GrpE protein homolog

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

co-chaperone GrpE, putative

Species:

Leishmania mexicana

UniProt:

E9B0J8_LEIMU

TriTrypDb:

LmxM.29.0730

Length:

219

Annotations

LeishMANIAdb annotations

Homologous to other Eukaryotic mitochondrial proteins. Likely non-TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0001405	PAM complex, Tim23 associated import motor	4	1
GO:0005759	mitochondrial matrix	5	8
GO:0031974	membrane-enclosed lumen	2	8
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	8
GO:0070013	intracellular organelle lumen	4	8
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

E9B0J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0J8

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0000774	adenyl-nucleotide exchange factor activity	3	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0036094	small molecule binding	2	11
GO:0042802	identical protein binding	3	11
GO:0042803	protein homodimerization activity	4	11
GO:0046983	protein dimerization activity	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.308
CLV_PCSK_KEX2_1	33	35	PF00082	0.729
CLV_PCSK_KEX2_1	87	89	PF00082	0.308
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.729
CLV_PCSK_SKI1_1	107	111	PF00082	0.308
CLV_PCSK_SKI1_1	149	153	PF00082	0.330
CLV_PCSK_SKI1_1	74	78	PF00082	0.321
DEG_Nend_UBRbox_1	1	4	PF02207	0.619
DOC_MAPK_gen_1	206	215	PF00069	0.508
DOC_USP7_MATH_1	12	16	PF00917	0.696

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM2	Leptomonas seymouri	34%	100%
A0A0N1ILR2	Leptomonas seymouri	71%	100%
A0A0S4JEA6	Bodo saltans	48%	100%
A0A1X0P2B4	Trypanosomatidae	55%	100%
A0A3Q8IEN8	Leishmania donovani	31%	86%
A0A3Q8IJ81	Leishmania donovani	97%	100%
A0A422P4T2	Trypanosoma rangeli	56%	100%
A0AIS5	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	31%	100%
A0B748	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	30%	100%
A0K4S6	Burkholderia cenocepacia (strain HI2424)	35%	100%

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