A0A1X0P359	Trypanosomatidae	33%	100%
A0A3S7X383	Leishmania donovani	89%	100%
A0A422P4T9	Trypanosoma rangeli	31%	100%
A4HI36	Leishmania braziliensis	78%	100%
A4I5B2	Leishmania infantum	89%	100%
C9ZQP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q7M4	Leishmania major	89%	100%