LeishMANIAdb
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Putative rac serine-threonine kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative rac serine-threonine kinase
Gene product:
rac serine-threonine kinase, putative
Species:
Leishmania mexicana
UniProt:
E9B0K7_LEIMU
TriTrypDb:
LmxM.29.0800
Length:
510

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005930 axoneme 2 2
GO:0005952 cAMP-dependent protein kinase complex 3 2
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0032991 protein-containing complex 1 2
GO:0043233 organelle lumen 3 2
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2
GO:1902554 serine/threonine protein kinase complex 6 2
GO:1902911 protein kinase complex 5 2
GO:1990234 transferase complex 3 2

Expansion

Sequence features

E9B0K7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0K7

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 20
GO:0006793 phosphorus metabolic process 3 20
GO:0006796 phosphate-containing compound metabolic process 4 20
GO:0006807 nitrogen compound metabolic process 2 20
GO:0008152 metabolic process 1 20
GO:0009987 cellular process 1 20
GO:0016310 phosphorylation 5 20
GO:0019538 protein metabolic process 3 20
GO:0036211 protein modification process 4 20
GO:0043170 macromolecule metabolic process 3 20
GO:0043412 macromolecule modification 4 20
GO:0044237 cellular metabolic process 2 20
GO:0044238 primary metabolic process 2 20
GO:0071704 organic substance metabolic process 2 20
GO:1901564 organonitrogen compound metabolic process 3 20
GO:0007165 signal transduction 2 3
GO:0018105 peptidyl-serine phosphorylation 6 3
GO:0018193 peptidyl-amino acid modification 5 3
GO:0018209 peptidyl-serine modification 6 3
GO:0050789 regulation of biological process 2 3
GO:0050794 regulation of cellular process 3 3
GO:0065007 biological regulation 1 3
GO:0035556 intracellular signal transduction 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 20
GO:0003824 catalytic activity 1 20
GO:0004672 protein kinase activity 3 20
GO:0004674 protein serine/threonine kinase activity 4 20
GO:0005488 binding 1 20
GO:0005524 ATP binding 5 20
GO:0016301 kinase activity 4 20
GO:0016740 transferase activity 2 20
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 20
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 20
GO:0017076 purine nucleotide binding 4 20
GO:0030554 adenyl nucleotide binding 5 20
GO:0032553 ribonucleotide binding 3 20
GO:0032555 purine ribonucleotide binding 4 20
GO:0032559 adenyl ribonucleotide binding 5 20
GO:0035639 purine ribonucleoside triphosphate binding 4 20
GO:0036094 small molecule binding 2 20
GO:0043167 ion binding 2 20
GO:0043168 anion binding 3 20
GO:0097159 organic cyclic compound binding 2 20
GO:0097367 carbohydrate derivative binding 2 20
GO:0140096 catalytic activity, acting on a protein 2 20
GO:1901265 nucleoside phosphate binding 3 20
GO:1901363 heterocyclic compound binding 2 20
GO:0004690 cyclic nucleotide-dependent protein kinase activity 5 2
GO:0004691 cAMP-dependent protein kinase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 345 347 PF00675 0.353
CLV_NRD_NRD_1 369 371 PF00675 0.403
CLV_NRD_NRD_1 437 439 PF00675 0.597
CLV_NRD_NRD_1 495 497 PF00675 0.721
CLV_NRD_NRD_1 79 81 PF00675 0.630
CLV_PCSK_FUR_1 435 439 PF00082 0.599
CLV_PCSK_KEX2_1 345 347 PF00082 0.434
CLV_PCSK_KEX2_1 437 439 PF00082 0.597
CLV_PCSK_SKI1_1 109 113 PF00082 0.537
CLV_PCSK_SKI1_1 154 158 PF00082 0.366
CLV_PCSK_SKI1_1 227 231 PF00082 0.375
CLV_PCSK_SKI1_1 313 317 PF00082 0.450
CLV_PCSK_SKI1_1 336 340 PF00082 0.384
CLV_PCSK_SKI1_1 370 374 PF00082 0.411
CLV_PCSK_SKI1_1 388 392 PF00082 0.489
CLV_PCSK_SKI1_1 442 446 PF00082 0.519
CLV_PCSK_SKI1_1 48 52 PF00082 0.464
CLV_PCSK_SKI1_1 497 501 PF00082 0.588
DEG_APCC_DBOX_1 153 161 PF00400 0.361
DOC_CKS1_1 375 380 PF01111 0.589
DOC_CYCLIN_RxL_1 40 51 PF00134 0.573
DOC_CYCLIN_yClb1_LxF_4 297 303 PF00134 0.450
DOC_CYCLIN_yCln2_LP_2 372 378 PF00134 0.447
DOC_MAPK_gen_1 227 236 PF00069 0.433
DOC_MAPK_gen_1 354 364 PF00069 0.590
DOC_PP1_RVXF_1 279 286 PF00149 0.375
DOC_PP2B_LxvP_1 372 375 PF13499 0.447
DOC_PP2B_PxIxI_1 322 328 PF00149 0.299
DOC_PP4_FxxP_1 505 508 PF00568 0.620
DOC_USP7_UBL2_3 126 130 PF12436 0.363
DOC_USP7_UBL2_3 503 507 PF12436 0.614
DOC_WW_Pin1_4 374 379 PF00397 0.579
DOC_WW_Pin1_4 397 402 PF00397 0.703
DOC_WW_Pin1_4 420 425 PF00397 0.752
DOC_WW_Pin1_4 450 455 PF00397 0.781
DOC_WW_Pin1_4 462 467 PF00397 0.853
DOC_WW_Pin1_4 488 493 PF00397 0.657
DOC_WW_Pin1_4 6 11 PF00397 0.402
LIG_14-3-3_CanoR_1 345 351 PF00244 0.450
LIG_14-3-3_CanoR_1 80 88 PF00244 0.599
LIG_Actin_WH2_2 38 55 PF00022 0.579
LIG_APCC_ABBAyCdc20_2 222 228 PF00400 0.396
LIG_BIR_II_1 1 5 PF00653 0.434
LIG_BRCT_BRCA1_1 69 73 PF00533 0.400
LIG_EH1_1 178 186 PF00400 0.431
LIG_eIF4E_1 179 185 PF01652 0.450
LIG_eIF4E_1 268 274 PF01652 0.450
LIG_FHA_1 14 20 PF00498 0.398
LIG_FHA_1 314 320 PF00498 0.394
LIG_FHA_1 329 335 PF00498 0.426
LIG_FHA_1 389 395 PF00498 0.608
LIG_FHA_1 58 64 PF00498 0.527
LIG_FHA_2 190 196 PF00498 0.450
LIG_FHA_2 29 35 PF00498 0.446
LIG_FHA_2 427 433 PF00498 0.802
LIG_FHA_2 49 55 PF00498 0.328
LIG_FHA_2 94 100 PF00498 0.433
LIG_LIR_Apic_2 265 271 PF02991 0.375
LIG_LIR_Apic_2 504 508 PF02991 0.617
LIG_LIR_Gen_1 15 26 PF02991 0.523
LIG_LIR_Gen_1 189 199 PF02991 0.496
LIG_LIR_Gen_1 2 10 PF02991 0.541
LIG_LIR_Gen_1 294 303 PF02991 0.382
LIG_LIR_Nem_3 116 120 PF02991 0.398
LIG_LIR_Nem_3 15 21 PF02991 0.362
LIG_LIR_Nem_3 189 194 PF02991 0.375
LIG_LIR_Nem_3 2 7 PF02991 0.420
LIG_LIR_Nem_3 284 288 PF02991 0.303
LIG_LIR_Nem_3 294 300 PF02991 0.370
LIG_LIR_Nem_3 363 367 PF02991 0.440
LIG_MLH1_MIPbox_1 69 73 PF16413 0.327
LIG_Pex14_1 14 18 PF04695 0.525
LIG_Pex14_2 106 110 PF04695 0.400
LIG_Pex14_2 386 390 PF04695 0.458
LIG_PTB_Apo_2 358 365 PF02174 0.484
LIG_SH2_CRK 117 121 PF00017 0.450
LIG_SH2_PTP2 18 21 PF00017 0.375
LIG_SH2_SRC 18 21 PF00017 0.375
LIG_SH2_SRC 218 221 PF00017 0.391
LIG_SH2_STAP1 208 212 PF00017 0.396
LIG_SH2_STAP1 413 417 PF00017 0.449
LIG_SH2_STAT3 170 173 PF00017 0.318
LIG_SH2_STAT3 193 196 PF00017 0.331
LIG_SH2_STAT5 18 21 PF00017 0.313
LIG_SH2_STAT5 193 196 PF00017 0.406
LIG_SH2_STAT5 218 221 PF00017 0.433
LIG_SH2_STAT5 262 265 PF00017 0.384
LIG_SH2_STAT5 268 271 PF00017 0.368
LIG_SH2_STAT5 4 7 PF00017 0.391
LIG_SH2_STAT5 411 414 PF00017 0.587
LIG_SH2_STAT5 72 75 PF00017 0.428
LIG_SH3_3 251 257 PF00018 0.519
LIG_SH3_3 316 322 PF00018 0.450
LIG_SH3_3 372 378 PF00018 0.480
LIG_SH3_3 4 10 PF00018 0.391
LIG_SH3_3 52 58 PF00018 0.555
LIG_TRAF2_1 171 174 PF00917 0.450
LIG_TRAF2_1 418 421 PF00917 0.568
LIG_TYR_ITIM 224 229 PF00017 0.410
LIG_TYR_ITSM 14 21 PF00017 0.513
LIG_UBA3_1 334 341 PF00899 0.450
MOD_CDK_SPxxK_3 6 13 PF00069 0.408
MOD_CK1_1 440 446 PF00069 0.651
MOD_CK1_1 453 459 PF00069 0.819
MOD_CK1_1 488 494 PF00069 0.562
MOD_CK1_1 93 99 PF00069 0.664
MOD_CK2_1 168 174 PF00069 0.396
MOD_CK2_1 189 195 PF00069 0.358
MOD_CK2_1 397 403 PF00069 0.545
MOD_CK2_1 415 421 PF00069 0.671
MOD_CK2_1 426 432 PF00069 0.791
MOD_CK2_1 48 54 PF00069 0.531
MOD_CK2_1 93 99 PF00069 0.622
MOD_GlcNHglycan 1 4 PF01048 0.414
MOD_GlcNHglycan 136 140 PF01048 0.394
MOD_GlcNHglycan 36 40 PF01048 0.615
MOD_GlcNHglycan 92 95 PF01048 0.568
MOD_GSK3_1 258 265 PF00069 0.377
MOD_GSK3_1 420 427 PF00069 0.724
MOD_GSK3_1 445 452 PF00069 0.708
MOD_GSK3_1 458 465 PF00069 0.767
MOD_GSK3_1 497 504 PF00069 0.726
MOD_GSK3_1 53 60 PF00069 0.590
MOD_GSK3_1 95 102 PF00069 0.545
MOD_N-GLC_1 397 402 PF02516 0.759
MOD_N-GLC_1 445 450 PF02516 0.798
MOD_N-GLC_1 458 463 PF02516 0.840
MOD_N-GLC_1 501 506 PF02516 0.636
MOD_NEK2_1 168 173 PF00069 0.387
MOD_NEK2_2 84 89 PF00069 0.485
MOD_PKA_1 125 131 PF00069 0.461
MOD_PKA_1 437 443 PF00069 0.741
MOD_PKA_1 497 503 PF00069 0.602
MOD_PKA_2 437 443 PF00069 0.771
MOD_PKA_2 79 85 PF00069 0.445
MOD_PKB_1 435 443 PF00069 0.607
MOD_Plk_1 501 507 PF00069 0.637
MOD_Plk_1 68 74 PF00069 0.452
MOD_Plk_2-3 189 195 PF00069 0.410
MOD_Plk_2-3 99 105 PF00069 0.462
MOD_Plk_4 68 74 PF00069 0.499
MOD_ProDKin_1 374 380 PF00069 0.591
MOD_ProDKin_1 397 403 PF00069 0.710
MOD_ProDKin_1 420 426 PF00069 0.757
MOD_ProDKin_1 450 456 PF00069 0.784
MOD_ProDKin_1 462 468 PF00069 0.853
MOD_ProDKin_1 488 494 PF00069 0.655
MOD_ProDKin_1 6 12 PF00069 0.406
MOD_SUMO_for_1 229 232 PF00179 0.375
MOD_SUMO_rev_2 105 111 PF00179 0.501
MOD_SUMO_rev_2 140 150 PF00179 0.450
MOD_SUMO_rev_2 20 26 PF00179 0.520
MOD_SUMO_rev_2 329 334 PF00179 0.499
MOD_SUMO_rev_2 44 50 PF00179 0.562
MOD_SUMO_rev_2 76 82 PF00179 0.562
TRG_DiLeu_BaEn_1 330 335 PF01217 0.396
TRG_ENDOCYTIC_2 117 120 PF00928 0.471
TRG_ENDOCYTIC_2 179 182 PF00928 0.387
TRG_ENDOCYTIC_2 18 21 PF00928 0.277
TRG_ENDOCYTIC_2 226 229 PF00928 0.410
TRG_ENDOCYTIC_2 4 7 PF00928 0.448
TRG_ER_diArg_1 345 347 PF00400 0.360
TRG_ER_diArg_1 434 437 PF00400 0.597
TRG_NLS_Bipartite_1 480 500 PF00514 0.592
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.361
TRG_Pf-PMV_PEXEL_1 227 232 PF00026 0.375
TRG_Pf-PMV_PEXEL_1 313 317 PF00026 0.450
TRG_Pf-PMV_PEXEL_1 415 419 PF00026 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4J7 Leptomonas seymouri 29% 100%
A0A0N1I191 Leptomonas seymouri 26% 69%
A0A0S4J4B3 Bodo saltans 27% 100%
A0A0S4JCG2 Bodo saltans 30% 100%
A0A0S4JER5 Bodo saltans 43% 100%
A0A0S4JI67 Bodo saltans 30% 100%
A0A0S4JNA1 Bodo saltans 25% 100%
A0A1X0P3J5 Trypanosomatidae 40% 100%
A0A3Q8IC87 Leishmania donovani 29% 100%
A0A3Q8IIG1 Leishmania donovani 25% 100%
A0A3Q8INQ4 Leishmania donovani 35% 100%
A0A3Q8IRT6 Leishmania donovani 97% 100%
A0A3Q8IVR8 Leishmania donovani 24% 100%
A0A3R7RLL1 Trypanosoma rangeli 29% 100%
A0A3S5H5U5 Leishmania donovani 28% 100%
A0A3S7WTN9 Leishmania donovani 31% 100%
A0A3S7WWE7 Leishmania donovani 25% 100%
A0A3S7X7Y2 Leishmania donovani 25% 100%
A0A3S7X9R4 Leishmania donovani 41% 100%
A0A3S7X9S2 Leishmania donovani 41% 100%
A0A422NZ62 Trypanosoma rangeli 37% 74%
A0A422P4V9 Trypanosoma rangeli 40% 100%
A4H4S9 Leishmania braziliensis 28% 100%
A4H8C4 Leishmania braziliensis 30% 100%
A4HAS1 Leishmania braziliensis 26% 100%
A4HBL4 Leishmania braziliensis 26% 100%
A4HCD7 Leishmania braziliensis 30% 100%
A4HCE6 Leishmania braziliensis 28% 100%
A4HED7 Leishmania braziliensis 34% 100%
A4HFF3 Leishmania braziliensis 26% 100%
A4HI35 Leishmania braziliensis 91% 100%
A4HLR0 Leishmania braziliensis 28% 100%
A4HN71 Leishmania braziliensis 41% 100%
A4HNT2 Leishmania braziliensis 23% 100%
A4HWP5 Leishmania infantum 31% 100%
A4HZA2 Leishmania infantum 25% 100%
A4HZV1 Leishmania infantum 29% 100%
A4I1T4 Leishmania infantum 35% 100%
A4I435 Leishmania infantum 25% 100%
A4I5B1 Leishmania infantum 96% 100%
A4I9Y5 Leishmania infantum 25% 100%
A4IBT4 Leishmania infantum 41% 100%
A4IBT9 Leishmania infantum 41% 100%
A4ICR2 Leishmania infantum 24% 100%
C6K3W8 Leptomonas seymouri 72% 97%
C9ZKX6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
C9ZQP5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZTP2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E8NHS0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AET0 Leishmania major 24% 100%
E9AFM1 Leishmania major 41% 100%
E9AG71 Leishmania infantum 28% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
P05130 Drosophila melanogaster 34% 75%
P16054 Mus musculus 32% 69%
P18652 Gallus gallus 39% 68%
P18654 Mus musculus 39% 69%
P18961 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 75%
P23443 Homo sapiens 38% 97%
P28867 Mus musculus 33% 76%
P31748 AKT8 murine leukemia virus 36% 100%
P31749 Homo sapiens 35% 100%
P31750 Mus musculus 36% 100%
P34885 Caenorhabditis elegans 35% 72%
P38070 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 97%
P47196 Rattus norvegicus 36% 100%
P51812 Homo sapiens 39% 69%
P53894 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 67%
P54265 Mus musculus 29% 81%
P54644 Dictyostelium discoideum 37% 100%
P67998 Oryctolagus cuniculus 38% 97%
P67999 Rattus norvegicus 38% 97%
Q01314 Bos taurus 35% 100%
Q09831 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 90%
Q09898 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 84%
Q39030 Arabidopsis thaliana 38% 100%
Q4Q0B0 Leishmania major 26% 100%
Q4Q204 Leishmania major 23% 100%
Q4Q2Z2 Leishmania major 25% 100%
Q4Q7M5 Leishmania major 96% 100%
Q4Q7W2 Leishmania major 27% 100%
Q4Q9K2 Leishmania major 34% 100%
Q4QBQ2 Leishmania major 28% 100%
Q4QBR6 Leishmania major 30% 98%
Q4QCK0 Leishmania major 25% 100%
Q4QF23 Leishmania major 33% 100%
Q4QIV8 Leishmania major 28% 100%
Q4R633 Macaca fascicularis 39% 100%
Q54IH8 Dictyostelium discoideum 28% 94%
Q5AP53 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 70%
Q5Q0U5 Fundulus heteroclitus 39% 100%
Q5R7A7 Pongo abelii 37% 100%
Q6BLJ9 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 31% 71%
Q6CFS5 Yarrowia lipolytica (strain CLIB 122 / E 150) 31% 87%
Q6TGC6 Pneumocystis carinii 32% 100%
Q6TJY3 Bos taurus 38% 97%
Q7LZQ8 Xenopus laevis 33% 76%
Q8BSK8 Mus musculus 38% 97%
Q8R4V0 Rattus norvegicus 38% 100%
Q90XF2 Danio rerio 36% 87%
Q96BR1 Homo sapiens 37% 100%
Q98TY9 Xenopus laevis 34% 100%
Q9ERE3 Mus musculus 38% 100%
Q9GNR4 Leishmania major 41% 100%
Q9UBS0 Homo sapiens 40% 100%
Q9UK32 Homo sapiens 25% 68%
Q9WUT3 Mus musculus 39% 70%
Q9Z1M4 Mus musculus 39% 100%
V5BCH2 Trypanosoma cruzi 34% 100%
V5DQT5 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS