DUF2040 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0I1_LEIMU

TriTrypDb:

LmxM.29.0560

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.682
CLV_C14_Caspase3-7	82	86	PF00656	0.524
CLV_NRD_NRD_1	122	124	PF00675	0.596
CLV_NRD_NRD_1	163	165	PF00675	0.541
CLV_NRD_NRD_1	244	246	PF00675	0.429
CLV_NRD_NRD_1	288	290	PF00675	0.502
CLV_NRD_NRD_1	89	91	PF00675	0.552
CLV_PCSK_KEX2_1	152	154	PF00082	0.379
CLV_PCSK_KEX2_1	244	246	PF00082	0.429
CLV_PCSK_KEX2_1	288	290	PF00082	0.502
CLV_PCSK_KEX2_1	97	99	PF00082	0.622
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.603
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.622
CLV_PCSK_SKI1_1	245	249	PF00082	0.301
CLV_PCSK_SKI1_1	288	292	PF00082	0.420
CLV_PCSK_SKI1_1	312	316	PF00082	0.432
CLV_PCSK_SKI1_1	45	49	PF00082	0.476
CLV_PCSK_SKI1_1	92	96	PF00082	0.543
DEG_APCC_DBOX_1	301	309	PF00400	0.480
DOC_ANK_TNKS_1	252	259	PF00023	0.491
DOC_CYCLIN_RxL_1	42	52	PF00134	0.520
DOC_MAPK_gen_1	210	219	PF00069	0.497
DOC_MAPK_gen_1	286	293	PF00069	0.437
DOC_MAPK_MEF2A_6	210	219	PF00069	0.497
DOC_MAPK_MEF2A_6	312	319	PF00069	0.465
DOC_USP7_MATH_1	243	247	PF00917	0.472
DOC_USP7_MATH_1	67	71	PF00917	0.390
DOC_USP7_UBL2_3	191	195	PF12436	0.569
DOC_USP7_UBL2_3	265	269	PF12436	0.570
DOC_USP7_UBL2_3	88	92	PF12436	0.591
DOC_WW_Pin1_4	37	42	PF00397	0.518
LIG_14-3-3_CanoR_1	244	254	PF00244	0.435
LIG_14-3-3_CanoR_1	281	285	PF00244	0.332
LIG_Actin_WH2_2	65	83	PF00022	0.502
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_FHA_1	18	24	PF00498	0.454
LIG_FHA_2	114	120	PF00498	0.452
LIG_FHA_2	229	235	PF00498	0.444
LIG_FHA_2	98	104	PF00498	0.722
LIG_LIR_Gen_1	143	150	PF02991	0.536
LIG_LIR_Gen_1	40	51	PF02991	0.447
LIG_LIR_Nem_3	143	148	PF02991	0.511
LIG_LIR_Nem_3	40	46	PF02991	0.517
LIG_LIR_Nem_3	49	54	PF02991	0.441
LIG_LIR_Nem_3	9	15	PF02991	0.523
LIG_PDZ_Class_3	320	325	PF00595	0.535
LIG_SH2_CRK	145	149	PF00017	0.504
LIG_SH2_STAP1	21	25	PF00017	0.529
LIG_SH2_STAP1	43	47	PF00017	0.406
LIG_SH2_STAP1	8	12	PF00017	0.480
LIG_SH2_STAT3	8	11	PF00017	0.568
LIG_SH2_STAT5	8	11	PF00017	0.488
LIG_SH3_2	260	265	PF14604	0.526
LIG_SH3_3	257	263	PF00018	0.519
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.493
LIG_SUMO_SIM_anti_2	303	310	PF11976	0.387
LIG_SUMO_SIM_par_1	303	310	PF11976	0.481
LIG_SUMO_SIM_par_1	46	52	PF11976	0.474
LIG_TRAF2_1	116	119	PF00917	0.540
LIG_TRAF2_1	125	128	PF00917	0.466
LIG_TRAF2_1	232	235	PF00917	0.543
LIG_TRAF2_1	239	242	PF00917	0.506
LIG_UBA3_1	50	56	PF00899	0.485
LIG_WRC_WIRS_1	7	12	PF05994	0.577
MOD_CK1_1	270	276	PF00069	0.482
MOD_CK2_1	113	119	PF00069	0.522
MOD_CK2_1	228	234	PF00069	0.441
MOD_CK2_1	243	249	PF00069	0.388
MOD_CK2_1	265	271	PF00069	0.568
MOD_CK2_1	304	310	PF00069	0.445
MOD_CK2_1	46	52	PF00069	0.479
MOD_GlcNHglycan	1	4	PF01048	0.588
MOD_GlcNHglycan	106	110	PF01048	0.612
MOD_GlcNHglycan	184	187	PF01048	0.772
MOD_GlcNHglycan	203	206	PF01048	0.480
MOD_GlcNHglycan	69	72	PF01048	0.346
MOD_GSK3_1	224	231	PF00069	0.389
MOD_GSK3_1	261	268	PF00069	0.654
MOD_GSK3_1	33	40	PF00069	0.642
MOD_GSK3_1	52	59	PF00069	0.336
MOD_NEK2_1	182	187	PF00069	0.610
MOD_NEK2_1	32	37	PF00069	0.466
MOD_NEK2_1	46	51	PF00069	0.526
MOD_PIKK_1	270	276	PF00454	0.518
MOD_PKA_1	97	103	PF00069	0.627
MOD_PKA_2	243	249	PF00069	0.419
MOD_PKA_2	280	286	PF00069	0.331
MOD_PKA_2	97	103	PF00069	0.588
MOD_Plk_1	270	276	PF00069	0.518
MOD_Plk_2-3	107	113	PF00069	0.683
MOD_Plk_2-3	304	310	PF00069	0.445
MOD_Plk_4	224	230	PF00069	0.323
MOD_Plk_4	304	310	PF00069	0.414
MOD_Plk_4	46	52	PF00069	0.551
MOD_ProDKin_1	37	43	PF00069	0.510
MOD_SUMO_rev_2	55	65	PF00179	0.531
MOD_SUMO_rev_2	85	93	PF00179	0.588
TRG_DiLeu_BaEn_1	213	218	PF01217	0.462
TRG_DiLeu_BaEn_3	213	219	PF01217	0.416
TRG_ENDOCYTIC_2	12	15	PF00928	0.546
TRG_ENDOCYTIC_2	145	148	PF00928	0.508
TRG_ENDOCYTIC_2	43	46	PF00928	0.433
TRG_NLS_MonoExtN_4	188	194	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM18	Leptomonas seymouri	70%	100%
A0A3Q8IFH1	Leishmania donovani	95%	100%
A0A422NIF5	Trypanosoma rangeli	38%	99%
A4HI07	Leishmania braziliensis	85%	100%
A4I584	Leishmania infantum	95%	100%
Q4Q7Q0	Leishmania major	94%	100%
V5AS86	Trypanosoma cruzi	36%	98%