Putative nitrate reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nitrate reductase, putative

Species:

Leishmania mexicana

UniProt:

E9B0I6_LEIMU

TriTrypDb:

LmxM.29.0610

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0I6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	10
GO:0008940	nitrate reductase activity	4	8
GO:0009703	nitrate reductase (NADH) activity	6	8
GO:0016491	oxidoreductase activity	2	11
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	8
GO:0020037	heme binding	4	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	4	8
GO:0046872	metal ion binding	4	10
GO:0046906	tetrapyrrole binding	3	10
GO:0050463	nitrate reductase [NAD(P)H] activity	5	8
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.402
CLV_C14_Caspase3-7	514	518	PF00656	0.389
CLV_NRD_NRD_1	127	129	PF00675	0.383
CLV_NRD_NRD_1	147	149	PF00675	0.402
CLV_NRD_NRD_1	443	445	PF00675	0.354
CLV_NRD_NRD_1	81	83	PF00675	0.529
CLV_PCSK_KEX2_1	127	129	PF00082	0.383
CLV_PCSK_KEX2_1	443	445	PF00082	0.444
CLV_PCSK_KEX2_1	71	73	PF00082	0.525
CLV_PCSK_KEX2_1	81	83	PF00082	0.414
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.525
CLV_PCSK_SKI1_1	123	127	PF00082	0.473
CLV_PCSK_SKI1_1	132	136	PF00082	0.413
CLV_PCSK_SKI1_1	196	200	PF00082	0.336
CLV_PCSK_SKI1_1	220	224	PF00082	0.289
CLV_PCSK_SKI1_1	461	465	PF00082	0.391
CLV_PCSK_SKI1_1	71	75	PF00082	0.833
CLV_PCSK_SKI1_1	83	87	PF00082	0.599
DEG_SCF_FBW7_1	50	56	PF00400	0.711
DEG_SPOP_SBC_1	161	165	PF00917	0.566
DEG_SPOP_SBC_1	476	480	PF00917	0.344
DEG_SPOP_SBC_1	53	57	PF00917	0.512
DOC_CKS1_1	333	338	PF01111	0.402
DOC_CKS1_1	50	55	PF01111	0.711
DOC_MAPK_gen_1	212	221	PF00069	0.480
DOC_MAPK_MEF2A_6	261	270	PF00069	0.546
DOC_MAPK_MEF2A_6	457	466	PF00069	0.449
DOC_PIKK_1	434	442	PF02985	0.188
DOC_PP2B_LxvP_1	158	161	PF13499	0.626
DOC_PP4_FxxP_1	306	309	PF00568	0.389
DOC_PP4_FxxP_1	333	336	PF00568	0.402
DOC_PP4_FxxP_1	371	374	PF00568	0.471
DOC_USP7_MATH_1	294	298	PF00917	0.490
DOC_USP7_MATH_1	452	456	PF00917	0.188
DOC_USP7_MATH_2	160	166	PF00917	0.562
DOC_USP7_MATH_2	65	71	PF00917	0.522
DOC_WW_Pin1_4	168	173	PF00397	0.769
DOC_WW_Pin1_4	206	211	PF00397	0.429
DOC_WW_Pin1_4	259	264	PF00397	0.619
DOC_WW_Pin1_4	332	337	PF00397	0.331
DOC_WW_Pin1_4	46	51	PF00397	0.828
DOC_WW_Pin1_4	467	472	PF00397	0.431
DOC_WW_Pin1_4	9	14	PF00397	0.570
LIG_14-3-3_CanoR_1	431	438	PF00244	0.411
LIG_14-3-3_CanoR_1	490	496	PF00244	0.496
LIG_14-3-3_CanoR_1	7	13	PF00244	0.790
LIG_14-3-3_CanoR_1	81	86	PF00244	0.626
LIG_APCC_ABBA_1	199	204	PF00400	0.424
LIG_BRCT_BRCA1_1	356	360	PF00533	0.383
LIG_BRCT_BRCA1_1	477	481	PF00533	0.363
LIG_FHA_1	111	117	PF00498	0.392
LIG_FHA_1	171	177	PF00498	0.733
LIG_FHA_1	185	191	PF00498	0.569
LIG_FHA_1	285	291	PF00498	0.488
LIG_FHA_1	296	302	PF00498	0.454
LIG_FHA_1	402	408	PF00498	0.305
LIG_FHA_1	457	463	PF00498	0.408
LIG_FHA_1	55	61	PF00498	0.559
LIG_FHA_1	99	105	PF00498	0.454
LIG_FHA_2	430	436	PF00498	0.480
LIG_FHA_2	512	518	PF00498	0.402
LIG_FHA_2	53	59	PF00498	0.734
LIG_FHA_2	84	90	PF00498	0.424
LIG_Integrin_isoDGR_2	226	228	PF01839	0.480
LIG_Integrin_isoDGR_2	353	355	PF01839	0.402
LIG_LIR_Apic_2	305	309	PF02991	0.393
LIG_LIR_Apic_2	330	336	PF02991	0.434
LIG_LIR_Apic_2	368	374	PF02991	0.355
LIG_LIR_Gen_1	232	242	PF02991	0.356
LIG_LIR_Nem_3	232	237	PF02991	0.320
LIG_LIR_Nem_3	300	306	PF02991	0.493
LIG_LIR_Nem_3	331	337	PF02991	0.385
LIG_LIR_Nem_3	357	363	PF02991	0.391
LIG_LIR_Nem_3	494	499	PF02991	0.327
LIG_MLH1_MIPbox_1	356	360	PF16413	0.383
LIG_Pex14_2	333	337	PF04695	0.480
LIG_REV1ctd_RIR_1	358	368	PF16727	0.383
LIG_SH2_CRK	323	327	PF00017	0.431
LIG_SH2_GRB2like	323	326	PF00017	0.480
LIG_SH2_STAP1	323	327	PF00017	0.188
LIG_SH2_STAP1	449	453	PF00017	0.480
LIG_SH2_STAT5	250	253	PF00017	0.361
LIG_SH2_STAT5	303	306	PF00017	0.487
LIG_SH2_STAT5	334	337	PF00017	0.365
LIG_SH2_STAT5	359	362	PF00017	0.378
LIG_SH3_3	257	263	PF00018	0.650
LIG_SH3_3	273	279	PF00018	0.584
LIG_SH3_3	371	377	PF00018	0.335
LIG_SH3_3	47	53	PF00018	0.804
LIG_SH3_3	506	512	PF00018	0.454
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.381
LIG_SUMO_SIM_anti_2	422	429	PF11976	0.295
LIG_SUMO_SIM_par_1	101	107	PF11976	0.480
LIG_SUMO_SIM_par_1	197	204	PF11976	0.363
LIG_SUMO_SIM_par_1	461	467	PF11976	0.468
LIG_TRAF2_1	14	17	PF00917	0.718
LIG_TRAF2_1	65	68	PF00917	0.803
LIG_TRFH_1	249	253	PF08558	0.480
LIG_WRC_WIRS_1	112	117	PF05994	0.408
LIG_WRC_WIRS_1	303	308	PF05994	0.480
LIG_WRC_WIRS_1	341	346	PF05994	0.424
MOD_CDC14_SPxK_1	262	265	PF00782	0.613
MOD_CDK_SPxK_1	206	212	PF00069	0.429
MOD_CDK_SPxK_1	259	265	PF00069	0.643
MOD_CDK_SPxK_1	332	338	PF00069	0.434
MOD_CK1_1	140	146	PF00069	0.487
MOD_CK1_1	297	303	PF00069	0.566
MOD_CK1_1	411	417	PF00069	0.480
MOD_CK1_1	422	428	PF00069	0.403
MOD_CK1_1	429	435	PF00069	0.431
MOD_CK1_1	467	473	PF00069	0.493
MOD_CK1_1	475	481	PF00069	0.451
MOD_CK2_1	52	58	PF00069	0.732
MOD_CK2_1	83	89	PF00069	0.570
MOD_GlcNHglycan	142	145	PF01048	0.480
MOD_GlcNHglycan	164	167	PF01048	0.757
MOD_GlcNHglycan	273	276	PF01048	0.650
MOD_GlcNHglycan	356	359	PF01048	0.487
MOD_GlcNHglycan	525	528	PF01048	0.317
MOD_GSK3_1	111	118	PF00069	0.395
MOD_GSK3_1	184	191	PF00069	0.598
MOD_GSK3_1	22	29	PF00069	0.788
MOD_GSK3_1	279	286	PF00069	0.525
MOD_GSK3_1	328	335	PF00069	0.417
MOD_GSK3_1	336	343	PF00069	0.380
MOD_GSK3_1	416	423	PF00069	0.342
MOD_GSK3_1	426	433	PF00069	0.288
MOD_GSK3_1	44	51	PF00069	0.797
MOD_GSK3_1	452	459	PF00069	0.322
MOD_GSK3_1	472	479	PF00069	0.480
MOD_GSK3_1	523	530	PF00069	0.368
MOD_GSK3_1	54	61	PF00069	0.799
MOD_LATS_1	319	325	PF00433	0.434
MOD_LATS_1	79	85	PF00433	0.536
MOD_N-GLC_1	295	300	PF02516	0.516
MOD_NEK2_1	115	120	PF00069	0.356
MOD_NEK2_1	222	227	PF00069	0.266
MOD_NEK2_1	304	309	PF00069	0.446
MOD_NEK2_1	426	431	PF00069	0.328
MOD_NEK2_1	44	49	PF00069	0.679
MOD_NEK2_1	464	469	PF00069	0.411
MOD_NEK2_2	137	142	PF00069	0.482
MOD_NMyristoyl	1	7	PF02799	0.492
MOD_PIKK_1	416	422	PF00454	0.480
MOD_PIKK_1	452	458	PF00454	0.188
MOD_PKA_1	81	87	PF00069	0.404
MOD_PKA_2	354	360	PF00069	0.440
MOD_PKA_2	430	436	PF00069	0.210
MOD_PKA_2	447	453	PF00069	0.447
MOD_PKA_2	489	495	PF00069	0.480
MOD_PKA_2	81	87	PF00069	0.397
MOD_Plk_1	110	116	PF00069	0.337
MOD_Plk_1	328	334	PF00069	0.440
MOD_Plk_1	44	50	PF00069	0.660
MOD_Plk_1	472	478	PF00069	0.480
MOD_Plk_1	98	104	PF00069	0.425
MOD_Plk_4	111	117	PF00069	0.482
MOD_Plk_4	121	127	PF00069	0.348
MOD_Plk_4	230	236	PF00069	0.402
MOD_Plk_4	422	428	PF00069	0.370
MOD_ProDKin_1	168	174	PF00069	0.767
MOD_ProDKin_1	206	212	PF00069	0.429
MOD_ProDKin_1	259	265	PF00069	0.614
MOD_ProDKin_1	332	338	PF00069	0.331
MOD_ProDKin_1	46	52	PF00069	0.826
MOD_ProDKin_1	467	473	PF00069	0.431
MOD_ProDKin_1	9	15	PF00069	0.572
TRG_DiLeu_BaEn_1	89	94	PF01217	0.480
TRG_DiLeu_BaEn_4	440	446	PF01217	0.383
TRG_ENDOCYTIC_2	303	306	PF00928	0.487
TRG_ENDOCYTIC_2	323	326	PF00928	0.150
TRG_ENDOCYTIC_2	334	337	PF00928	0.212
TRG_ER_diArg_1	126	128	PF00400	0.383
TRG_ER_diArg_1	442	444	PF00400	0.444
TRG_ER_diArg_1	80	82	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN6	Leptomonas seymouri	44%	85%
A0A1X0P389	Trypanosomatidae	36%	100%
A0A3Q8IJ69	Leishmania donovani	85%	100%
A0A422NIH2	Trypanosoma rangeli	32%	100%
A4HI12	Leishmania braziliensis	71%	100%
A4I589	Leishmania infantum	85%	100%
C9ZQM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q7P5	Leishmania major	82%	100%
V5B7R2	Trypanosoma cruzi	34%	100%