PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pdz domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0J1_LEIMU

TriTrypDb:

LmxM.29.0660

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0J1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0007165	signal transduction	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0035556	intracellular signal transduction	3	12
GO:0044238	primary metabolic process	2	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12
GO:0071704	organic substance metabolic process	2	12
GO:0048015	phosphatidylinositol-mediated signaling	5	1
GO:0048017	inositol lipid-mediated signaling	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0004435	phosphatidylinositol phospholipase C activity	7	1
GO:0004620	phospholipase activity	5	1
GO:0004629	phospholipase C activity	6	1
GO:0016298	lipase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.534
CLV_C14_Caspase3-7	620	624	PF00656	0.503
CLV_NRD_NRD_1	170	172	PF00675	0.298
CLV_NRD_NRD_1	496	498	PF00675	0.459
CLV_NRD_NRD_1	555	557	PF00675	0.488
CLV_PCSK_KEX2_1	19	21	PF00082	0.846
CLV_PCSK_KEX2_1	314	316	PF00082	0.485
CLV_PCSK_KEX2_1	496	498	PF00082	0.516
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.846
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.485
CLV_PCSK_SKI1_1	133	137	PF00082	0.442
CLV_PCSK_SKI1_1	158	162	PF00082	0.491
CLV_PCSK_SKI1_1	557	561	PF00082	0.576
CLV_PCSK_SKI1_1	690	694	PF00082	0.519
CLV_PCSK_SKI1_1	78	82	PF00082	0.375
DEG_APCC_DBOX_1	117	125	PF00400	0.508
DEG_APCC_DBOX_1	480	488	PF00400	0.375
DEG_APCC_DBOX_1	496	504	PF00400	0.508
DEG_SCF_FBW7_1	368	374	PF00400	0.337
DOC_ANK_TNKS_1	314	321	PF00023	0.474
DOC_CKS1_1	368	373	PF01111	0.381
DOC_CYCLIN_RxL_1	130	141	PF00134	0.472
DOC_CYCLIN_RxL_1	155	165	PF00134	0.495
DOC_MAPK_gen_1	114	123	PF00069	0.430
DOC_MAPK_gen_1	425	432	PF00069	0.494
DOC_MAPK_MEF2A_6	114	123	PF00069	0.446
DOC_MAPK_MEF2A_6	425	432	PF00069	0.471
DOC_MAPK_MEF2A_6	439	446	PF00069	0.248
DOC_MAPK_MEF2A_6	98	105	PF00069	0.421
DOC_MAPK_NFAT4_5	116	124	PF00069	0.562
DOC_PP2B_LxvP_1	135	138	PF13499	0.525
DOC_USP7_MATH_1	284	288	PF00917	0.574
DOC_USP7_MATH_1	518	522	PF00917	0.463
DOC_USP7_MATH_1	545	549	PF00917	0.546
DOC_USP7_MATH_1	571	575	PF00917	0.602
DOC_USP7_MATH_1	645	649	PF00917	0.535
DOC_USP7_MATH_1	707	711	PF00917	0.581
DOC_USP7_UBL2_3	116	120	PF12436	0.484
DOC_USP7_UBL2_3	26	30	PF12436	0.834
DOC_USP7_UBL2_3	553	557	PF12436	0.560
DOC_WW_Pin1_4	12	17	PF00397	0.667
DOC_WW_Pin1_4	364	369	PF00397	0.368
DOC_WW_Pin1_4	371	376	PF00397	0.403
DOC_WW_Pin1_4	406	411	PF00397	0.316
DOC_WW_Pin1_4	450	455	PF00397	0.316
DOC_WW_Pin1_4	624	629	PF00397	0.683
DOC_WW_Pin1_4	641	646	PF00397	0.400
LIG_14-3-3_CanoR_1	285	293	PF00244	0.531
LIG_14-3-3_CanoR_1	690	700	PF00244	0.511
LIG_Actin_WH2_2	298	316	PF00022	0.323
LIG_Actin_WH2_2	465	483	PF00022	0.381
LIG_BRCT_BRCA1_1	194	198	PF00533	0.375
LIG_BRCT_BRCA1_1	523	527	PF00533	0.527
LIG_BRCT_BRCA1_2	523	529	PF00533	0.509
LIG_deltaCOP1_diTrp_1	288	297	PF00928	0.465
LIG_FHA_1	123	129	PF00498	0.424
LIG_FHA_1	171	177	PF00498	0.516
LIG_FHA_1	183	189	PF00498	0.439
LIG_FHA_1	284	290	PF00498	0.445
LIG_FHA_1	319	325	PF00498	0.462
LIG_FHA_1	357	363	PF00498	0.419
LIG_FHA_1	539	545	PF00498	0.480
LIG_FHA_1	549	555	PF00498	0.449
LIG_FHA_1	673	679	PF00498	0.371
LIG_FHA_2	307	313	PF00498	0.471
LIG_FHA_2	343	349	PF00498	0.370
LIG_FHA_2	389	395	PF00498	0.329
LIG_FHA_2	553	559	PF00498	0.541
LIG_FHA_2	618	624	PF00498	0.598
LIG_GBD_Chelix_1	380	388	PF00786	0.350
LIG_Integrin_isoDGR_2	611	613	PF01839	0.473
LIG_LIR_Gen_1	153	164	PF02991	0.396
LIG_LIR_Gen_1	195	206	PF02991	0.368
LIG_LIR_Gen_1	216	223	PF02991	0.472
LIG_LIR_Gen_1	287	297	PF02991	0.431
LIG_LIR_Gen_1	629	640	PF02991	0.360
LIG_LIR_Nem_3	153	159	PF02991	0.379
LIG_LIR_Nem_3	185	190	PF02991	0.420
LIG_LIR_Nem_3	195	201	PF02991	0.317
LIG_LIR_Nem_3	216	222	PF02991	0.463
LIG_LIR_Nem_3	294	300	PF02991	0.519
LIG_LIR_Nem_3	357	363	PF02991	0.336
LIG_LIR_Nem_3	524	530	PF02991	0.417
LIG_LIR_Nem_3	629	635	PF02991	0.400
LIG_LIR_Nem_3	85	91	PF02991	0.559
LIG_LYPXL_yS_3	360	363	PF13949	0.316
LIG_NRBOX	126	132	PF00104	0.249
LIG_PCNA_PIPBox_1	180	189	PF02747	0.510
LIG_PCNA_yPIPBox_3	180	189	PF02747	0.538
LIG_Pex14_2	255	259	PF04695	0.561
LIG_Pex14_2	692	696	PF04695	0.368
LIG_PTB_Apo_2	164	171	PF02174	0.490
LIG_PTB_Apo_2	181	188	PF02174	0.459
LIG_PTB_Phospho_1	181	187	PF10480	0.590
LIG_REV1ctd_RIR_1	525	533	PF16727	0.525
LIG_SH2_CRK	266	270	PF00017	0.427
LIG_SH2_CRK	42	46	PF00017	0.632
LIG_SH2_CRK	705	709	PF00017	0.389
LIG_SH2_CRK	727	731	PF00017	0.396
LIG_SH2_STAT5	187	190	PF00017	0.506
LIG_SH2_STAT5	257	260	PF00017	0.490
LIG_SH2_STAT5	616	619	PF00017	0.370
LIG_SH2_STAT5	727	730	PF00017	0.391
LIG_SH3_1	706	712	PF00018	0.511
LIG_SH3_3	365	371	PF00018	0.410
LIG_SH3_3	706	712	PF00018	0.485
LIG_SUMO_SIM_anti_2	122	129	PF11976	0.485
LIG_SUMO_SIM_anti_2	675	680	PF11976	0.380
LIG_SUMO_SIM_par_1	124	129	PF11976	0.424
LIG_SUMO_SIM_par_1	99	104	PF11976	0.430
LIG_TRAF2_1	713	716	PF00917	0.507
LIG_TYR_ITIM	40	45	PF00017	0.511
LIG_UBA3_1	127	136	PF00899	0.397
MOD_CDK_SPxxK_3	12	19	PF00069	0.648
MOD_CDK_SPxxK_3	450	457	PF00069	0.316
MOD_CK1_1	228	234	PF00069	0.599
MOD_CK1_1	244	250	PF00069	0.425
MOD_CK1_1	274	280	PF00069	0.426
MOD_CK1_1	356	362	PF00069	0.390
MOD_CK1_1	367	373	PF00069	0.517
MOD_CK1_1	421	427	PF00069	0.560
MOD_CK1_1	521	527	PF00069	0.536
MOD_CK1_1	548	554	PF00069	0.514
MOD_CK1_1	6	12	PF00069	0.820
MOD_CK1_1	624	630	PF00069	0.599
MOD_CK1_1	644	650	PF00069	0.564
MOD_CK1_1	664	670	PF00069	0.490
MOD_CK1_1	710	716	PF00069	0.537
MOD_CK1_1	732	738	PF00069	0.559
MOD_CK2_1	105	111	PF00069	0.402
MOD_CK2_1	342	348	PF00069	0.350
MOD_CK2_1	388	394	PF00069	0.217
MOD_CK2_1	5	11	PF00069	0.829
MOD_CK2_1	710	716	PF00069	0.487
MOD_CK2_1	76	82	PF00069	0.398
MOD_GlcNHglycan	209	212	PF01048	0.383
MOD_GlcNHglycan	42	45	PF01048	0.632
MOD_GlcNHglycan	518	521	PF01048	0.420
MOD_GlcNHglycan	569	572	PF01048	0.514
MOD_GlcNHglycan	623	626	PF01048	0.578
MOD_GlcNHglycan	693	696	PF01048	0.424
MOD_GlcNHglycan	71	74	PF01048	0.612
MOD_GlcNHglycan	712	715	PF01048	0.361
MOD_GlcNHglycan	88	91	PF01048	0.338
MOD_GSK3_1	101	108	PF00069	0.410
MOD_GSK3_1	122	129	PF00069	0.470
MOD_GSK3_1	162	169	PF00069	0.434
MOD_GSK3_1	170	177	PF00069	0.462
MOD_GSK3_1	267	274	PF00069	0.401
MOD_GSK3_1	291	298	PF00069	0.405
MOD_GSK3_1	367	374	PF00069	0.471
MOD_GSK3_1	514	521	PF00069	0.436
MOD_GSK3_1	544	551	PF00069	0.496
MOD_GSK3_1	567	574	PF00069	0.466
MOD_GSK3_1	6	13	PF00069	0.798
MOD_GSK3_1	617	624	PF00069	0.494
MOD_GSK3_1	641	648	PF00069	0.553
MOD_GSK3_1	729	736	PF00069	0.404
MOD_N-GLC_1	192	197	PF02516	0.389
MOD_N-GLC_1	271	276	PF02516	0.528
MOD_N-GLC_1	641	646	PF02516	0.582
MOD_N-GLC_1	649	654	PF02516	0.519
MOD_N-GLC_1	661	666	PF02516	0.295
MOD_N-GLC_2	107	109	PF02516	0.372
MOD_NEK2_1	103	108	PF00069	0.278
MOD_NEK2_1	170	175	PF00069	0.592
MOD_NEK2_1	293	298	PF00069	0.478
MOD_NEK2_1	388	393	PF00069	0.249
MOD_NEK2_1	40	45	PF00069	0.511
MOD_NEK2_1	418	423	PF00069	0.414
MOD_NEK2_1	480	485	PF00069	0.381
MOD_NEK2_1	549	554	PF00069	0.574
MOD_NEK2_1	630	635	PF00069	0.481
MOD_NEK2_1	649	654	PF00069	0.423
MOD_NEK2_1	729	734	PF00069	0.377
MOD_NEK2_1	76	81	PF00069	0.417
MOD_NMyristoyl	1	7	PF02799	0.651
MOD_PIKK_1	291	297	PF00454	0.385
MOD_PIKK_1	661	667	PF00454	0.517
MOD_PIKK_1	91	97	PF00454	0.478
MOD_PKA_2	170	176	PF00069	0.294
MOD_PKA_2	284	290	PF00069	0.459
MOD_PKA_2	444	450	PF00069	0.320
MOD_PKA_2	480	486	PF00069	0.381
MOD_PKA_2	606	612	PF00069	0.504
MOD_Plk_1	140	146	PF00069	0.536
MOD_Plk_1	192	198	PF00069	0.467
MOD_Plk_1	388	394	PF00069	0.318
MOD_Plk_1	491	497	PF00069	0.331
MOD_Plk_1	628	634	PF00069	0.455
MOD_Plk_1	649	655	PF00069	0.603
MOD_Plk_1	688	694	PF00069	0.468
MOD_Plk_2-3	342	348	PF00069	0.461
MOD_Plk_4	126	132	PF00069	0.310
MOD_Plk_4	182	188	PF00069	0.457
MOD_Plk_4	271	277	PF00069	0.381
MOD_Plk_4	342	348	PF00069	0.404
MOD_Plk_4	733	739	PF00069	0.438
MOD_ProDKin_1	12	18	PF00069	0.669
MOD_ProDKin_1	364	370	PF00069	0.368
MOD_ProDKin_1	371	377	PF00069	0.403
MOD_ProDKin_1	406	412	PF00069	0.316
MOD_ProDKin_1	450	456	PF00069	0.316
MOD_ProDKin_1	624	630	PF00069	0.670
MOD_ProDKin_1	641	647	PF00069	0.399
MOD_SPalmitoyl_4	1	7	PF01529	0.711
MOD_SUMO_rev_2	308	316	PF00179	0.498
MOD_SUMO_rev_2	399	409	PF00179	0.309
MOD_SUMO_rev_2	498	506	PF00179	0.462
MOD_SUMO_rev_2	531	538	PF00179	0.590
MOD_SUMO_rev_2	576	585	PF00179	0.441
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.535
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.507
TRG_ENDOCYTIC_2	266	269	PF00928	0.422
TRG_ENDOCYTIC_2	360	363	PF00928	0.316
TRG_ENDOCYTIC_2	42	45	PF00928	0.632
TRG_ENDOCYTIC_2	705	708	PF00928	0.382
TRG_ENDOCYTIC_2	727	730	PF00928	0.391
TRG_ER_diArg_1	495	497	PF00400	0.461
TRG_ER_diArg_1	605	608	PF00400	0.513
TRG_NES_CRM1_1	478	492	PF08389	0.275
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S8	Leptomonas seymouri	73%	100%
A0A0S4KHF2	Bodo saltans	42%	100%
A0A1X0P2U3	Trypanosomatidae	48%	100%
A0A3Q8IES3	Leishmania donovani	95%	100%
A0A3R7MG69	Trypanosoma rangeli	46%	97%
A4HI17	Leishmania braziliensis	86%	100%
A4I594	Leishmania infantum	95%	100%
C9ZQM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q7P2	Leishmania major	94%	100%
V5AS75	Trypanosoma cruzi	48%	100%