Mitochondrial oligo_U binding protein TBRGG1,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial oligo_U binding protein TBRGG1, putative

Species:

Leishmania mexicana

UniProt:

E9B0K5_LEIMU

TriTrypDb:

LmxM.29.0780

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0K5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.739
CLV_NRD_NRD_1	112	114	PF00675	0.656
CLV_NRD_NRD_1	126	128	PF00675	0.680
CLV_NRD_NRD_1	151	153	PF00675	0.698
CLV_NRD_NRD_1	189	191	PF00675	0.515
CLV_PCSK_KEX2_1	101	103	PF00082	0.739
CLV_PCSK_KEX2_1	112	114	PF00082	0.656
CLV_PCSK_KEX2_1	126	128	PF00082	0.680
CLV_PCSK_KEX2_1	151	153	PF00082	0.707
CLV_PCSK_KEX2_1	189	191	PF00082	0.589
CLV_PCSK_SKI1_1	173	177	PF00082	0.564
CLV_PCSK_SKI1_1	189	193	PF00082	0.515
CLV_PCSK_SKI1_1	4	8	PF00082	0.749
CLV_PCSK_SKI1_1	447	451	PF00082	0.517
CLV_PCSK_SKI1_1	599	603	PF00082	0.422
DEG_APCC_DBOX_1	598	606	PF00400	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.784
DOC_CDC14_PxL_1	369	377	PF14671	0.393
DOC_MAPK_gen_1	176	184	PF00069	0.496
DOC_MAPK_MEF2A_6	277	286	PF00069	0.508
DOC_PP1_RVXF_1	480	487	PF00149	0.394
DOC_PP1_RVXF_1	647	653	PF00149	0.297
DOC_PP2B_LxvP_1	610	613	PF13499	0.544
DOC_PP4_FxxP_1	137	140	PF00568	0.521
DOC_PP4_FxxP_1	217	220	PF00568	0.565
DOC_USP7_MATH_1	271	275	PF00917	0.468
DOC_USP7_MATH_1	312	316	PF00917	0.496
DOC_USP7_MATH_1	456	460	PF00917	0.540
DOC_USP7_MATH_1	511	515	PF00917	0.551
DOC_USP7_MATH_1	520	524	PF00917	0.554
DOC_USP7_MATH_1	528	532	PF00917	0.523
DOC_USP7_MATH_1	658	662	PF00917	0.607
DOC_USP7_UBL2_3	169	173	PF12436	0.483
DOC_WW_Pin1_4	238	243	PF00397	0.448
DOC_WW_Pin1_4	253	258	PF00397	0.427
DOC_WW_Pin1_4	643	648	PF00397	0.601
LIG_14-3-3_CanoR_1	133	138	PF00244	0.724
LIG_14-3-3_CanoR_1	16	22	PF00244	0.587
LIG_14-3-3_CanoR_1	388	395	PF00244	0.418
LIG_14-3-3_CanoR_1	4	9	PF00244	0.742
LIG_14-3-3_CanoR_1	412	418	PF00244	0.558
LIG_14-3-3_CanoR_1	42	46	PF00244	0.543
LIG_14-3-3_CanoR_1	563	567	PF00244	0.532
LIG_14-3-3_CanoR_1	599	608	PF00244	0.495
LIG_14-3-3_CanoR_1	618	626	PF00244	0.322
LIG_14-3-3_CanoR_1	627	631	PF00244	0.534
LIG_14-3-3_CanoR_1	74	81	PF00244	0.593
LIG_Actin_WH2_2	578	593	PF00022	0.584
LIG_BRCT_BRCA1_1	552	556	PF00533	0.544
LIG_FHA_1	388	394	PF00498	0.554
LIG_FHA_1	421	427	PF00498	0.531
LIG_FHA_1	496	502	PF00498	0.551
LIG_FHA_1	601	607	PF00498	0.453
LIG_FHA_2	193	199	PF00498	0.517
LIG_FHA_2	556	562	PF00498	0.509
LIG_FHA_2	582	588	PF00498	0.558
LIG_IRF3_LxIS_1	559	565	PF10401	0.442
LIG_LIR_Apic_2	136	140	PF02991	0.517
LIG_LIR_Apic_2	216	220	PF02991	0.559
LIG_LIR_Gen_1	227	237	PF02991	0.564
LIG_LIR_Nem_3	480	484	PF02991	0.504
LIG_LIR_Nem_3	553	559	PF02991	0.446
LIG_PCNA_PIPBox_1	303	312	PF02747	0.559
LIG_SH2_CRK	18	22	PF00017	0.665
LIG_SH2_GRB2like	109	112	PF00017	0.764
LIG_SH2_GRB2like	81	84	PF00017	0.817
LIG_SH2_GRB2like	88	91	PF00017	0.771
LIG_SH2_NCK_1	455	459	PF00017	0.552
LIG_SH2_SRC	455	458	PF00017	0.549
LIG_SH2_SRC	88	91	PF00017	0.794
LIG_SH2_STAP1	18	22	PF00017	0.679
LIG_SH2_STAP1	552	556	PF00017	0.442
LIG_SH2_STAT3	157	160	PF00017	0.607
LIG_SH2_STAT3	57	60	PF00017	0.699
LIG_SH2_STAT5	157	160	PF00017	0.607
LIG_SH2_STAT5	95	98	PF00017	0.753
LIG_SH3_2	519	524	PF14604	0.627
LIG_SH3_2	613	618	PF14604	0.414
LIG_SH3_3	412	418	PF00018	0.555
LIG_SH3_3	458	464	PF00018	0.489
LIG_SH3_3	514	520	PF00018	0.562
LIG_SH3_3	610	616	PF00018	0.420
LIG_SH3_3	93	99	PF00018	0.634
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.470
LIG_SUMO_SIM_anti_2	283	289	PF11976	0.399
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.406
LIG_SUMO_SIM_anti_2	505	511	PF11976	0.484
LIG_TRAF2_1	466	469	PF00917	0.550
LIG_TRAF2_1	527	530	PF00917	0.674
LIG_UBA3_1	165	173	PF00899	0.456
LIG_UBA3_1	433	439	PF00899	0.501
LIG_UBA3_1	492	500	PF00899	0.540
LIG_WRC_WIRS_1	478	483	PF05994	0.574
LIG_WW_3	50	54	PF00397	0.748
LIG_WW_3	518	522	PF00397	0.546
MOD_CDC14_SPxK_1	646	649	PF00782	0.322
MOD_CDK_SPxK_1	643	649	PF00069	0.531
MOD_CK1_1	416	422	PF00069	0.550
MOD_CK1_1	495	501	PF00069	0.542
MOD_CK1_1	643	649	PF00069	0.547
MOD_CK2_1	198	204	PF00069	0.485
MOD_CK2_1	253	259	PF00069	0.496
MOD_CK2_1	305	311	PF00069	0.516
MOD_CK2_1	456	462	PF00069	0.577
MOD_CK2_1	555	561	PF00069	0.469
MOD_CK2_1	581	587	PF00069	0.539
MOD_GlcNHglycan	147	150	PF01048	0.768
MOD_GlcNHglycan	217	220	PF01048	0.274
MOD_GlcNHglycan	405	408	PF01048	0.441
MOD_GlcNHglycan	440	443	PF01048	0.471
MOD_GlcNHglycan	447	450	PF01048	0.373
MOD_GlcNHglycan	464	467	PF01048	0.381
MOD_GlcNHglycan	502	505	PF01048	0.571
MOD_GlcNHglycan	662	665	PF01048	0.579
MOD_GSK3_1	16	23	PF00069	0.501
MOD_GSK3_1	320	327	PF00069	0.479
MOD_GSK3_1	416	423	PF00069	0.579
MOD_GSK3_1	467	474	PF00069	0.462
MOD_N-GLC_1	511	516	PF02516	0.554
MOD_N-GLC_1	618	623	PF02516	0.513
MOD_NEK2_1	192	197	PF00069	0.533
MOD_NEK2_1	375	380	PF00069	0.514
MOD_NEK2_1	471	476	PF00069	0.465
MOD_NEK2_1	492	497	PF00069	0.528
MOD_NEK2_1	581	586	PF00069	0.466
MOD_NEK2_1	653	658	PF00069	0.577
MOD_PIKK_1	156	162	PF00454	0.587
MOD_PIKK_1	198	204	PF00454	0.485
MOD_PIKK_1	375	381	PF00454	0.542
MOD_PIKK_1	396	402	PF00454	0.344
MOD_PIKK_1	495	501	PF00454	0.543
MOD_PKA_2	387	393	PF00069	0.477
MOD_PKA_2	41	47	PF00069	0.543
MOD_PKA_2	520	526	PF00069	0.547
MOD_PKA_2	562	568	PF00069	0.546
MOD_PKA_2	626	632	PF00069	0.336
MOD_PKA_2	73	79	PF00069	0.643
MOD_PKB_1	14	22	PF00069	0.655
MOD_PKB_1	72	80	PF00069	0.756
MOD_Plk_1	203	209	PF00069	0.445
MOD_Plk_1	511	517	PF00069	0.563
MOD_Plk_4	17	23	PF00069	0.647
MOD_Plk_4	271	277	PF00069	0.518
MOD_Plk_4	324	330	PF00069	0.474
MOD_Plk_4	471	477	PF00069	0.417
MOD_Plk_4	626	632	PF00069	0.433
MOD_ProDKin_1	238	244	PF00069	0.441
MOD_ProDKin_1	253	259	PF00069	0.429
MOD_ProDKin_1	643	649	PF00069	0.596
MOD_SUMO_for_1	221	224	PF00179	0.587
TRG_DiLeu_BaEn_1	187	192	PF01217	0.508
TRG_DiLeu_BaEn_1	364	369	PF01217	0.403
TRG_DiLeu_BaEn_4	297	303	PF01217	0.505
TRG_DiLeu_LyEn_5	187	192	PF01217	0.547
TRG_ENDOCYTIC_2	18	21	PF00928	0.668
TRG_ER_diArg_1	13	16	PF00400	0.715
TRG_ER_diArg_1	150	152	PF00400	0.764
TRG_ER_diArg_1	189	191	PF00400	0.496
TRG_ER_diArg_1	194	197	PF00400	0.489
TRG_ER_diArg_1	293	296	PF00400	0.394
TRG_NES_CRM1_1	278	292	PF08389	0.454
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I169	Leptomonas seymouri	44%	100%
A0A0S4JB89	Bodo saltans	25%	91%
A0A1X0P251	Trypanosomatidae	38%	100%
A0A3S7X349	Leishmania donovani	91%	100%
A0A422P4U2	Trypanosoma rangeli	39%	100%
A4HI33	Leishmania braziliensis	79%	100%
A4I5A9	Leishmania infantum	91%	100%
C9ZQP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
Q4Q7M7	Leishmania major	89%	97%