Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0J7_LEIMU

TriTrypDb:

LmxM.29.0720

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.457
CLV_NRD_NRD_1	257	259	PF00675	0.357
CLV_NRD_NRD_1	36	38	PF00675	0.555
CLV_PCSK_KEX2_1	166	168	PF00082	0.419
CLV_PCSK_KEX2_1	2	4	PF00082	0.457
CLV_PCSK_KEX2_1	230	232	PF00082	0.427
CLV_PCSK_KEX2_1	35	37	PF00082	0.543
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.444
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.452
CLV_PCSK_PC7_1	32	38	PF00082	0.533
CLV_PCSK_SKI1_1	201	205	PF00082	0.345
CLV_PCSK_SKI1_1	3	7	PF00082	0.484
CLV_PCSK_SKI1_1	70	74	PF00082	0.377
DEG_MDM2_SWIB_1	250	257	PF02201	0.328
DEG_MDM2_SWIB_1	73	81	PF02201	0.436
DEG_Nend_UBRbox_1	1	4	PF02207	0.487
DEG_SCF_FBW7_1	203	210	PF00400	0.486
DOC_CKS1_1	204	209	PF01111	0.419
DOC_CKS1_1	262	267	PF01111	0.427
DOC_CYCLIN_yCln2_LP_2	274	277	PF00134	0.432
DOC_MAPK_DCC_7	174	182	PF00069	0.453
DOC_MAPK_gen_1	163	173	PF00069	0.414
DOC_MAPK_gen_1	230	236	PF00069	0.446
DOC_MAPK_MEF2A_6	174	182	PF00069	0.482
DOC_MAPK_MEF2A_6	189	197	PF00069	0.309
DOC_PP1_RVXF_1	1	8	PF00149	0.456
DOC_PP1_RVXF_1	56	63	PF00149	0.383
DOC_PP2B_LxvP_1	274	277	PF13499	0.432
DOC_USP7_MATH_1	123	127	PF00917	0.421
DOC_USP7_MATH_1	135	139	PF00917	0.294
DOC_USP7_MATH_1	25	29	PF00917	0.466
DOC_WW_Pin1_4	203	208	PF00397	0.449
DOC_WW_Pin1_4	261	266	PF00397	0.370
DOC_WW_Pin1_4	27	32	PF00397	0.567
DOC_WW_Pin1_4	42	47	PF00397	0.512
LIG_14-3-3_CanoR_1	189	194	PF00244	0.340
LIG_14-3-3_CanoR_1	2	8	PF00244	0.633
LIG_APCC_ABBAyCdc20_2	205	211	PF00400	0.476
LIG_BRCT_BRCA1_1	58	62	PF00533	0.378
LIG_CtBP_PxDLS_1	265	269	PF00389	0.481
LIG_deltaCOP1_diTrp_1	75	80	PF00928	0.432
LIG_FHA_1	88	94	PF00498	0.430
LIG_FHA_1	98	104	PF00498	0.426
LIG_FHA_2	262	268	PF00498	0.360
LIG_FHA_2	74	80	PF00498	0.532
LIG_LIR_Apic_2	260	265	PF02991	0.418
LIG_LIR_Gen_1	206	217	PF02991	0.355
LIG_LIR_Gen_1	75	84	PF02991	0.423
LIG_LIR_Gen_1	88	97	PF02991	0.483
LIG_LIR_Nem_3	206	212	PF02991	0.376
LIG_LIR_Nem_3	59	65	PF02991	0.422
LIG_LIR_Nem_3	6	10	PF02991	0.635
LIG_LIR_Nem_3	75	80	PF02991	0.445
LIG_PCNA_PIPBox_1	102	111	PF02747	0.425
LIG_Pex14_2	250	254	PF04695	0.333
LIG_Pex14_2	73	77	PF04695	0.447
LIG_PTB_Apo_2	235	242	PF02174	0.428
LIG_SH2_CRK	65	69	PF00017	0.315
LIG_SH2_STAP1	252	256	PF00017	0.400
LIG_SH3_3	14	20	PF00018	0.500
LIG_SH3_3	175	181	PF00018	0.403
LIG_SH3_3	41	47	PF00018	0.525
LIG_SH3_3	65	71	PF00018	0.350
LIG_SUMO_SIM_anti_2	158	164	PF11976	0.496
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.334
LIG_SUMO_SIM_par_1	158	164	PF11976	0.440
LIG_TRAF2_1	76	79	PF00917	0.456
MOD_CDK_SPK_2	27	32	PF00069	0.507
MOD_CK1_1	210	216	PF00069	0.370
MOD_CK1_1	26	32	PF00069	0.526
MOD_CK1_1	261	267	PF00069	0.358
MOD_CK1_1	45	51	PF00069	0.656
MOD_CK2_1	142	148	PF00069	0.431
MOD_CK2_1	261	267	PF00069	0.358
MOD_CK2_1	73	79	PF00069	0.534
MOD_Cter_Amidation	33	36	PF01082	0.605
MOD_GlcNHglycan	125	128	PF01048	0.444
MOD_GlcNHglycan	25	28	PF01048	0.598
MOD_GlcNHglycan	95	98	PF01048	0.452
MOD_GSK3_1	189	196	PF00069	0.340
MOD_GSK3_1	19	26	PF00069	0.578
MOD_GSK3_1	199	206	PF00069	0.406
MOD_GSK3_1	89	96	PF00069	0.407
MOD_N-GLC_1	123	128	PF02516	0.462
MOD_N-GLC_1	155	160	PF02516	0.226
MOD_NEK2_1	161	166	PF00069	0.457
MOD_NEK2_1	221	226	PF00069	0.383
MOD_NEK2_1	73	78	PF00069	0.480
MOD_NEK2_1	89	94	PF00069	0.353
MOD_PIKK_1	137	143	PF00454	0.472
MOD_PK_1	189	195	PF00069	0.340
MOD_PKA_1	258	264	PF00069	0.358
MOD_PKA_2	188	194	PF00069	0.364
MOD_Plk_1	155	161	PF00069	0.291
MOD_Plk_1	210	216	PF00069	0.340
MOD_Plk_1	87	93	PF00069	0.288
MOD_Plk_4	155	161	PF00069	0.404
MOD_Plk_4	193	199	PF00069	0.333
MOD_Plk_4	258	264	PF00069	0.327
MOD_ProDKin_1	203	209	PF00069	0.441
MOD_ProDKin_1	261	267	PF00069	0.383
MOD_ProDKin_1	27	33	PF00069	0.571
MOD_ProDKin_1	42	48	PF00069	0.508
MOD_SUMO_rev_2	113	122	PF00179	0.382
MOD_SUMO_rev_2	194	203	PF00179	0.416
MOD_SUMO_rev_2	50	60	PF00179	0.436
TRG_DiLeu_BaEn_1	270	275	PF01217	0.393
TRG_DiLeu_BaEn_2	62	68	PF01217	0.323
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.396
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.454
TRG_ENDOCYTIC_2	219	222	PF00928	0.357
TRG_ENDOCYTIC_2	65	68	PF00928	0.292
TRG_ER_diArg_1	1	3	PF00400	0.465
TRG_ER_diArg_1	35	37	PF00400	0.556
TRG_ER_FFAT_1	126	138	PF00635	0.471
TRG_NLS_MonoExtC_3	164	170	PF00514	0.472
TRG_NLS_MonoExtN_4	163	169	PF00514	0.284
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC7	Leptomonas seymouri	70%	100%
A0A0S4JDI3	Bodo saltans	34%	80%
A0A1X0P267	Trypanosomatidae	51%	95%
A0A3Q8IE40	Leishmania donovani	95%	88%
A0A422P4V6	Trypanosoma rangeli	47%	95%
A4HI24	Leishmania braziliensis	89%	100%
A4I5A1	Leishmania infantum	94%	100%
C9ZQN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	94%
Q4Q7N5	Leishmania major	95%	100%