LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9B0I5_LEIMU
TriTrypDb:
LmxM.29.0600
Length:
927

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0I5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0I5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016310 phosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:0007165 signal transduction 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140096 catalytic activity, acting on a protein 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 355 361 PF00089 0.304
CLV_NRD_NRD_1 107 109 PF00675 0.592
CLV_NRD_NRD_1 136 138 PF00675 0.600
CLV_NRD_NRD_1 212 214 PF00675 0.615
CLV_NRD_NRD_1 3 5 PF00675 0.545
CLV_NRD_NRD_1 35 37 PF00675 0.592
CLV_NRD_NRD_1 409 411 PF00675 0.304
CLV_NRD_NRD_1 631 633 PF00675 0.688
CLV_NRD_NRD_1 689 691 PF00675 0.549
CLV_NRD_NRD_1 803 805 PF00675 0.718
CLV_NRD_NRD_1 845 847 PF00675 0.711
CLV_PCSK_FUR_1 134 138 PF00082 0.600
CLV_PCSK_FUR_1 801 805 PF00082 0.718
CLV_PCSK_KEX2_1 107 109 PF00082 0.592
CLV_PCSK_KEX2_1 136 138 PF00082 0.600
CLV_PCSK_KEX2_1 35 37 PF00082 0.592
CLV_PCSK_KEX2_1 409 411 PF00082 0.304
CLV_PCSK_KEX2_1 689 691 PF00082 0.520
CLV_PCSK_KEX2_1 803 805 PF00082 0.718
CLV_PCSK_KEX2_1 844 846 PF00082 0.710
CLV_PCSK_KEX2_1 908 910 PF00082 0.668
CLV_PCSK_PC1ET2_1 844 846 PF00082 0.646
CLV_PCSK_PC1ET2_1 908 910 PF00082 0.695
CLV_PCSK_PC7_1 132 138 PF00082 0.600
CLV_PCSK_SKI1_1 39 43 PF00082 0.589
CLV_PCSK_SKI1_1 478 482 PF00082 0.350
CLV_PCSK_SKI1_1 664 668 PF00082 0.615
DEG_APCC_DBOX_1 83 91 PF00400 0.602
DEG_SCF_TRCP1_1 55 60 PF00400 0.674
DEG_SPOP_SBC_1 839 843 PF00917 0.651
DOC_CKS1_1 514 519 PF01111 0.304
DOC_CKS1_1 778 783 PF01111 0.531
DOC_CKS1_1 856 861 PF01111 0.694
DOC_CYCLIN_yCln2_LP_2 814 820 PF00134 0.541
DOC_CYCLIN_yCln2_LP_2 856 862 PF00134 0.531
DOC_MAPK_gen_1 347 355 PF00069 0.454
DOC_MAPK_gen_1 478 487 PF00069 0.304
DOC_MAPK_gen_1 752 759 PF00069 0.597
DOC_MAPK_MEF2A_6 11 19 PF00069 0.655
DOC_MAPK_MEF2A_6 275 282 PF00069 0.614
DOC_MAPK_MEF2A_6 424 433 PF00069 0.304
DOC_PP2B_LxvP_1 306 309 PF13499 0.489
DOC_PP2B_LxvP_1 814 817 PF13499 0.540
DOC_PP4_FxxP_1 212 215 PF00568 0.625
DOC_PP4_FxxP_1 519 522 PF00568 0.304
DOC_USP7_MATH_1 140 144 PF00917 0.616
DOC_USP7_MATH_1 162 166 PF00917 0.651
DOC_USP7_MATH_1 191 195 PF00917 0.573
DOC_USP7_MATH_1 23 27 PF00917 0.482
DOC_USP7_MATH_1 284 288 PF00917 0.664
DOC_USP7_MATH_1 309 313 PF00917 0.529
DOC_USP7_MATH_1 325 329 PF00917 0.528
DOC_USP7_MATH_1 400 404 PF00917 0.304
DOC_USP7_MATH_1 53 57 PF00917 0.752
DOC_USP7_MATH_1 577 581 PF00917 0.325
DOC_USP7_MATH_1 619 623 PF00917 0.485
DOC_USP7_MATH_1 676 680 PF00917 0.586
DOC_USP7_MATH_1 762 766 PF00917 0.741
DOC_USP7_MATH_1 78 82 PF00917 0.635
DOC_USP7_MATH_1 838 842 PF00917 0.765
DOC_USP7_MATH_1 880 884 PF00917 0.672
DOC_USP7_UBL2_3 392 396 PF12436 0.304
DOC_USP7_UBL2_3 592 596 PF12436 0.304
DOC_USP7_UBL2_3 922 926 PF12436 0.636
DOC_WW_Pin1_4 280 285 PF00397 0.598
DOC_WW_Pin1_4 335 340 PF00397 0.639
DOC_WW_Pin1_4 513 518 PF00397 0.318
DOC_WW_Pin1_4 718 723 PF00397 0.827
DOC_WW_Pin1_4 738 743 PF00397 0.690
DOC_WW_Pin1_4 752 757 PF00397 0.527
DOC_WW_Pin1_4 777 782 PF00397 0.755
DOC_WW_Pin1_4 803 808 PF00397 0.833
DOC_WW_Pin1_4 822 827 PF00397 0.526
DOC_WW_Pin1_4 847 852 PF00397 0.648
DOC_WW_Pin1_4 855 860 PF00397 0.606
DOC_WW_Pin1_4 867 872 PF00397 0.573
DOC_WW_Pin1_4 896 901 PF00397 0.660
LIG_14-3-3_CanoR_1 134 140 PF00244 0.599
LIG_14-3-3_CanoR_1 29 38 PF00244 0.618
LIG_14-3-3_CanoR_1 349 354 PF00244 0.506
LIG_14-3-3_CanoR_1 598 608 PF00244 0.342
LIG_14-3-3_CanoR_1 68 75 PF00244 0.674
LIG_14-3-3_CanoR_1 695 699 PF00244 0.532
LIG_ActinCP_TwfCPI_2 212 222 PF01115 0.615
LIG_APCC_ABBA_1 429 434 PF00400 0.304
LIG_BRCT_BRCA1_1 100 104 PF00533 0.611
LIG_BRCT_BRCA1_1 223 227 PF00533 0.615
LIG_Clathr_ClatBox_1 51 55 PF01394 0.599
LIG_FHA_1 301 307 PF00498 0.607
LIG_FHA_1 389 395 PF00498 0.437
LIG_FHA_1 458 464 PF00498 0.304
LIG_FHA_1 508 514 PF00498 0.350
LIG_FHA_1 668 674 PF00498 0.560
LIG_FHA_1 69 75 PF00498 0.650
LIG_FHA_1 851 857 PF00498 0.528
LIG_FHA_2 361 367 PF00498 0.304
LIG_FHA_2 486 492 PF00498 0.338
LIG_LIR_Apic_2 210 215 PF02991 0.624
LIG_LIR_Apic_2 516 522 PF02991 0.304
LIG_LIR_Gen_1 180 191 PF02991 0.586
LIG_LIR_Gen_1 468 476 PF02991 0.369
LIG_LIR_LC3C_4 785 789 PF02991 0.571
LIG_LIR_Nem_3 148 154 PF02991 0.648
LIG_LIR_Nem_3 180 186 PF02991 0.598
LIG_LIR_Nem_3 224 230 PF02991 0.690
LIG_LIR_Nem_3 363 367 PF02991 0.304
LIG_LIR_Nem_3 468 472 PF02991 0.369
LIG_MAD2 36 44 PF02301 0.578
LIG_MLH1_MIPbox_1 100 104 PF16413 0.606
LIG_Pex14_1 208 212 PF04695 0.602
LIG_Pex14_2 227 231 PF04695 0.665
LIG_REV1ctd_RIR_1 101 112 PF16727 0.593
LIG_SH2_CRK 183 187 PF00017 0.587
LIG_SH2_CRK 9 13 PF00017 0.659
LIG_SH2_NCK_1 183 187 PF00017 0.587
LIG_SH2_NCK_1 9 13 PF00017 0.659
LIG_SH2_SRC 469 472 PF00017 0.304
LIG_SH2_STAP1 459 463 PF00017 0.304
LIG_SH2_STAP1 530 534 PF00017 0.304
LIG_SH2_STAT3 368 371 PF00017 0.325
LIG_SH2_STAT3 459 462 PF00017 0.304
LIG_SH2_STAT5 183 186 PF00017 0.593
LIG_SH2_STAT5 419 422 PF00017 0.304
LIG_SH2_STAT5 459 462 PF00017 0.331
LIG_SH2_STAT5 469 472 PF00017 0.383
LIG_SH3_1 804 810 PF00018 0.695
LIG_SH3_2 63 68 PF14604 0.508
LIG_SH3_2 817 822 PF14604 0.544
LIG_SH3_3 212 218 PF00018 0.623
LIG_SH3_3 278 284 PF00018 0.622
LIG_SH3_3 60 66 PF00018 0.507
LIG_SH3_3 804 810 PF00018 0.667
LIG_SH3_3 814 820 PF00018 0.603
LIG_SUMO_SIM_anti_2 785 791 PF11976 0.572
LIG_SUMO_SIM_par_1 276 283 PF11976 0.653
LIG_SUMO_SIM_par_1 374 383 PF11976 0.306
LIG_TRAF2_1 91 94 PF00917 0.604
LIG_TYR_ITIM 467 472 PF00017 0.369
LIG_UBA3_1 563 570 PF00899 0.304
LIG_WW_3 661 665 PF00397 0.576
MOD_CDC14_SPxK_1 870 873 PF00782 0.690
MOD_CDK_SPK_2 822 827 PF00069 0.638
MOD_CDK_SPxK_1 867 873 PF00069 0.692
MOD_CDK_SPxK_1 896 902 PF00069 0.656
MOD_CDK_SPxxK_3 718 725 PF00069 0.601
MOD_CDK_SPxxK_3 822 829 PF00069 0.619
MOD_CDK_SPxxK_3 847 854 PF00069 0.647
MOD_CK1_1 117 123 PF00069 0.612
MOD_CK1_1 138 144 PF00069 0.582
MOD_CK1_1 150 156 PF00069 0.578
MOD_CK1_1 165 171 PF00069 0.605
MOD_CK1_1 177 183 PF00069 0.586
MOD_CK1_1 189 195 PF00069 0.573
MOD_CK1_1 226 232 PF00069 0.628
MOD_CK1_1 283 289 PF00069 0.653
MOD_CK1_1 307 313 PF00069 0.626
MOD_CK1_1 338 344 PF00069 0.633
MOD_CK1_1 518 524 PF00069 0.352
MOD_CK1_1 528 534 PF00069 0.352
MOD_CK1_1 713 719 PF00069 0.640
MOD_CK1_1 73 79 PF00069 0.596
MOD_CK1_1 738 744 PF00069 0.682
MOD_CK1_1 748 754 PF00069 0.608
MOD_CK1_1 795 801 PF00069 0.662
MOD_CK1_1 847 853 PF00069 0.654
MOD_CK1_1 869 875 PF00069 0.547
MOD_CK1_1 895 901 PF00069 0.783
MOD_CK1_1 99 105 PF00069 0.601
MOD_CK2_1 140 146 PF00069 0.591
MOD_CK2_1 440 446 PF00069 0.304
MOD_CK2_1 566 572 PF00069 0.304
MOD_CK2_1 714 720 PF00069 0.616
MOD_CK2_1 76 82 PF00069 0.593
MOD_CK2_1 803 809 PF00069 0.702
MOD_Cter_Amidation 801 804 PF01082 0.719
MOD_Cter_Amidation 905 908 PF01082 0.662
MOD_GlcNHglycan 140 143 PF01048 0.658
MOD_GlcNHglycan 170 173 PF01048 0.625
MOD_GlcNHglycan 232 235 PF01048 0.670
MOD_GlcNHglycan 252 255 PF01048 0.488
MOD_GlcNHglycan 286 289 PF01048 0.631
MOD_GlcNHglycan 306 309 PF01048 0.661
MOD_GlcNHglycan 311 314 PF01048 0.705
MOD_GlcNHglycan 527 530 PF01048 0.304
MOD_GlcNHglycan 55 58 PF01048 0.671
MOD_GlcNHglycan 621 624 PF01048 0.565
MOD_GlcNHglycan 634 637 PF01048 0.518
MOD_GlcNHglycan 737 740 PF01048 0.782
MOD_GlcNHglycan 764 767 PF01048 0.668
MOD_GlcNHglycan 793 797 PF01048 0.662
MOD_GlcNHglycan 834 837 PF01048 0.674
MOD_GlcNHglycan 888 891 PF01048 0.621
MOD_GlcNHglycan 904 907 PF01048 0.542
MOD_GSK3_1 113 120 PF00069 0.478
MOD_GSK3_1 152 159 PF00069 0.629
MOD_GSK3_1 162 169 PF00069 0.651
MOD_GSK3_1 171 178 PF00069 0.510
MOD_GSK3_1 189 196 PF00069 0.518
MOD_GSK3_1 203 210 PF00069 0.586
MOD_GSK3_1 21 28 PF00069 0.577
MOD_GSK3_1 226 233 PF00069 0.692
MOD_GSK3_1 280 287 PF00069 0.633
MOD_GSK3_1 290 297 PF00069 0.582
MOD_GSK3_1 300 307 PF00069 0.483
MOD_GSK3_1 321 328 PF00069 0.786
MOD_GSK3_1 331 338 PF00069 0.587
MOD_GSK3_1 440 447 PF00069 0.317
MOD_GSK3_1 449 456 PF00069 0.331
MOD_GSK3_1 509 516 PF00069 0.340
MOD_GSK3_1 53 60 PF00069 0.670
MOD_GSK3_1 64 71 PF00069 0.650
MOD_GSK3_1 676 683 PF00069 0.625
MOD_GSK3_1 709 716 PF00069 0.642
MOD_GSK3_1 737 744 PF00069 0.742
MOD_GSK3_1 748 755 PF00069 0.589
MOD_GSK3_1 78 85 PF00069 0.520
MOD_GSK3_1 840 847 PF00069 0.687
MOD_GSK3_1 861 868 PF00069 0.661
MOD_GSK3_1 892 899 PF00069 0.731
MOD_GSK3_1 93 100 PF00069 0.599
MOD_N-GLC_1 326 331 PF02516 0.715
MOD_N-GLC_1 425 430 PF02516 0.325
MOD_N-GLC_1 713 718 PF02516 0.660
MOD_N-GLC_1 892 897 PF02516 0.774
MOD_N-GLC_1 900 905 PF02516 0.646
MOD_NEK2_1 119 124 PF00069 0.615
MOD_NEK2_1 135 140 PF00069 0.598
MOD_NEK2_1 181 186 PF00069 0.729
MOD_NEK2_1 373 378 PF00069 0.205
MOD_NEK2_1 470 475 PF00069 0.334
MOD_NEK2_1 504 509 PF00069 0.328
MOD_NEK2_1 667 672 PF00069 0.580
MOD_NEK2_1 737 742 PF00069 0.646
MOD_NEK2_1 832 837 PF00069 0.617
MOD_NEK2_1 866 871 PF00069 0.579
MOD_NEK2_2 881 886 PF00069 0.653
MOD_PIKK_1 599 605 PF00454 0.304
MOD_PK_1 349 355 PF00069 0.503
MOD_PK_1 444 450 PF00069 0.369
MOD_PKA_1 632 638 PF00069 0.490
MOD_PKA_1 844 850 PF00069 0.640
MOD_PKA_2 122 128 PF00069 0.681
MOD_PKA_2 135 141 PF00069 0.533
MOD_PKA_2 221 227 PF00069 0.643
MOD_PKA_2 250 256 PF00069 0.587
MOD_PKA_2 294 300 PF00069 0.637
MOD_PKA_2 360 366 PF00069 0.304
MOD_PKA_2 597 603 PF00069 0.272
MOD_PKA_2 694 700 PF00069 0.511
MOD_PKA_2 844 850 PF00069 0.640
MOD_PKA_2 886 892 PF00069 0.665
MOD_PKA_2 901 907 PF00069 0.569
MOD_PKA_2 914 920 PF00069 0.791
MOD_PKB_1 347 355 PF00069 0.518
MOD_Plk_1 147 153 PF00069 0.590
MOD_Plk_1 21 27 PF00069 0.482
MOD_Plk_1 325 331 PF00069 0.666
MOD_Plk_1 425 431 PF00069 0.325
MOD_Plk_1 76 82 PF00069 0.593
MOD_Plk_2-3 745 751 PF00069 0.657
MOD_Plk_2-3 93 99 PF00069 0.661
MOD_Plk_4 147 153 PF00069 0.579
MOD_Plk_4 156 162 PF00069 0.578
MOD_Plk_4 226 232 PF00069 0.598
MOD_Plk_4 415 421 PF00069 0.304
MOD_Plk_4 504 510 PF00069 0.333
MOD_Plk_4 515 521 PF00069 0.304
MOD_Plk_4 783 789 PF00069 0.695
MOD_Plk_4 881 887 PF00069 0.635
MOD_Plk_4 99 105 PF00069 0.601
MOD_ProDKin_1 280 286 PF00069 0.597
MOD_ProDKin_1 335 341 PF00069 0.637
MOD_ProDKin_1 513 519 PF00069 0.318
MOD_ProDKin_1 718 724 PF00069 0.824
MOD_ProDKin_1 738 744 PF00069 0.689
MOD_ProDKin_1 752 758 PF00069 0.528
MOD_ProDKin_1 777 783 PF00069 0.759
MOD_ProDKin_1 803 809 PF00069 0.836
MOD_ProDKin_1 822 828 PF00069 0.527
MOD_ProDKin_1 847 853 PF00069 0.649
MOD_ProDKin_1 855 861 PF00069 0.609
MOD_ProDKin_1 867 873 PF00069 0.573
MOD_ProDKin_1 896 902 PF00069 0.662
MOD_SUMO_rev_2 194 204 PF00179 0.641
MOD_SUMO_rev_2 447 456 PF00179 0.308
MOD_SUMO_rev_2 923 927 PF00179 0.607
TRG_ENDOCYTIC_2 183 186 PF00928 0.593
TRG_ENDOCYTIC_2 469 472 PF00928 0.369
TRG_ER_diArg_1 107 110 PF00400 0.569
TRG_ER_diArg_1 131 134 PF00400 0.604
TRG_ER_diArg_1 135 137 PF00400 0.596
TRG_ER_diArg_1 347 350 PF00400 0.539
TRG_ER_diArg_1 35 37 PF00400 0.597
TRG_ER_diArg_1 408 410 PF00400 0.304
TRG_ER_diArg_1 689 691 PF00400 0.531
TRG_ER_diArg_1 801 804 PF00400 0.719
TRG_ER_diArg_1 826 829 PF00400 0.618
TRG_Pf-PMV_PEXEL_1 478 483 PF00026 0.304

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILR5 Leptomonas seymouri 55% 99%
A0A3S7X353 Leishmania donovani 92% 100%
A4HI11 Leishmania braziliensis 80% 100%
A4I588 Leishmania infantum 92% 100%
Q4Q7P6 Leishmania major 91% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS