Putative nuclear movement protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDC-like protein

Species:

Leishmania mexicana

UniProt:

E9B0J4_LEIMU

TriTrypDb:

LmxM.29.0700

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0J4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	152	154	PF00082	0.544
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.544
CLV_PCSK_SKI1_1	122	126	PF00082	0.395
CLV_PCSK_SKI1_1	34	38	PF00082	0.335
DEG_ODPH_VHL_1	42	55	PF01847	0.422
DOC_MAPK_DCC_7	122	131	PF00069	0.411
DOC_MAPK_gen_1	122	131	PF00069	0.411
DOC_MAPK_gen_1	47	55	PF00069	0.422
DOC_MAPK_gen_1	56	64	PF00069	0.382
DOC_MAPK_HePTP_8	119	131	PF00069	0.388
DOC_MAPK_MEF2A_6	122	131	PF00069	0.411
DOC_MAPK_MEF2A_6	34	42	PF00069	0.405
DOC_MAPK_MEF2A_6	47	55	PF00069	0.381
DOC_MAPK_MEF2A_6	56	64	PF00069	0.382
DOC_PP2B_LxvP_1	124	127	PF13499	0.447
LIG_14-3-3_CanoR_1	47	52	PF00244	0.572
LIG_BIR_II_1	1	5	PF00653	0.357
LIG_BRCT_BRCA1_1	127	131	PF00533	0.447
LIG_FHA_1	35	41	PF00498	0.421
LIG_FHA_1	83	89	PF00498	0.453
LIG_FHA_1	9	15	PF00498	0.332
LIG_LIR_Gen_1	128	138	PF02991	0.427
LIG_LIR_LC3C_4	93	96	PF02991	0.472
LIG_LIR_Nem_3	106	112	PF02991	0.281
LIG_LIR_Nem_3	128	134	PF02991	0.427
LIG_LIR_Nem_3	23	27	PF02991	0.313
LIG_LIR_Nem_3	74	79	PF02991	0.398
LIG_NRBOX	93	99	PF00104	0.343
LIG_PCNA_yPIPBox_3	139	153	PF02747	0.411
LIG_PDZ_Class_1	156	161	PF00595	0.499
LIG_SH2_CRK	76	80	PF00017	0.398
LIG_SH2_STAP1	105	109	PF00017	0.426
LIG_SH2_STAT5	24	27	PF00017	0.502
LIG_SH3_3	35	41	PF00018	0.396
LIG_SUMO_SIM_anti_2	93	99	PF11976	0.422
LIG_SUMO_SIM_par_1	93	99	PF11976	0.390
LIG_TRAF2_1	5	8	PF00917	0.321
LIG_WRC_WIRS_1	26	31	PF05994	0.257
MOD_CK2_1	29	35	PF00069	0.462
MOD_GSK3_1	125	132	PF00069	0.432
MOD_GSK3_1	25	32	PF00069	0.287
MOD_GSK3_1	43	50	PF00069	0.355
MOD_NEK2_1	98	103	PF00069	0.525
MOD_NEK2_2	22	27	PF00069	0.335
MOD_PIKK_1	3	9	PF00454	0.357
MOD_PK_1	125	131	PF00069	0.434
MOD_PKA_2	129	135	PF00069	0.435
MOD_Plk_1	22	28	PF00069	0.361
MOD_Plk_1	34	40	PF00069	0.391
MOD_Plk_1	81	87	PF00069	0.399
MOD_Plk_4	22	28	PF00069	0.334
MOD_Plk_4	66	72	PF00069	0.480
MOD_SUMO_rev_2	116	124	PF00179	0.303
MOD_SUMO_rev_2	50	57	PF00179	0.422
MOD_SUMO_rev_2	84	94	PF00179	0.388
TRG_DiLeu_BaEn_1	93	98	PF01217	0.351
TRG_ENDOCYTIC_2	76	79	PF00928	0.388
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.201

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KHK6	Bodo saltans	58%	89%
A0A1X0P2C4	Trypanosomatidae	60%	92%
A0A3R7L0Q9	Trypanosoma rangeli	59%	92%
A0A3S7X365	Leishmania donovani	98%	100%
A4HI21	Leishmania braziliensis	85%	100%
A4I598	Leishmania infantum	98%	100%
O60166	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	97%
P17624	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	81%
Q4Q7N8	Leishmania major	94%	100%
Q54M64	Dictyostelium discoideum	32%	94%
Q5M823	Rattus norvegicus	29%	100%
Q8WVJ2	Homo sapiens	29%	100%
Q9CQ48	Mus musculus	29%	100%