Armadillo-type fold

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Armadillo-type fold

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0K3_LEIMU

TriTrypDb:

LmxM.29.0760

Length:

1058

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.452
CLV_C14_Caspase3-7	502	506	PF00656	0.496
CLV_MEL_PAP_1	953	959	PF00089	0.742
CLV_NRD_NRD_1	1022	1024	PF00675	0.788
CLV_NRD_NRD_1	1040	1042	PF00675	0.501
CLV_NRD_NRD_1	304	306	PF00675	0.470
CLV_NRD_NRD_1	349	351	PF00675	0.502
CLV_NRD_NRD_1	518	520	PF00675	0.361
CLV_NRD_NRD_1	59	61	PF00675	0.406
CLV_NRD_NRD_1	799	801	PF00675	0.424
CLV_NRD_NRD_1	868	870	PF00675	0.804
CLV_NRD_NRD_1	895	897	PF00675	0.656
CLV_NRD_NRD_1	919	921	PF00675	0.716
CLV_NRD_NRD_1	959	961	PF00675	0.726
CLV_PCSK_KEX2_1	1022	1024	PF00082	0.724
CLV_PCSK_KEX2_1	1040	1042	PF00082	0.500
CLV_PCSK_KEX2_1	349	351	PF00082	0.502
CLV_PCSK_KEX2_1	518	520	PF00082	0.361
CLV_PCSK_KEX2_1	562	564	PF00082	0.484
CLV_PCSK_KEX2_1	59	61	PF00082	0.406
CLV_PCSK_KEX2_1	868	870	PF00082	0.681
CLV_PCSK_KEX2_1	894	896	PF00082	0.657
CLV_PCSK_KEX2_1	919	921	PF00082	0.716
CLV_PCSK_KEX2_1	959	961	PF00082	0.721
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.484
CLV_PCSK_PC7_1	1036	1042	PF00082	0.661
CLV_PCSK_PC7_1	890	896	PF00082	0.631
CLV_PCSK_SKI1_1	241	245	PF00082	0.459
CLV_PCSK_SKI1_1	590	594	PF00082	0.321
CLV_PCSK_SKI1_1	60	64	PF00082	0.415
CLV_PCSK_SKI1_1	718	722	PF00082	0.335
CLV_PCSK_SKI1_1	749	753	PF00082	0.309
CLV_PCSK_SKI1_1	796	800	PF00082	0.433
CLV_PCSK_SKI1_1	974	978	PF00082	0.753
CLV_PCSK_SKI1_1	99	103	PF00082	0.461
CLV_Separin_Metazoa	258	262	PF03568	0.346
DOC_CKS1_1	824	829	PF01111	0.730
DOC_CYCLIN_RxL_1	653	663	PF00134	0.332
DOC_CYCLIN_RxL_1	793	803	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	817	823	PF00134	0.577
DOC_MAPK_gen_1	562	569	PF00069	0.483
DOC_MAPK_gen_1	606	616	PF00069	0.452
DOC_MAPK_MEF2A_6	379	387	PF00069	0.353
DOC_MAPK_MEF2A_6	532	539	PF00069	0.323
DOC_MAPK_MEF2A_6	562	569	PF00069	0.492
DOC_MAPK_MEF2A_6	594	602	PF00069	0.458
DOC_MAPK_MEF2A_6	609	616	PF00069	0.499
DOC_PP1_RVXF_1	204	211	PF00149	0.367
DOC_PP1_RVXF_1	794	800	PF00149	0.398
DOC_PP4_FxxP_1	42	45	PF00568	0.378
DOC_USP7_MATH_1	120	124	PF00917	0.565
DOC_USP7_MATH_1	411	415	PF00917	0.392
DOC_USP7_MATH_1	711	715	PF00917	0.356
DOC_USP7_UBL2_3	609	613	PF12436	0.514
DOC_WW_Pin1_4	169	174	PF00397	0.435
DOC_WW_Pin1_4	538	543	PF00397	0.388
DOC_WW_Pin1_4	608	613	PF00397	0.504
DOC_WW_Pin1_4	802	807	PF00397	0.504
DOC_WW_Pin1_4	811	816	PF00397	0.578
DOC_WW_Pin1_4	823	828	PF00397	0.528
DOC_WW_Pin1_4	835	840	PF00397	0.570
LIG_14-3-3_CanoR_1	121	127	PF00244	0.553
LIG_14-3-3_CanoR_1	532	538	PF00244	0.315
LIG_14-3-3_CanoR_1	59	63	PF00244	0.350
LIG_14-3-3_CanoR_1	606	612	PF00244	0.488
LIG_14-3-3_CanoR_1	705	712	PF00244	0.314
LIG_14-3-3_CanoR_1	735	745	PF00244	0.323
LIG_14-3-3_CanoR_1	800	808	PF00244	0.586
LIG_APCC_ABBA_1	36	41	PF00400	0.329
LIG_BIR_III_2	681	685	PF00653	0.472
LIG_BIR_III_4	128	132	PF00653	0.486
LIG_BRCT_BRCA1_1	122	126	PF00533	0.372
LIG_BRCT_BRCA1_1	213	217	PF00533	0.425
LIG_Clathr_ClatBox_1	224	228	PF01394	0.444
LIG_deltaCOP1_diTrp_1	209	217	PF00928	0.354
LIG_eIF4E_1	394	400	PF01652	0.327
LIG_FHA_1	100	106	PF00498	0.216
LIG_FHA_1	1003	1009	PF00498	0.676
LIG_FHA_1	147	153	PF00498	0.341
LIG_FHA_1	248	254	PF00498	0.347
LIG_FHA_1	286	292	PF00498	0.322
LIG_FHA_1	33	39	PF00498	0.402
LIG_FHA_1	502	508	PF00498	0.436
LIG_FHA_1	534	540	PF00498	0.331
LIG_FHA_1	738	744	PF00498	0.348
LIG_FHA_1	782	788	PF00498	0.536
LIG_FHA_1	824	830	PF00498	0.766
LIG_FHA_1	83	89	PF00498	0.425
LIG_FHA_2	102	108	PF00498	0.373
LIG_FHA_2	218	224	PF00498	0.355
LIG_FHA_2	455	461	PF00498	0.477
LIG_HCF-1_HBM_1	847	850	PF13415	0.740
LIG_LIR_Apic_2	40	45	PF02991	0.389
LIG_LIR_Apic_2	847	853	PF02991	0.706
LIG_LIR_Apic_2	977	983	PF02991	0.585
LIG_LIR_Gen_1	209	217	PF02991	0.342
LIG_LIR_Gen_1	278	287	PF02991	0.344
LIG_LIR_Gen_1	37	47	PF02991	0.380
LIG_LIR_Gen_1	546	557	PF02991	0.392
LIG_LIR_Gen_1	650	660	PF02991	0.377
LIG_LIR_LC3C_4	222	226	PF02991	0.453
LIG_LIR_Nem_3	107	111	PF02991	0.318
LIG_LIR_Nem_3	117	122	PF02991	0.358
LIG_LIR_Nem_3	209	213	PF02991	0.363
LIG_LIR_Nem_3	278	282	PF02991	0.327
LIG_LIR_Nem_3	37	42	PF02991	0.387
LIG_LIR_Nem_3	546	552	PF02991	0.411
LIG_LIR_Nem_3	650	655	PF02991	0.400
LIG_LIR_Nem_3	70	75	PF02991	0.343
LIG_LIR_Nem_3	826	831	PF02991	0.616
LIG_PCNA_PIPBox_1	387	396	PF02747	0.336
LIG_PCNA_PIPBox_1	842	851	PF02747	0.489
LIG_PCNA_yPIPBox_3	767	776	PF02747	0.413
LIG_SH2_CRK	471	475	PF00017	0.338
LIG_SH2_CRK	850	854	PF00017	0.603
LIG_SH2_GRB2like	831	834	PF00017	0.619
LIG_SH2_NCK_1	440	444	PF00017	0.347
LIG_SH2_NCK_1	583	587	PF00017	0.265
LIG_SH2_NCK_1	831	835	PF00017	0.618
LIG_SH2_SRC	583	586	PF00017	0.245
LIG_SH2_SRC	831	834	PF00017	0.619
LIG_SH2_STAT5	151	154	PF00017	0.353
LIG_SH2_STAT5	177	180	PF00017	0.329
LIG_SH2_STAT5	207	210	PF00017	0.360
LIG_SH2_STAT5	248	251	PF00017	0.365
LIG_SH2_STAT5	279	282	PF00017	0.334
LIG_SH2_STAT5	29	32	PF00017	0.361
LIG_SH2_STAT5	394	397	PF00017	0.347
LIG_SH2_STAT5	453	456	PF00017	0.325
LIG_SH2_STAT5	753	756	PF00017	0.323
LIG_SH3_1	831	837	PF00018	0.612
LIG_SH3_3	810	816	PF00018	0.668
LIG_SH3_3	831	837	PF00018	0.675
LIG_Sin3_3	554	561	PF02671	0.441
LIG_SUMO_SIM_anti_2	536	541	PF11976	0.339
LIG_SUMO_SIM_par_1	31	41	PF11976	0.358
LIG_SUMO_SIM_par_1	533	538	PF11976	0.314
LIG_TRAF2_1	268	271	PF00917	0.321
LIG_TRAF2_1	840	843	PF00917	0.811
LIG_UBA3_1	297	306	PF00899	0.349
LIG_UBA3_1	344	353	PF00899	0.346
LIG_UBA3_1	601	609	PF00899	0.327
LIG_WRC_WIRS_1	279	284	PF05994	0.343
MOD_CDK_SPK_2	608	613	PF00069	0.504
MOD_CDK_SPxxK_3	538	545	PF00069	0.374
MOD_CDK_SPxxK_3	804	811	PF00069	0.567
MOD_CDK_SPxxK_3	823	830	PF00069	0.676
MOD_CK1_1	275	281	PF00069	0.306
MOD_CK1_1	322	328	PF00069	0.319
MOD_CK1_1	363	369	PF00069	0.372
MOD_CK1_1	37	43	PF00069	0.353
MOD_CK1_1	452	458	PF00069	0.328
MOD_CK1_1	499	505	PF00069	0.460
MOD_CK1_1	538	544	PF00069	0.360
MOD_CK1_1	93	99	PF00069	0.466
MOD_CK2_1	101	107	PF00069	0.427
MOD_CK2_1	130	136	PF00069	0.434
MOD_CK2_1	217	223	PF00069	0.347
MOD_CK2_1	287	293	PF00069	0.468
MOD_CK2_1	37	43	PF00069	0.481
MOD_Cter_Amidation	350	353	PF01082	0.540
MOD_Cter_Amidation	957	960	PF01082	0.671
MOD_GlcNHglycan	161	164	PF01048	0.387
MOD_GlcNHglycan	293	296	PF01048	0.480
MOD_GlcNHglycan	315	318	PF01048	0.327
MOD_GlcNHglycan	321	324	PF01048	0.336
MOD_GlcNHglycan	396	399	PF01048	0.399
MOD_GlcNHglycan	419	424	PF01048	0.401
MOD_GlcNHglycan	622	625	PF01048	0.303
MOD_GlcNHglycan	723	726	PF01048	0.336
MOD_GlcNHglycan	850	853	PF01048	0.717
MOD_GlcNHglycan	881	884	PF01048	0.797
MOD_GlcNHglycan	940	943	PF01048	0.591
MOD_GlcNHglycan	970	973	PF01048	0.662
MOD_GSK3_1	28	35	PF00069	0.418
MOD_GSK3_1	281	288	PF00069	0.351
MOD_GSK3_1	499	506	PF00069	0.454
MOD_GSK3_1	604	611	PF00069	0.426
MOD_GSK3_1	660	667	PF00069	0.296
MOD_GSK3_1	800	807	PF00069	0.540
MOD_GSK3_1	911	918	PF00069	0.568
MOD_N-GLC_1	157	162	PF02516	0.337
MOD_N-GLC_1	217	222	PF02516	0.468
MOD_N-GLC_1	327	332	PF02516	0.449
MOD_N-GLC_1	496	501	PF02516	0.438
MOD_N-GLC_1	521	526	PF02516	0.501
MOD_N-GLC_2	359	361	PF02516	0.320
MOD_N-GLC_2	402	404	PF02516	0.295
MOD_N-GLC_2	617	619	PF02516	0.309
MOD_N-GLC_2	90	92	PF02516	0.411
MOD_NEK2_1	1004	1009	PF00069	0.603
MOD_NEK2_1	217	222	PF00069	0.426
MOD_NEK2_1	232	237	PF00069	0.227
MOD_NEK2_1	313	318	PF00069	0.309
MOD_NEK2_1	34	39	PF00069	0.409
MOD_NEK2_1	503	508	PF00069	0.474
MOD_NEK2_1	627	632	PF00069	0.376
MOD_NEK2_1	660	665	PF00069	0.297
MOD_NEK2_1	699	704	PF00069	0.308
MOD_NEK2_1	721	726	PF00069	0.327
MOD_NEK2_1	799	804	PF00069	0.585
MOD_NEK2_2	212	217	PF00069	0.365
MOD_PIKK_1	120	126	PF00454	0.484
MOD_PIKK_1	705	711	PF00454	0.307
MOD_PIKK_1	756	762	PF00454	0.396
MOD_PIKK_1	79	85	PF00454	0.314
MOD_PK_1	130	136	PF00069	0.248
MOD_PKA_1	800	806	PF00069	0.511
MOD_PKA_2	120	126	PF00069	0.365
MOD_PKA_2	58	64	PF00069	0.321
MOD_PKA_2	799	805	PF00069	0.601
MOD_PKA_2	911	917	PF00069	0.759
MOD_PKA_2	938	944	PF00069	0.803
MOD_PKB_1	888	896	PF00069	0.642
MOD_Plk_1	106	112	PF00069	0.248
MOD_Plk_1	146	152	PF00069	0.339
MOD_Plk_1	16	22	PF00069	0.435
MOD_Plk_1	32	38	PF00069	0.257
MOD_Plk_1	499	505	PF00069	0.444
MOD_Plk_1	627	633	PF00069	0.368
MOD_Plk_1	756	762	PF00069	0.396
MOD_Plk_1	863	869	PF00069	0.502
MOD_Plk_1	93	99	PF00069	0.421
MOD_Plk_4	107	113	PF00069	0.263
MOD_Plk_4	147	153	PF00069	0.480
MOD_Plk_4	212	218	PF00069	0.351
MOD_Plk_4	272	278	PF00069	0.294
MOD_Plk_4	34	40	PF00069	0.340
MOD_Plk_4	449	455	PF00069	0.306
MOD_Plk_4	535	541	PF00069	0.336
MOD_Plk_4	596	602	PF00069	0.353
MOD_Plk_4	64	70	PF00069	0.398
MOD_Plk_4	660	666	PF00069	0.296
MOD_Plk_4	749	755	PF00069	0.302
MOD_Plk_4	761	767	PF00069	0.359
MOD_Plk_4	93	99	PF00069	0.408
MOD_ProDKin_1	169	175	PF00069	0.427
MOD_ProDKin_1	538	544	PF00069	0.379
MOD_ProDKin_1	608	614	PF00069	0.497
MOD_ProDKin_1	802	808	PF00069	0.510
MOD_ProDKin_1	811	817	PF00069	0.579
MOD_ProDKin_1	823	829	PF00069	0.531
MOD_ProDKin_1	835	841	PF00069	0.573
MOD_SUMO_rev_2	123	132	PF00179	0.476
MOD_SUMO_rev_2	371	375	PF00179	0.350
TRG_DiLeu_BaEn_1	272	277	PF01217	0.384
TRG_DiLeu_BaEn_1	293	298	PF01217	0.461
TRG_DiLeu_BaEn_2	227	233	PF01217	0.326
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.340
TRG_ENDOCYTIC_2	1015	1018	PF00928	0.603
TRG_ENDOCYTIC_2	112	115	PF00928	0.522
TRG_ENDOCYTIC_2	279	282	PF00928	0.334
TRG_ENDOCYTIC_2	471	474	PF00928	0.341
TRG_ENDOCYTIC_2	549	552	PF00928	0.420
TRG_ER_diArg_1	1039	1041	PF00400	0.633
TRG_ER_diArg_1	1045	1048	PF00400	0.631
TRG_ER_diArg_1	203	206	PF00400	0.367
TRG_ER_diArg_1	348	350	PF00400	0.496
TRG_ER_diArg_1	517	519	PF00400	0.356
TRG_ER_diArg_1	654	657	PF00400	0.364
TRG_ER_diArg_1	867	869	PF00400	0.503
TRG_ER_diArg_1	894	896	PF00400	0.657
TRG_ER_diArg_1	959	961	PF00400	0.774
TRG_ER_diArg_1	963	966	PF00400	0.757
TRG_NES_CRM1_1	228	242	PF08389	0.406
TRG_NLS_MonoExtN_4	349	356	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	705	709	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	718	723	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	992	996	PF00026	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAU2	Bodo saltans	59%	88%
A0A1X0P218	Trypanosomatidae	63%	96%
A0A3Q8IET2	Leishmania donovani	96%	100%
A0A422P4T6	Trypanosoma rangeli	61%	97%
A4HI31	Leishmania braziliensis	91%	100%
A4I5A7	Leishmania infantum	97%	100%
C6K3W4	Leptomonas seymouri	79%	92%
C9ZQP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
Q4Q7M9	Leishmania major	95%	100%
V5BPP6	Trypanosoma cruzi	60%	97%